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5. COVID-19 vaccine-induced immune thrombotic thrombocytopenia

Author

A. B. Sugraliyev and P. Cirillo

Subjects
vaccine-induced immune thrombotic thrombocytopenia, adenoviral vaccines, covid-19, thrombocytopenia, thrombosis, Internal medicine, RC31-1245
Abstract

The coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) stimulated the development of highly effective vaccines that were produced with unprecedented speed with the use of new technologies. All the newly developed vaccines are highly effective with minimal adverse effects. Clinical introduction of the AstraZeneca Covid-19 vaccine has raised public alarm regarding the rare, but serious thrombotic events, known as vaccine-induced immune thrombotic thrombocytopenia (VITT). VITT is characterized clinical and laboratory syndromes like: venous (acute cerebral sinus venous thrombosis and abdominal vein thrombosis) or arterial thrombosis; mild-to-severe thrombocytopenia; positive antiplatelet factor 4 (PF4)-polyanion antibodies or anti-PF4–heparin antibodies detected by ELISA; occurring 5–30 days after ChAdOx1 nCoV-19 (AstraZeneca) or Ad26. COV2.S (Johnson & Johnson/Janssen) vaccination and elevated D-dimer. From a pathophysiological point of view, VITT is an autoimmune disease characterized by the development of antibodies that directly activate platelets, causing thrombosis in the arterial or venous systems of the body. At the same time, the components of the vaccine serve as an antigen for the formation of autoantibodies, which enhance the production of platelet factor PF4, which contributes to the formation of blood clots. It has established that intravenous use of immunoglobulin at a dose of 1 g/kg of the patient’s body weight per day, in addition to neutralizing antibodies, makes it possible to suppress VITT-mediated platelet activation. Fondaparinux, direct oral anticoagulants (DOACs), danaparoid or argatroban are the main anticoagulant drugs effective in the treatment of thrombotic conditions in VITT.

Published
2022
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7. Risk assessment and prevention of venous thromboembolism among hospitalized patients: Results of the regional multicenter study

Author

A. B. Sugraliyev, Sh. S. Aktayeva, Sh. B. Zhangelova, S. A. Shiller, Zh. M. Kussymzhanova, S. K. Tuganbekova, Zh. S. Sheriyazdan, B. L. Danyarova, and V. E. Tsai

Subjects
prophylaxis of venous thromboembolism, guidelines, venous thromboembolism, caprini score, level of prophylaxis among hospitalized patients, Internal medicine, RC31-1245
Abstract

Introduction. Venous thromboembolism (VTE) is a major public health issue that is frequently underestimated. The primary objective of this multicenter study was to identify patients at risk for VTE, and to define the rate of patients receiving appropriate prophylaxis in the regions of Kazakhstan.Materials and methods. Standardized case report forms were filled by trained medical doctors on one predefined day in selected hospitals. Data were analyzed by independent biostatistician. Risk of VTE was categorized according to Caprini score which was recommended by 2004 American College of Chest Physicians (ACCP) guidelines.Results. 432 patients from 4 regions of Kazakhstan; 169 (39.10%) medical patients and 263 (60.9%) surgical patients were eligible for the study. Patients were at low (10%), moderate (19.2%), high (33.6%) and very high risk (37.3%) for VTE. The main risk factors (RF) of VTE among hospitalized patients were heart failure (HF), obesity, prolonged bed rest, and the presence of acute non-infective inflammation. From total number of hospitalized patients with RF with indications to VTE prophylaxis, 58.1% of patients received pharmacological prophylaxis and only 24.6% of them received VTE prophylaxis according ACCP. On the other hand, 23.5% patients with the risk of VTE but who were not eligible for it received pharmacological prophylaxis.Conclusion. These results indicate the existence of inconsistency between eligibility for VTE prophylaxis on one hand and its application in practice (p < 0.001). Risk factors for VTE and eligibility for VTE prophylaxis are common, but VTE prophylaxis and guidelines application are low.

Published
2021
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8. Uric Acid Induces a Proatherothrombotic Phenotype in Human Endothelial Cells by Imbalancing the Tissue Factor/Tissue Factor Pathway Inhibitor Pathway

Author

Giovanni Cimmino, Stefano Conte, Laura Marra, Andrea Morello, Mariarosaria Morello, Gennaro De Rosa, Martino Pepe, Akhmetzhan Sugraliyev, Paolo Golino, Plinio Cirillo, Cimmino, Giovanni, Conte, Stefano, Marra, Laura, Morello, Andrea, Morello, Mariarosaria, De Rosa, Gennaro, Pepe, Martino, Sugraliyev, Akhmetzhan, Golino, Paolo, and Cirillo, Plinio

Subjects
Hematology
Abstract

Background Several evidence show that elevated plasma levels of uric acid (UA) are associated with the increased risk of developing atherothrombotic cardiovascular events. Hyperuricemia is a risk factor for endothelial dysfunction (ED). ED is involved in the pathophysiology of atherothrombosis since dysfunctional cells lose their physiological, antithrombotic properties. We have investigated whether UA might promote ED by modulating the tissue factor (TF)/TF pathway inhibitor (TFPI) balance by finally changing the antithrombotic characteristics of endothelial cells. Methods Human umbilical vein endothelial cells were incubated with increasing doses of UA (up to 9 mg/dL). TF gene and protein expressions were evaluated by real-time polymerase chain reaction (PCR) and Western blot. Surface expression and procoagulant activity were assessed by FACS (fluorescence activated cell sorting) analysis and coagulation assay. The mRNA and protein levels of TFPI were measured by real-time PCR and Western blot. The roles of inflammasome and nuclear factor-κB (NF-κB) as possible mechanism(s) of action of the UA on TF/TFPI balance were also investigated. Results UA significantly increased TF gene and protein levels, surface expression, and procoagulant activity. In parallel, TFPI levels were significantly reduced. The NF-κB pathways appeared to be involved in modulating these phenomena. Additionally, inflammasome might also play a role. Conclusion The present in vitro study shows that one of the mechanisms by which high levels of UA contribute to ED might be the imbalance between TF/TFPI levels in endothelial cells, shifting them to a nonphysiological, prothrombotic phenotype. These UA effects might hypothetically explain, at least in part, the relationship observed between elevated plasma levels of UA and cardiovascular events.

Published
2022
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9. A rare case of deep vein and right atrial thrombosis in a patient with chronic heart failure and pulmonary embolism

Author

Akhmetzhan Sugraliyev, Shynar Aktayeva, Gulnur Tanbayeva, Almat Kodasbayev, Plinio Cirillo, and Klara Iskakova

Subjects
Chronic heart failure, thrombosis, pulmonary embolism, Medicine
Abstract

Deep vein thrombosis (DVT) is frequently observed in patients with chronic heart failure (CHF), increasing the risk of pulmonary embolism (PE). Clinical evaluation of CHF patients with suspected acute PE is challenging since these diseases share several symptoms and signs such as dyspnea. Thus, it is intuitive that correct and fast diagnosis of PE in these patients might be able to significantly change their clinical outcome. In the present report, we describe a rare case of a patient with CHF and PE due to a huge thrombosis of deep veins and of right atrium in whom echo evaluation permitted the correct diagnosis and therapy.

Published
2020
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10. The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting report.

