Search

Your search keyword '"Sturm, Nathalie"' showing total 403 results
Start Over Author "Sturm, Nathalie"
403 results on '"Sturm, Nathalie"'

1. PIT-EASY survey: validation of the European Pituitary Pathology Group proposal for reporting pituitary neuroendocrine tumors

Author

Birtolo, Maria Francesca, Jouinot, Anne, Vasiljevic, Alexandre, Boulagnon-Rombi, Camille, Asioli, Sofia, Bousdira, Ghizelaine, Tetka, Louise Marie Mboua, Perbet, Romain, Maurage, Claude-Alain, Appay, Romain, Figarella-Branger, Dominique, Gauchotte, Guillaume, Sturm, Nathalie, Baussart, Bertrand, Roncaroli, Federico, Bertherat, Jérôme, Brue, Thierry, and Villa, Chiara

Published
2024
Full Text
View/download PDF

3. Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

Author

Calderaro, Julien, Ghaffari Laleh, Narmin, Zeng, Qinghe, Maille, Pascale, Favre, Loetitia, Pujals, Anaïs, Klein, Christophe, Bazille, Céline, Heij, Lara R., Uguen, Arnaud, Luedde, Tom, Di Tommaso, Luca, Beaufrère, Aurélie, Chatain, Augustin, Gastineau, Delphine, Nguyen, Cong Trung, Nguyen-Canh, Hiep, Thi, Khuyen Nguyen, Gnemmi, Viviane, Graham, Rondell P., Charlotte, Frédéric, Wendum, Dominique, Vij, Mukul, Allende, Daniela S., Aucejo, Federico, Diaz, Alba, Rivière, Benjamin, Herrero, Astrid, Evert, Katja, Calvisi, Diego Francesco, Augustin, Jérémy, Leow, Wei Qiang, Leung, Howard Ho Wai, Boleslawski, Emmanuel, Rela, Mohamed, François, Arnaud, Cha, Anthony Wing-Hung, Forner, Alejandro, Reig, Maria, Allaire, Manon, Scatton, Olivier, Chatelain, Denis, Boulagnon-Rombi, Camille, Sturm, Nathalie, Menahem, Benjamin, Frouin, Eric, Tougeron, David, Tournigand, Christophe, Kempf, Emmanuelle, Kim, Haeryoung, Ningarhari, Massih, Michalak-Provost, Sophie, Gopal, Purva, Brustia, Raffaele, Vibert, Eric, Schulze, Kornelius, Rüther, Darius F., Weidemann, Sören A., Rhaiem, Rami, Pawlotsky, Jean-Michel, Zhang, Xuchen, Luciani, Alain, Mulé, Sébastien, Laurent, Alexis, Amaddeo, Giuliana, Regnault, Hélène, De Martin, Eleonora, Sempoux, Christine, Navale, Pooja, Westerhoff, Maria, Lo, Regina Cheuk-Lam, Bednarsch, Jan, Gouw, Annette, Guettier, Catherine, Lequoy, Marie, Harada, Kenichi, Sripongpun, Pimsiri, Wetwittayaklang, Poowadon, Loménie, Nicolas, Tantipisit, Jarukit, Kaewdech, Apichat, Shen, Jeanne, Paradis, Valérie, Caruso, Stefano, and Kather, Jakob Nikolas

Published
2023
Full Text
View/download PDF

6. Validation of the Blood Test MACK-3 for the Noninvasive Diagnosis of Fibrotic Nonalcoholic Steatohepatitis: An International Study With 1924 Patients

Author

Canivet, Clémence M., Zheng, Ming-Hua, Qadri, Sami, Vonghia, Luisa, Chuah, Kee-Huat, Costentin, Charlotte, George, Jacob, Armandi, Angelo, Adams, Leon A., Lange, Naomi F., Blanchet, Odile, Moal, Valérie, Younes, Ramy, Roux, Marine, Chan, Wah-Kheong, Sturm, Nathalie, Eslam, Mohammed, Bugianesi, Elisabetta, Wang, Zhengyi, Dufour, Jean-François, Francque, Sven, Yki-Järvinen, Hannele, Zheng, Kenneth I., and Boursier, Jérôme

