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Your search keyword '"Sueyoshi, Ryo"' showing total 44 results
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44 results on '"Sueyoshi, Ryo"'

21. Perforation in pediatric non-complicated appendicitis treated by antibiotics: the real incidence

Author

Mikami, Takafumi, primary, Sueyoshi, Ryo, additional, Kosaka, Seitaro, additional, Yoshida, Shiho, additional, Miyano, Go, additional, Ochi, Takanori, additional, Koga, Hiroyuki, additional, Okazaki, Tadaharu, additional, Yanai, Toshihiro, additional, Urao, Masahiko, additional, Lane, Geoffrey, additional, Jimbo, Keisuke, additional, Suzuki, Kazuhiro, additional, Kuwatsuru, Ryohei, additional, Shimizu, Toshiaki, additional, and Yamataka, Atsuyuki, additional

Published
2019
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29. Reconstructive surgery for recurrent penile curvature.

Author

Takeda, Masahiro, Seo, Shogo, Sueyoshi, Ryo, Nakamura, Hiroki, Suda, Kazuto, Lane, Geoffrey J., and Yamataka, Atsuyuki

Subjects
PLASTIC surgery, PENIS curvatures, DISEASE relapse, PREOPERATIVE care, PENIS abnormalities, FOLLOW-up studies (Medicine), THERAPEUTICS
Abstract

Purpose: There are surprisingly few reports about reconstructive surgery for severe recurrent/persistent penile curvature (redo-PC). We present our experience.Methods: We reviewed 9 redo-PC cases we treated between 1998 and 2016.Results: Cases 1-3 and 5 were identified from 111 consecutive hypospadias patients we treated between 1998 and 2016 (4/111; 3.6%). Cases 4 and 6-9 had initial surgery elsewhere. Initial PC was severe (> 45°; n = 5), moderate (30°-45°; n = 1), or unknown (n = 3), treated by dorsal plication (DP) in 4/9 (cases 1-4), chordectomy in 2/9 (cases 5, 6), and unknown in 3/9 (cases 7-9); no case had tunica albuginea incision (TAI). Straightening after initial surgery was confirmed by artificial erection (AE) in 4/9, not confirmed (2/9), and unknown (3/9). Cases 1, 2, 7 and 8 had had previous failed redos. Scarring of buccal mucosa used for urethroplasty caused worse PC in cases 7 and 9. After TAI (n = 6; cases 1, 3-6, and 8) or scar removal with DP (n = 3; cases 2, 7, and 9), AE confirmed successful straightening in all cases, without sequelae after a mean follow-up of 2.6 years.Conclusion: TAI was most effective for redo-PC surgery. Preoperative AE and examination under anesthesia should be used to customize treatment. [ABSTRACT FROM AUTHOR]

Published
2018
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31. Rectal mucosal dissection commencing directly on the anorectal line versus commencing above the dentate line in laparoscopy-assisted transanal pull-through for Hirschsprung's disease: Prospective medium-term follow-up

Author

Miyano, Go, primary, Koga, Hiroyuki, additional, Okawada, Manabu, additional, Doi, Takashi, additional, Sueyoshi, Ryo, additional, Nakamura, Hiroki, additional, Seo, Shogo, additional, Ochi, Takanori, additional, Yamada, Susumu, additional, Imaizumi, Takaaki, additional, Lane, Geoffrey J., additional, Okazaki, Tadaharu, additional, Urao, Masahiko, additional, and Yamataka, Atsuyuki, additional

Published
2015
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32. Stimulation of intestinal growth and function with DPP-IV inhibition in a mouse short bowel syndrome model

Author

Sueyoshi, Ryo, Ignatoski, Kathleen M Woods, Okawada, Manabu, Hartmann, Bolette, Holst, Jens Juul, Teitelbaum, Daniel H, Sueyoshi, Ryo, Ignatoski, Kathleen M Woods, Okawada, Manabu, Hartmann, Bolette, Holst, Jens Juul, and Teitelbaum, Daniel H

Abstract

Glucagon-like peptide-2 (GLP-2) has been shown to be effective in patients with short bowel syndrome (SBS), but is rapidly inactivated by dipeptidyl peptidase-IV (DPP4). We used an orally-active DPP4 inhibitor (DPP4-I), MK-0626, to determine the efficacy of this approach to promote adaptation after SBS, determined optimal dosing, and identified further functional actions in a SBS mouse model. Ten week old mice underwent a 50% proximal small bowel resection (SBR). Dose optimization was determined over a 3-day post-SBS period. The established optimal dose was given for 7 days, 30 days, 90 days, and 7 days followed by 23 days washout period. Adaptive response was assessed by morphology, intestinal epithelial cell (IEC) proliferation (PCNA), epithelial barrier function (transepithelial resistance), RT-PCR for intestinal transport proteins, GLP-2R, and IGF-1R, and GLP-2 plasma levels. Glucose-stimulated sodium transport was assessed for intestinal absorptive function. Seven days of DPP4-I treatment facilitated an increase in GLP-2R levels, intestinal growth, and IEC proliferation. Treatment led to differential effects over time with greater absorptive function early, and enhanced proliferation at later time points. Interestingly, 7 day treatment followed by 23 days of non-treatment showed continued adaptation. DPP-IV-I enhanced IEC proliferative action up to 90-days post-resection, but this action seemed to peak by 30 days, as did GLP-2 plasma levels. Thus, use of DPP4-I treatment may prove to be a viable treatment for accelerating intestinal adaptation with SBS.

