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28. Looking to the Future of Viral Vectors in Ocular Gene Therapy: Clinical Review.

Author

Kharisova, Chulpan B., Kitaeva, Kristina V., Solovyeva, Valeriya V., Sufianov, Albert A., Sufianova, Galina Z., Akhmetshin, Rustem F., Bulgar, Sofia N., and Rizvanov, Albert A.

Abstract

Eye diseases can significantly affect the quality of life of patients due to decreased visual acuity. Although modern ophthalmological diagnostic methods exist, some diseases of the visual system are asymptomatic in the early stages. Most patients seek advice from an ophthalmologist as a result of rapidly progressive manifestation of symptoms. A number of inherited and acquired eye diseases have only supportive treatment without eliminating the etiologic factor. A promising solution to this problem may be gene therapy, which has proven efficacy and safety shown in a number of clinical studies. By directly altering or replacing defective genes, this therapeutic approach will stop as well as reverse the progression of eye diseases. This review examines the concept of gene therapy and its application in the field of ocular pathologies, emphasizing the most recent scientific advances and their potential impacts on visual function status. [ABSTRACT FROM AUTHOR]

Published
2025
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38. Adeno-Associated Viral Vectors in the Treatment of Epilepsy.

Author

Mullagulova, Aysilu I., Timechko, Elena E., Solovyeva, Valeriya V., Yakimov, Alexey M., Ibrahim, Ahmad, Dmitrenko, Diana D., Sufianov, Albert A., Sufianova, Galina Z., and Rizvanov, Albert A.

Subjects
GENETIC vectors, EPILEPSY, GENE therapy, TRANSCRIPTION factors, ADENO-associated virus
Abstract

Epilepsy is a brain disorder characterized by a persistent predisposition to epileptic seizures. With various etiologies of epilepsy, a significant proportion of patients develop pharmacoresistance to antiepileptic drugs, which necessitates the search for new therapeutic methods, in particular, using gene therapy. This review discusses the use of adeno-associated viral (AAV) vectors in gene therapy for epilepsy, emphasizing their advantages, such as high efficiency of neuronal tissue transduction and low immunogenicity/cytotoxicity. AAV vectors provide the possibility of personalized therapy due to the diversity of serotypes and genomic constructs, which allows for increasing the specificity and effectiveness of treatment. Promising orientations include the modulation of the expression of neuropeptides, ion channels, transcription, and neurotrophic factors, as well as the use of antisense oligonucleotides to regulate seizure activity, which can reduce the severity of epileptic disorders. This review summarizes the current advances in the use of AAV vectors for the treatment of epilepsy of various etiologies, demonstrating the significant potential of AAV vectors for the development of personalized and more effective approaches to reducing seizure activity and improving patient prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Low-Cost 3D Models for Cervical Spine Tumor Removal Training for Neurosurgery Residents

Author

Sufianov, Albert, primary, Ovalle, Carlos Salvador, additional, Cruz, Omar, additional, Contreras, Javier, additional, Begagić, Emir, additional, Kannan, Siddarth, additional, Rosario Rosario, Andreina, additional, Chmutin, Gennady, additional, Askatovna, Garifullina Nargiza, additional, Lafuente, Jesus, additional, Sanchez, Jose Soriano, additional, Nurmukhametov, Renat, additional, Soto García, Manuel Eduardo, additional, Peev, Nikolay, additional, Pojskić, Mirza, additional, Reyes-Soto, Gervith, additional, Bozkurt, Ismail, additional, and Encarnación Ramírez, Manuel De Jesus, additional

Published
2024
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41. Extra-Articular Endoscopic BP Decompression—Surgical Technique

Author

Belyak, Evgeniy Aleksandrovich, primary, Lazko, Fjodor Leonidovich, additional, Sufianov, Albert Akramovich, additional, Paskhin, Dmitriy Lvovich, additional, Prizov, Alexey Petrovich, additional, Lazko, Maxim Fjodorovich, additional, Sagdiev, Ranel Khamitovich, additional, and Zagorodniy, Nikolay Vasil`evich, additional