Author

Grigorian-Shamagian, Lilian, Coca, Antonio, Morais, Joao, Perez-Martinez, Pablo, the Multinational Discussion Group, Barragan, Adriana, Barrientos, Ana Isabel, e Silva, Alexandre Amaral, Sugraliyev, Akhmetzhan, Parkhomenko, Alexander, Liprandi, Álvaro Sosa, Parapid, Biljana, Olivares, Carlos, Negretti, Carlos Ignacio Ponte, Quesada, Daniel, Kosevic, Dragana, Gastelum, Edith Ruiz, López, Emilio Samael Peralta, Araujo, Francisco, and Padilla Padilla, Francisco Gerardo

Subjects
SECONDARY prevention, MEDICAL care costs, PATIENT compliance, CARDIOVASCULAR diseases, CARDIOVASCULAR diseases risk factors, DYSLIPIDEMIA, HYPERTENSION
Abstract

Although the cardiovascular (CV) polypill concept is not new and several guidelines state that a CV polypill should be considered an integral part of a comprehensive CV disease (CVD) prevention strategy, there are still some barriers to its implementation in the real-world setting, mainly in secondary CV prevention. As the CNIC-polypill is the only one approved for secondary CV prevention in patients with atherosclerotic CVD in 27 countries worldwide, a panel of four discussants and 30 participants from 18 countries conveyed in a virtual meeting on April 21, 2022, to discuss key clinical questions regarding the practical use of the CNIC-Polypill and barriers to its implementation. Data presented showed that, although the use of the CV polypill is not explicitly mentioned in the current 2021 European Society of Cardiology guidelines on CVD prevention, it may be used in any patient for secondary CVD prevention tolerating all their components to improve outcomes through different aspects. The favourable results of the Secondary Prevention of Cardiovascular Disease in the Elderly (SECURE) trial now reinforce this recommendation. The panellists presented algorithms on how to switch from any baseline regimen when starting treatment with the CNIC-polypill in different situations, including patients with hypertension, dyslipidaemia, and a previous CV event; at discharge after a cardiovascular event; in chronic ischemic conditions; and in cases of polypharmacy. The panellists and expert discussants did agree that available studies conducted so far with the CNIC-polypill demonstrate that it is as efficacious as the monocomponents, equipotent drugs, or other therapies; reduces the risk of experiencing recurrent major CV events; improves medication adherence; reduces health care costs and resources compared to patients treated with loose drugs; and the patients prefer it over the multipill strategy. In conclusion, the data presented by the participants provided the evidence behind the use of the CNIC-polypill to help fulfil the goal of encouraging its adoption by physicians. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Effects of colchicine on tissue factor in oxLDL-activated T-lymphocytes

Author

Giusi Barra, Giovanni Cimmino, Paolo Golino, Raffaele De Palma, Plinio Cirillo, Stefano Conte, Grazia Pellegrino, Akhmetzhan Sugraliyev, Cirillo, Plinio, Conte, Stefano, Pellegrino, Grazia, Barra, Giusi, De Palma, Raffaele, Sugraliyev, Akhmetzhan, Golino, Paolo, Cimmino, Giovanni, Cirillo, P., Conte, S., Pellegrino, G., Barra, G., De Palma, R., Sugraliyev, A., Golino, P., and Cimmino, G.

Subjects
medicine.medical_specialty, Cell type, T-lymphocyte, T-Lymphocytes, Pharmacology, Thromboplastin, Rosuvastatin, Tissue factor, chemistry.chemical_compound, Western blot, Internal medicine, Colchicine, Thrombosis, medicine, Humans, Acute Coronary Syndrome, Rosuvastatin Calcium, Transcription factor, Hematology, medicine.diagnostic_test, business.industry, NF-kappa B, Pathophysiology, Lipoproteins, LDL, chemistry, Thrombosi, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Several studies have shown that T-cells might be involved in pathophysiology of acute coronary syndromes (ACS). Tissue factor (TF) plays a key role in ACS. Many evidences have indicated that some statins reduce TF expression in several cell types. However, literature about rosuvastatin and TF and about statins effects on T-cells is still scanty. Colchicine is an anti-inflammatory drug recently proven to have beneficial effects in ACS via unknown mechanisms. This study investigates the effects of colchicine and rosuvastatin on TF expression in oxLDL-activated T-cells. T-cells, isolated from buffy coats of healthy volunteers, were stimulated with oxLDL (50µg/dL). T-cells were pre-incubated with colchicine (10µM) or rosuvastatin (5µM) for 1h and then stimulated with oxLDL (50μg/mL). TF gene (RT-PCR), protein (western blot), surface expression (FACS) and procoagulant activity (FXa generation assay) were measured. NF-κB/IκB axis was examined by western blot analysis and translocation assay. Colchicine and rosuvastatin significantly reduced TF gene, and protein expression and procoagulant activity in oxLDL stimulated T-cells. This effect was associated with a significant reduction in TF surface expression as well as its procoagulant activity. These phenomena appear modulated by drug effects on the transcription factor NF-kB. Rosuvastatin and colchicine prevent TF expression in oxLDL-stimulated T-cells by modulating the NF-κB/IκB axis. Thus, we speculate that this might be another mechanism by which these drugs exert benefic cardiovascular effects.

Published
2021

12. Uric Acid Induces a Proatherothrombotic Phenotype in Human Endothelial Cells by Imbalancing the Tissue Factor/Tissue Factor Pathway Inhibitor Pathway

Author

Cimmino, Giovanni, additional, Conte, Stefano, additional, Marra, Laura, additional, Morello, Andrea, additional, Morello, Mariarosaria, additional, De Rosa, Gennaro, additional, Pepe, Martino, additional, Sugraliyev, Akhmetzhan, additional, Golino, Paolo, additional, and Cirillo, Plinio, additional

Published
2022
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14. Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome. Prevention of venous thromboembolism in patients with COVID-19

Author

Akhmetzhan Sugraliyev and Рlinio Cirillo

Subjects
medicine.medical_specialty, Lung, medicine.anatomical_structure, Coronavirus disease 2019 (COVID-19), business.industry, Internal medicine, medicine, Cardiology, In patient, business, Venous thromboembolism
Abstract

In this review, the authors describe the new concept of MicroCLOTS (microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome) - proposed by Italian multidisciplinary team headed by Ciceri F, et al. as the cause of atypical acute respiratory distress syndrome. Ciceri F, etal. hypothesise that, in predisposed individuals, alveolar viral damage is followed by an inflammatory reaction and by microvascular pulmonary thrombosis. This progressive endothelial thromboinflammatory syndrome may also involve the microvascular bed of the brain and other vital organs, leading to multiple organ failure and death. In addition, patients with COVID-19 often develop macrovascular venous thrombosis as a result of the activation of the Virchow triad. Microvascular and macrovascular thrombosis development in patients with COVID-19 is confirmed by ultrasound examination of the veins of the lower extremities and complete autopsy study. The data obtained indicate the importance of the prevention of venous thrombosis with LMWH (nadroparin, enoxaparin) and Fondaparinux sodium in all hospitalized patients with COVID-19. Keywords: COVID-19, аtypical acute respiratory distress syndrome, MicroCLOTS (microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome), thrombosis, hemostasis.