Published
2023
Full Text
View/download PDF

8. Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications

Author

Boursier, Jérôme, Canivet, Clémence M., Costentin, Charlotte, Lannes, Adrien, Delamarre, Adèle, Sturm, Nathalie, Le Bail, Brigitte, Michalak, Sophie, Oberti, Frédéric, Hilleret, Marie-Noelle, Irles-Depé, Marie, Fouchard, Isabelle, Hermabessiere, Paul, Barthelon, Justine, Calès, Paul, Cariou, Bertrand, de Ledinghen, Victor, and Roux, Marine

Published
2023
Full Text
View/download PDF

9. Nestin as a diagnostic and prognostic marker for combined hepatocellular-cholangiocarcinoma

Author

Calderaro, Julien, Di Tommaso, Luca, Maillé, Pascale, Beaufrère, Aurélie, Nguyen, Cong Trung, Heij, Lara, Gnemmi, Viviane, Graham, Rondell P., Charlotte, Frédéric, Chartier, Suzanne, Wendum, Dominique, Vij, Mukul, Allende, Daniela, Diaz, Alba, Fuster, Carla, Rivière, Benjamin, Herrero, Astrid, Augustin, Jérémy, Evert, Katja, Calvisi, Diego Francesco, Leow, Wei Qiang, Leung, Howard Ho Wai, Bednarsch, Jan, Boleslawski, Emmanuel, Rela, Mohamed, Chan, Anthony Wing-Hung, Forner, Alejandro, Reig, Maria, Pujals, Anaïs, Favre, Loetitia, Allaire, Manon, Scatton, Olivier, Uguen, Arnaud, Trépo, Eric, Sanchez, Lukas Otero, Chatelain, Denis, Remmelink, Myriam, Boulagnon-Rombi, Camille, Bazille, Céline, Sturm, Nathalie, Menahem, Benjamin, Frouin, Eric, Tougeron, David, Tournigand, Christophe, Kempf, Emmanuelle, Kim, Haeryoung, Ningarhari, Massih, Michalak-Provost, Sophie, Kather, Jakob Nikolas, Gouw, Annette S.H., Gopal, Purva, Brustia, Raffaele, Vibert, Eric, Schulze, Kornelius, Rüther, Darius F., Weidemann, Sören A., Rhaiem, Rami, Nault, Jean-Charles, Laurent, Alexis, Amaddeo, Giuliana, Regnault, Hélène, de Martin, Eleonora, Sempoux, Christine, Navale, Pooja, Shinde, Jayendra, Bacchuwar, Ketan, Westerhoff, Maria, Lo, Regina Cheuk-Lam, Sebbagh, Mylène, Guettier, Catherine, Lequoy, Marie, Komuta, Mina, Ziol, Marianne, Paradis, Valérie, Shen, Jeanne, and Caruso, Stefano

Published
2022
Full Text
View/download PDF

11. Contributors

Author

Abdoli, Amir, primary, Andersen, Catherine J., additional, Badirzadeh, Alireza, additional, Banday, Aaqib Zaffar, additional, Barbosa, Arsénio, additional, Barnie, Prince Amoah, additional, Baron, Byron, additional, Bellengier, Cécilia, additional, Bjourson, Anthony J., additional, Bogdanos, Dimitrios P., additional, Borges, Tiago, additional, Dardiotis, Efthymios, additional, Duez, Hélène, additional, Egan, Phil, additional, Falak, Reza, additional, Farrugia, Mark, additional, Gibson, David S., additional, Greco, Julia M., additional, Guo, Guangran, additional, Habibi-Anbouhi, Mahdi, additional, Hajizadeh-Saffar, Ensiyeh, additional, Huard, Bertrand, additional, Izadi, Zhila, additional, Jahangir, Shahrbanoo, additional, Jindal, Ankur Kumar, additional, Kelly, Catriona, additional, Lapsley, Coral R., additional, Lin, Xia, additional, Martin, Chloe A., additional, Martins, Luísa Sales, additional, Matchett, Kyle B., additional, Mavropoulos, Athanasios, additional, McAllister, Roisin, additional, McClean, Paula, additional, McGilligan, Victoria, additional, Meamar, Ahmadreza, additional, Mirjalili, Seyedeh Zohreh, additional, Mojtabavi, Nazanin, additional, Murray, Elaine K., additional, de Oliveira, Gislane Lelis Vilela, additional, Pourcet, Benoit, additional, Pradhan, Madhulika, additional, Rai, Taranjit Singh, additional, Ramos, Stephan, additional, Rezaei, Nima, additional, Rodrigues, Guilherme Siqueira Pardo, additional, Russ, Holger A., additional, Sabourian, Reyhaneh, additional, Sakkas, Lazaros I., additional, de Salis, Larissa Vedovato Vilela, additional, Silva, Sérgio, additional, Singh, Deependra, additional, Singh, Manju Rawat, additional, Sitar, Mustafa Erinç, additional, Sturm, Nathalie, additional, Tobón, Gabriel J., additional, Tyagi, Rahul, additional, Vivas, Álvaro J., additional, Yadav, Krishna, additional, Yazdanpanah, Niloufar, additional, Zafiriou, Efterpi, additional, Zeydabadinejad, Sareh, additional, and Zhaoliang, Su, additional

