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13 results on '"Su, Kuo-Chen"'

9. Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation

Author

Chen, Bo-Yie, Lin, David Pei-Cheng, Wu, Chia-Yung, Teng, Mei-Ching, Sun, Chi-Yun, Tsai, Yuan-Ting, Su, Kuo-Chen, Wang, Soo-Ray, and Chang, Han-Hsin

Subjects
Keratitis, Dose-Response Relationship, Drug, Tumor Necrosis Factor-alpha, Ultraviolet Rays, NF-kappa B, Corneal Topography, Gene Expression, Nitric Oxide Synthase Type II, Mice, Inbred Strains, Glutathione, Cornea, Mice, Glutathione Reductase, Lissamine Green Dyes, Neutrophil Infiltration, Malondialdehyde, Models, Animal, Animals, Female, Sesquiterpenes, Research Article, Diet Therapy
Abstract

Purpose Ultraviolet B (UVB) irradiation activates nuclear factor-kappa B (NF-κB) and inducible nitric oxide synthase (iNOS) in the cornea, resulting in inflammatory responses and malondialdehyde (MDA) accumulation. This study aims to determine the effect of zerumbone, a potent NF-κB inhibitor and inflammation modulators, on UVB-induced corneal damages in a mouse model. Methods Fifty female imprinting control region (ICR) mice were randomly divided into five groups. The mice were anaesthetized with their ocular surfaces exposed to UVB light (0.72J/cm2/daily), followed by daily dietary zerumbone supplements at 0, 1, 10, and 100 mg/kg of bodyweight. Mice without zerumbone supplements were used as treatment controls and mice without UVB irradiation as blank controls. Corneal surface damages were graded according to smoothness, opacity, and the extent of lissamine green staining. Histopathological changes were also examined, along with the expression of NF-κB, iNOS, and tumor necrosis factor-α (TNF-α). MDA accumulation and the levels of two antioxidant enzymes, glutathione (GSH) and GSH reductase (GR) were also examined. Results UVB irradiation caused significant damages to cornea, including sustained inflammation, apparent corneal ulcer, and severe epithelial exfoliation, leading to thinning of corneal epithelial layer, and infiltration of polymorphonuclear leukocytes. NF-κB expression was highly activated with nuclear translocation. The expression of iNOS and TNF-α were increased. MDA accumulation was also increased in both the corneal epithelial layer and the stroma. With dietary zerumbone, corneal damages were ameliorated in a dose-dependent manner. NF-κB activation and its nuclear translocation were blocked with decreased expression of iNOS and TNF-α. Infiltration of polymorphonuclear leukocytes was also blocked by dietary zerumbone. Besides, MDA accumulation was reduced with concomitant increase of GSH and GR levels. Conclusions Dietary zerumbone prevents UVB-induced corneal damages by inhibition of NF-κB, iNOS, and TNF-α, with concomitant reduction of MDA accumulation and increase of GSH and GR levels in the mouse model. Results of this study suggest that dietary zerumbone may be used as a prophylactic agent against UVB-induced photokeratitis.

Published
2011

11. Characterising visual deficits in children of an urban elementary school in Taiwan

Author

Cheng, Hong‐ming, primary, Sun, Han‐yin, additional, Lin, David Pei‐cheng, additional, Chang, Han‐hsin, additional, Chen, Shyan‐tarng, additional, Yeh, Shang‐min, additional, Peng, Mei‐ling, additional, Tseng, Jung‐kai, additional, Su, Kuo‐chen, additional, Tseng, Kuang‐wen, additional, Chen, Bo‐yie, additional, Hsiao, Ching‐jen, additional, Huang, Shuan‐yu, additional, and Cheng, Ching‐ying, additional

Published
2012
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12. Visual Function and Visual Perception among Senior Citizens with Mild Cognitive Impairment in Taiwan.

Author

Chang, Chi-Wu, Su, Kuo-Chen, Lu, Fang-Chun, Cheng, Hong-Ming, and Cheng, Ching-Ying

Subjects
VISION, VISUAL perception, MILD cognitive impairment, OLDER people, EYE movements, BINOCULAR vision, OPTIC nerve diseases
Abstract

Purpose: With the benefits of advanced medical technology, Taiwan has gradually changed from an aged society to a super-aged society. According to previous studies, the prevalence rate of mild cognitive impairment (MCI) over the age of 60 is 15% to 20%. Therefore, the main purpose of our study was to analyze the correlation of cognitive function with visual function (specifically, binocular vision and visual perception) in Taiwanese volunteers aged 60 years or older. Methods: Thirty-six healthy participants who were not taking psychiatric medications and who had not been diagnosed with any retinal or optic nerve diseases were enrolled. Addenbrooke's cognitive examination III (ACE-III), binocular visual function, and visual perception evaluation were performed, and the data analyzed statistically by t-test, χ2, linear regression, and MANOVA. Results: Cognitive function was closely correlated with visual function and visual perception; the horizontal adjustment time of binocular eye movement, stereopsis, the motor-free visual perception test-4 (MVPT-4), and peripheral awareness actually displayed higher explanatory power in predicting cognitive function. In addition, various interactive parameters between visual function and visual perception were found to affect specific aspects of ACE-III. Discussion: Our study revealed that there was a close correlation of cognitive function with visual function; as such, it may be possible to predict visual function deficits in patients with mild cognitive impairment. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Dietary zerumbone prevents against ultraviolet B-induced cataractogenesis in the mouse.

Author

Chen BY, Lin DP, Su KC, Chen YL, Wu CY, Teng MC, Tsai YT, Sun CY, Wang SR, and Chang HH

Subjects
Animals, Antioxidants metabolism, Cataract chemically induced, Cataract enzymology, Female, Glutathione metabolism, Glutathione Peroxidase metabolism, Glutathione Reductase metabolism, Lens, Crystalline drug effects, Lens, Crystalline enzymology, Lens, Crystalline pathology, Lens, Crystalline radiation effects, Malondialdehyde metabolism, Mice, Mice, Inbred ICR, Sesquiterpenes chemistry, Superoxide Dismutase metabolism, Cataract prevention & control, Diet, Sesquiterpenes pharmacology, Ultraviolet Rays
Abstract

Purpose: To investigate the preventive effect of dietary zerumbone against UVB-induced cataractogenesis., Methods: A total of 50 six-week-old female ICR mice were split into five groups (each contained 10 mice) and exposed to UVB (0.72 J/cm(2)/daily) at noon for 7 days, except for the blank control group. The mice with UVB exposure were fed with zerumbone as a dietary supplement at 0, 1, 10, and 100 mg/kg of bodyweight, respectively, starting from one day before UVB exposure. On day 7, at 4 h after UVB exposure, all mice were subjected to cataract examination and lens opacity scoring, in correlation with levels of MDA (malondialdehyde), GSH (glutathione), GR (GSH reductase), GPx (glutathione peroxidase), and SOD (superoxide dismutase) in the lens., Results: Dietary zerumbone at 100 mg/kg after UVB exposure was effective in decreasing lens opacity scores (p<0.001) and to reduce MDA (p<0.001), while GSH and GR levels were significantly increased (both p<0.001) in the lens. SOD was also increased with dietary zerumbone at 100 mg/kg (p=0.115), whereas GPx (p=0.171) levels were lower as compared with those without zerumbone after UVB exposure., Conclusions: These results suggest that zerumbone may protect against UVB-induced cataractogensis through reducing lipid peroxides and enhancing the endogenous antioxidant GSH level and GR activity.

Published
2011

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