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11. CaCO3 powder-mediated biomineralization of antigen nanosponges synergize with PD-1 blockade to potentiate anti-tumor immunity.

Author

Su, Runping, Gu, Jingjing, Sun, Juanjuan, Zang, Jie, Zhao, Yuge, Zhang, Tingting, Chen, Yingna, Chong, Gaowei, Yin, Weimin, Zheng, Xiao, Liu, Bingbing, Huang, Li, Ruan, Shuangrong, Dong, Haiqing, Li, Yan, and Li, Yongyong

Subjects
*T helper cells, *BIOMINERALIZATION, *CYTOTOXIC T cells, *PROGRAMMED cell death 1 receptors, *T cells, *ANTIGENS, *IMMUNITY
Abstract

Antigen self-assembly nanovaccines advance the minimalist design of therapeutic cancer vaccines, but the issue of inefficient cross-presentation has not yet been fully addressed. Herein, we report a unique approach by combining the concepts of "antigen multi-copy display" and "calcium carbonate (CaCO3) biomineralization" to increase cross-presentation. Based on this strategy, we successfully construct sub-100 nm biomineralized antigen nanosponges (BANSs) with high CaCO3 loading (38.13 wt%) and antigen density (61.87%). BANSs can be effectively uptaken by immature antigen-presenting cells (APCs) in the lymph node upon subcutaneous injection. Achieving efficient spatiotemporal coordination of antigen cross-presentation and immune effects, BANSs induce the production of CD4+ T helper cells and cytotoxic T lymphocytes, resulting in effective tumor growth inhibition. BANSs combined with anti-PD-1 antibodies synergistically enhance anti-tumor immunity and reverse the tumor immunosuppressive microenvironment. Overall, this CaCO3 powder-mediated biomineralization of antigen nanosponges offer a robust and safe strategy for cancer immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2023
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15. CaCO 3 Powder-Mediated Biomineralization of Antigen Nanosponges Synergize with PD-1 Blockade to Potentiate Anti-Tumor Immunity

Author

Su, Runping, primary, Gu, Jingjing, additional, Sun, Juanjuan, additional, Zang, Jie, additional, Zhao, Yuge, additional, Zhang, Tingting, additional, Chen, Yingna, additional, Chong, Gaowei, additional, Yin, Weimin, additional, Zheng, Xiao, additional, Liu, Bingbing, additional, Huang, Li, additional, Ruan, Shuangrong, additional, Dong, Haiqing, additional, Li, Yan, additional, and Li, Yongyong, additional

Published
2022
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18. Catalytic Nanovaccine for Cancer Immunotherapy: A NADPH Oxidase-Inspired Fe-Polyphenol Network Nanovaccine for Enhanced Antigen Cross-Presentation

Author

Chong, Gaowei, primary, Su, Runping, additional, Gu, Jingjing, additional, Zhang, Tingting, additional, Zang, Jie, additional, Zhao, Yuge, additional, Zheng, Xiao, additional, Liu, Ying, additional, Ruan, Shuangrong, additional, He, Ruiqing, additional, Yin, Weimin, additional, Dong, Haiqing, additional, and Li, Yongyong, additional

Published
2021
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21. Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB

Author

Yue Wang, Li Yang, Jin Xiangqun, Qianqian Zhao, Su Runping, Guo Yu, Shanshan Yu, and Deng Jiayu

Subjects
nanoemulsions, Medicine (General), Chemistry, Pharmaceutical, Dispersity, Biophysics, Polysorbates, Pharmaceutical Science, Bioengineering, 02 engineering and technology, polydispersity index, Administration, Cutaneous, Ceramides, 030226 pharmacology & pharmacy, Polyvinyl alcohol, response surface methodology, Biomaterials, 03 medical and health sciences, chemistry.chemical_compound, Drug Delivery Systems, R5-920, 0302 clinical medicine, Drug Stability, International Journal of Nanomedicine, Drug Discovery, Glycerol, Response surface methodology, Water content, Original Research, Transdermal, Chromatography, Organic Chemistry, Water, General Medicine, particle size, 021001 nanoscience & nanotechnology, Nanostructures, chemistry, Emulsions, Titration, nano-emulsions, Particle size, Fatty Alcohols, 0210 nano-technology, optimization
Abstract

Runping Su,1 Li Yang,2 Yue Wang,1 Shanshan Yu,1 Yu Guo,1 Jiayu Deng,1 Qianqian Zhao,1 Xiangqun Jin1 1Department of Pharmaceutics, School of Pharmacy, 2Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China Abstract: This research aimed to develop and optimize a nanoemulsion-based formulation containing ceramide IIIB using phase-inversion composition for transdermal delivery. The effects of ethanol, propylene glycol (PG), and glycerol in octyldodecanol and Tween 80 systems on the size of the nanoemulsion region in the phase diagrams were investigated using water titration. Subsequently, ceramide IIIB loading was kept constant (0.05 wt%), and the proposed formulation and conditions were optimized via preliminary screening and experimental design. Factors such as octyldodecanol/(Tween 80:glycerol) weight ratio, water content, temperature, addition rate, and mixing rate were investigated in the preliminary screening experiment. Response surface methodology was employed to study the effect of water content (30%–70%, w/w), mixing rate (400–720 rpm), temperature (20°C–60°C), and addition rate (0.3–1.8 mL/min) on droplet size and polydispersity index. The mathematical model showed that the optimum formulation and conditions for preparation of ceramide IIIB nanoemulsion with desirable criteria were a temperature of 41.49°C, addition rate of 1.74 mL/min, water content of 55.08 wt%, and mixing rate of 720 rpm. Under optimum formulation conditions, the corresponding predicted response values for droplet size and polydispersity index were 15.51 nm and 0.12, respectively, which showed excellent agreement with the actual values (15.8 nm and 0.108, respectively), with no significant (P>0.05) differences. Keywords: response surface methodology, nanoemulsions, optimization, particle size, polydispersity index

Published
2017

22. Peptide-TLR7/8a-Coordinated DNA Vaccines Elicit Enhanced Immune Responses against Infectious Diseases

Author

Yang, Rong, Yao, Tingting, Xu, Jinliang, Liu, Xiaoxiao, Yang, Yaqi, Ding, Junqiang, Cao, Cong, Su, Runping, Li, Sha, Lu, Wuyuan, and Gao, Xihui

Abstract

DNA vaccines represent an innovative approach for the immunization of diverse diseases. However, their clinical trial outcomes are constrained by suboptimal transfection efficiency and immunogenicity. In this work, we present a universal methodology involving the codelivery of Toll-like receptor 7/8 agonists (TLR7/8a) and antigen gene using TLR7/8a-conjugated peptide-coated poly(β-amino ester) (PBAE) nanoparticles (NPs) to augment delivery efficiency and immune response. Peptide-TLR7/8a-coated PBAE NPs exhibit advantageous biophysical attributes, encompassing diminutive particle dimensions, nearly neutral ζ potential, and stability in the physiological environment. This synergistic approach not only ameliorates the stability of plasmid DNA (pDNA) and gene delivery efficacy but also facilitates subsequent antigen production. Furthermore, under optimal formulation conditions, the TLR7/8a-conjugated peptide coated PBAE NPs exhibit a potent capacity to induce robust immune responses. Collectively, this nanoparticulate gene delivery system demonstrates heightened transfection efficacy, stability, biodegradability, immunostimulatory effect, and low toxicity, making it a promising platform for the clinical advancement of DNA vaccines.

Published
2024
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