Published
2024
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42. Endoscopic Treatment of Deep Gluteal Syndrome: 3-Portal Technique

Author

Belyak, Evgeniy Aleksandrovich, primary, Lazko, Fjodor Leonidovich, additional, Sufianov, Albert Akramovich, additional, Paskhin, Dmitrij L’vovich, additional, Prizov, Aleksej Petrovich, additional, Lazko, Maksim Fjodorovich, additional, Sagdiev, Ranel Khamitovich, additional, and Zagorodnij, Nikolaj Vasil’evich, additional

Published
2024
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45. Low-cost 3D Models for Cervical Spine Tumor Removal Training for Neurosurgery Residents

Author

Sufianov, Albert, Ovalle, Carlos Salvador, Cruz, Omar, Contreras, Javier, Begagić, Emir, Kannan, Siddarth, Rosario, Andreina Rosario, Chmutin, Gennady, Askatovna, Garifullina Nargiza, Lafuente, Jesus, Sanchez, Jose Soriano, Nurmukhametov, Renat, Garcia, Manuel Eduardo Soto, Peev, Nikolay, Pojskić, Mirza, Reyes-Soto, Gervith, Bozkurt, Ismail, Ramirez, Manuel De Jesus Encarnación, Sufianov, Albert, Ovalle, Carlos Salvador, Cruz, Omar, Contreras, Javier, Begagić, Emir, Kannan, Siddarth, Rosario, Andreina Rosario, Chmutin, Gennady, Askatovna, Garifullina Nargiza, Lafuente, Jesus, Sanchez, Jose Soriano, Nurmukhametov, Renat, Garcia, Manuel Eduardo Soto, Peev, Nikolay, Pojskić, Mirza, Reyes-Soto, Gervith, Bozkurt, Ismail, and Ramirez, Manuel De Jesus Encarnación

Abstract

Background and Objectives: Spinal surgery, particularly for cervical pathologies like myelopathy and radiculopathy, requires a blend of theoretical knowledge and practical skill. The complexity of these conditions, often necessitating surgical intervention, underscores the need for intricate understanding and precision in execution. Advancements in neurosurgical training, especially with the use of low-cost 3D models for simulating cervical spine tumor removal, are revolutionizing this field. These models provide a realistic and hands-on experience crucial for mastering complex neurosurgical techniques, filling gaps left by traditional educational methods. Materials and Methods: This study aimed to assess the effectiveness of 3D-printed cervical vertebrae models in enhancing surgical skills, focusing on tumor removal and involving 20 young neurosurgery residents. These models, featuring silicone materials to simulate the spinal cord and tumor tissues, provided a realistic training experience. The training protocol included a laminectomy, dural incision, and tumor resection, using a range of microsurgical tools, focusing on steps usually performed by senior surgeons. Results: The training program received high satisfaction rates, with 85% of participants extremely satisfied and 15% satisfied. The 3D models were deemed very realistic by 85% of participants, effectively replicating real-life scenarios. 80% found the pathologies simulated varied and accurate, and 90% appreciated the models' accurate tactile feedback. The training was extremely useful for 85% in developing surgical skills, with significant post-training confidence boosts and a strong willingness to recommend the program to peers. Conclusions: Continuing laboratory training for residents is crucial. Our model offers essential, accessible training for all hospitals, regardless of their resources, promising improved surgical quality and patient outcomes across various pathologies.

