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5. Clinical and molecular characterisation of Vibrio furnissii isolates from patients with diarrhoea

Author

Yan-yan ZHOU, Nan Zheng, YU Li, and SU Jian-rong

Abstract

Background: Vibrio furnissii is an emerging human pathogen closely related to Vibrio fluvialis that causes acute gastroenteritis. However, the distribution of virulence factors, antibiotic resistance and molecular epidemiological features of V. furnissii isolates in China remain unknown. Results: We collected seven V. furnissii strains from 1,985 stool samples from people over 14 years old with acute diarrhoea at a general hospital in Beijing, China between April and October 2018. Blood agar plates with 20 μg/mL ampicillin helped to isolate more V. furnissii compared with only using TCBS ( thiosulfate-citrate-bile salts-sucrose agar). Phylogenetic analysis based on SNPs (single-nucleotide polymorphisms) was used to assess the relatedness of isolates. Virulence genes T2SS, T3SS, vfh, hupO and vfp were detected in all V. furnissii strains, and T6SS also occurred at a high frequency of 85.7%. High resistance to cefazolin and tetracycline was found in the V. furnissii isolates at respective rates of 100.0% and 57.1%, and intermediate resistance to ampicillin/sulbactam and imipenem was found at respective rates of 85.7% and 85.7%. Of the tested strains, 42.9% showed resistance to at least three antibiotics. Transposon islands with concentrations of resistance genes occurred in two strains. Phylogenetic analysis separated the V. furnissii strains into three major clades. Conclusion: This study provided detailed bioinformatic, antibiotic susceptibility and clinical features of V. furnissii in China. However, continued and enhanced laboratory-based surveillance is needed for prevention and control of V. furnissii infection.

Published
2022

9. Characterization of the Clinical Features in HBV-Related Acute-on-Chronic Liver Failure.

Author

Yuan, Hong-Xiang, Su, Jian-Rong, Zhang, Qiu-Yun, Zhao, Yan, Yu, Yan-Hua, and Lou, Jin-Li

Subjects
*DRUG therapy for asthma, *EOSINOPHILS, *RNA, *LEUKOCYTE count, *RESEARCH funding, *BRONCHIECTASIS
Abstract

Objective: Acute-on-chronic liver failure (ACLF) is a type of liver failure commonly found in China, and currently the mechanism of the disease remains unknown. This study aimed to investigate the epidemiology, clinical features and prognostic factors in ACLF.Methods: This study retrospectively included 170 patients with ACLF admitted to Beijing Friendship Hospital in Beijing, China from November 2017 to May 2019. Patients were divided into 2 groups: the improved group and the deteriorated group, according to the severity of their disease. Patients' demographic data; clinical manifestations; complications; laboratory indicators including platelets (PLT), alanine aminotransferase (ALT), aspartate amino transferase (AST), total bilirubin (TBIL), prothrombin time (PT), activated partial thromboplastin time (APTT), prothrombin activity (PTA), international normalized ratio (INR), and alkaline phosphatase (ALP) were collected. The relationship between these factors and the patients' prognosis were analyzed by logistic multivariate regression analysis.Results: The highest morbidity rate was in the age group 40 to 49 years (29.41%). The age group with the second highest morbidity was between 50 and 59 years (25.29%), followed by >60 (21.18%), 30 to 39 (20.59%), 20 to 29 (2.94%) and <20 years (0.59%). A total of 53 patients (31.18%) had a family history of hepatitis B virus infection. The patients' main clinical manifestations were ascites (77.65%) and weakness (68.23%). The most common complications were hypoalbuminemia (80%), infection (67.65%) and electrolyte imbalance (44.12%). In addition, the PTA (P = .009), hepatorenal syndrome (P = .005) and hepatic encephalopathy (level IV) (P = .005) were independently related to the prognosis of ACLF. There is a significant relationship between complications and prognosis (χ2 = 8.502; P = .004).Conclusion: This study showed that prothrombin activity, hepatorenal syndrome and hepatic encephalopathy were independently related to the prognosis of ACLF. This outcome provided more options for reducing patient mortality in clinic. [ABSTRACT FROM AUTHOR]

Published
2022

10. The tcdA-negative and tcdB-positive Clostridium difficile ST81 clone exhibits a high level of resistance to fluoroquinolones: a multi-centre study in Beijing, China

Author

Cheng, Jing-Wei, primary, Liu, Chang, additional, Kudinha, Timothy, additional, Xiao, Meng, additional, Fan, Xin, additional, Yang, Chun-Xia, additional, Wei, Ming, additional, Liang, Guo-Wei, additional, Shao, Dong-Hua, additional, Xiong, Zhu-Jia, additional, Hou, Xin, additional, Yu, Shu-Ying, additional, Wang, Yao, additional, Yang, Qi-Wen, additional, Su, Jian-Rong, additional, and Xu, Ying-Chun, additional

Published
2020
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16. Epidemiology and antifungal susceptibilities of yeast isolates causing invasive infections across urban Beijing, China