Published
2022
Full Text
View/download PDF

14. Discontinuation of Drug Treatment in Cushing's Disease Not Cured by Pituitary Surgery.

Author

Ghalawinji, Adel, Drezet, Lucas, Chaffanjon, Philippe, Muller, Marie, Sturm, Nathalie, Simiand, Anna, Lazard, Arnaud, Gay, Emmanuel, Chabre, Olivier, and Cristante, Justine

Abstract

Objective When transsphenoidal surgery (TSS) does not cure Cushing's disease (CD), 4 treatments are available: drug treatment (DT), second TSS (2nd TSS), bilateral adrenalectomy (BA), and pituitary radiotherapy (PR). DT is attractive but supposes long-term continuation, which we aimed to evaluate. Design and Methods Retrospective study, in a center prioritizing 2nd TSS, of 36 patients, including 19 with TSS failure and 17 with recurrence, out of 119 patients with CD treated by a first TSS, average follow-up 6.1 years (95% confidence interval 5.27-6.91). Control was defined as normalization of urinary free cortisol (UFC) and final treatment (FT) as the treatment allowing control at last follow-up. We also analyzed discontinuation rates of DT in published CD prospective clinical trials. Results Control was achieved in 33/36 patients (92%). DT was initiated in 29/36 patients (81%), allowing at least 1 normal UFC in 23/29 patients (79%) but was discontinued before last follow-up in 18/29 patients (62%). DT was FT in 11/29 patients (38%), all treated with cortisol synthesis inhibitors. Second TSS was FT in 8/16 (50%), BA in 14/14 (100%), and PR in 0/5. In published trials, discontinuation of DT was 11% to 51% at 1 year and 32% to 74% before 5 years. Conclusion DT allowed at least 1 normal UFC in 23/29 patients (79%) but obtained long-term control in only 11/29 (38%), as discontinuation rate was high, although similar to published data. Interestingly, a successful 2nd TSS was the cause for discontinuing efficient and well-tolerated DT in 5 patients. Further studies will show whether different strategies with cortisol synthesis inhibitors may allow for a lower discontinuation rate in patients not candidates for a 2nd TSS so that BA may be avoided in these patients. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

17. Clinicopathological description of 43 oncocytic adrenocortical tumors: importance of Ki-67 in histoprognostic evaluation

Author

Renaudin, Karine, Smati, Sarra, Wargny, Matthieu, Al Ghuzlan, Abir, Aubert, Sébastien, Leteurtre, Emmanuelle, Patey, Martine, Sibony, Mathilde, Sturm, Nathalie, Tissier, Frédérique, Amar, Laurence, Bertherat, Jérôme, Berthozat, Claudine, Chabre, Olivier, Do Cao, Christine, Haissaguerre, Magalie, Pierre, Peggy, Briet, Claire, Vezzosi, Delphine, Lifante, Jean Christophe, Pattou, François, Mirallie, Eric, Baudin, Eric, Cariou, Bertrand, Libe, Rossella, and Drui, Delphine