Published
2020
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15. Use of Statins, Anticoagulants, Antiaggregants and Antiarrhythmic Drugs in Patients With COVID-19. The Agreed Experts’ Position of Russian Society of Cardiology, Eurasian Association of Therapists, National Society on Atherothrombosis, Societies of Experts in Urgent Cardiology, Eurasian Arrhythmology Association

Author

N P Mitkovskaya, A O Konradi, Komarov Al, E I Tarlovskaya, Ye V Shlyakhto, V A Snezhitskiy, S V Malchikova, A I Chesnikova, L V Kolotsey, M M Petrova, A B Sugraliyev, V V Skibitsky, A G Arutyunov, N. A. Koziolova, Ya A Orlova, Tereshchenko Sn, Kropacheva Es, G P Arutyunov, I. V. Fomin, Yu N Belenkov, Panchenko Ep, I. S. Yavelov, Ardashev Av, I I Shaposhnik, N Yu Grigorieva, G A Dzhunusbekova, S G Kanorskii, A P Rebrov, Hamayak Sisakian, E G Zhelyakov, and O. M. Drapkina

Subjects
medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Heart rhythm disorders, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Cardiology, MEDLINE, 030204 cardiovascular system & hematology, Russia, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Antithrombotic, Humans, Medicine, In patient, 030212 general & internal medicine, Intensive care medicine, Pandemics, Societies, Medical, SARS-CoV-2, business.industry, Anticoagulants, COVID-19, COVID-19 Drug Treatment, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Coronavirus Infections, Cardiology and Cardiovascular Medicine, business, Anti-Arrhythmia Agents
Abstract

This article discusses relevant aspects in the treatment of patients with COVID-19. Up-to-date information about principles for administration of statins, antithrombotics, and antiarrhythmics is presented. The authors addressed in detail specific features of reversing heart rhythm disorders in patients with coronavirus infection and the interaction of antiarrhythmic and antiviral drugs. Recommendations are provided for outpatient and inpatient antithrombotic therapy for patients with COVID-19. Issues of antithrombotic and antiviral drug interaction are discussed.

Published
2020
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17. A rare case of deep vein and right atrial thrombosis in a patient with chronic heart failure and pulmonary embolism

Author

Shynar Aktayeva, Almat Kodasbayev, Gulnur Tanbayeva, Plinio Cirillo, Klara Iskakova, Akhmetzhan Sugraliyev, Sugraliyev, A., Aktayeva, S., Tanbayeva, G., Kodasbayev, A., Cirillo, P., and Iskakova, K.

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, pulmonary embolism, Deep vein, lcsh:Medicine, Right atrial, Internal medicine, Natriuretic Peptide, Brain, Rare case, medicine, Humans, In patient, Heart Atria, cardiovascular diseases, thrombosis, Aged, Ultrasonography, Heart Failure, Venous Thrombosis, Heparin, business.industry, lcsh:R, Anticoagulants, medicine.disease, Thrombosis, Peptide Fragments, Chronic heart failure, Pulmonary embolism, Treatment Outcome, medicine.anatomical_structure, Echocardiography, Heart failure, Chronic Disease, Cardiology, cardiovascular system, Right atrium, Cardiology and Cardiovascular Medicine, business, Factor Xa Inhibitors
Abstract

Deep vein thrombosis (DVT) is frequently observed in patients with chronic heart failure (CHF), increasing the risk of pulmonary embolism (PE). Clinical evaluation of CHF patients with suspected acute PE is challenging since these diseases share several symptoms and signs such as dyspnea. Thus, it is intuitive that correct and fast diagnosis of PE in these patients might be able to significantly change their clinical outcome. In the present report, we describe a rare case of a patient with CHF and PE due to a huge thrombosis of deep veins and of right atrium in whom echo evaluation permitted the correct diagnosis and therapy. [1,2]. This variability might be due to the different sensitivity of diagnostic criteria in reports: those hospitals, in which the screening for DVT is more accurate, are likely to find more cases of DVT and pulmonary embolism (PE) [3]. Myocardial infarction and heart failure increase the risk of PE. Conversely, patients with DVT have an increased risk of developing myocardial infarction and stroke [4]. Thus, a correct and fast diagnosis of PE in these patients plays a pivotal role to change their clinical outcome. In the present report, we describe the case of a patient with CHF complicated by PE due to a huge venous thrombosis that extended from pheripheral vein till the right atrium, where echocardiographic evaluation showed a rare image of thrombus floating in the cavity of cardiac chamber.

Published
2020

20. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)

Author

Konstantinides, Stavros V., Meyer, Guy, Becattini, Cecilia, Bueno, Hector, Geersing, Geert-Jan, Harjola, Veli-Pekka, Huisman, Menno V., Humbert, Marc, Jennings, Catriona Sian, Jimenez, David, Kucher, Nils, Lang, Irene Marthe, Lankeit, Mareike, Lorusso, Roberto, Mazzolai, Lucia, Meneveau, Nicolas, Ni Ainle, Fionnuala, Prandoni, Paolo, Pruszczyk, Piotr, Righini, Marc, Torbicki, Adam, Van Belle, Eric, Luis Zamorano, Jose, Nazzareno, Galié, J Simon, R Gibbs, Victor, Aboyans, Walter, Ageno, Stefan, Agewall, Ana, G Almeida, Felicita, Andreotti, Emanuele, Barbato, Johann, Bauersachs, Andreas, Baumbach, Farzin, Beygui, Jørn, Carlsen, Marco De Carlo, Marion, Delcroix, Victoria, Delgado, Pilar Escribano Subias, Donna, Fitzsimons, Sean, Gaine, Samuel, Z Goldhaber, Deepa, Gopalan, Gilbert, Habib, Sigrun, Halvorsen, David, Jenkins, Hugo, A Katus, Barbro, Kjellström, Mitja, Lainscak, Patrizio, Lancellotti, Geraldine, Lee, Grégoire Le Gal, Emmanuel, Messas, Joao, Morais, Steffen, E Petersen, Anna Sonia Petronio, Massimo Francesco Piepoli, Susanna, Price, Marco, Roffi, Aldo, Salvi, Olivier, Sanchez, Evgeny, Shlyakhto, Iain, A Simpson, Stefan, Stortecky, Matthias, Thielmann, Anton Vonk Noordegraaf, Cecilia, Becattini, Héctor, Bueno, Geert-Jan, Geersing, Veli-Pekka, Harjola, Menno, V Huisman, Marc, Humbert, Catriona Sian Jennings, David, Jiménez, Nils, Kucher, Irene Marthe Lang, Mareike, Lankeit, Roberto, Lorusso, Lucia, Mazzolai, Nicolas, Meneveau, Fionnuala Ní Áinle, Paolo, Prandoni, Piotr, Pruszczyk, Marc, Righini, Adam, Torbicki, Eric, Vanbelle, José, Luiszamorano, Stephan, Windecker, Colin, Baigent, Jean-Philippe, Collet, Veronica, Dean, Chris, P Gale, Diederick, Grobbee, Gerhard, Hindricks, Bernard, Iung, Peter, Jüni, Ulf, Landmesser, Christophe, Leclercq, Maddalena, Lettino, Basil, S Lewis, Bela, Merkely, Christian, Mueller, Dimitrios, J Richter, Miguel, Sousa-Uva, Rhian, M Touyz, Naima, Hammoudi, Hamlet, Hayrapetyan, Julia, Mascherbauer, Firdovsi, Ibrahimov, Oleg, Polonetsky, Mariya, Tokmakova, Bosko, Skoric, Ioannis, Michaloliakos, Martin, Hutyra, Søren, Mellemkjaer, Mansour, Mostafa, Julia, Reinmets, Pertti, Jääskeläinen, Denis, Angoulvant, George, Giannakoulas, Endre, Zima, Vizza, Carmine Dario, Akhmetzhan, Sugraliyev, Ibadete, Bytyçi, Aija, Maca, Egle, Ereminiene, Steve, Huijnen, Robert, Xuereb, Nadejda, Diaconu, Nebojsa, Bulatovic, Ilyasse, Asfalou, Marijan, Bosevski, Bożena, Sobkowicz, Daniel, Ferreira, Antoniu Octavian Petris, Olga, Moiseeva, Marco, Zavatta, Slobodan, Obradovic, Iveta, Šimkova, Peter, Radsel, Borja, Ibanez, Gerhard, Wikström, Drahomir, Aujesky, Cihangir, Kaymaz, Alexander, Parkhomenko, Joanna, Pepke-Zaba, University of Zurich, Konstantinides, Stavros V, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Konstantinides S.V., Meyer G., Bueno H., Galie N., Gibbs J.S.R., Ageno W., Agewall S., Almeida A.G., Andreotti F., Barbato E., Baumbach A., Beygui F., Carlsen J., De Carlo M., Delcroix M., Subias P.E., Gaine S., Goldhaber S.Z., Gopalan D., Habib G., Jenkins D., Kjellstrom B., Lainscak M., Lee G., Le Gal G., Messas E., Morais J., Piepoli M.F., Price S., Salvi A., Sanchez O., Stortecky S., Thielmann M., Noordegraaf A.V., Becattini C., Geersing G.-J., Harjola V.-P., Huisman M.V., Humbert M., Jennings C.S., Jimenez D., Kucher N., Lang I., Lankeit M., Lorusso R., Mazzolai L., Meneveau N., Ainle F.N., Prandoni P., Pruszczyk P., Righini M., Torbicki A., Van Belle E., Zamorano J.L., Windecker S., Aboyans V., Baigent C., Collet J.-P., Dean V., Delgado V., Fitzsimons D., Gale C.P., Grobbee D.E., Hindricks G., Iung B., Juni P., Katus H.A., Landmesser U., Leclercq C., Lettino M., Lewis B.S., Merkely B., Mueller C., Petersen S.E., Petronio A.S., Richter D.J., Roffi M., Shlyakhto E., Simpson I.A., Sousa-Uva M., Touyz R.M., Hammoudi N., Hayrapetyan H., Mascherbauer J., Ibrahimov F., Polonetsky O., Lancellotti P., Tokmakova M., Skoric B., Michaloliakos I., Hutyra M., Mellemkjaer S., Mansour M., Reinmets J., Jaaskelainen P., Angoulvant D., Bauersachs J., Giannakoulas G., Zima E., Vizza C.D., Sugraliyev A., Bytyci I., Maca A., Ereminiene E., Huijnen S., Xuereb R., Diaconu N., Bulatovic N., Asfalou I., Bosevski M., Halvorsen S., Sobkowicz B., Ferreira D., Petris A.O., Moiseeva O., Zavatta M., Obradovic S., Simkova I., Radsel P., Ibanez B., Wikstrom G., Aujesky D., Kaymaz C., Parkhomenko A., Pepke-Zaba J., CTC, MUMC+: MA Med Staf Spec CTC (9), and RS: Carim - V04 Surgical intervention

