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Doxycycline is regarded as an effective treatment for periodontal inflammation. In humans, it has been shown that the long-term administration of a subantimicrobial dose of doxycycline (SDD) does not induce antimicrobial effects on the subgingival microflora and furthermore does not affect antimicrobial susceptibility. The present study was designed to evaluate the influence of oral administration of SDD on normal periodontal microflora and antimicrobial susceptibility in dogs. Experimental periodontitis was induced in 12 experimental dogs using a silk and wire-twisted ligature for 60 days. After the periodontitis induction period, the ligature was removed, and dental cleaning (subgingival and supragingival ultrasonic scaling) was performed. The dogs were randomly assigned to one of two groups: an SDD group with six dogs receiving 2 mg/kg PO once daily and a control group with six dogs receiving a placebo. At weeks 0, 4 and 8, clinical periodontal parameters were evaluated. After the clinical assessments, subgingival plaque was sampled and then cultured in an anaerobic system for one week, and the total anaerobes, Porphyromonas spp., Bacteroides spp. and Pasteurella spp. counts were investigated. Using the agar dilution method, the minimum bactericidal concentration of doxycycline was evaluated and the resistance for doxycycline was monitored during this experimental phase. The clinical periodontal status of the SDD group was significantly improved compared to the control group ( P  <   0.05). Bacterial counts were not significantly different between the two experimental groups ( P  > 0.05), and antibacterial resistance was not established in the SDD group during the experimental periods ( P  <   0.05). These results suggest that the once daily oral regimen of 2 mg/kg of doxycycline could serve as a SDD in dogs. [ABSTRACT FROM AUTHOR]

Statement of Problem: Chronic periodontitis is one of the most prevalent periodontal diseases in the world"nwhich may be treated through surgical or non-surgical approaches."nPurpose: The aim of this study was to compare the efficacy of Doxycycline and placebo following SRP in"nnon-surgical treatment of chronic periodontitis."nMaterials and Methods: This double blind interventional study was conducted on patients attended to the"nperiodontology department of Tehran faculty of dentistry from 2002 to 2003. After SRP, 22 cases and 23"ncontrols were received Doxycycline and placebo, 20 mg twice a day for 3 months, respectively. Bleeding on"nprobing (BOP), pocket depth (PD)7mm, and also clinical attachment level (CAL)7mm in cases and controls after 3 and 6 months were compared by student t-test."nResults: BOP after 3 and 6 months in Doxycycline recipients following SRP were significantly lower than in"nplacebo recipients (P^0.007 and P=0.045 respectively). PD7mm, CAL7mm in 3"nand 6 months after SRP in cases were much lower than controls."nConclusion: This study showed that the administration of Doxycycline for 3 months after SRP resulted in"nimprovement of clinical indices as compared with SRP alone. Therefore, Doxycycline administration is"nrecommended for chronic periodontitis treatment after SRP.