Published
2018
Full Text
View/download PDF

19. Practical diagnosis of cirrhosis by liver specialists in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests

Author

Boursier, Jerome, primary, Roux, Marine, additional, Costentin, Charlotte, additional, Chaigneau, Julien, additional, Fournier-Poizat, Céline, additional, Trylesinski, Aldo, additional, Canivet, Clémence M, additional, Michalak, Sophie, additional, Le Bail, Brigitte, additional, Paradis, Valérie, additional, Bedossa, Pierre, additional, Sturm, Nathalie, additional, de Lédinghen, Victor, additional, and Newsome, Philip N, additional

Published
2023
Full Text
View/download PDF

20. Sarcomatoid adrenocortical carcinoma: a comprehensive pathological, immunohistochemical, and targeted next-generation sequencing analysis

Author

Papathomas, Thomas G., Duregon, Eleonora, Korpershoek, Esther, Restuccia, David F., van Marion, Ronald, Cappellesso, Rocco, Sturm, Nathalie, Rossi, Giulio, Coli, Antonella, Zucchini, Nicola, Stoop, Hans, Oosterhuis, Wolter, Ventura, Laura, Volante, Marco, Fassina, Ambrogio, Dinjens, Winand N.M., Papotti, Mauro, and de Krijger, Ronald R.

Published
2016
Full Text
View/download PDF

22. Supplementary Figure S3 from CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL

Author

Manfroi, Benoit, primary, McKee, Thomas, primary, Mayol, Jean Francois, primary, Tabruyn, Sebastien, primary, Moret, Sebastien, primary, Villiers, Christian, primary, Righini, Christian, primary, Dyer, Martin, primary, Callanan, Mary, primary, Schneider, Pascal, primary, Tzankov, Alexandar, primary, Matthes, Thomas, primary, Sturm, Nathalie, primary, and Huard, Bertrand, primary

Published
2023
Full Text
View/download PDF

23. Data from CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL

Author

Manfroi, Benoit, primary, McKee, Thomas, primary, Mayol, Jean Francois, primary, Tabruyn, Sebastien, primary, Moret, Sebastien, primary, Villiers, Christian, primary, Righini, Christian, primary, Dyer, Martin, primary, Callanan, Mary, primary, Schneider, Pascal, primary, Tzankov, Alexandar, primary, Matthes, Thomas, primary, Sturm, Nathalie, primary, and Huard, Bertrand, primary

Published
2023
Full Text
View/download PDF

24. Data from Association of CYP1B1 Germ Line Mutations with Hepatocyte Nuclear Factor 1α–Mutated Hepatocellular Adenoma

Author

Jeannot, Emmanuelle, primary, Poussin, Karine, primary, Chiche, Laurence, primary, Bacq, Yannick, primary, Sturm, Nathalie, primary, Scoazec, Jean-Yves, primary, Buffet, Catherine, primary, Nhieu, Jeanne Tran Van, primary, Bellanné-Chantelot, Christine, primary, de Toma, Claudia, primary, Laurent-Puig, Pierre, primary, Bioulac-Sage, Paulette, primary, and Zucman-Rossi, Jessica, primary

Published
2023
Full Text
View/download PDF

25. Supplementary Table 1 from Association of CYP1B1 Germ Line Mutations with Hepatocyte Nuclear Factor 1α–Mutated Hepatocellular Adenoma

Author

Jeannot, Emmanuelle, primary, Poussin, Karine, primary, Chiche, Laurence, primary, Bacq, Yannick, primary, Sturm, Nathalie, primary, Scoazec, Jean-Yves, primary, Buffet, Catherine, primary, Nhieu, Jeanne Tran Van, primary, Bellanné-Chantelot, Christine, primary, de Toma, Claudia, primary, Laurent-Puig, Pierre, primary, Bioulac-Sage, Paulette, primary, and Zucman-Rossi, Jessica, primary

Published
2023
Full Text
View/download PDF

26. Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues

Author

Giovannini, Diane, primary, Belbezier, Aude, additional, Baillet, Athan, additional, Bouillet, Laurence, additional, Kawano, Mitsuhiro, additional, Dumestre-Perard, Chantal, additional, Clavarino, Giovanna, additional, Noble, Johan, additional, Pers, Jacques-Olivier, additional, Sturm, Nathalie, additional, and Huard, Bertrand, additional