Subjects
ORAL ANTICOAGULANT-THERAPY, diagnosis, [SDV]Life Sciences [q-bio], Medizin, 030204 cardiovascular system & hematology, Embolectomy, Guideline, RECURRENT VENOUS THROMBOEMBOLISM, 0302 clinical medicine, Pregnancy, Daily practice, Diagnosis, Pulmonary medicine, Venous thrombosis, Pulmonary Medicine, Thrombolytic Therapy, DEEP-VEIN THROMBOSIS, Disease management (health), Societies, Medical, ComputingMilieux_MISCELLANEOUS, health care economics and organizations, Risk assessment, ddc:616, RIGHT-VENTRICULAR DYSFUNCTION, Disease Management, Shock, MOLECULAR-WEIGHT HEPARIN, Thrombolysis, humanities, 3. Good health, Pulmonary embolism, Europe, Anticoagulation, Biomarkers, Dyspnoea, Echocardiography, Guidelines, Heart failure, Right ventricle, Treatment, Venous thromboembolism, medicine.vein, Acute Disease, Medical emergency, Cardiology and Cardiovascular Medicine, guidelines, pulmonary embolism, venous thrombosis, shock dyspnoea, heart failure: right ventricle: diagnosis, risk assessment: echocardiography, biomarkers, treatment, anticoagulation, thrombolysis, pregnancy, venous thromboembolism, embolectomy, Diagnosi, education, Cardiology, MEDLINE, Thrombolysi, 610 Medicine & health, Inferior vena cava, 2705 Cardiology and Cardiovascular Medicine, EXTRACORPOREAL MEMBRANE-OXYGENATION, 03 medical and health sciences, Medical, medicine, Humans, RIGHT HEART THROMBI, VENTILATION-PERFUSION SCINTIGRAPHY, Health professionals, business.industry, INFERIOR VENA-CAVA, 10031 Clinic for Angiology, Anticoagulants, 030229 sport sciences, Biomarker, medicine.disease, INHALED NITRIC-OXIDE, Societies, business
Abstract

Guidelines summarize and evaluate available evidence with the aim of assisting health professionals in proposing the best management strategies for an individual patient with a given condition. Guidelines and their recommendations should facilitate decision making of health professionals in their daily practice. However, the final decisions concerning an individual patient must be made by the responsible health professional(s) in consultation with the patient and caregiver as appropriate.

Published
2019
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22. [Cardiac Involvement in COVID-19]

Author

A B Sugraliyev

Subjects
medicine.medical_specialty, Myocarditis, Angiotensin-Converting Enzyme Inhibitors, 030204 cardiovascular system & hematology, medicine.disease_cause, Renin-Angiotensin System, 03 medical and health sciences, Angiotensin Receptor Antagonists, 0302 clinical medicine, Viral entry, Internal medicine, Renin–angiotensin system, medicine, Humans, 030212 general & internal medicine, Respiratory system, Coronavirus, business.industry, SARS-CoV-2, COVID-19, medicine.disease, Coronary arteries, medicine.anatomical_structure, Heart failure, Hypertension, Cardiology, Viral disease, Cardiology and Cardiovascular Medicine, business
Abstract

The novel coronavirus infection, COVID-19, is a highly contagious viral disease associated with acute, severe respiratory syndrome, which is based on the development of pronounced thrombo-inflammatory syndrome. As the number of patients with COVID-19 increased, heart damage has been reported, especially in patients with severe and critical COVID-19. This review describes the role of angiotensin-converting enzyme 2 receptor in the regulation of viral entry, the variety of damages to the heart and coronary arteries, and the importance of arterial hypertension and of the use of renin-angiotensin-aldosterone system inhibitors in the prognosis of patients with COVID-19.

Published
2020

23. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European respiratory society (ERS) : The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC)

Author

Konstantinides, Stavros V., Meyer, Guy, Bueno, Hector, Galié, Nazzareno, Gibbs, J. Simon R., Ageno, Walter, Agewall, Stefan, Almeida, Ana G., Andreotti, Felicita, Barbato, Emanuele, Baumbach, Andreas, Beygui, Farzin, Carlsen, Jørn, De Carlo, Marco, Delcroix, Marion, Subias, Pilar Escribano, Gaine, Sean, Goldhaber, Samuel Z., Gopalan, Deepa, Habib, Gilbert, Jenkins, David, Kjellström, Barbro, Lainscak, Mitja, Lee, Geraldine, Le Gal, Grégoire, Messas, Emmanuel, Morais, Joao, Piepoli, Massimo Francesco, Price, Susanna, Salvi, Aldo, Sanchez, Olivier, Stortecky, Stefan, Thielmann, Matthias, Noordegraaf, Anton Vonk, Becattini, Cecilia, Bueno, Héctor, Geersing, Geert Jan, Harjola, Veli Pekka, Huisman, Menno V., Humbert, Marc, Jennings, Catriona Sian, Jiménez, David, Kucher, Nils, Lang, Irene Marthe, Lankeit, Mareike, Lorusso, Roberto, Mazzolai, Lucia, Meneveau, Nicolas, Áinle, Fionnuala Ní, Prandoni, Paolo, Pruszczyk, Piotr, Righini, Marc, Torbicki, Adam, Van Belle, Eric, Zamorano, José Luis, Windecker, Stephan, Aboyans, Victor, Baigent, Colin, Collet, Jean Philippe, Dean, Veronica, Delgado, Victoria, Fitzsimons, Donna, Gale, Chris P., Grobbee, Diederick E., Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Landmesser, Ulf, Leclercq, Christophe, Lettino, Maddalena, Lewis, Basil S., Merkely, Bela, Mueller, Christian, Petersen, Steffen E., Petronio, Anna Sonia, Richter, Dimitrios J., Roffi, Marco, Shlyakhto, Evgeny, Simpson, Iain A., Sousa-Uva, Miguel, Touyz, Rhian M., Hammoudi, Naima, Hayrapetyan, Hamlet, Mascherbauer, Julia, Ibrahimov, Firdovsi, Polonetsky, Oleg, Lancellotti, Patrizio, Tokmakova, Mariya, Skoric, Bosko, Michaloliakos, Ioannis, Hutyra, Martin, Mellemkjaer, Søren, Mansour, Mostafa, Reinmets, Julia, Jääskeläinen, Pertti, Angoulvant, Denis, Bauersachs, Johann, Giannakoulas, George, Zima, Endre, Vizza, Carmine Dario, Sugraliyev, Akhmetzhan, Bytyçi, Ibadete, Maca, Aija, Ereminiene, Egle, Huijnen, Steve, Xuereb, Robert, Diaconu, Nadejda, Bulatovic, Nebojsa, Asfalou, Ilyasse, Bosevski, Marijan, Halvorsen, Sigrun, Sobkowicz, Bozena, Ferreira, Daniel, Petris, Antoniu Octavian, Moiseeva, Olga, Zavatta, Marco, Obradovic, Slobodan, Šimkova, Iveta, Radsel, Peter, Ibanez, Borja, Wikström, Gerhard, Aujesky, Drahomir, Kaymaz, Cihangir, Parkhomenko, Alexander, and Pepke-Zaba, Joanna

