Tribal population of Odisha and ethnozoological study have been undertaken to document the different ethnic communities of Mayurbhanj district of Odisha, India. The investigation is also an attempt to present a list of traditional medicaments from animal sources used for therapeutic purposes by different communities. A total 66 informants (male 48; female 18) were interacted and questioned with 58 number of similar type of query. Approximately 46, varieties of traditional medicaments from different animal sources have been identified which are traditionally being consumed for various diseases as per the opinion of 66 number of healers who have been practicing zootherapy. As per the data, it is found that 21 are mammals, i.e., 46.66% of the total numbers of animals are preferred to the treatment of asthma and respiratory diseases. Others are being used for the treatment of piles, production of semen, gastric disorder, fever, rheumatism, colic pain and some other related problems. 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