Published
2023
Full Text
View/download PDF

28. Validation of the blood test MACK-3 for the noninvasive diagnosis of fibrotic NASH: an international study with 1,924 patients

Author

Canivet, Clémence M, Zheng, Ming-Hua, Qadri, Sami, Vonghia, Luisa, Chuah, Kee-Huat, Costentin, Charlotte, George, Jacob, Armandi, Angelo, Adams, Leon A, Lange, Naomi F, Blanchet, Odile, Moal, Valérie, Younes, Ramy, Roux, Marine, Chan, Wah-Kheong, Sturm, Nathalie, Eslam, Mohammed, Bugianesi, Elisabetta, Wang, Zhengyi, Dufour, Jean-François, Francque, Sven, Yki-Järvinen, Hannele, Zheng, Kenneth I, and Boursier, Jérôme

Subjects
610 Medizin und Gesundheit
Abstract

BACKGROUND AND AIMS Drug development in NASH is hampered by a high screening failure rate that reaches 60-80% in therapeutic trials, mainly because of the absence of fibrotic NASH on baseline liver histology. MACK-3, a blood test including three biomarkers (aspartate aminotransferase, homeostasis model assessment and cytokeratin 18), was recently developed for the noninvasive diagnosis of fibrotic NASH. We aimed to validate the diagnostic accuracy of this noninvasive test in an international multicenter study. METHODS 1,924 patients with biopsy-proven NAFLD from 10 centers in Asia, Australia, and Europe were included. The blood test MACK-3 was calculated for all patients. FAST, an elastography-based test for fibrotic NASH, was also available in a subset of 655 patients. Fibrotic NASH was defined as the presence of NASH on liver biopsy with NAFLD Activity Score ≥4 and fibrosis stage F≥2 according to the NASH CRN scoring system. RESULTS AUROC of MACK-3 for fibrotic NASH was 0.791 [0.768-0.814]. Sensitivity at the previously published MACK-3 threshold of 0.549 threshold was 85%. The MACK-3 AUROC was not affected by age, sex, diabetes, or BMI. MACK-3 and FAST results were well correlated (Rs=0.781, P < .001). Except an 8% higher rate of patients included in the grey zone, MACK-3 provided similar accuracy to that of FAST. Both tests included 27% of patients in their rule-in zone, with 85% specificity and 35% false positives (screen failure rate). CONCLUSION The blood test MACK-3 is an accurate tool to improve patient selection in NASH therapeutic trials.

Published
2023
Full Text
View/download PDF

31. Management of a Composite Pheochromocytoma (Pheochromocytoma/Neuroblastoma) in Adult Patient Recurring After Several Years: A Complex Case Report.

Author

Magnier, Orlane, Chabre, Olivier, Schiff, Isabelle, Sartelet, Hervé, Combaret, Valérie, Roux, Julie, Sturm, Nathalie, Berthozat, Claudine, Pavillet, Julien, and Plantaz, Dominique

Subjects
NEUROBLASTOMA, BIOPSY, CANCER relapse, METASTASIS, BONE tumors, PHEOCHROMOCYTOMA, POSITRON emission tomography, RADIOTHERAPY, TUMOR markers, RARE diseases, DISEASE risk factors, ADULTS
Abstract

Pheochromocytoma/neuroblastoma composite tumors are rare entities for which little is known. We report an atypical case of a 39-year-old man with secondary bone locations of a composite tumor, 7 years after resection of adrenal neuroblastoma, with constitutional alteration of SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4 whose role is unknown. The diagnosis of a peripheral neuroblastic tumor in adulthood is difficult and even more so when it is a composite tumor. In the absence of a standard of care, management is varied and discussions about treatment modalities for these patients are complex. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

32. Effect of Novel AKT Inhibitor Vevorisertib as Single Agent and in Combination with Sorafenib on Hepatocellular Carcinoma in a Cirrhotic Rat Model