Subjects
thrombolysis, pulmonary embolism, treatment, diagnosis, education, venous thromboembolism, biomarkers, heart failure, shock, Embolectomy, Guidelines, dyspnoea, right ventricle, humanities, Anticoagulation, Pregnancy, Venous thrombosis, Journal Article, echocardiography, Cardiology and Cardiovascular Medicine, health care economics and organizations, Risk assessment
Abstract

Guidelines summarize and evaluate available evidence with the aim of assisting health professionals in proposing the best management strategies for an individual patient with a given condition. Guidelines and their recommendations should facilitate decision making of health professionals in their daily practice. However, the final decisions concerning an individual patient must be made by the responsible health professional(s) in consultation with the patient and caregiver as appropriate.

Published
2020

24. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European respiratory society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC)

Author

HAG Trombose, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cancer, Global Health, Cardiovasculaire Epi Team 9, Konstantinides, Stavros V., Meyer, Guy, Bueno, Hector, Galié, Nazzareno, Gibbs, J. Simon R., Ageno, Walter, Agewall, Stefan, Almeida, Ana G., Andreotti, Felicita, Barbato, Emanuele, Baumbach, Andreas, Beygui, Farzin, Carlsen, Jørn, De Carlo, Marco, Delcroix, Marion, Subias, Pilar Escribano, Gaine, Sean, Goldhaber, Samuel Z., Gopalan, Deepa, Habib, Gilbert, Jenkins, David, Kjellström, Barbro, Lainscak, Mitja, Lee, Geraldine, Le Gal, Grégoire, Messas, Emmanuel, Morais, Joao, Piepoli, Massimo Francesco, Price, Susanna, Salvi, Aldo, Sanchez, Olivier, Stortecky, Stefan, Thielmann, Matthias, Noordegraaf, Anton Vonk, Becattini, Cecilia, Bueno, Héctor, Geersing, Geert Jan, Harjola, Veli Pekka, Huisman, Menno V., Humbert, Marc, Jennings, Catriona Sian, Jiménez, David, Kucher, Nils, Lang, Irene Marthe, Lankeit, Mareike, Lorusso, Roberto, Mazzolai, Lucia, Meneveau, Nicolas, Áinle, Fionnuala Ní, Prandoni, Paolo, Pruszczyk, Piotr, Righini, Marc, Torbicki, Adam, Van Belle, Eric, Zamorano, José Luis, Windecker, Stephan, Aboyans, Victor, Baigent, Colin, Collet, Jean Philippe, Dean, Veronica, Delgado, Victoria, Fitzsimons, Donna, Gale, Chris P., Grobbee, Diederick E., Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Landmesser, Ulf, Leclercq, Christophe, Lettino, Maddalena, Lewis, Basil S., Merkely, Bela, Mueller, Christian, Petersen, Steffen E., Petronio, Anna Sonia, Richter, Dimitrios J., Roffi, Marco, Shlyakhto, Evgeny, Simpson, Iain A., Sousa-Uva, Miguel, Touyz, Rhian M., Hammoudi, Naima, Hayrapetyan, Hamlet, Mascherbauer, Julia, Ibrahimov, Firdovsi, Polonetsky, Oleg, Lancellotti, Patrizio, Tokmakova, Mariya, Skoric, Bosko, Michaloliakos, Ioannis, Hutyra, Martin, Mellemkjaer, Søren, Mansour, Mostafa, Reinmets, Julia, Jääskeläinen, Pertti, Angoulvant, Denis, Bauersachs, Johann, Giannakoulas, George, Zima, Endre, Vizza, Carmine Dario, Sugraliyev, Akhmetzhan, Bytyçi, Ibadete, Maca, Aija, Ereminiene, Egle, Huijnen, Steve, Xuereb, Robert, Diaconu, Nadejda, Bulatovic, Nebojsa, Asfalou, Ilyasse, Bosevski, Marijan, Halvorsen, Sigrun, Sobkowicz, Bozena, Ferreira, Daniel, Petris, Antoniu Octavian, Moiseeva, Olga, Zavatta, Marco, Obradovic, Slobodan, Šimkova, Iveta, Radsel, Peter, Ibanez, Borja, Wikström, Gerhard, Aujesky, Drahomir, Kaymaz, Cihangir, Parkhomenko, Alexander, Pepke-Zaba, Joanna, HAG Trombose, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cancer, Global Health, Cardiovasculaire Epi Team 9, Konstantinides, Stavros V., Meyer, Guy, Bueno, Hector, Galié, Nazzareno, Gibbs, J. Simon R., Ageno, Walter, Agewall, Stefan, Almeida, Ana G., Andreotti, Felicita, Barbato, Emanuele, Baumbach, Andreas, Beygui, Farzin, Carlsen, Jørn, De Carlo, Marco, Delcroix, Marion, Subias, Pilar Escribano, Gaine, Sean, Goldhaber, Samuel Z., Gopalan, Deepa, Habib, Gilbert, Jenkins, David, Kjellström, Barbro, Lainscak, Mitja, Lee, Geraldine, Le Gal, Grégoire, Messas, Emmanuel, Morais, Joao, Piepoli, Massimo Francesco, Price, Susanna, Salvi, Aldo, Sanchez, Olivier, Stortecky, Stefan, Thielmann, Matthias, Noordegraaf, Anton Vonk, Becattini, Cecilia, Bueno, Héctor, Geersing, Geert Jan, Harjola, Veli Pekka, Huisman, Menno V., Humbert, Marc, Jennings, Catriona Sian, Jiménez, David, Kucher, Nils, Lang, Irene Marthe, Lankeit, Mareike, Lorusso, Roberto, Mazzolai, Lucia, Meneveau, Nicolas, Áinle, Fionnuala Ní, Prandoni, Paolo, Pruszczyk, Piotr, Righini, Marc, Torbicki, Adam, Van Belle, Eric, Zamorano, José Luis, Windecker, Stephan, Aboyans, Victor, Baigent, Colin, Collet, Jean Philippe, Dean, Veronica, Delgado, Victoria, Fitzsimons, Donna, Gale, Chris P., Grobbee, Diederick E., Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Landmesser, Ulf, Leclercq, Christophe, Lettino, Maddalena, Lewis, Basil S., Merkely, Bela, Mueller, Christian, Petersen, Steffen E., Petronio, Anna Sonia, Richter, Dimitrios J., Roffi, Marco, Shlyakhto, Evgeny, Simpson, Iain A., Sousa-Uva, Miguel, Touyz, Rhian M., Hammoudi, Naima, Hayrapetyan, Hamlet, Mascherbauer, Julia, Ibrahimov, Firdovsi, Polonetsky, Oleg, Lancellotti, Patrizio, Tokmakova, Mariya, Skoric, Bosko, Michaloliakos, Ioannis, Hutyra, Martin, Mellemkjaer, Søren, Mansour, Mostafa, Reinmets, Julia, Jääskeläinen, Pertti, Angoulvant, Denis, Bauersachs, Johann, Giannakoulas, George, Zima, Endre, Vizza, Carmine Dario, Sugraliyev, Akhmetzhan, Bytyçi, Ibadete, Maca, Aija, Ereminiene, Egle, Huijnen, Steve, Xuereb, Robert, Diaconu, Nadejda, Bulatovic, Nebojsa, Asfalou, Ilyasse, Bosevski, Marijan, Halvorsen, Sigrun, Sobkowicz, Bozena, Ferreira, Daniel, Petris, Antoniu Octavian, Moiseeva, Olga, Zavatta, Marco, Obradovic, Slobodan, Šimkova, Iveta, Radsel, Peter, Ibanez, Borja, Wikström, Gerhard, Aujesky, Drahomir, Kaymaz, Cihangir, Parkhomenko, Alexander, and Pepke-Zaba, Joanna

