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725 results on '"Studer, R."'

1. WS05.02 A novel uniquely efficacious type of CFTR corrector with complementary mode of action

Author

Marchesin, V., primary, Monnier, L., additional, Blattmann, P., additional, Chevillard, F., additional, Kuntz, C., additional, Forny, C., additional, Kamper, J., additional, Studer, R., additional, Bossu, A., additional, Ertel, E.A., additional, Nayler, O., additional, Brotschi, C., additional, Williams, J.T., additional, and Gatfield, J., additional

Published
2024
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3. Essential Bacillus subtilis Genes

Author

Kobayashi, K., Ehrlich, S. D., Albertini, A., Amati, G., Andersen, K. K., Arnaud, M., Asai, K., Ashikaga, S., Aymerich, S., Bessieres, P., Boland, F., Brignell, S. C., Bron, S., Bunai, K., Chapuis, J., Christiansen, L. C., Danchin, A., Débarbouillé, M., Dervyn, E., Deuerling, E., Devine, K., Devine, S. K., Dreesen, O., Errington, J., Fillinger, S., Foster, S. J., Fujita, Y., Galizzi, A., Gardan, R., Eschevins, C., Fukushima, T., Haga, K., Harwood, C. R., Hecker, M., Hosoya, D., Hullo, M. F., Kakeshita, H., Karamata, D., Kasahara, Y., Kawamura, F., Koga, K., Koski, P., Kuwana, R., Imamura, D., Ishimaru, M., Ishikawa, S., Ishio, I., Le Coq, D., Masson, A., Mauël, C., Meima, R., Mellado, R. P., Moir, A., Moriya, S., Nagakawa, E., Nanamiya, H., Nakai, S., Nygaard, P., Ogura, M., Ohanan, T., O'Reilly, M., O'Rourke, M., Pragai, Z., Pooley, H. M., Rapoport, G., Rawlins, J. P., Rivas, L. A., Rivolta, C., Sadaie, A., Sadaie, Y., Sarvas, M., Sato, T., Saxild, H. H., Scanlan, E., Schumann, W., Sekiguchi, J., Sekowska, A., Séror, S. J., Simon, M., Stragier, P., Studer, R., Takamatsu, H., Tanaka, T., Takeuchi, M., Thomaides, H. B., Vagner, V., van Dijl, J. M., Watabe, K., Wipat, A., Yamamoto, H., Yamamoto, M., Yamamoto, Y., Yamane, K., Yata, K., Yoshida, K., Yoshikawa, H., Zuber, U., and Ogasawara, N.

Published
2003

4. Lessons Learned from Flight Observations of the GOES-R Magnetometer

Author

Schnurr, R, Bonalsky, T, Todirita, M, Kronenwetter, J, Early, D, Grotenhuis, M, Studer, R, Carter, D, Dence, R, Wolf, M, and Mandi, J

Subjects
Earth Resources And Remote Sensing
Abstract

The Geostationary Operational Environmental Satellite (GOES)-16 observatory was launched on 19 November 2016. During daily on-orbit operations, shadowing of the inboard magnetometer sensor unit occurs due to spacecraft geometry and solar angle. Throughout the shadowing periods of the inboard magnetometer, anomalous excursions of 20 nanotesla (nT) are observed. In addition to the excursions during shadow events, the measurement difference between the inboard and outboard magnetometer varies over the day, indicating erroneous measurements by one or both magnetometers. In addition, based on the deployment rotations, the zero offsets of the X and Y axes were found to be significantly different, ~30nT, from ground calibration data. Because of these observations, an extensive root cause investigation was undertaken to correct the magnetometer system for the next spacecraft in the GOES-R series. This paper documents the efforts of that activity and the lessons learned as a result of the investigation.