Author

Kurma, Keerthi, primary, Zeybek Kuyucu, Ayca, additional, Roth, Gaël S., additional, Sturm, Nathalie, additional, Mercey-Ressejac, Marion, additional, Abbadessa, Giovanni, additional, Yu, Yi, additional, Lerat, Herve, additional, Marche, Patrice N., additional, Decaens, Thomas, additional, and Macek Jilkova, Zuzana, additional

Published
2022
Full Text
View/download PDF

34. Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD

Author

Canivet, Clémence M., primary, Costentin, Charlotte, additional, Irvine, Katharina M., additional, Delamarre, Adèle, additional, Lannes, Adrien, additional, Sturm, Nathalie, additional, Oberti, Frederic, additional, Patel, Preya J., additional, Decaens, Thomas, additional, Irles‐Depé, Marie, additional, Fouchard, Isabelle, additional, Hermabessière, Paul, additional, Roux, Marine, additional, Barthelon, Justine, additional, Calès, Paul, additional, Powell, Elizabeth E., additional, de Ledinghen, Victor, additional, and Boursier, Jérôme, additional

Published
2022
Full Text
View/download PDF

35. Succinimido–Ferrocidiphenol Complexed with Cyclodextrins Inhibits Glioblastoma Tumor Growth In Vitro and In Vivo without Noticeable Adverse Toxicity

Author

Najlaoui, Feten, primary, Busser, Benoit, additional, Taïwe, Germain Sotoing, additional, Pigeon, Pascal, additional, Sturm, Nathalie, additional, Giovannini, Diane, additional, Marrakchi, Naziha, additional, Rhouma, Ali, additional, Jaouen, Gérard, additional, Gibaud, Stéphane, additional, and De Waard, Michel, additional

Published
2022
Full Text
View/download PDF

36. Validation of the new 2021 EASL algorithm for the non-invasive diagnosis of advanced liver fibrosis in non-alcoholic fatty liver disease

Author

Canivet, Clémence M., primary, Lannes, Adrien, additional, Costentin, Charlotte, additional, Delamarre, Adele, additional, Sturm, Nathalie, additional, Oberti, Frédéric, additional, Decaens, Thomas, additional, Irles-Depe, Marie, additional, Fouchard, Isabelle, additional, Hermabessière, Paul, additional, Barthemon, Justine, additional, de Lédinghen, Victor, additional, and Boursier, Jerome, additional

Published
2022
Full Text
View/download PDF

37. Impact of type 2 diabetes on the accuracy of non-invasive tests of liver fibrosis: a comprehensive analysis of 1, 051 biopsy proven NAFLD patients showing clinical implications

Author

Boursier, Jerome, primary, Canivet, Clémence M., additional, Costentin, Charlotte, additional, Lannes, Adrien, additional, Delamarre, Adele, additional, Sturm, Nathalie, additional, Le Bail, Brigitte, additional, Michalak, Sophie, additional, Oberti, Frédéric, additional, Hilleret, Marie-Noëlle, additional, Irles-Depe, Marie, additional, Fouchard, Isabelle, additional, Hermabessière, Paul, additional, Barthemon, Justine, additional, Cariou, Bertrand, additional, de Lédinghen, Victor, additional, and Roux, Marine, additional

Published
2022
Full Text
View/download PDF

41. Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD.

Author

Canivet, Clémence M., Costentin, Charlotte, Irvine, Katharina M., Delamarre, Adèle, Lannes, Adrien, Sturm, Nathalie, Oberti, Frederic, Patel, Preya J., Decaens, Thomas, Irles‐Depé, Marie, Fouchard, Isabelle, Hermabessière, Paul, Roux, Marine, Barthelon, Justine, Calès, Paul, Powell, Elizabeth E., de Ledinghen, Victor, and Boursier, Jérôme

Published
2023
Full Text
View/download PDF

42. Biliary cytology: A diagnostic tree for adenocarcinoma based on a cohort of 135 patients with endoscopic retrograde cholangiopancreatography for stenosis of the extrahepatic bile duct