Published
2020

26. Use of Statins, Anticoagulants, Antiaggregants and Antiarrhythmic Drugs in Patients With COVID-19. The Agreed Experts’ Position of Russian Society of Cardiology, Eurasian Association of Therapists, National Society on Atherothrombosis, Societies of Experts in Urgent Cardiology, Eurasian Arrhythmology Association

Author

Shlyakhto, Ye. V., primary, Arutyunov, G. P., additional, Belenkov, Yu. N., additional, Tarlovskaya, E. I., additional, Konradi, A. O., additional, Panchenko, E. P., additional, Yavelov, I. S., additional, Tereshchenko, S. N., additional, Ardashev, A. V., additional, Arutyunov, A. G., additional, Grigorieva, N. Yu., additional, Dzhunusbekova, G. A., additional, Drapkina, O. M., additional, Koziolova, N. A., additional, Komarov, A. L., additional, Kropacheva, E. S., additional, Malchikova, S. V., additional, Mitkovskaya, N. P., additional, Orlova, Ya. A., additional, Petrova, M. M., additional, Rebrov, A. P., additional, Sisakian, H., additional, Skibitsky, V. V., additional, Sugraliyev, A. B., additional, Fomin, I. V., additional, Chesnikova, A. I., additional, Shaposhnik, I. I., additional, Zhelyakov, E. G., additional, Kanorskii, S. G., additional, Kolotsey, L. V., additional, and Snezhitskiy, V. A., additional

Published
2020
Full Text
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28. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

Author

Valgimigli, Marco, Bueno, Héctor, Byrne, Robert A, Collet, Jean-Philippe, Costa, Francesco, Jeppsson, Anders, Jüni, Peter, Kastrati, Adnan, Kolh, Philippe, Mauri, Laura, Montalescot, Gilles, Neumann, Franz-Josef, Petricevic, Mate, Roffi, Marco, Steg, Philippe Gabriel, Windecker, Stephan, Zamorano, Jose Luis, Levine, Glenn N, Badimon, Lina, Vranckx, Pascal, Agewall, Stefan, Andreotti, Felicita, Antman, Elliott, Barbato, Emanuele, Bassand, Jean-Pierre, Bugiardini, Raffaele, Cikirikcioglu, Mustafa, Cuisset, Thomas, De Bonis, Michele, Delgado, Victora, Fitzsimons, Donna, Gaemperli, Oliver, Galiè, Nazzareno, Gilard, Martine, Hamm, Christian W, Ibanez, Borja, Iung, Bernard, James, Stefan, Knuuti, Juhani, Landmesser, Ulf, Leclercq, Christophe, Lettino, Maddalena, Lip, Gregory, Piepoli, Massimo Francesco, Pierard, Luc, Schwerzmann, Markus, Sechtem, Udo, Simpson, Iain A, Uva, Miguel Sousa, Stabile, Eugenio, Storey, Robert F, Tendera, Michal, Van de Werf, Frans, Verheugt, Freek, Aboyans, Victor, Coca, Antonio, Collet, Jean- Philippe, Coman, Ioan Mircea, Dean, Veronica, Delgado, Victoria, Hindricks, Gerhard, Katus, Hugo A, Lancellotti, Patrizio, McDonagh, Theresa, Ponikowski, Piotr, Richter, Dimitrios J, Shlyakhto, Evgeny, Roithinger, Franz Xaver, Aliyev, Farid, Stelmashok, Valeriy, Desmet, Walter, Postadzhiyan, Arman, Georghiou, Georgios P, Motovska, Zuzana, Grove, Erik Lerkevang, Marandi, Toomas, Kiviniemi, Tuomas, Kedev, Sasko, Massberg, Steffen, Alexopoulos, Dimitrios, Kiss, Robert Gabor, Gudmundsdottir, Ingibjorg Jona, McFadden, Eugène P, Lev, Eli, De Luca, Leonardo, Sugraliyev, Akhmetzhan, Haliti, Edmond, Mirrakhimov, Erkin, Latkovskis, Gustavs, Petrauskiene, Birute, Huijnen, Steve, Magri, Caroline Jane, Cherradi, Rhizlan, Ten Berg, Jurrien M, Eritsland, Jan, Budaj, Andrzej, Aguiar, Carlos Tavares, Duplyakov, Dmitry, Zavatta, Marco, Antonijevic, Nebojsa M, Fras, Zlatko, Montoliu, Antonio Tello, Varenhorst, Christoph, Tsakiris, Dimitri, Addad, Faouzi, Aydogdu, Sinan, Parkhomenko, Alexander, Kinnaird, Tim, ESC Scientific Document Group, ESC Committee for Practice Guidelines (CPG), ESC National Cardiac Societies, Valgimigli, Marco, Bueno, Héctor, Byrne, Robert A., Collet, Jean-Philippe, Costa, Francesco, Jeppsson, Ander, Kastrati, Adnan, Kolh, Philippe, Mauri, Laura, Montalescot, Gille, Neumann, Franz-Josef, Petricevic, Mate, Roffi, Marco, Steg, Philippe Gabriel, Zamorano, Jose Lui, Levine, Glenn N., Badimon, Lina, Vranckx, Pascal, Agewall, Stefan, Andreotti, Felicita, Antman, Elliott, Barbato, Emanuele, Bassand, Jean-Pierre, Bugiardini, Raffaele, Cikirikcioglu, Mustafa, Cuisset, Thoma, De Bonis, Michele, Delgado, Victora, Fitzsimons, Donna, Galiè, Nazzareno, Gilard, Martine, Hamm, Christian W., Ibanez, Borja, James, Stefan, Knuuti, Juhani, Landmesser, Ulf, Leclercq, Christophe, Lettino, Maddalena, Lip, Gregory, Piepoli, Massimo Francesco, Pierard, Luc, Schwerzmann, Marku, Sechtem, Udo, Simpson, Iain A., Uva, Miguel Sousa, Stabile, Eugenio, Storey, Robert F., Tendera, Michal, Van De Werf, Fran, Verheugt, Freek, Aboyans, Victor, Windecker, Stephan, Coca, Antonio, Coman, Ioan Mircea, Dean, Veronica, Delgado, Victoria, Gaemperli, Oliver, Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Lancellotti, Patrizio, McDonagh, Theresa, Ponikowski, Piotr, Richter, DImitrios J., Shlyakhto, Evgeny, Roithinger, Franz Xaver, Aliyev, Farid, Stelmashok, Valeriy, Desmet, Walter, Postadzhiyan, Arman, Georghiou, Georgios P., Motovska, Zuzana, Grove, Erik Lerkevang, Marandi, Tooma, Kiviniemi, Tuoma, Kedev, Sasko, Massberg, Steffen, Alexopoulos, DImitrio, Kiss, Robert Gabor, Gudmundsdottir, Ingibjorg Jona, McFadden, Eugène P., Lev, Eli, De Luca, Leonardo, Sugraliyev, Akhmetzhan, Haliti, Edmond, Mirrakhimov, Erkin, Latkovskis, Gustav, Petrauskiene, Birute, Huijnen, Steve, Magri, Caroline Jane, Cherradi, Rhizlan, Ten Berg, Jurrien M., Eritsland, Jan, Budaj, Andrzej, Aguiar, Carlos Tavare, Duplyakov, Dmitry, Zavatta, Marco, Antonijevic, Nebojsa M., Fras, Zlatko, Montoliu, Antonio Tello, Varenhorst, Christoph, Tsakiris, DImitri, Addad, Faouzi, Aydogdu, Sinan, Parkhomenko, Alexander, Kinnaird, Tim, Valgimigli, M, Bueno, H, Byrne, Ra, Collet, Jp, Costa, F, Jeppsson, A, Juni, P, Kastrati, A, Kolh, P, Mauri, L, Montalescot, G, Neumann, Fj, Petricevic, M, Roffi, M, Steg, Pg, Windecker, S, Zamorano, Jl, Levine, Gn, Badimon, L, Vranckx, P, Agewall, S, Andreotti, F, Antman, E, Barbato, E, Bassand, Jp, Bugiardini, R, Cikirikcioglu, M, Cuisset, T, De Bonis, M, Delgado, V, Fitzsimons, D, Oliver, G, Galie, N, Gilard, M, Hamm, Cw, Ibanez, B, Iung, B, James, S, Knuuti, J, Landmesser, U, Leclercq, C, Lettino, M, Lip, G, Piepoli, Mf, Pierard, L, Schwerzmann, M, Sechtem, U, Simpson, Ia, Uva, M, Stabile, E, Storey, Rf, Tendera, M, Van De Werf, F, Verheugt, F, Aboyans, V, Byrne, Robert A, Levine, Glenn N, Badimon L, Vranckx P, Agewall S, Andreotti F, Antman E, Barbato E, Bassand JP, Bugiardini R, Cikirikcioglu M, Cuisset T, De Bonis M, Delgado V, Fitzsimons D, Gaemperli O, Galiè N, Gilard M, Hamm CW, Ibanez B, Iung B, James S, Knuuti J, Landmesser U, Leclercq C, Lettino M, Lip G, Piepoli MF, Pierard L, Schwerzmann M, Sechtem U, Simpson IA, Uva MS, Stabile E, Storey RF, Tendera M, Van de Werf F, Verheugt F, Aboyans V, Alma Mater Studiorum Universita' di Bologna, DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE, DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE, Da definire, and AREA MIN. 06 - Scienze mediche