Author

Guo, Li-Na, primary, Xiao, Meng, additional, Cao, Bin, additional, Qu, Fen, additional, Zhan, Yu-Liang, additional, Hu, Yun-Jian, additional, Wang, Xin-Ru, additional, Liang, Guo-Wei, additional, Gu, Hai-Tong, additional, Qi, Jun, additional, Yuan, Hui, additional, Min, Rong, additional, Wang, Fei-Yan, additional, Liu, Lin-Juan, additional, Wang, Hai-Bin, additional, Jiang, Wei, additional, Duan, Xue-Guang, additional, Xu, Wen-Jian, additional, Yu, Yan-Hua, additional, Su, Jian-Rong, additional, Zhang, Jian-Zhong, additional, Nong, Jin-Qing, additional, Liu, Shu-Mei, additional, Li, Jun, additional, Liu, Jun-Ting, additional, Yue, Zhi-Gang, additional, Yang, Duo, additional, Guo, Jie, additional, Zhao, Rui, additional, Zhang, Ya-Nan, additional, Yang, Xi-Ming, additional, Liu, Xiao-Qing, additional, Hsueh, Po-Ren, additional, and Xu, Ying-Chun, additional

Published
2017
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18. A taxonomic revision of the genus Cephalotaxus Taxaceae

Author

Lang, Xue-Dong, Su, Jian-Rong, Lu, Shu-Gang, and Zhang, Zhi-Jun

Subjects
Tracheophyta, Cephalotaxaceae, Pinales, Pinopsida, Biodiversity, Plantae, Taxonomy
Abstract

Lang, Xue-Dong, Su, Jian-Rong, Lu, Shu-Gang, Zhang, Zhi-Jun (2013): A taxonomic revision of the genus Cephalotaxus Taxaceae. Phytotaxa 84 (1): 1-24, DOI: 10.11646/phytotaxa.84.1.1, URL: http://dx.doi.org/10.11646/phytotaxa.84.1.1

Published
2013

24. Bis(μ-3-hydroxy­benzoato)-κ2 O 1:O 3;κ2 O 3:O 1-bis­[bis­(1H-benzimidazole-κN 3)(3-hydroxy­benzoato-κO)nickel(II)] bis­(1H-benzimidazole-κN 3)bis­(3-hy­droxy­benzoato-κO 1)nickel(II) hexa­hydrate

Author

Shen, Hong, Nie, Jing-Jing, Su, Jian-Rong, and Xu, Duan-Jun

Subjects
Metal-Organic Papers
Abstract

The title compound, [Ni(2)(C(7)H(5)O(3))(4)(C(7)H(6)N(2))(4)][Ni(C(7)H(5)O(3))(2)(C(7)H(6)N(2))(2)]·6H(2)O, is a mononuclear/dinuclear nickel(II) cocrystal, the two mol-ecular species inter-acting through hydrogen bonds that involve the uncoordinated water mol-ecules. In the mononuclear species, the Ni(II) ion, located on an inversion center, is coordinated by two 1H-benzimidazole (bzim) ligands and two 3-hydroxy-benzoate (hba) anions in a square-planar geometry. In the centrosymmetric dinuclear species, the Ni(II) ion is coordinated by two bzim ligands and three hba anions in a square-pyramidal geometry; of the two independent hba anions, one bridges two Ni(II) ions with both carboxylate and hydroxyl groups whereas the other coordin-ates in a unidentate manner to the Ni(II) ion. The apical Ni-O(hydrox-yl) bond is 0.39 Å longer than the basal Ni-O(carbox-yl) bonds. The face-to-face separation of 3.326 (9) Å indicates the existence of π-π stacking between parallel bzim ligands of adjacent dinuclear entities. Extensive N-H⋯O and O-H⋯O hydrogen bonds help to stabilize the crystal structure.

Published
2008

26. Preferable procedure for the screening of syphilis in clinical laboratories in China.

Author

Wang, Ke-Di, Xu, Dong-Jiang, and Su, Jian-Rong

Abstract

Background: With the rapid expansion of infectious syphilis all over the world, optimal procedures for screening syphilis are urgently required. Conventional methods for the diagnosis of syphilis are time- and labor-consuming. We compared automated chemiluminescent micro-particle immunoassay (CLIA) with conventional methods to verify whether CLIA is feasible for syphilis screening. Methods: A cross-sectional assay was conducted on 3962 serum samples tested by CLIA, rapid plasma reagin test (RPR), and Treponema pallidum particle agglutination (TPPA). Meanwhile, another 36 000 sera were screened for syphilis using CLIA and the positive samples were confirmed using TPPA, RPR or Western blotting. Results: The sensitivity and specificity were 100% and 99.8% for CLIA, and 65% and 99.6% for RPR. With the elevation of the optical density value of samples to cut-off ratio (S/CO) value, the true-positive rate of CLIA increased significantly, and when the S/CO value exceeded 10, the true-positive rate of CLIA reached 100%. The false-positive rate of CLIA was 0.22%; pregnant women had the most false-positive results, followed by elderly people and cancer patients. Conclusion: CLIA is suggested as a screening test for the diagnosis of syphilis, while TPPA and RPR are required for confirming the positive samples and monitoring their activity. [ABSTRACT FROM AUTHOR]

Published
2016
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