Published
2019

5. Real-world effectiveness and safety of sacubitril/valsartan in heart failure: A systematic review

Author

Proudfoot, C, Studer, R, Rajput, T, Jindal, R, Agrawal, R, Corda, S, Senni, M, Proudfoot C, Studer R, Rajput T, Jindal R, Agrawal R, Corda S, Senni M, Proudfoot, C, Studer, R, Rajput, T, Jindal, R, Agrawal, R, Corda, S, Senni, M, Proudfoot C, Studer R, Rajput T, Jindal R, Agrawal R, Corda S, and Senni M

Abstract

Background: PARADIGM-HF demonstrated superiority of sacubitril/valsartan (sac/val) over enalapril in patients with heart failure with reduced ejection fraction (HFrEF). However, patients in clinical practice may differ in their characteristics and overall risk compared with patients in clinical trials, and additional outcomes can be observed in real world (RW). Hence, a systematic review was conducted to identify and describe RW data on sac/val. Methods: RW studies evaluating the effects of sac/val in adult patients with HFrEF with a sample size ≥100 were identified via MEDLINE® and Embase® from 2015 to January 2020. Citations were screened, critically appraised and relevant data were extracted. Results: A total of 68 unique studies were identified. Nearly half of the studies were conducted in Europe (n = 34), followed by the US (n = 15) and Asia (n = 11). Median follow-up period varied from 1 to 19 months. Mean age ranged between 48.7 and 79.0 years; patients were mostly male and in New York Heart Association (NYHA) functional class II/III, and mean left ventricular ejection fraction varied between 23%and 38%. Of studies performing comparisons, most reported superior efficacy of sac/val in reducing the risk of HF hospitalisations, all-cause hospitalisations, and all-cause mortality as compared to standard-of-care. Many studies reported significant improvements in NYHA functional class and reduction in biomarker levels post sac/val. Hypotension and hyperkalaemia were the most frequently reported adverse events. Conclusions: This comprehensive overview of currently available RW evidence on sac/val complements the evidence from randomised controlled trials, substantiating its effectiveness in heterogeneous real-world HF populations.

Published
2021

12. Touching Strands of the Educational Web: The Professional School Counselor's Role in Inclusion.

Author

Quigney, Theresa A. and Studer, R.

Abstract

The school counselor is a logical choice for leadership in making "inclusion" a successful experience for those involved. Counselors' active involvement in networking among students, educational professionals, families, community, and social agencies should work toward the realization of many of the goals of inclusive education and inclusive society. (EMK)

Published
1998

21. Lithiases et sténoses salivaires. Une classification pratique des pathologies non tumorales

Author

Marchal, F., Chossegros, C., Faure, F., Delas, B., Bizeau, A., Mortensen, B., Schaitkin, B., Buchwald, C., Cenjor, C., Yu, C., Campisi, D., Eisele, D., Greger, D., Trikeriotis, D., Pabst, G., Kolenda, J., Hagemann, M., Tarabichi, M., Guntinas-Lichius, O., Homoe, P., Carrau, R., Irvine, R., Studer, R., Wang, S., Fischer, U., Van der Poorten, V., Saban, Y., and Barki, G.

Published
2009
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23. Outgassing Characterization of Rod Heaters Used for GOES-R Thermal Vacuum Testing

Author

Brieda, L, Gordon, T, Studer, R, Pfeiffer, R, Bush, J, and Van Loon, S

Subjects
Ground Support Systems And Facilities (Space)
Abstract

This talk summarizes experimental effort to characterize the outgassing rate of rod heaters (Watrods) used for GOES-R thermal vacuum testing. QCM data obtained with unbaked rods indicated that the outgassing exceeded the allowable budget. We then pre-baked the watrods for 16 hours at ambient pressure and determined that pre-baking reduced the amount of outgassed material by a factor of 4.

Published
2015

24. Salivary stones and stenosis. A comprehensive classification

Author

Marchal, F., Chossegros, C., Faure, F., Delas, B., Bizeau, A., Mortensen, B., Schaitkin, B., Buchwald, C., Cenjor, C., Yu, C., Campisi, D., Eisele, D., Greger, D., Trikeriotis, D., Pabst, G., Kolenda, J., Hagemann, M., Tarabichi, M., Guntinas-Lichius, O., Homoe, P., Carrau, R., Irvine, R., Studer, R., Wang, S., Fischer, U., Van der Poorten, V., Saban, Y., and Barki, G.

