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Your search keyword '"Stuhlmann-Laeisz, Christiane"' showing total 18 results
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18 results on '"Stuhlmann-Laeisz, Christiane"'

1. Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas: Molecular Diagnostics

Author

Stögbauer, Fabian, Wirth, Markus, Lauterbach, Maren, Wollenberg, Barbara, Schmidl, Benedikt, Hoch, Cosima C., Ourailidis, Iordanis, Hess, Jochen, Eckstein, Markus, Hartmann, Arndt, Iro, Heinrich, Gostian, Antoniu-Oreste, Balk, Matthias, Jesinghaus, Moritz, Ribbat-Idel, Julika, Sailer, Verena-Wilbeth, Perner, Sven, Bruchhage, Karl-Ludwig, Hoffmann, Markus, Lükewille, Lukas, Stuhlmann-Laeisz, Christiane Maria, Röcken, Christoph, Mogler, Carolin, Budczies, Jan, and Boxberg, Melanie

Published
2025
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9. Ectopic pregnancy in noncommunicating horn of unicornuate uterus: 3D‐ultrasound and primary laparoscopic management

Author

Dhanawat, Juhi, Pape, Julian, Stuhlmann‐Laeisz, Christiane, Maass, Nicolai, Freytag, Damaris, Gitas, Georgios, and Alkatout, Ibrahim

Subjects
unicornuate uterus, rudimentary horn pregnancy, Medicine (General), R5-920, 3D ultrasound, laparoscopy, Medicine, Case Report, Case Reports
Abstract

Unicornuate uterus with pregnancy in the noncommunicating rudimentary horn is extremely rare. Diagnosis requires awareness, high suspicion index, 3D ultrasound, and MRI. If missed, it can be catastrophic. Treatment varies across literature. We present a case where detection was done by 3D ultrasound and primary laparoscopic surgery done for treatment., All pregnant women should be eyed with suspicion of a mullerian anomaly and ectopic pregnancy. Being aware is the key to avoid catastrophes. A good ultrasound, 2D with 3D confirms diagnosis. Laparoscopic intervention is a good treatment choice.

Published
2021

10. Localized immunoglobulin light chain amyloidosis: Novel insights including prognostic factors for local progression

Author

Basset, Marco, primary, Hummedah, Kamal, additional, Kimmich, Christoph, additional, Veelken, Kaya, additional, Dittrich, Tobias, additional, Brandelik, Simone, additional, Kreuter, Michael, additional, Hassel, Jessica, additional, Bosch, Nikolaus, additional, Stuhlmann‐Laeisz, Christiane, additional, Blank, Norbert, additional, Müller‐Tidow, Carsten, additional, Röcken, Christoph, additional, Hegenbart, Ute, additional, and Schönland, Stefan, additional

Published
2020
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15. Reproducibility of Her2/neu scoring in gastric cancer and assessment of the 10% cut‐off rule

Author

Behrens, Hans‐Michael, primary, Warneke, Viktoria S., additional, Böger, Christine, additional, Garbrecht, Nele, additional, Jüttner, Eva, additional, Klapper, Wolfram, additional, Mathiak, Micaela, additional, Oschlies, Ilske, additional, Rudolph, Ursula, additional, Stuhlmann‐Laeisz, Christiane, additional, Trick, David, additional, Röcken, Christoph, additional, and Hufnagl, Peter, additional

Published
2014
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17. Forced Dimerization of gp130 Leads to Constitutive STAT3 Activation, Cytokine-independent Growth, and Blockade of Differentiation of Embryonic Stem Cells

Author

Stuhlmann-Laeisz, Christiane, primary, Lang, Sigrid, additional, Chalaris, Athena, additional, Krzysztof, Paliga, additional, Enge, Sudarman, additional, Eichler, Jutta, additional, Klingmüller, Ursula, additional, Samuel, Michael, additional, Ernst, Matthias, additional, Rose-John, Stefan, additional, and Scheller, Jürgen, additional

Published
2006
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18. Reproducibility of Her2/neu scoring in gastric cancer and assessment of the 10% cut-off rule.

Author

Behrens, Hans‐Michael, Warneke, Viktoria S., Böger, Christine, Garbrecht, Nele, Jüttner, Eva, Klapper, Wolfram, Mathiak, Micaela, Oschlies, Ilske, Rudolph, Ursula, Stuhlmann‐Laeisz, Christiane, Trick, David, Röcken, Christoph, and Hufnagl, Peter

Subjects
TRASTUZUMAB, IMMUNOSTAINING, GASTRIC mucosa, IMMUNOHISTOCHEMISTRY, VIRTUAL microscopy, TUMORS
Abstract

The application of Trastuzumab on gastric cancer patients is based on Her2/neu immunostaining. The testing method relies on visual estimation of both membranous staining intensity, and positive tumor ratio with respect to a 10% cutoff. We evaluated the effect of inter- and intraobserver variations of both factors on therapeutic decision, especially if the positive tumor ratio hovers around the 10% cutoff. Ten pathologists scored 12 Her2/neu immunohistologically stained whole sections of gastric cancer. Applying the common rules for Her2/neu testing for gastric cancer, they separately noted the strongest identifiable staining intensity and the corresponding positive tumor ratio. Scoring was done repeatedly using the microscope, plain virtual microscopy, and virtual microscopy with a manual outline drawing function. Agreements on the strongest identified staining intensities were moderate. Overall concordance correlation coefficients of positive tumor ratios ranged from 0.55 to 0.81. Reproducibility was not improved by virtual microscopy. Pathologists have a good ability to estimate ratios of clearly demarcated areas, but gradients in staining intensities hinder reproducible visual demarcation of positive tumor areas. When hovering around the 10% positive tumor ratio cutoff there is a risk of misinterpretation of the staining results. This could lead to a denial of Trastuzumab therapy. Assessment of Her2/neu expression should be carried out by experienced pathologists because they can more reproducibly rate membranous staining intensities. The low reproducibility of positive tumor ratio is inherent in the testing method and cannot be improved by virtual microscopy. Therefore, we propose to reconsider the 10% cut-off limit. [ABSTRACT FROM AUTHOR]

Published
2015
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