Subjects
Stable angina, Ticagrelor, Prasugrel, Stent thrombosi, Stent thrombosis, medicine.medical_treatment, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Coronary artery bypass grafting, 030204 cardiovascular system & hematology, Guideline, Coronary artery disease, Percutaneous coronary intervention, 0302 clinical medicine, Stent, DAPT score, 030212 general & internal medicine, Myocardial infarction, Drug-eluting stents, reproductive and urinary physiology, Societies, Medical, dual antiplatelet therapy, coronary artery disease, General Medicine, Clopidogrel, Europe, Cardiothoracic surgery, Non cardiac surgery, embryonic structures, Dual antiplatelet therapy, Cardiology, Stents, Stable coronary artery disease, Radiology, Acute coronary syndrome, biological phenomena, cell phenomena, and immunity, Cardiology and Cardiovascular Medicine, PRECISE-DAPT score, circulatory and respiratory physiology, medicine.drug, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Acute coronary syndromes, Guidelines, 03 medical and health sciences, Non-cardiac surgery, Internal medicine, medicine, Humans, cardiovascular diseases, Triple therapy, Risk stratification, Aspirin, business.industry, urogenital system, Revascularization, Bleeding, Oral anticoagulant, Recommendation, medicine.disease, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Surgery, Drug-eluting stent, business, Platelet Aggregation Inhibitors
Abstract