Author

Giovannini, Diane, primary, Bailly, Adeline, additional, Seigneurin, Arnaud, additional, Fior‐Gozlan, Michèle, additional, Eyraud, Pierre‐Yves, additional, Roth, Gael, additional, Laverrière, Marie‐Hélène, additional, McLeer, Anne, additional, and Sturm, Nathalie, additional

Published
2022
Full Text
View/download PDF

43. Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications

Author

Boursier, Jérôme, primary, Canivet, Clémence M., additional, Costentin, Charlotte, additional, Lannes, Adrien, additional, Delamarre, Adèle, additional, Sturm, Nathalie, additional, Le Bail, Brigitte, additional, Michalak, Sophie, additional, Oberti, Frédéric, additional, Hilleret, Marie-Noelle, additional, Irles-Depé, Marie, additional, Fouchard, Isabelle, additional, Hermabessiere, Paul, additional, Barthelon, Justine, additional, Calès, Paul, additional, Cariou, Bertrand, additional, de Ledinghen, Victor, additional, and Roux, Marine, additional

Published
2022
Full Text
View/download PDF

44. Increased Intrahepatic Expression of Immune Checkpoint Molecules in Autoimmune Liver Disease

Author

Jilkova, Zuzana Macek, Hilleret, Marie Noelle, Gerster, Theophile, Sturm, Nathalie, Mercey-Ressejac, Marion, Zarski, Jean-Pierre, Leroy, Vincent, Marche, Patrice N., Costentin, Charlotte, and Decaens, Thomas

Subjects
Male, autoimmune hepatitis, QH301-705.5, Liver Diseases, autoimmune liver disease, CD8-Positive T-Lymphocytes, Middle Aged, Immune Checkpoint Proteins, Models, Biological, Article, Autoimmune Diseases, 4-1BB, Liver, immune checkpoint molecules, embryonic structures, PD-1, Humans, Female, Lymphocytes, Biology (General), Biomarkers
Abstract

Immune checkpoint molecules (ICM) are critical in maintaining immunologic homeostasis and participate in preventing or promoting autoimmune disease development. Exploring a large panel of intrahepatic inhibitory and stimulatory ICM is necessary for drawing a general picture of the immune alterations in autoimmune hepatitis (AIH). Here, we performed a multiparametric analysis of ICM, including PD-1, TIM3, LAG3, CTLA-4, OX40 and 4-1BB, and we determined their expression on intrahepatic lymphocyte subsets in untreated and in treated patients with AIH in comparison to normal liver tissue. AIH patient-derived liver tissue revealed the overexpression of ICM, mainly PD-1 and 4-1BB, as well as the strong correlation between PD-1+ CD8+ T-cell abundance and severity of AIH (alanine transaminase and aspartate transaminase levels). Our results show that the ICM play an important role in the loss of immune homeostasis in the liver, providing an attractive approach to investigate their role as targets for effective therapeutic interventions.

Published
2021

46. DEN-Induced Rat Model Reproduces Key Features of Human Hepatocellular Carcinoma

Author

Kurma, Keerthi, primary, Manches, Olivier, additional, Chuffart, Florent, additional, Sturm, Nathalie, additional, Gharzeddine, Khaldoun, additional, Zhang, Jianhui, additional, Mercey-Ressejac, Marion, additional, Rousseaux, Sophie, additional, Millet, Arnaud, additional, Lerat, Herve, additional, Marche, Patrice N., additional, Macek Jilkova, Zuzana, additional, and Decaens, Thomas, additional

Published
2021
Full Text
View/download PDF

47. Precise evaluation of liver histology by computerized morphometry shows that steatosis influences liver stiffness measured by transient elastography in chronic hepatitis C

Author

Boursier, Jérôme, de Ledinghen, Victor, Sturm, Nathalie, Amrani, Laïla, Bacq, Yannick, Sandrini, Jérémy, Le Bail, Brigitte, Chaigneau, Julien, Zarski, Jean-Pierre, Gallois, Yves, Leroy, Vincent, Al Hamany, Zaytouna, Oberti, Frédéric, Fouchard-Hubert, Isabelle, Dib, Nina, Bertrais, Sandrine, Rousselet, Marie-Christine, Calès, Paul, and Multicentre group ANRS HC EP23 FIBROSTAR

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results