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2. A low abundance of genus Bacteroides in gut microbiota is negatively correlated with blood phenylalanine levels in Uygur patients with phenylketonuria

Author

Su Yajie, Long Li, Haili Jiang, Jingfang Liu, Rena Tuerdi, Qiaolibang Shadike, Wenhao Zhou, Wanying Liu, and Mingbang Wang

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, education.field_of_study, biology, Firmicutes, business.industry, Population, nutritional and metabolic diseases, Bacteroidetes, Ribosomal RNA, Gut flora, biology.organism_classification, medicine.disease, Microbiology, Actinobacteria, Pediatrics, Perinatology and Child Health, medicine, Phenylketonuria (PKU), Proteobacteria, education, business
Abstract

Background A low-phenylalanine (Phe) diet affects the metabolism and diversity of gut microbial communities in children with phenylketonuria (PKU). Our study examined gut microbiota characteristics and metabolic pathways, and their correlations with clinical phenotypes in a high-incidence population. Methods We assessed clinical phenotypes and gut microbiota by 16S ribosomal RNA (rRNA) sequencing, and performed a correlation analysis between phenotype and gut microbiota in a PKU group (n=11) and a healthy group (n=11). Results The PKU group had significantly lower microbiota diversity than the healthy group (Pshannon=0.014). Phylum-level composition differed significantly between the PKU and healthy groups (Firmicutes: 44.3% vs. 43.1%; Actinobacteria: 25.9% vs. 3.3%; Bacteroidetes: 16.6% vs. 53.2%; and Proteobacteria: 10.9% vs. 0.12%, respectively). Further, a significantly decreased level of genus Bacteroidetes (P

Published
2021

4. Pore-Scale Simulation of Water Flooding Using Volume of Fluid Method.

Author

Huang, Chuanqing, Zhang, Jiaosheng, Lu, Xuejiao, Jihong, Li, Huang, Yingsong, Liu, Lijie, Su, Yajie, and Bai, Jianguang

Subjects
OIL field flooding, WATER use, POROUS materials, POROSITY, FLOW velocity, WATER laws
Abstract

Water flooding is a commonly used method in oilfield development, and the water flooding process is essentially the process of oil-water movement in porous media. Pore-scale flow law in water flooding process can guide the oilfield development plan, to improve the oil recovery efficiency. In this paper, the computational domain is constructed from the CT scan images of real cores. The oil-water flow process of the water flooding in the pore structure is simulated using the interFoam solver in OpenFOAM. The influence of the displacement process and the distribution of the remaining oil is analyzed in three aspects: the water cut curve, the state of the same water injection amount, and the final displacement state. The flow rate velocity affects the water flooding swept range, and the recovery factor increases gradually with the increase of the flow rate. With different injection velocity, the sweeping sequence of pores is different, and the location and shape of remaining oil are very different. Due to the different dominant forces under different wettability states, the swept patterns of the core are also different. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Application of Full-Spectrum Rapid Clinical Genome Sequencing Improves Diagnostic Rate and Clinical Outcomes in Critically Ill Infants in the China Neonatal Genomes Project*

Author

Wu, Bingbing, primary, Kang, Wenqing, additional, Wang, Yingyuan, additional, Zhuang, Deyi, additional, Chen, Liping, additional, Li, Long, additional, Su, Yajie, additional, Pan, Xinnian, additional, Wei, Qiufen, additional, Tang, Zezhong, additional, Li, Yangfang, additional, Gao, Jin, additional, Cheng, Rui, additional, Zhou, Wei, additional, Wang, Zhangxing, additional, Qiu, Gang, additional, Wang, Jian, additional, Yang, Lin, additional, Zhang, Ping, additional, Zhao, Xuemei, additional, Wang, Yao, additional, Gan, Mingyu, additional, Li, Gang, additional, Liu, Renchao, additional, Ni, Qi, additional, Xiao, Feifan, additional, Yan, Kai, additional, Cao, Yun, additional, Lu, Guoping, additional, Lu, Yulan, additional, Wang, Huijun, additional, and Zhou, Wenhao, additional

Published
2021
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9. The molecular epidemiology of hyperphenylalaninemia in Uygur population: incidence from newborn screening and mutational spectra

Author

Su, Yajie, primary, Wang, Huijun, additional, Rejiafu, Nuerya, additional, Wu, Bingbing, additional, Jiang, Haili, additional, Chen, Hongbo, additional, A, Xian, additional, Qian, Yanyan, additional, Li, Mingzhu, additional, Lu, Yulan, additional, Ren, Yan, additional, Li, Long, additional, and Zhou, Wenhao, additional

Published
2019
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