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171 results on '"Sugimoto, Akihiko"'

6. Validation of the BEST-J score, a prediction model for bleeding after endoscopic submucosal dissection for early gastric cancer: a multicenter retrospective observational study

Author

Kagawa, Yasuyuki, Fukuzawa, Masakatsu, Sugimoto, Mitsushige, Nemoto, Daiki, Muramatsu, Takahiro, Shinohara, Hirokazu, Matsumoto, Taisuke, Madarame, Akira, Yamaguchi, Hayato, Uchida, Kumiko, Morise, Takashi, Koyama, Yohei, Sugimoto, Akihiko, Yamauchi, Yoshiya, Kono, Shin, Naito, Sakiko, Yamamoto, Kei, Kishimoto, Yoshiko, Inuyama, Mitsuko, Kawai, Takashi, and Itoi, Takao

Published
2022
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12. Hyalinizing Clear Cell Carcinoma in the Sphenoid Sinus

Author

80781913, 20360844, Takamura, Toshiya, Koyasu, Sho, Sugimoto, Akihiko, Yamamoto, Takayuki, Nakamoto, Yuji, 80781913, 20360844, Takamura, Toshiya, Koyasu, Sho, Sugimoto, Akihiko, Yamamoto, Takayuki, and Nakamoto, Yuji

Abstract

A 39-year-old man presented with a 1-month history of headaches. Imaging revealed a mass with extensive destruction. T2-weighted imaging displayed mixture of low and sponge-like high intensities and also dark area, with FDG PET/CT showing uneven but intense accumulation. Biopsy confirmed EWSR1 rearrangement, and hyalinizing clear cell carcinoma (HCCC) was diagnosed. HCCC, recently renamed from clear cell carcinoma in the fifth edition of the World Health Organization Classification of Head and Neck Tumors, is a rare tumor. This case describes the features of T2-weighted imaging and FDG PET patterns in HCCC, possibly contributing to their consideration in the differential diagnosis.

Published
2024

17. A case of stratified bronchiolar adenoma with immunofluorescence analysis: comments on “Frequent EGFR exon 20 insertion in the so‐called peripheral type squamous cell neoplasm of uncertain malignant potential: a variant of bronchiolar adenoma or under‐recognized entity?”

Author

Sugimoto, Akihiko, primary, Hirata, Masahiro, additional, Jinnouchi, Keita, additional, Ohata, Keiji, additional, Kikuchi, Ryutaro, additional, Haga, Hironori, additional, and Yoshizawa, Akihiko, additional

Published
2023
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19. A case of stratified bronchiolar adenoma with immunofluorescence analysis: comments on "Frequent EGFR exon 20 insertion in the so‐called peripheral type squamous cell neoplasm of uncertain malignant potential: a variant of bronchiolar adenoma or under‐recognized entity?"

Author

Sugimoto, Akihiko, Hirata, Masahiro, Jinnouchi, Keita, Ohata, Keiji, Kikuchi, Ryutaro, Haga, Hironori, and Yoshizawa, Akihiko

Subjects
*EPIDERMAL growth factor receptors, *IMMUNOFLUORESCENCE, *ADENOMA, *TUMORS, *LUNGS, *ADENOMATOUS polyps
Abstract

This article discusses a case of a rare lung tumor called stratified bronchiolar adenoma. The tumor was found in a 67-year-old woman with no history of smoking. The tumor was composed of stratified epithelial cells and was accompanied by an EGFR exon 20 insertion. Immunofluorescence analysis showed that the tumor cells in the basal area coexpressed p40 and TTF-1, while those in the apical area expressed only TTF-1. The authors argue that this tumor should be described as stratified bronchiolar adenoma rather than a squamous cell neoplasm. Further research is needed to understand the origin and clinical importance of this tumor. [Extracted from the article]

Published
2024
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23. Factors associated with long-term efficacy of lubiprostone for chronic constipation

Author

Morise, Takashi, primary, Fukuzawa, Masakatsu, additional, Sugimoto, Mitsushige, additional, Nagata, Naoyoshi, additional, Kono, Shin, additional, Yamauchi, Yoshiya, additional, Sugimoto, Akihiko, additional, Uchida, Kumiko, additional, Koyama, Yohei, additional, Madarame, Akira, additional, Yamaguchi, Hayato, additional, Matsumoto, Taisuke, additional, Kagawa, Yasuyuki, additional, Kawai, Takashi, additional, and Itoi, Takao, additional

Published
2023
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24. Targeted Metabolomic Profiling of Plasma Samples in Gastric Cancer by Liquid Chromatography-Mass Spectrometry

Author

Matsumoto, Taisuke, primary, Fukuzawa, Masakatsu, additional, Itoi, Takao, additional, Sugimoto, Masahiro, additional, Aizawa, Yumi, additional, Sunamura, Makoto, additional, Kawai, Takashi, additional, Nemoto, Daiki, additional, Shinohara, Hirokazu, additional, Muramatsu, Takahiro, additional, Suzuki, Yuka, additional, Kagawa, Yasuyuki, additional, Suguro, Maya, additional, Uchida, Kumiko, additional, Koyama, Yohei, additional, Madarame, Akira, additional, Morise, Takashi, additional, Yamaguchi, Hayato, additional, Sugimoto, Akihiko, additional, Yamauchi, Yoshiya, additional, Kono, Shin, additional, and Naito, Sakiko, additional

Published
2022
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28. Fatal case of methotrexate‐associated primary cutaneous extranodal NK/T‐cell lymphoma of gamma delta phenotype

Author

Sugimoto, Akihiko, primary, Fujimoto, Masakazu, additional, Fujii, Hirotake, additional, Takeuchi, Yasuhide, additional, Hirata, Masahiro, additional, Usui, Shunya, additional, Nakamizo, Satoshi, additional, Ikezoe, Kohei, additional, Ikeo, Satoshi, additional, Yamada, Yosuke, additional, Minamiguchi, Sachiko, additional, Morinobu, Akio, additional, and Haga, Hironori, additional

Published
2022
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30. The association of ectopic craniopharyngioma in the fourth ventricle with familial adenomatous polyposis: illustrative case

Author

00335283, 90468372, 50252432, 50716602, 20378649, 90598921, Uemura, Hiroya, Tanji, Masahiro, Natsuhara, Hiroki, Takeuchi, Yasuhide, Hoki, Masahito, Sugimoto, Akihiko, Minamiguchi, Sachiko, Kawasaki, Hidenori, Torishima, Masako, Kosugi, Shinji, Mineharu, Yohei, Arakawa, Yoshiki, Yoshida, Kazumichi, Miyamoto, Susumu, 00335283, 90468372, 50252432, 50716602, 20378649, 90598921, Uemura, Hiroya, Tanji, Masahiro, Natsuhara, Hiroki, Takeuchi, Yasuhide, Hoki, Masahito, Sugimoto, Akihiko, Minamiguchi, Sachiko, Kawasaki, Hidenori, Torishima, Masako, Kosugi, Shinji, Mineharu, Yohei, Arakawa, Yoshiki, Yoshida, Kazumichi, and Miyamoto, Susumu

Abstract

[BACKGROUND] Craniopharyngioma (CP) often arises in the sellar and suprasellar areas; ectopic CP in the posterior fossa is rare. Familial adenomatous polyposis (FAP) is a genetic disorder involving the formation of numerous adenomatous polyps in the gastrointestinal tract, and it is associated with other extraintestinal manifestations. [OBSERVATIONS] The authors reported the case of a 63-year-old woman with FAP who presented with headache and harbored a growing mass in the fourth ventricle. Magnetic resonance imaging (MRI) findings revealed a well-circumscribed mass with high intensity on T1-weighted images and low intensity on T2-weighted images and exhibited no contrast enhancement. Gross total resection was performed and histopathology revealed an adamantinomatous CP (aCP). The authors also reviewed the previous reports of ectopic CP in the posterior fossa and found a high percentage of FAP cases among the ectopic CP group, thus suggesting a possible association between the two diseases. [LESSONS] An ectopic CP may be reasonably included in the differential diagnosis in patients with FAP who present with well-circumscribed tumors in the posterior fossa.

Published
2022

31. POU2F3 beyond thymic carcinomas: expression across the spectrum of thymomas hints to medullary differentiation in type A thymoma

Author

40742622, 80378645, 60252962, 10252462, Yamada, Yosuke, Sugimoto, Akihiko, Hoki, Masahito, Yoshizawa, Akihiko, Hamaji, Masatsugu, Date, Hiroshi, Haga, Hironori, Marx, Alexander, 40742622, 80378645, 60252962, 10252462, Yamada, Yosuke, Sugimoto, Akihiko, Hoki, Masahito, Yoshizawa, Akihiko, Hamaji, Masatsugu, Date, Hiroshi, Haga, Hironori, and Marx, Alexander

Abstract

The thymic medulla comprises various cell types, including tuft cells that are involved in innate immunity. We recently reported that in Western cohorts of patients, most thymic squamous cell carcinomas (TSQCCs), in contrast to thymomas, exhibit strong and extensive expression of tuft cell markers, including the tuft cell master regulator, POU2F3. On closer inspection of 94 thymomas that cover the full spectrum of thymoma histotypes, we now find by immunohistochemistry that approximately half of types A, AB, and B1 thymomas contain small numbers (< 10%) of cells expressing POU2F3, while most types B2 and B3 thymomas do not (p < 0.05). Further, in rarer types A and AB thymomas with adenoid growth pattern, POU2F3( +) cells formed aggregates and co-expressed KIT, as did the tumor cells in 100% (9/9) of TSQCCs expressing POU2F3. However, the expression of another tuft cell marker, L1CAM, still distinguished TSQCC from the spectrum of thymomas that were all L1CAM-negative. This study is the first to demonstrate the high frequency of POU2F3 expression in an Asian cohort of TSQCCs. The common occurrence of scattered POU2F3( +) cells in types A and AB thymomas hints at their variable degree of medullary differentiation and supports the historical hypothesis of the medullary nature of type A thymomas. Immunohistochemistry of L1CAM may be a valuable tool to differentiate TSQCCs from thymomas.

Published
2022

32. A case of intestinal amoebiasis mimicking intestinal Behçet’s disease

Author

Fukui, Ayaka, primary, Nakayama, Yoichi, additional, Yoshida, Tsuneyasu, additional, Murakami, Kosaku, additional, Kadoba, Keiichiro, additional, Onizawa, Hideo, additional, Akizuki, Shuji, additional, Nakashima, Ran, additional, Yoshifuji, Hajime, additional, Ohmura, Koichiro, additional, Sugimoto, Akihiko, additional, Yamamoto, Shuji, additional, and Morinobu, Akio, additional

Published
2022
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34. Targeted Metabolomic Profiling of Plasma Samples in Gastric Cancer by Liquid Chromatography-Mass Spectrometry.

Author

Matsumoto, Taisuke, Fukuzawa, Masakatsu, Itoi, Takao, Sugimoto, Masahiro, Aizawa, Yumi, Sunamura, Makoto, Kawai, Takashi, Nemoto, Daiki, Shinohara, Hirokazu, Muramatsu, Takahiro, Suzuki, Yuka, Kagawa, Yasuyuki, Suguro, Maya, Uchida, Kumiko, Koyama, Yohei, Madarame, Akira, Morise, Takashi, Yamaguchi, Hayato, Sugimoto, Akihiko, and Yamauchi, Yoshiya

Subjects
LIQUID chromatography-mass spectrometry, STOMACH cancer, RECEIVER operating characteristic curves, METABOLOMICS, RADIAL basis functions
Abstract

Introduction: As the high mortality rate of gastric cancer (GC) is due to delayed diagnosis, early detection is vital for improved patient outcomes. Metabolic deregulation plays an important role in GC. Although various metabolite-level biomarkers for early detection have been assessed, there is still no unified early detection method. We conducted a plasma metabolome study to assess metabolites that may distinguish GC samples from non-GC samples. Methods: Blood samples were collected from 72 GC patients and 29 control participants (non-GC group) at the Tokyo Medical University Hospital between March 2020 and November 2020. Hydrophilic metabolites were identified and quantified using liquid chromatography-time-of-flight mass spectrometry. Differences in metabolite concentrations between the GC and non-GC groups were evaluated using the Mann-Whitney test. The discrimination ability of each metabolite was evaluated by the area under the receiver operating characteristic curve. A radial basis function (RBF) kernel-based support vector machine (SVM) model was developed to assess the discrimination ability of multiple metabolites. The selection of variables used for the SVM utilized a step-wise regression method. Results: Of the 96 quantified metabolites, 8 were significantly different between the GC and non-GC groups. Of these, N1-acetylspermine, succinate, and histidine were used in the RBF-SVM model to discriminate GC samples from non-GC samples. The area under the curve (AUC) of the RBF-SVM model was higher (0.915; 95% CI: 0.865–0.965, p < 0.0001), indicating good performance of the RBF-SVM model. The application of this RBF-SVM to the validation dataset resulted from the AUC of the RBF-SVM model was (0.885; 95% CI: 0.797–0.973, p < 0.0001), indicating the good performance of the RBF-SVM model. The sensitivity of the RBF-SVM model was better (69.0%) than those of the common tumor markers carcinoembryonic antigen (CEA) (10.5%) and carbohydrate antigen 19-9 (CA19-9) (2.86%). The RBF-SVM showed a low correlation with CEA and CA19-9, indicating its independence. Conclusion: We analyzed plasma metabolomics, and a combination of the quantified metabolites showed high sensitivity for the detection of GC. The independence of the RBF-SVM from tumor markers suggested that their complementary use would be helpful for GC screening. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Decidualization of Stromal Cells Promotes Involvement of Mast Cells in Successful Human Pregnancy by Increasing Stem Cell Factor Expression

Author

Ueshima, Chiyuki, primary, Kataoka, Tatsuki R., additional, Osakabe, Mitsumasa, additional, Sugimoto, Akihiko, additional, Ushirokawa, Akihiko, additional, Shibata, Yuji, additional, Nakamura, Hiroya, additional, Shibuya, Rintaro, additional, Minamiguchi, Sachiko, additional, Sugai, Tamotsu, additional, and Haga, Hironori, additional

Published
2022
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36. The association of ectopic craniopharyngioma in the fourth ventricle with familial adenomatous polyposis: illustrative case

Author

Uemura, Hiroya, primary, Tanji, Masahiro, additional, Natsuhara, Hiroki, additional, Takeuchi, Yasuhide, additional, Hoki, Masahito, additional, Sugimoto, Akihiko, additional, Minamiguchi, Sachiko, additional, Kawasaki, Hidenori, additional, Torishima, Masako, additional, Kosugi, Shinji, additional, Mineharu, Yohei, additional, Arakawa, Yoshiki, additional, Yoshida, Kazumichi, additional, and Miyamoto, Susumu, additional

Published
2022
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37. Diagnostic efficacy of the Japan NBI Expert Team classification with dual-focus magnification for colorectal tumors

Author

Koyama, Yohei, primary, Fukuzawa, Masakatsu, additional, Kono, Shin, additional, Madarame, Akira, additional, Morise, Takashi, additional, Uchida, Kumiko, additional, Yamaguchi, Hayato, additional, Sugimoto, Akihiko, additional, Nagata, Naoyoshi, additional, Kawai, Takashi, additional, Takamaru, Hiroyuki, additional, Sekiguchi, Masau, additional, Yamada, Masayoshi, additional, Sakamoto, Taku, additional, Matsuda, Takahisa, additional, Saito, Yutaka, additional, and Itoi, Takao, additional

Published
2021
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39. Predictive factors of relapse after dose reduction of oral 5-aminosalicylic acid in patients with ulcerative colitis in the remission phase

Author

Madarame, Akira, primary, Fukuzawa, Masakatsu, additional, Yamauchi, Yoshiya, additional, Kono, Shin, additional, Sugimoto, Akihiko, additional, Yamaguchi, Hayato, additional, Morise, Takashi, additional, Koyama, Yohei, additional, Uchida, Kumiko, additional, Suguro, Maya, additional, Matsumoto, Taisuke, additional, Yasuyuki, Kagawa, additional, Kawai, Takashi, additional, and Itoi, Takao, additional

Published
2021
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41. Diffuse Large B-cell Lymphoma

Author

Sakurada, Hiroki, primary, Koyasu, Sho, additional, Sugimoto, Akihiko, additional, Nakanishi, Etsuro, additional, and Nakamoto, Yuji, additional

Published
2021
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42. Angiomatous Nasal Polyp Diagnosed by Preoperative Imaging and Successfully Resected by Endonasal Endoscopic Surgery: A Case Report

Author

90443564, 80781913, 10252462, 20360844, 10233272, Iemura-Kashiwagi, Maho, Kikuchi, Masahiro, Koyasu, Sho, Kitada, Yuji, Sugimoto, Akihiko, Haga, Hironori, Nakamoto, Yuji, Nakagawa, Takayuki, Omori, Koichi, 90443564, 80781913, 10252462, 20360844, 10233272, Iemura-Kashiwagi, Maho, Kikuchi, Masahiro, Koyasu, Sho, Kitada, Yuji, Sugimoto, Akihiko, Haga, Hironori, Nakamoto, Yuji, Nakagawa, Takayuki, and Omori, Koichi

Abstract

Angiomatous polyp is a benign, nonneoplastic nasal polyp that accounts for 4-5% of all inflammatory nasal polyps but is rarely reported in the literature. It can grow rapidly and exhibit an aggressive clinical behavior that can simulate malignant sinonasal tumor. We herein report a case of a 13-year-old boy with a rapidly growing angiomatous polyp in the nasal cavity. We had followed up the patient without significant changes for two years, but the tumor had rapidly grown in the last six months. At first, the rapid growth of the tumor and the bone erosion of the maxilla were suggestive of a malignant tumor. However, with preoperative magnetic resonance imaging (MRI) and [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography imaging findings, we established the corrective diagnosis of an angiomatous polyp. After the diagnostic imaging, we performed an endoscopic endonasal surgery and totally resected the tumor without unnecessary excessive surgery. Recognition of this disease that can mimic malignancy is important to avoid excessive surgery such as en bloc resection by craniofacial approach, and we believe that MRI findings can be helpful for the imaging diagnosis.

Published
2021

43. A multilocular thymic cyst associated with mediastinal seminoma: evidence for its medullary epithelial origin highlighted by POU2F3-positive thymic tuft cells and concomitant myoid cell proliferation

Author

40742622, 90573676, 00335283, 10252462, Sugimoto, Akihiko, Yamada, Yosuke, Fujimoto, Masakazu, Minamiguchi, Sachiko, Sato, Takuma, Akamatsu, Shusuke, Marx, Alexander, Haga, Hironori, 40742622, 90573676, 00335283, 10252462, Sugimoto, Akihiko, Yamada, Yosuke, Fujimoto, Masakazu, Minamiguchi, Sachiko, Sato, Takuma, Akamatsu, Shusuke, Marx, Alexander, and Haga, Hironori

Abstract

Multilocular thymic cyst (MTC) and germ cell tumors are common diseases that impact the mediastinum. Correctly diagnosing these diseases can be difficult because several other conditions can mimic them. We report a male patient with MTC associated with mediastinal seminoma. A needle biopsy of the mediastinal tumor revealed numerous epithelioid cell granulomas that mimicked sarcoidosis or mycobacterial infection. However, large atypical cells positive for Oct3/4 and KIT were noted between the granulomas; thus, we diagnosed the patient with mediastinal seminoma. The resected tumor, after chemotherapy, consisted of multiple cystic lesions, and a residual germ cell tumor was first considered. However, thymic medulla-specific elements, namely, POU2F3-positive thymic tuft cells and rhabdomyomatous myoid cells accompanying the epithelium, led to the correct diagnosis of MTC. Our case underscores the importance of recognizing the histological features associated with mediastinal seminoma and provides novel findings for MTC pathogenesis, namely, the presence of thymic tuft cells.

Published
2021

50. CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells

Author

Ueshima, Chiyuki, Kataoka, Tatsuki R., Takei, Yusuke, Hirata, Masahiro, Sugimoto, Akihiko, Hirokawa, Mitsuyoshi, Okayama, Yoshimichi, Blumberg, Richard S., and Haga, Hironori

Subjects
medullary thyroid carcinoma, SHP-1, Src family kinases, mast cell, CEACAM1
Abstract

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed in a number of tumor cell types. The immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing isoforms of this molecule which possess a long cytoplasmic tail (CEACAM1-L) generally play inhibitory roles in cell function by interacting with Src homology 2 domain-containing tyrosine phosphatase (SHP)-1 and/or SHP-2. Src family kinases (SFKs) are also known to bind to and phosphorylate CEACAM1-L isoforms. Here, we report that CEACAM1 was uniquely expressed at high levels in both human neoplastic mast cells (mastocytosis) and medullary thyroid carcinoma cell (MTC) lines, when compared with their expression in nonneoplastic mast cells or nonneoplastic C cells. This expression was mainly derived from CEACAM1-L isoforms based upon assessment of CEACAM1 mRNA expression. CEACAM1 knockdown upregulated cell growth of HMC1.2 cells harboring KIT mutations detected in clinical mastocytosis, whereas downregulated the growth of TT cells harboring RET mutations detected in clinical MTCs. Immunoblotting, ELISA and immunoprecipitaion analysis showed that activated SHP-1 is preferentially associated with CEACAM1 in HMC1.2 cells harboring KIT mutations, whereas Src family kinases (SFKs) are preferentially associated with CEACAM1 in TT cells harboring RET mutations. These studies suggest that the dominantly interacting proteins SHP1 or SFK determine whether CEACAM1-L displays a positive or negative role in tumor cells.

Published
2017

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