none 107 si Non presente mixed Valgimigli, Marco*; Bueno, Héctor; Byrne, Robert A.; Collet, Jean-Philippe; Costa, Francesco; Jeppsson, Anders; Kastrati, Adnan; Kolh, Philippe; Mauri, Laura; Montalescot, Gilles; Neumann, Franz-Josef; Petricevic, Mate; Roffi, Marco; Steg, Philippe Gabriel; Zamorano, Jose Luis; Levine, Glenn N.; Badimon, Lina; Vranckx, Pascal; Agewall, Stefan; Andreotti, Felicita; Antman, Elliott; Barbato, Emanuele; Bassand, Jean-Pierre; Bugiardini, Raffaele; Cikirikcioglu, Mustafa; Cuisset, Thomas; De Bonis, Michele; Delgado, Victora; Fitzsimons, Donna; Galiè, Nazzareno; Gilard, Martine; Hamm, Christian W.; Ibanez, Borja; James, Stefan; Knuuti, Juhani; Landmesser, Ulf; Leclercq, Christophe; Lettino, Maddalena; Lip, Gregory; Piepoli, Massimo Francesco; Pierard, Luc; Schwerzmann, Markus; Sechtem, Udo; Simpson, Iain A.; Uva, Miguel Sousa; Stabile, Eugenio; Storey, Robert F.; Tendera, Michal; Van De Werf, Frans; Verheugt, Freek; Aboyans, Victor; Windecker, Stephan; Coca, Antonio; Coman, Ioan Mircea; Dean, Veronica; Delgado, Victoria; Gaemperli, Oliver; Hindricks, Gerhard; Iung, Bernard; Jüni, Peter; Katus, Hugo A.; Lancellotti, Patrizio; McDonagh, Theresa; Ponikowski, Piotr; Richter, DImitrios J.; Shlyakhto, Evgeny; Roithinger, Franz Xaver; Aliyev, Farid; Stelmashok, Valeriy; Desmet, Walter; Postadzhiyan, Arman; Georghiou, Georgios P.; Motovska, Zuzana; Grove, Erik Lerkevang; Marandi, Toomas; Kiviniemi, Tuomas; Kedev, Sasko; Massberg, Steffen; Alexopoulos, DImitrios; Kiss, Robert Gabor; Gudmundsdottir, Ingibjorg Jona; McFadden, Eugène P.; Lev, Eli; De Luca, Leonardo; Sugraliyev, Akhmetzhan; Haliti, Edmond; Mirrakhimov, Erkin; Latkovskis, Gustavs; Petrauskiene, Birute; Huijnen, Steve; Magri, Caroline Jane; Cherradi, Rhizlan; Ten Berg, Jurrien M.; Eritsland, Jan; Budaj, Andrzej; Aguiar, Carlos Tavares; Duplyakov, Dmitry; Zavatta, Marco; Antonijevic, Nebojsa M.; Fras, Zlatko; Montoliu, Antonio Tello; Varenhorst, Christoph; Tsakiris, DImitri; Addad, Faouzi; Aydogdu, Sinan; Parkhomenko, Alexander; Kinnaird, Tim Valgimigli, Marco*; Bueno, Héctor; Byrne, Robert A.; Collet, Jean-Philippe; Costa, Francesco; Jeppsson, Anders; Kastrati, Adnan; Kolh, Philippe; Mauri, Laura; Montalescot, Gilles; Neumann, Franz-Josef; Petricevic, Mate; Roffi, Marco; Steg, Philippe Gabriel; Zamorano, Jose Luis; Levine, Glenn N.; Badimon, Lina; Vranckx, Pascal; Agewall, Stefan; Andreotti, Felicita; Antman, Elliott; Barbato, Emanuele; Bassand, Jean-Pierre; Bugiardini, Raffaele; Cikirikcioglu, Mustafa; Cuisset, Thomas; De Bonis, Michele; Delgado, Victora; Fitzsimons, Donna; Galiè, Nazzareno; Gilard, Martine; Hamm, Christian W.; Ibanez, Borja; James, Stefan; Knuuti, Juhani; Landmesser, Ulf; Leclercq, Christophe; Lettino, Maddalena; Lip, Gregory; Piepoli, Massimo Francesco; Pierard, Luc; Schwerzmann, Markus; Sechtem, Udo; Simpson, Iain A.; Uva, Miguel Sousa; Stabile, Eugenio; Storey, Robert F.; Tendera, Michal; Van De Werf, Frans; Verheugt, Freek; Aboyans, Victor; Windecker, Stephan; Coca, Antonio; Coman, Ioan Mircea; Dean, Veronica; Delgado, Victoria; Gaemperli, Oliver; Hindricks, Gerhard; Iung, Bernard; Jüni, Peter; Katus, Hugo A.; Lancellotti, Patrizio; McDonagh, Theresa; Ponikowski, Piotr; Richter, DImitrios J.; Shlyakhto, Evgeny; Roithinger, Franz Xaver; Aliyev, Farid; Stelmashok, Valeriy; Desmet, Walter; Postadzhiyan, Arman; Georghiou, Georgios P.; Motovska, Zuzana; Grove, Erik Lerkevang; Marandi, Toomas; Kiviniemi, Tuomas; Kedev, Sasko; Massberg, Steffen; Alexopoulos, DImitrios; Kiss, Robert Gabor; Gudmundsdottir, Ingibjorg Jona; McFadden, Eugène P.; Lev, Eli; De Luca, Leonardo; Sugraliyev, Akhmetzhan; Haliti, Edmond; Mirrakhimov, Erkin; Latkovskis, Gustavs; Petrauskiene, Birute; Huijnen, Steve; Magri, Caroline Jane; Cherradi, Rhizlan; Ten Berg, Jurrien M.; Eritsland, Jan; Budaj, Andrzej; Aguiar, Carlos Tavares; Duplyakov, Dmitry; Zavatta, Marco; Antonijevic, Nebojsa M.; Fras, Zlatko; Montoliu, Antonio Tello; Varenhorst, Christoph; Tsakiris, DImitri; Addad, Faouzi; Aydogdu, Sinan; Parkhomenko, Alexander; Kinnaird, Tim

Published
2018

29. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

Author

Valgimigli, M., Bueno, H., Byrne, R. A., Collet, J. -P., Costa, F., Jeppsson, A., Kastrati, A., Kolh, P., Mauri, L., Montalescot, G., Neumann, F. -J., Petricevic, M., Roffi, M., Steg, P. G., Zamorano, J. L., Levine, G. N., Badimon, L., Vranckx, P., Agewall, S., Andreotti, Felicita, Antman, E., Barbato, E., Bassand, J. -P., Bugiardini, R., Cikirikcioglu, M., Cuisset, T., De Bonis, M., Delgado, V., Fitzsimons, D., Galie, N., Gilard, M., Hamm, C. W., Ibanez, B., James, S., Knuuti, J., Landmesser, U., Leclercq, C., Lettino, M., Lip, G., Piepoli, M. F., Pierard, L., Schwerzmann, M., Sechtem, U., Simpson, I. A., Uva, M. S., Stabile, E., Storey, R. F., Tendera, M., Van De Werf, F., Verheugt, F., Aboyans, V., Windecker, S., Coca, A., Coman, I. M., Dean, V., Gaemperli, O., Hindricks, G., Iung, B., Juni, P., Katus, H. A., Lancellotti, P., Mcdonagh, T., Ponikowski, P., Richter, D. J., Shlyakhto, E., Roithinger, F. X., Aliyev, F., Stelmashok, V., Desmet, W., Postadzhiyan, A., Georghiou, G. P., Motovska, Z., Grove, E. L., Marandi, T., Kiviniemi, T., Kedev, S., Massberg, S., Alexopoulos, D., Kiss, R. G., Gudmundsdottir, I. J., Mcfadden, E. P., Lev, E., De Luca, L., Sugraliyev, A., Haliti, E., Mirrakhimov, E., Latkovskis, G., Petrauskiene, B., Huijnen, S., Magri, C. J., Cherradi, R., Ten Berg, J. M., Eritsland, J., Budaj, A., Aguiar, C. T., Duplyakov, D., Zavatta, M., Antonijevic, N. M., Fras, Z., Montoliu, A. T., Varenhorst, C., Tsakiris, D., Addad, F., Aydogdu, S., Parkhomenko, A., Kinnaird, T., Andreotti F. (ORCID:0000-0002-1456-6430), Valgimigli, M., Bueno, H., Byrne, R. A., Collet, J. -P., Costa, F., Jeppsson, A., Kastrati, A., Kolh, P., Mauri, L., Montalescot, G., Neumann, F. -J., Petricevic, M., Roffi, M., Steg, P. G., Zamorano, J. L., Levine, G. N., Badimon, L., Vranckx, P., Agewall, S., Andreotti, Felicita, Antman, E., Barbato, E., Bassand, J. -P., Bugiardini, R., Cikirikcioglu, M., Cuisset, T., De Bonis, M., Delgado, V., Fitzsimons, D., Galie, N., Gilard, M., Hamm, C. W., Ibanez, B., James, S., Knuuti, J., Landmesser, U., Leclercq, C., Lettino, M., Lip, G., Piepoli, M. F., Pierard, L., Schwerzmann, M., Sechtem, U., Simpson, I. A., Uva, M. S., Stabile, E., Storey, R. F., Tendera, M., Van De Werf, F., Verheugt, F., Aboyans, V., Windecker, S., Coca, A., Coman, I. M., Dean, V., Gaemperli, O., Hindricks, G., Iung, B., Juni, P., Katus, H. A., Lancellotti, P., Mcdonagh, T., Ponikowski, P., Richter, D. J., Shlyakhto, E., Roithinger, F. X., Aliyev, F., Stelmashok, V., Desmet, W., Postadzhiyan, A., Georghiou, G. P., Motovska, Z., Grove, E. L., Marandi, T., Kiviniemi, T., Kedev, S., Massberg, S., Alexopoulos, D., Kiss, R. G., Gudmundsdottir, I. J., Mcfadden, E. P., Lev, E., De Luca, L., Sugraliyev, A., Haliti, E., Mirrakhimov, E., Latkovskis, G., Petrauskiene, B., Huijnen, S., Magri, C. J., Cherradi, R., Ten Berg, J. M., Eritsland, J., Budaj, A., Aguiar, C. T., Duplyakov, D., Zavatta, M., Antonijevic, N. M., Fras, Z., Montoliu, A. T., Varenhorst, C., Tsakiris, D., Addad, F., Aydogdu, S., Parkhomenko, A., Kinnaird, T., and Andreotti F. (ORCID:0000-0002-1456-6430)

Abstract

N/A

Published
2018

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