Published
2024

46. Challenging Assumptions: 'Unveiling Meritocracy's Reality in Neurosurgery'

Author

De Jesus Encarnion Ramirez, Manuel, Baez, Ismael Peralta, Reyes, Gervith Reyes Soto, Mukengeshay, Jeff Ntalaja, Tshiunza, Cherubin M., Rosario, Andreina, Vladimir, Nikolenko, Nurmukhametov, Renat, Kannan, Siddarth, Simfukwe, Keith, Rodriguez, Luis M. Duchén, Chumtin, Gennady, Chumtin, Egor, Sufianov, Albert, Sanchez, Jose A. Soriano, Demetriades, Andreas K., Baldoncini, Matias, Campero, Alvaro, Piavchenko, Gennadii, de Oca, Juan C. Montes, Kalangu, Kazadi K., Jenkins, Alistair, Lafuente, Jesus, De Jesus Encarnion Ramirez, Manuel, Baez, Ismael Peralta, Reyes, Gervith Reyes Soto, Mukengeshay, Jeff Ntalaja, Tshiunza, Cherubin M., Rosario, Andreina, Vladimir, Nikolenko, Nurmukhametov, Renat, Kannan, Siddarth, Simfukwe, Keith, Rodriguez, Luis M. Duchén, Chumtin, Gennady, Chumtin, Egor, Sufianov, Albert, Sanchez, Jose A. Soriano, Demetriades, Andreas K., Baldoncini, Matias, Campero, Alvaro, Piavchenko, Gennadii, de Oca, Juan C. Montes, Kalangu, Kazadi K., Jenkins, Alistair, and Lafuente, Jesus

Abstract

Introduction: Meritocracy, a concept revered as the cornerstone of fairness and equal opportunity, is critically examined in the context of neurosurgery. This article challenges the notion that success in this demanding field is solely determined by individual abilities and effort. By investigating how these systemic barriers impact admissions to neurosurgical training programs and professional advancement, the paper underscores the complexity of meritocracy in neurosurgery, suggesting that the meritocratic ideal is more nuanced and influenced by external variables than commonly believed. Results: Certain universities deemed elite offer a curriculum divergent from that of their counterparts in low and middle-income countries. Students at these "elite" institutions gain exposure to new technologies and research incentives, which brings us to the realm of research. Remarkably, 75% of articles originating from developed nations account for just 25% of traumatic brain injury cases. This disparity highlights a significant research imbalance, and the common refrain underscores the need to bolster research capabilities in low-income countries. Neurosurgeons in the United States receive a median? salary of $412,000 dollars per year, compared to $13200 dollars in Latin America, as of June 2023. Given such incongruities, the prospect of even attending conferences or workshops abroad remains difficult for neurosurgeons from developing nations. Research isn't cast aside due to a lack of interest but due to resource. The narrative promotes a collective endeavour to dismantle barriers and embrace innovation, emphasizing the importance of mentorship, cross-institutional collaboration, and the amplification of underrepresented voices.

Published
2024

47. Surgical management for large vestibular schwannomas: a systematic review, meta-analysis, and consensus statement on behalf of the EANS skull base section

Author

Starnoni, Daniele, Giammattei, Lorenzo, Cossu, Giulia, Link, Michael J., Roche, Pierre-Hugues, Chacko, Ari G., Ohata, Kenji, Samii, Majid, Suri, Ashish, Bruneau, Michael, Cornelius, Jan F., Cavallo, Luigi, Meling, Torstein R., Froelich, Sebastien, Tatagiba, Marcos, Sufianov, Albert, Paraskevopoulos, Dimitrios, Zazpe, Idoya, Berhouma, Moncef, Jouanneau, Emmanuel, Verheul, Jeroen B., Tuleasca, Constantin, George, Mercy, Levivier, Marc, Messerer, Mahmoud, and Daniel, Roy Thomas

Published
2020
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50. The Vertebrobasilar Trunk and Its Anatomical Variants: A Microsurgical Anatomical Study

Author

Reyes-Soto, Gervith, primary, Pérez-Cruz, Julio C., additional, Delgado-Reyes, Luis, additional, Castillo-Rangel, Carlos, additional, Cacho Diaz, Bernardo, additional, Chmutin, Gennady, additional, Nurmukhametov, Renat, additional, Sufianova, Galina, additional, Sufianov, Albert, additional, Nikolenko, Vladimir, additional, Sufianov, Rinat, additional, Goncharov, Evgeniy, additional, Montemurro, Nicola, additional, and Encarnacion Ramirez, Manuel De Jesus, additional

Published
2024
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