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20 results on '"Su, Yutao"'

11. Intraoperative transit-time ultrasonography combined with FLOW800 predicts the occurrence of cerebral hyperperfusion syndrome after direct revascularization of Moyamoya disease: a preliminary study

Author

Yang, Dongxu, primary, Zhang, Xiaohong, additional, Tan, Cunxin, additional, Han, Zhiguang, additional, Su, Yutao, additional, Duan, Ran, additional, Shi, Guangchao, additional, Shao, Junshi, additional, Cao, Penghui, additional, He, Shihao, additional, and Wang, Rong, additional

Published
2020
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13. Survival in the Tropics despite isolation, inbreeding and asexual reproduction: insights from the genome of the world’s southernmost poplar (Populus ilicifolia)

Author

Chen, Zeyuan, primary, Ai, Fandi, additional, Zhang, Junlin, additional, Ma, Xinzhi, additional, Yang, Wenlu, additional, Wang, Weiwei, additional, Su, Yutao, additional, Wang, Mingcheng, additional, Yang, Yongzhi, additional, Mao, Kangshan, additional, Wang, Qingfeng, additional, Lascoux, Martin, additional, Liu, Jianquan, additional, and Ma, Tao, additional

Published
2020
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14. FGF20‐FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti.

Author

Su, Yutao, Yang, Lu M., and Ornitz, David M.

Subjects
CORTI'S organ, PHOSPHATIDYLINOSITOL 3-kinases, HAIR cells, MITOGEN-activated protein kinases, PTEN protein
Abstract

Background: Fibroblast Growth Factor 20 (FGF20)‐FGF receptor 1 (FGFR1) signaling is essential for cochlear hair cell (HC) and supporting cell (SC) differentiation. In other organ systems, FGFR1 signals through several intracellular pathways including MAPK (ERK), PI3K, phospholipase C ɣ (PLCɣ), and p38. Previous studies implicated MAPK and PI3K pathways in HC and SC development. We hypothesized that one or both would be important downstream mediators of FGF20‐FGFR1 signaling for HC differentiation. Results: By inhibiting pathways downstream of FGFR1 in cochlea explant cultures, we established that both MAPK and PI3K pathways are required for HC differentiation while PLCɣ and p38 pathways are not. Examining the canonical PI3K pathway, we found that while AKT is necessary for HC differentiation, it is not sufficient to rescue the Fgf20−/− phenotype. To determine whether PI3K functions downstream of FGF20, we inhibited Phosphatase and Tensin Homolog (PTEN) in Fgf20−/− explants. Overactivation of PI3K resulted in a partial rescue of the Fgf20−/− phenotype, demonstrating a requirement for PI3K downstream of FGF20. Consistent with a requirement for the MAPK pathway for FGF20‐regulated HC differentiation, we show that treating Fgf20−/− explants with FGF9 increased levels of dpERK. Conclusions: Together, these data provide evidence that both MAPK and PI3K are important downstream mediators of FGF20‐FGFR1 signaling during HC and SC differentiation. Key Findings: PI3K and MEK1/2 are necessary for hair cell differentiation while p38 and PLCγ are not.pAKT is necessary but not sufficient for hair cell differentiation.PTEN inhibition partially rescues Fgf20 knockout phenotype.dpERK is downstream of FGF20‐FGFR1 signaling. [ABSTRACT FROM AUTHOR]

Published
2021
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16. Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent

Author

Mok, Ka-Wai, primary, Saxena, Nivedita, additional, Heitman, Nicholas, additional, Grisanti, Laura, additional, Srivastava, Devika, additional, Muraro, Mauro J., additional, Jacob, Tina, additional, Sennett, Rachel, additional, Wang, Zichen, additional, Su, Yutao, additional, Yang, Lu M., additional, Ma’ayan, Avi, additional, Ornitz, David M., additional, Kasper, Maria, additional, and Rendl, Michael, additional

Published
2019
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17. Fate Before Function: Specification of the Hair Follicle Niche Occurs Prior to its Formation and Is Progenitor Dependent

Author

Mok, Ka-Wai, primary, Saxena, Nivedita, additional, Heitman, Nicholas, additional, Grisanti, Laura, additional, Srivastava, Devika, additional, Muraro, Mauro, additional, Jacob, Tina, additional, Sennett, Rachel, additional, Wang, Zichen, additional, Su, Yutao, additional, Yang, Lu M., additional, Ma’ayan, Avi, additional, Ornitz, David M., additional, Kasper, Maria, additional, and Rendl, Michael, additional

Published
2018
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20. Resistance to Zinc and Cadmium in Staphylococcus aureusof Human and Animal Origin

Author

Nair, Rajeshwari, Thapaliya, Dipendra, Su, Yutao, and Smith, Tara C.

Abstract

Objective.Studies conducted in Europe have observed resistance to trace metals such as zinc chloride and copper sulfate in livestock-associated Staphylococcus aureus. This study was conducted to determine the prevalence of zinc and cadmium resistance in S. aureusisolated in the United States.Design.Cross-sectional study of convenience sample of S. aureusisolates.Participants.Three hundred forty-nine S. aureusisolates, including methicillin-resistant S. aureus(MRSA) and methicillin-susceptible S. aureus(MSSA) obtained from human, swine, and retail meat were included in the sample set.Methods.Polymerase chain reaction was used to test for the presence of genes for zinc and cadmium resistance (czrC), methicillin resistance (mecA), and staphylococcal complement inhibitor (scn). Antibiotic susceptibility of isolates was tested using the broth microdilution method. Data were analyzed using the multivariable logistic regression method.Results.Twenty-nine percent (102/349) of S. aureusisolates were czrCpositive. MRSA isolates were more likely to be czrCpositive compared to MSSA (MRSA czrCpositive: 12/61, 19.6%; MSSA czrCpositive: 12/183, 6.6%). After adjustment for oxacillin and clindamycin susceptibility in analysis, multidrug-resistant S. aureuswas observed to have low odds of being czrCpositive (P= .03). The odds of being czrCpositive were observed to be significantly high in tetracycline-resistant S. aureusisolated from noninfection samples (P = .009) and swine (P< .0001).Conclusions.Resistance to zinc and cadmium was observed to be associated with MRSA, a finding consistently observed in European studies. Prolonged exposure to zinc in livestock feeds and fertilizers could propagate resistance to the metal ion, thereby hindering use of zinc-based topical agents in treating S. aureusinfections.

Published
2014
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