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170 results on '"Su, Zhongzhen"'

17. Association of renal elasticity evaluated by real-time shear wave elastography with renal fibrosis in patients with chronic kidney disease.

Author

Chen, Ziman, Wang, Yingli, Ying, Michael Tin Cheung, Su, Zhongzhen, Han, Xinyang, and Gunda, Simon Takadiyi

Subjects
RENAL fibrosis, CHRONIC kidney failure, SHEAR waves, CHRONICALLY ill, KIDNEY cortex
Abstract

Objective Renal fibrosis is a final common pathological hallmark in the progression of chronic kidney disease (CKD). Non-invasive evaluation of renal fibrosis by mapping renal stiffness obtained by shear wave elastography (SWE) may facilitate the clinical therapeutic regimen for CKD patients. Methods A cohort of 162 patients diagnosed with CKD, who underwent renal biopsy, was prospectively and consecutively recruited between April 2019 and December 2021. The assessment of renal cortex stiffness was performed using SWE imaging. The patients were classified into different groups based on pathological renal fibrosis (mild group: n  = 74; moderate-to-severe group: n  = 88). Binary logistic regression model and generalized additive model were conducted to investigate the association of renal elasticity with renal fibrosis. Results Compared with the mildly impaired group, the moderate-to-severe group showed a significant decline in renal elasticity (P  <  .001). In the fully adjusted model, each 10 kPa drop in renal elasticity was associated with a 3.5-fold increment in the risk of moderate-to-severe renal fibrosis (fully adjusted odds ratio, 4.54; 95% CI, 2.41-8.57). Particularly, participants in the lowest elasticity group (≤29.92 kPa) had a 20-fold increased chance of moderate-to-severe renal fibrosis than those in the group with highest elasticity (≥37.93 kPa). An inverse linear association was observed between renal elasticity increment and moderate-to-severe renal fibrosis risk. Conclusion There is a negative linear association between increased renal elasticity and moderate-to-severe renal fibrosis risk among CKD patients. Patients with diminished renal stiffness have a higher risk of moderate-to-severe renal fibrosis. Advances in knowledge CKD patients with reduced renal stiffness have a higher likelihood of moderate-to-severe renal fibrosis. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Contrast-enhanced US with Sulfur Hexafluoride and Perfluorobutane: LI-RADS for Diagnosing Hepatocellular Carcinoma

Author

Li, Lingling, primary, Zou, Xuebin, additional, Zheng, Wei, additional, Li, Yu, additional, Xu, Xiaohong, additional, Li, Kai, additional, Su, Zhongzhen, additional, Han, Jing, additional, Li, Qing, additional, Zuo, Yanling, additional, Xie, Shousong, additional, Wen, Hong, additional, Wang, Jianwei, additional, Guo, Zhixing, additional, Zou, Ruhai, additional, and Zhou, Jianhua, additional

Published
2023
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22. Nomogram Analysis Based on Clinical and Sonographic Characteristics for the Assessment of Postpartum Stress Urinary Incontinence.

Author

Xiao, Ting, Cao, Yunqing, Zhen, Chaojiong, Chen, Ziman, Huang, Weijun, and Su, Zhongzhen

Subjects
NOMOGRAPHY (Mathematics), URINARY stress incontinence, DELIVERY (Obstetrics), PUERPERIUM, RECEIVER operating characteristic curves, DECISION making
Abstract

Objectives: We aimed to develop and validate a nomogram integrating clinical and sonographic characteristics for the individualized SUI risk evaluation in the early postpartum stage. Methods: This was a prospective cross‐sectional study. From June 2020 to September 2022, singleton primiparas who underwent TPUS examination at 6–8 weeks postpartum were recruited. They were divided into the training and validation cohorts at a ratio of 8:2 according to the temporal split. All subjects were interviewed before TPUS examination. Univariate and multivariate logistic analyses were performed to develop three models: the clinical, sonographic, and combined models. The ROC curve was plotted to evaluate model discrimination ability. Finally, the combined model was selected to establish the nomogram. The nomogram's discrimination, calibration, and clinical usefulness were evaluated in the training and validation cohorts. Results: The performance of the combined model was better than that of the clinical and sonographic models. Six predictors (BMI, delivery mode, lateral episiotomy, SUI during pregnancy, cystocele, and bladder neck funneling) remained in the combined model. The nomogram based on the combined model had good discrimination with AUCs of 0.848 (95% CI: 0.796–0.900) and 0.872 (95% CI: 0.789–0.955) in the training and validation cohorts, respectively, and the calibration curve showed good efficiency in assessing postpartum SUI. Decision curve analysis showed that the nomogram was clinically useful. Conclusions: The nomogram based on clinical and sonographic characteristics showed good efficiency in assessing postpartum SUI risk and can be a convenient and reliable tool for individual SUI risk assessment. [ABSTRACT FROM AUTHOR]

Published
2023
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44. c-Met-targeted near-infrared fluorescent probe for real-time depiction and dissection of perineural invasion and lymph node metastasis lesions in pancreatic ductal adenocarcinoma xenograft models

Author

Li, Dan, primary, Yang, Meilin, additional, Liang, Mingzhu, additional, Mei, Chaoming, additional, Lin, Yujing, additional, Yang, Fan, additional, Xiao, Yitai, additional, Chen, Yuechuan, additional, Wang, Fen, additional, Mao, Junjie, additional, and Su, Zhongzhen, additional

Published
2021
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48. ZnAs@SiO2 nanoparticles as a potential anti-tumor drug for targeting stemness and epithelial-mesenchymal transition in hepatocellular carcinoma via SHP-1/JAK2/STAT3 signaling

Author

Huang, Yongquan, primary, Zhou, Bin, additional, Luo, Hui, additional, Mao, Junjie, additional, Huang, Yin, additional, Zhang, Ke, additional, Mei, Chaoming, additional, Yan, Yan, additional, Jin, Hongjun, additional, Gao, Jinhao, additional, Su, Zhongzhen, additional, Pang, Pengfei, additional, Li, Dan, additional, and Shan, Hong, additional

Published
2019
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