Published
2008
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28. The NOAA Goes-12 Solar X-Ray Imager (SXI) 1. Instrument, Operations, and Data

Author

Hill, S. M., Pizzo, V. J., Balch, C. C., Biesecker, D. A., Bornmann, P., Hildner, E., Lewis, L. D., Grubb, R. N., Husler, M. P., Prendergast, K., Vickroy, J., Greer, S., Defoor, T., Wilkinson, D. C., Hooker, R., Mulligan, P., Chipman, E., Bysal, H., Douglas, J. P., Reynolds, R., Davis, J. M., Wallace, K. S., Russell, K., Freestone, K., Bagdigian, D., Page, T., Kerns, S., Hoffman, R., Cauffman, S. A., Davis, M. A., Studer, R., Berthiaume, F. E., Saha, T. T., Berthiume, G. D., Farthing, H., and Zimmermann, F.

Published
2005
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29. A schizophrenia-related sensorimotor deficit links [alpha]3-containing [GABA.sub.A] receptors to a dopamine hyperfunction

Author

Yee, B.K., Keist, R., von Boehmer, L., Studer, R., Benke, D., Hagenbuch, N., Dong, Y., Malenka, R.C., Fritschy, J.-M., Bluethmann, H., Feldon, J., Mohler, H., and Rudolph, U.

Subjects
Schizophrenia -- Genetic aspects, Sensorimotor integration -- Analysis, Science and technology
Abstract

Overactivity of the dopaminergic system in the brain is considered to be a contributing factor to the development and symptomatology of schizophrenia. Therefore, the GABAergic control of dopamine functions was assessed by disrupting the gene encoding the [alpha]3 subunit of the GAB[A.sub.A] receptor. [alpha]3 knockout ([alpha]3KO) mice exhibited neither an obvious developmental defect nor apparent morphological brain abnormalities, and there was no evidence for compensatory up-regulation of other major GAB[A.sub.A]-receptor subunits. Anxiety-related behavior in the elevated-plus-maze test was undisturbed, and the anxiolytic-like effect of diazepam, which is mediated by [alpha]2-containing GAB[A.sub.A] receptors, was preserved. As a result of the loss of [alpha]3 GAB[A.sub.A] receptors, the GABA-induced whole-cell current recorded from midbrain dopamine neurons was significantly reduced. Spontaneous locomotor activity was slightly elevated in [alpha]3KO mice. Most notably, prepulse inhibition of the acoustic startle reflex was markedly attenuated in the [alpha]3KO mice, pointing to a deficit in sensorimotor information processing. This deficit was completely normalized by treatment with the antipsychotic D2-receptor antagonist haloperidol. The amphetamine-induced hyperlocomotion was not altered in [alpha]3KO mice compared with WT mice. These results suggest that the absence of [alpha]3-subunit-containing GAB[A.sub.A] receptors induces a hyperdopaminergic phenotype, including a severe deficit in sensorimotor gating, a common feature among psychiatric conditions, including schizophrenia. Hence, agonists acting at [alpha]3-containing GAB[A.sub.A] receptors may constitute an avenue for an effective treatment of sensorimotor-gating deficits in various psychiatric conditions. haloperidol | sensorimotor gating

Published
2005

43. PCV28 CHARACTERIZATION OF COSTS AND PATIENTS WITH INCIDENT HEART FAILURE (HF) INCURRING THE HIGHEST HEALTHCARE COSTS FROM SECONDARY CARE: A RETROSPECTIVE, POPULATION-BASED COHORT STUDY IN SWEDEN

Author

Boman, K., primary, Lindmark, K., additional, Olofsson, M., additional, Stålhammar, J., additional, Fonseca, A.F., additional, Lahoz, R., additional, Studer, R., additional, Costa-Scharplatz, M., additional, Calado, F., additional, Castelo-branco, A., additional, Johansson, S., additional, Heller, V., additional, Törnblom, M., additional, and Wikström, G., additional

Published
2019
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