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Objective: To evaluate the safety and effectiveness of vacuum-assisted excision for benign intraductal papilloma of breast. Methods: The databases including PubMed, Embase, Cochrane Library, WangFang, CNIK, VIP and Web of Science were searched by computer, according the inclusion and exclusion criteria after screening of literature. The Cochrane handbook and Newcastle-Ottawa scale was used to evaluate the studies. Then the Review Manager 5.3 software was to used analyze the data. Results: A total of 1 016 patients was included in 9 articles. The amount of blood loss in vacuum-assisted surgery was less than that in open surgery [MD=- 6.38,95%CI(-9.90,-2.86),P<0.05]. The drainage[MD=-2.56,95%CI(-4.97,-0.15,P<0.05] and drainage time[MD=-0.25,95%CI(-0.40,-0.09),P<0.05] in vacuum-assisted surgery was less than that in open surgery. There were also few postoperative complications than that in open surgery [RR=0.43,95%CI(0.29,0.64),P<0.05]. Compared with open surgery, the postoperative recurrence rate was lower in vacuum-assisted surgery [RR=0.26,95%CI (0.14, 0.49), P<0.05]. Last, there was no statistically significant difference in the operative time between vacuum-assisted surgery and open surgery,[SD=-12.82,95%CI (-25.70, 0.06),P=0.05]. Conclusion: Compared with open surgery, vacuum-assisted excision has the advantages of less blood loss and lower postoperative complications, but the operative time is not statistically significant compared with open surgery. In addition, compared with open surgery in this study, vacuum-assisted excision has the advantages of lower recurrence rate, but it still needs long-term dynamic observation. [ABSTRACT FROM AUTHOR]

Objective: To investigate the intervention effects of curcumin (Curc) on liver injury induced by chronic alcohol addiction in mice. Methods: Thirty Balb/c mice were randomly divided into normal control group (Control), model group (Model), low-dose Curc group (5 mg/kg, Curc-L), medium dose Curc group (10 mg/kg, Curc-M) and high-dose Curc group (15 mg/kg, Curc-H), with 6 mice in each group. The chronic alcohol addiction liver injury model was prepared with 20% liquor. The mice in control group were given 2 ml of normal saline every day. The mice in model group were given 5 ml/kg of 20% liquor every day, and the mice in Curc treatment group were treated with Curc at the doses of 5, 10, 15 mg/kg in 2 ml saline every day for 35 days. The weight of liver was measured and the health status of mice was observed. Serum ALT, AST, ALP and liver TG, TC, HDL-C, LDL-C, MDA, SOD, GSH-Px and NO were measured. The pathological changes of liver tissues stained with hematoxylin and eosin were observed. Results: Compared with the control group, the liver mass and serum levels of ALT, AST, ALP, MDA, NO, TC, TG, HDL-C, LDL-C in the model group were increased significantly ( P ＜0.05, P ＜0.01), the activities of SOD and GSH-Px were decreased significantly ( P ＜0.05, P ＜0.01), the liver cells were vacuolated and infiltrated with inflammatory cells, and the expression levels of NF-κB and MAPK protein in liver tissues were increased significantly ( P ＜0.01). Compared with the model group, the levels of ALT, AST, ALP, MDA, NO, TC, TG, HDL-C, LDL-C in Curc group were decreased significantly nd the activities of SOD and GSH-Px were increased significantly ( P ＜0.05, P ＜0.01). Conclusion: Curc can effectively reduce liver tissue damage by regulating NF-κB/MAPK signal pathway.