Published
2014

43. Distraction-Induced Intestinal Growth: The Role of Mechanotransduction Mechanisms in a Mouse Model of Short Bowel Syndrome

Author

Sueyoshi, Ryo, Ignatoski, Kathleen M. Woods, Okawada, Manabu, and Teitelbaum, Daniel H.

Abstract

Novel strategies are needed to address the problem of patients with short bowel syndrome. We previously demonstrated a three-fold lengthening of pig bowel after 2 weeks of applied distractive forces, but we have not elucidated the mechanisms facilitating this growth. We used a mouse model of distraction-induced enterogenesis. High molecular weight polyethylene glycol (PEG) osmotically stretched an isolated small bowel segment (PEG-stretch). Significant increases in villus height and crypt depth and in intestinal epithelial cell length and numbers suggested epithelial remodeling in addition to proliferation during enterogenesis. LC-MS/MS analysis showed a two-fold upregulation of α-actinin-1 and -4. We also demonstrated that p-focal adhesion kinase (FAK), FAK, α-actinin, and Rac1 were significantly upregulated and that F-actin was relocalized in PEG-stretch versus controls. Blockade of the phosphotidyl inositol 3′ kinase pathway failed to influence the increase in proliferation or decline in apoptosis after stretch, suggesting alternative signaling pathways are used, including MEK and P38MAPK, which were both upregulated during enterogenesis. Our data suggests that several known mechanotransduction pathways drive distraction-induced enterogenesis.

Published
2014
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44. Stimulation of intestinal growth and function with DPP4 inhibition in a mouse short bowel syndrome model.

Author

Sueyoshi R, Woods Ignatoski KM, Okawada M, Hartmann B, Holst J, and Teitelbaum DH

Subjects
Adaptation, Physiological, Amylases blood, Animals, Blood Glucose metabolism, Cell Proliferation drug effects, Dipeptidyl Peptidase 4 metabolism, Disease Models, Animal, Glucagon-Like Peptide 2 metabolism, Glucagon-Like Peptide-2 Receptor, Intestinal Absorption drug effects, Intestinal Mucosa cytology, Jejunum drug effects, Jejunum ultrastructure, Male, Mice, Receptor, IGF Type 1 biosynthesis, Receptors, Glucagon biosynthesis, Sodium-Glucose Transporter 1 biosynthesis, Triazoles therapeutic use, Up-Regulation, Dipeptidyl-Peptidase IV Inhibitors pharmacology, Short Bowel Syndrome metabolism
Abstract

Glucagon-like peptide-2 (GLP-2) has been shown to be effective in patients with short bowel syndrome (SBS), but it is rapidly inactivated by dipeptidyl peptidase IV (DPP4). We used an orally active DPP4 inhibitor (DPP4-I), MK-0626, to determine the efficacy of this approach to promote adaptation after SBS, determined optimal dosing, and identified further functional actions in a mouse model of SBS. Ten-week-old mice underwent a 50% proximal small bowel resection. Dose optimization was determined over a 3-day post-small bowel resection period. The established optimal dose was given for 7, 30, and 90 days and for 7 days followed by a 23-day washout period. Adaptive response was assessed by morphology, intestinal epithelial cell (IEC) proliferation (proliferating cell nuclear antigen), epithelial barrier function (transepithelial resistance), RT-PCR for intestinal transport proteins and GLP-2 receptor, IGF type 1 receptor, and GLP-2 plasma levels. Glucose-stimulated sodium transport was assessed for intestinal absorptive function. Seven days of DPP4-I treatment facilitated an increase in GLP-2 receptor levels, intestinal growth, and IEC proliferation. Treatment led to differential effects over time, with greater absorptive function at early time points and enhanced proliferation at later time points. Interestingly, adaptation continued in the group treated for 7 days followed by a 23-day washout. DPP4-I enhanced IEC proliferative action up to 90 days postresection, but this action seemed to peak by 30 days, as did GLP-2 plasma levels. Thus DPP4-I treatment may prove to be a viable option for accelerating intestinal adaptation with SBS., (Copyright © 2014 the American Physiological Society.)

Published
2014
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