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1. What is the impact of one’s chronic illness on his or her spouse’s future chronic illness: a community-based prospective cohort study

Author

An, Hoyoung, Yang, Hee Won, Oh, Dae Jong, Lim, Eunji, Shin, Jin, Moon, Dong Gyu, Suh, Seung Wan, Byun, Seonjeong, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, Bae, Jong Bin, Han, Ji Won, and Kim, Ki Woong

Published
2023
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4. A cross‐national study of depression in preclinical dementia: A COSMIC collaboration study

Author

Carles, Sophie, Carrière, Isabelle, Reppermund, Simone, Davin, Annalisa, Guaita, Antonio, Vaccaro, Roberta, Ganguli, Mary, Jacobsen, Erin P, Beer, Joanne C, Riedel‐Heller, Steffi G, Roehr, Susanne, Pabst, Alexander, Haan, Mary N, Brodaty, Henry, Kochan, Nicole A, Trollor, Julian N, Kim, Ki Woong, Han, Ji Won, Suh, Seung Wan, Lobo, Antonio, De Camara, Concepción, Lobo, Elena, Lipnicki, Darren M, Sachdev, Perminder S, Ancelin, Marie‐Laure, Ritchie, Karen, and Consortium, for Cohort Studies of Memory in an International

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Brain Disorders, Mental Health, Aging, Depression, Alzheimer's Disease, Acquired Cognitive Impairment, Neurodegenerative, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Neurological, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Incidence, Longitudinal Studies, Male, Prodromal Symptoms, dementia, depression, incidence, for Cohort Studies of Memory in an International Consortium, Geriatrics, Clinical sciences, Biological psychology
Abstract

IntroductionDepression commonly accompanies Alzheimer's disease, but the nature of this association remains uncertain.MethodsLongitudinal data from the COSMIC consortium were harmonized for eight population-based cohorts from four continents. Incident dementia was diagnosed in 646 participants, with a median follow-up time of 5.6 years to diagnosis. The association between years to dementia diagnosis and successive depressive states was assessed using a mixed effect logistic regression model. A generic inverse variance method was used to group study results, construct forest plots, and generate heterogeneity statistics.ResultsA common trajectory was observed showing an increase in the incidence of depression as the time to dementia diagnosis decreased despite cross-national variability in depression rates.DiscussionThe results support the hypothesis that depression occurring in the preclinical phases of dementia is more likely to be attributable to dementia-related brain changes than environment or reverse causality.

Published
2020

5. Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment

Author

Makkar, Steve R, Lipnicki, Darren M, Crawford, John D, Kochan, Nicole A, Castro-Costa, Erico, Lima-Costa, Maria Fernanda, Diniz, Breno Satler, Brayne, Carol, Stephan, Blossom, Matthews, Fiona, Llibre-Rodriguez, Juan J, Llibre-Guerra, Jorge J, Valhuerdi-Cepero, Adolfo J, Lipton, Richard B, Katz, Mindy J, Zammit, Andrea, Ritchie, Karen, Carles, Sophie, Carriere, Isabelle, Scarmeas, Nikolaos, Yannakoulia, Mary, Kosmidis, Mary, Lam, Linda, Fung, Ada, Chan, Wai Chi, Guaita, Antonio, Vaccaro, Roberta, Davin, Annalisa, Kim, Ki Woong, Han, Ji Won, Suh, Seung Wan, Riedel-Heller, Steffi G, Roehr, Susanne, Pabst, Alexander, Ganguli, Mary, Hughes, Tiffany F, Jacobsen, Erin P, Anstey, Kaarin J, Cherbuin, Nicolas, Haan, Mary N, Aiello, Allison E, Dang, Kristina, Kumagai, Shuzo, Narazaki, Kenji, Chen, Sanmei, Ng, Tze Pin, Gao, Qi, Nyunt, Ma Shwe Zin, Meguro, Kenichi, Yamaguchi, Satoshi, Ishii, Hiroshi, Lobo, Antonio, Escolar, Elena Lobo, De la Cámara, Concepción, Brodaty, Henry, Trollor, Julian N, Leung, Yvonne, Lo, Jessica W, Sachdev, Perminder, and Consortium, for Cohort Studies of Memory in an International

Subjects
Public Health, Health Sciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurodegenerative, Alzheimer's Disease, Neurosciences, Brain Disorders, Acquired Cognitive Impairment, Women's Health, Behavioral and Social Science, Dementia, Aging, Quality Education, Aged, Aged, 80 and over, Apolipoprotein E4, Cognitive Dysfunction, Educational Status, Ethnicity, Female, Humans, Longitudinal Studies, Male, Risk Factors, Cognitive decline, Education, Ageing, Sex, Age, for Cohort Studies of Memory in an International Consortium
Abstract

BackgroundWe examined how the relationship between education and latelife cognitive impairment (defined as a Mini Mental State Examination score below 24) is influenced by age, sex, ethnicity, and Apolipoprotein E epsilon 4 (APOE*4).MethodsParticipants were 30,785 dementia-free individuals aged 55-103 years, from 18 longitudinal cohort studies, with an average follow-up ranging between 2 and 10 years. Pooled hazard ratios were obtained from multilevel parametric survival analyses predicting cognitive impairment (CI) from education and its interactions with baseline age, sex, APOE*4 and ethnicity. In separate models, education was treated as continuous (years) and categorical, with participants assigned to one of four education completion levels: Incomplete Elementary; Elementary; Middle; and High School.ResultsCompared to Elementary, Middle (HR = 0.645, P = 0.004) and High School (HR = 0.472, P

Published
2020

6. APOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline

Author

Makkar, Steve R, Lipnicki, Darren M, Crawford, John D, Kochan, Nicole A, Castro-Costa, Erico, Lima-Costa, Maria Fernanda, Diniz, Breno Satler, Brayne, Carol, Stephan, Blossom, Matthews, Fiona, Llibre-Rodriguez, Juan J, Llibre-Guerra, Jorge J, Valhuerdi-Cepero, Adolfo J, Lipton, Richard B, Katz, Mindy J, Wang, Cuiling, Ritchie, Karen, Carles, Sophie, Carriere, Isabelle, Scarmeas, Nikolaos, Yannakoulia, Mary, Kosmidis, Mary, Lam, Linda, Chan, Wai Chi, Fung, Ada, Guaita, Antonio, Vaccaro, Roberta, Davin, Annalisa, Kim, Ki Woong, Han, Ji Won, Suh, Seung Wan, Riedel-Heller, Steffi G, Roehr, Susanne, Pabst, Alexander, Ganguli, Mary, Hughes, Tiffany F, Snitz, Beth, Anstey, Kaarin J, Cherbuin, Nicolas, Easteal, Simon, Haan, Mary N, Aiello, Allison E, Dang, Kristina, Ng, Tze Pin, Gao, Qi, Nyunt, Ma Shwe Zin, Brodaty, Henry, Trollor, Julian N, Leung, Yvonne, Lo, Jessica W, and Sachdev, Perminder

Subjects
Health Sciences, Neurosciences, Clinical Research, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Genetics, Neurodegenerative, Alzheimer's Disease, Acquired Cognitive Impairment, Aging, Prevention, Dementia, Brain Disorders, Behavioral and Social Science, 2.4 Surveillance and distribution, Aetiology, Age Factors, Aged, Aged, 80 and over, Alleles, Apolipoprotein E4, Cognitive Dysfunction, Female, Genotype, Humans, Longitudinal Studies, Male, Middle Aged, Risk Factors, Sex Factors, Cognitive decline, APOE genotype, Epidemiology, Sex, Ethnicity, Clinical Sciences, Gerontology, Biomedical and clinical sciences, Health sciences
Abstract

We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals aged 54-103 years from 15 longitudinal cohort studies with a mean follow-up duration ranging between 1.2 and 10.7 years. Two-step individual participant data meta-analysis was used to pool results of study-wise analyses predicting memory and general cognitive decline from carriage of one or two APOE*4 alleles, and moderation of these associations by age, sex, vascular risk factors, and ethnicity. Separate pooled estimates were calculated in both men and women who were younger (ie, 62 years) and older (ie, 80 years) at baseline. Results showed that APOE*4 carriage was related to faster general cognitive decline in women, and faster memory decline in men. A stronger dose-dependent effect was observed in older men, with faster general cognitive and memory decline in those carrying two versus one APOE*4 allele. Vascular risk factors were related to an increased effect of APOE*4 on memory decline in younger women, but a weaker effect of APOE*4 on general cognitive decline in older men. The relationship between APOE*4 carriage and memory decline was larger in older-aged Asians than Whites. In sum, APOE*4 is related to cognitive decline in men and women, although these effects are enhanced by age and carriage of two APOE*4 alleles in men, a higher numbers of vascular risk factors during the early stages of late adulthood in women, and Asian ethnicity.

Published
2020

7. Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study.

Author

Lipnicki, Darren M, Makkar, Steve R, Crawford, John D, Thalamuthu, Anbupalam, Kochan, Nicole A, Lima-Costa, Maria Fernanda, Castro-Costa, Erico, Ferri, Cleusa Pinheiro, Brayne, Carol, Stephan, Blossom, Llibre-Rodriguez, Juan J, Llibre-Guerra, Jorge J, Valhuerdi-Cepero, Adolfo J, Lipton, Richard B, Katz, Mindy J, Derby, Carol A, Ritchie, Karen, Ancelin, Marie-Laure, Carrière, Isabelle, Scarmeas, Nikolaos, Yannakoulia, Mary, Hadjigeorgiou, Georgios M, Lam, Linda, Chan, Wai-Chi, Fung, Ada, Guaita, Antonio, Vaccaro, Roberta, Davin, Annalisa, Kim, Ki Woong, Han, Ji Won, Suh, Seung Wan, Riedel-Heller, Steffi G, Roehr, Susanne, Pabst, Alexander, van Boxtel, Martin, Köhler, Sebastian, Deckers, Kay, Ganguli, Mary, Jacobsen, Erin P, Hughes, Tiffany F, Anstey, Kaarin J, Cherbuin, Nicolas, Haan, Mary N, Aiello, Allison E, Dang, Kristina, Kumagai, Shuzo, Chen, Tao, Narazaki, Kenji, Ng, Tze Pin, Gao, Qi, Nyunt, Ma Shwe Zin, Scazufca, Marcia, Brodaty, Henry, Numbers, Katya, Trollor, Julian N, Meguro, Kenichi, Yamaguchi, Satoshi, Ishii, Hiroshi, Lobo, Antonio, Lopez-Anton, Raul, Santabárbara, Javier, Leung, Yvonne, Lo, Jessica W, Popovic, Gordana, Sachdev, Perminder S, and for Cohort Studies of Memory in an International Consortium (COSMIC)

Subjects
for Cohort Studies of Memory in an International Consortium, Humans, Diabetes Mellitus, Exercise, Risk Assessment, Risk Factors, Smoking, Cognition, Age Factors, Comorbidity, Health Education, Aged, Aged, 80 and over, Middle Aged, Ethnic Groups, Female, Male, Stroke, Cognitive Dysfunction, and over, General & Internal Medicine, Medical and Health Sciences
Abstract

BackgroundWith no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups.Methods and findingsWe harmonized longitudinal data from 20 population-based cohorts from 15 countries over 5 continents, including 48,522 individuals (58.4% women) aged 54-105 (mean = 72.7) years and without dementia at baseline. Studies had 2-15 years of follow-up. The risk factors investigated were age, sex, education, alcohol consumption, anxiety, apolipoprotein E ε4 allele (APOE*4) status, atrial fibrillation, blood pressure and pulse pressure, body mass index, cardiovascular disease, depression, diabetes, self-rated health, high cholesterol, hypertension, peripheral vascular disease, physical activity, smoking, and history of stroke. Associations with risk factors were determined for a global cognitive composite outcome (memory, language, processing speed, and executive functioning tests) and Mini-Mental State Examination score. Individual participant data meta-analyses of multivariable linear mixed model results pooled across cohorts revealed that for at least 1 cognitive outcome, age (B = -0.1, SE = 0.01), APOE*4 carriage (B = -0.31, SE = 0.11), depression (B = -0.11, SE = 0.06), diabetes (B = -0.23, SE = 0.10), current smoking (B = -0.20, SE = 0.08), and history of stroke (B = -0.22, SE = 0.09) were independently associated with poorer cognitive performance (p < 0.05 for all), and higher levels of education (B = 0.12, SE = 0.02) and vigorous physical activity (B = 0.17, SE = 0.06) were associated with better performance (p < 0.01 for both). Age (B = -0.07, SE = 0.01), APOE*4 carriage (B = -0.41, SE = 0.18), and diabetes (B = -0.18, SE = 0.10) were independently associated with faster cognitive decline (p < 0.05 for all). Different effects between Asian people and white people included stronger associations for Asian people between ever smoking and poorer cognition (group by risk factor interaction: B = -0.24, SE = 0.12), and between diabetes and cognitive decline (B = -0.66, SE = 0.27; p < 0.05 for both). Limitations of our study include a loss or distortion of risk factor data with harmonization, and not investigating factors at midlife.ConclusionsThese results suggest that education, smoking, physical activity, diabetes, and stroke are all modifiable factors associated with cognitive decline. If these factors are determined to be causal, controlling them could minimize worldwide levels of cognitive decline. However, any global prevention strategy may need to consider ethno-regional differences.

Published
2019

11. Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment

Author

Makkar, Steve R., Lipnicki, Darren M., Crawford, John D., Kochan, Nicole A., Castro-Costa, Erico, Lima-Costa, Maria Fernanda, Diniz, Breno Satler, Brayne, Carol, Stephan, Blossom, Matthews, Fiona, Llibre-Rodriguez, Juan J., Llibre-Guerra, Jorge J., Valhuerdi-Cepero, Adolfo J., Lipton, Richard B., Katz, Mindy J., Zammit, Andrea, Ritchie, Karen, Carles, Sophie, Carriere, Isabelle, Scarmeas, Nikolaos, Yannakoulia, Mary, Kosmidis, Mary, Lam, Linda, Fung, Ada, Chan, Wai Chi, Guaita, Antonio, Vaccaro, Roberta, Davin, Annalisa, Kim, Ki Woong, Han, Ji Won, Suh, Seung Wan, Riedel-Heller, Steffi G., Roehr, Susanne, Pabst, Alexander, Ganguli, Mary, Hughes, Tiffany F., Jacobsen, Erin P., Anstey, Kaarin J., Cherbuin, Nicolas, Haan, Mary N., Aiello, Allison E., Dang, Kristina, Kumagai, Shuzo, Narazaki, Kenji, Chen, Sanmei, Ng, Tze Pin, Gao, Qi, Nyunt, Ma Shwe Zin, Meguro, Kenichi, Yamaguchi, Satoshi, Ishii, Hiroshi, Lobo, Antonio, Lobo Escolar, Elena, De la Cámara, Concepción, Brodaty, Henry, Trollor, Julian N., Leung, Yvonne, Lo, Jessica W., and Sachdev, Perminder

Published
2020
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16. The impact of the COVID-19 pandemic on depression in community-dwelling older adults: a prospective cohort study.

Author

Oh, Dae Jong, Yang, Hee Won, Suh, Seung Wan, Byun, Seonjeong, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, Bae, Jong Bin, Han, Ji Won, and Kim, Ki Woong

Subjects
MENTAL depression risk factors, SOCIAL participation, CONFIDENCE intervals, SPIRITUALITY, PSYCHOLOGICAL vulnerability, MULTIPLE regression analysis, AGE distribution, ECONOMIC status, INTERVIEWING, GERIATRIC Depression Scale, DISEASE incidence, RISK assessment, PSYCHOLOGICAL tests, SEVERITY of illness index, SEX distribution, INDEPENDENT living, DESCRIPTIVE statistics, MENTAL depression, RESEARCH funding, LOGISTIC regression analysis, ODDS ratio, DATA analysis software, SMOKING, COVID-19 pandemic, LONGITUDINAL method, COMORBIDITY
Abstract

Background: There are growing concerns about the impact of the COVID-19 pandemic on the mental health of older adults. We examined the effect of the pandemic on the risk of depression in older adults. Methods: We analyzed data from the prospective cohort study of Korean older adults, which has been followed every 2 years. Among the 2308 participants who completed both the third and the fourth follow-up assessments, 58.4% completed their fourth follow-up before the outbreak of COVID-19 and the rest completed it during the pandemic. We conducted face-to-face diagnostic interviews using Mini International Neuropsychiatric Interview and used Geriatric Depression Scale. We performed generalized estimating equations and logistic regression analyses. Results: The COVID-19 pandemic was associated with increased depressive symptoms in older adults [ b (standard error) = 0.42 (0.20), p = 0.040] and a doubling of the risk for incident depressive disorder even in euthymic older adults without a history of depression (odds ratio = 2.44, 95% confidence interval 1.18–5.02, p = 0.016). Less social activities, which was associated with the risk of depressive disorder before the pandemic, was not associated with the risk of depressive disorder during the pandemic. However, less family gatherings, which was not associated with the risk of depressive disorder before the pandemic, was associated with the doubled risk of depressive disorder during the pandemic. Conclusions: The COVID-19 pandemic significantly influences the risk of late-life depression in the community. Older adults with a lack of family gatherings may be particularly vulnerable. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Effects of lifetime cumulative ginseng intake on cognitive function in late life

Author

Lho, Silvia Kyungjin, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Kayoung, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Kim, Tae Hyun, Moon, Seok Woo, Park, Jae Young, Park, Joon Hyuk, Byun, Seonjeong, Suh, Seung Wan, Seo, Ji Young, So, Yoonseop, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Kyoung Hwan, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Lee, Ju Ri, Jeong, Hyeon, Jeong, Hyun-Ghang, Jhoo, Jin Hyeong, Han, Kyuhee, Hong, Jong Woo, Han, Ji Won, and Kim, Ki Woong

Published
2018
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18. Clinical Approaches to Late-Onset Psychosis

Author

Kim, Kiwon, primary, Jeon, Hong Jin, additional, Myung, Woojae, additional, Suh, Seung Wan, additional, Seong, Su Jeong, additional, Hwang, Jae Yeon, additional, Ryu, Je il, additional, and Park, Seon-Cheol, additional

Published
2022
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21. Driving-Related Adverse Events in the Elderly Men: A Population-Based Prospective Cohort Study

Author

Kim, Jae Sung, Bae, Jong Bin, Han, Kyuhee, