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16. Dry skin conditions are related to the recovery rate of skin temperature after cold stress rather than to blood flow.

Author

Yoshida‐Amano, Yasuko, Nomura, Tomoko, Sugiyama, Yoshinori, Iwata, Kayoko, Higaki, Yuko, and Tanahashi, Masanori

Subjects
BLOOD flow, SKIN physiology, SKIN diseases, BLOOD vessels, HOMEOSTASIS
Abstract

Background Cutaneous blood flow plays an important role in the thermoregulation, oxygen supply, and nutritional support necessary to maintain the skin. However, there is little evidence for a link between blood flow and skin physiology. Therefore, we conducted surveys of healthy volunteers to determine the relationship(s) between dry skin properties and cutaneous vascular function. Methods Water content of the stratum corneum, transepidermal water loss, and visual dryness score were investigated as dry skin parameters. Cutaneous blood flow in the resting state, the recovery rate ( RR) of skin temperature on the hand after a cold-stress test, and the responsiveness of facial skin blood flow to local cooling were examined as indices of cutaneous vascular functions. The relationships between dry skin parameters and cutaneous vascular functions were assessed. Results The RR correlated negatively with the visual dryness score of skin on the leg but correlated positively with water content of the stratum corneum on the arm. No significant correlation between the resting state of blood flow and dry skin parameters was observed. In both the face and the body, deterioration in skin dryness from summer to winter was significant in subjects with low RR. The RR correlated well with the responsiveness of facial skin blood flow to local cooling, indicating that the RR affects systemic dry skin conditions. Conclusions These results suggest that the RR but not blood flow at the resting state is associated with dry skin conditions and is involved in skin homeostasis during seasonal environmental changes. [ABSTRACT FROM AUTHOR]

Published
2017
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23. A New Objective Histological Scale for Studying Human Photoaged skin

Author

Kawabata, Keigo, primary, Kobayashi, Masaki, additional, Kusaka-Kikushima, Ayumi, additional, Akasaka, Emiko, additional, Mabuchi, Tomotaka, additional, Fukui, Tsuyoshi, additional, Sugiyama, Yoshinori, additional, Takekoshi, Susumu, additional, Miyasaka, Muneo, additional, Ozawa, Akira, additional, and Sakai, Shingo, additional

Published
2013
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37. Conditional inactivation ofHas2reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb

Author

Matsumoto, Kazu, primary, Li, Yingcui, additional, Jakuba, Caroline, additional, Sugiyama, Yoshinori, additional, Sayo, Tetsuya, additional, Okuno, Misako, additional, Dealy, Caroline N., additional, Toole, Bryan P., additional, Takeda, Junji, additional, Yamaguchi, Yu, additional, and Kosher, Robert A., additional

Published
2009
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43. N-terminal signal sequence is required for cellular trafficking and hyaluronan-depolymerization of KIAA1199.

Author

Yoshida, Hiroyuki, Nagaoka, Aya, Nakamura, Sachiko, Tobiishi, Megumi, Sugiyama, Yoshinori, and Inoue, Shintaro

Subjects
N-terminal residues, SIGNAL peptides, DEPOLYMERIZATION, HYALURONIC acid, GENE expression, AMINO acid sequence, CELLULAR signal transduction
Abstract

Highlights: [•] Expression of full-length KIAA1199 is essential for HA depolymerizing activity. [•] The cleavage of N-terminal 30 amino acids occurs in functionally matured KIAA1199. [•] The deletion of the N-terminal portion results in altered localization of KIAA1199. [•] The N-terminal 30 amino acids of KIAA1199 are indeed the cleavable signal sequence. [Copyright &y& Elsevier]

Published
2014
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47. Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells.

Author

Hara-Chikuma, Mariko, Sugiyama, Yoshinori, Kabashima, Kenji, Sohara, Eisei, Uchida, Shinichi, Sasaki, Sei, Inoue, Shintaro, and Miyachi, Yoshiki

Subjects
*DENDRITIC cells, *AQUAPORINS, *IMMUNE response, *LYMPH nodes, *T cells, *PHAGOCYTOSIS
Abstract

Dendritic cells (DCs) have the ability to present antigen and play a critical role in the induction of the acquired immune response. Skin DCs uptake antigen and subsequently migrate to regional draining lymph nodes (LNs), where they activate naive T cells. Here we show that the water/glycerol channel protein aquaporin 7 (AQP7) is expressed on epidermal and dermal DCs and involved in the initiation of primary immune responses. AQP7-deficient DCs showed a decreased cellular uptake of low-molecular-mass compounds (fluorescein isothiocyanate and Lucifer yellow) and high-molecular-mass substances (ovalbumin and dextran), suggesting that AQP7 is involved in antigen uptake. AQP7-deficient DCs also exhibited reduced chemokine-dependent cell migration in comparison to wild-type DCs. Consistent with these in vitro results, AQP7-deficient mice demonstrated a reduced accumulation of antigen-retaining DCs in the LNs after antigen application to the skin, which could be attributed to decreased antigen uptake and migration. Coincidentally, AQP7-deficient mice had impaired antigen-induced sensitization in a contact hypersensitivity model. These observations suggested that AQP7 in skin DCs is primarily involved in antigen uptake and in the subsequent migration of DCs and is responsible for antigen presentation and the promotion of downstream immune responses. [ABSTRACT FROM AUTHOR]

Published
2012
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48. Adiponectin resides in mouse skin and upregulates hyaluronan synthesis in dermal fibroblasts.

Author

Akazawa, Yumiko, Sayo, Tetsuya, Sugiyama, Yoshinori, Sato, Takashi, Akimoto, Noriko, Ito, Akira, and Inoue, Shintaro

Subjects
ADIPONECTIN, LABORATORY mice, HYALURONIC acid, FIBROBLASTS, GENETIC regulation, ADIPOSE tissues, MESSENGER RNA, AGING
Abstract

Adipose tissue is a hormonally active tissue that produces adipokines that influence the activity of other tissues. Adiponectin is an adipocyte-specific adipokine involved in systemic metabolism. We detected the expression of adiponectin receptors (AdipoR1 and AdipoR2) mRNA in cultured dermal fibroblasts. The full-length adiponectin (fAd), but not the globular adiponectin (gAd), increased hyaluronan (HA) production and upregulated HA synthase (HAS) 2 mRNA expression. AdipoR1 and AdipoR2 mRNAs were also expressed in keratinocytes, though neither fAd nor gAd had any effect on HA synthesis. In mouse skin, we found that adiponectin was present and decreased markedly with aging. The age-dependent pattern of adiponectin decrease in skin, correlated well with that of HA in skin. Our experiments were also the first to identify adiponectin production in cultured mouse sebocytes, a finding that suggests that skin adiponectin may derive not only from plasma and//or subcutaneous adipose tissue, but also from the sebaceous gland. These results indicated that adiponectin plays an important role in the HA metabolism of skin. [ABSTRACT FROM AUTHOR]

Published
2011
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49. Sinusoid development and morphogenesis may be stimulated by VEGF-Flk-1 signaling during fetal mouse liver development.

Author

Sugiyama, Yoshinori, Takabe, Yurie, Nakakura, Takashi, Tanaka, Shigeyasu, Koike, Toru, and Shiojiri, Nobuyoshi

Abstract

Early morphogenesis of hepatic sinusoids was histochemically and experimentally analyzed, and the importance of VEGF-Flk-1 signaling in the vascular development was examined during murine liver organogenesis. FITC-gelatin injection experiments into young murine fetuses demonstrated that all primitive sinusoidal structures were confluent with portal and central veins, suggesting that hepatic vessel development may occur via angiogenesis. At 12.5-14.5 days of gestation, VEGF receptors designated Flk-1, especially their mature form, were highly expressed in endothelial cells of primitive sinusoidal structures and highly phosphorylated on their tyrosine residues. At the same time, VEGF was also detected in hepatoblasts/hepatocytes, hemopoietic cells, and megakaryocytes of the whole liver parenchyma. Furthermore, the addition of VEGF to E12.5 liver cell cultures significantly induced the growth and branching morphogenesis of sinusoidal endothelial cells. Therefore, VEGF-Flk-1 signaling may play an important role in the growth and morphogenesis of primitive sinusoids during fetal liver development. Developmental Dynamics 239:386-397, 2010. © 2009 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

Published
2010
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50. A New Tobacco Mosaic Virus Vector and its Use for the Systemic Production of Angiotensin-I-Converting Enzyme Inhibitor in Transgenic Tobacco and Tomato

Author

Hamamoto, Hiroshi, Sugiyama, Yoshinori, Nakagawa, Noriaki, Hashida, Eiji, Matsunaga, Yuji, Takemoto, Shizume, Watanabe, Yuichiro, and Okada, Yoshimi

Abstract

We have developed a new tobacco mosaic virus (TMV) RNA vector and have used it initially to systemically produce an angiotensin-I-converting enzyme inhibitor peptide (ACEI) in tobacco and tomato plants. This vector incorporates a six base 3′ context sequence, which permits readthrough of the stop codon for the TMV 130K protein gene, inserted between the stop codon for the coat protein (CP) gene and ACEI gene. In contrast to previous TMV RNA vectors, the new vector produced both an intact CP and a fused protein consisting of CP and ACEI (CP-ACEI). As a result, the vector could form virus particles and spread systemically from inoculated to non-inoculated leaves. In tomato plants, production of ACEI in fruit was also achieved.

Published
1993
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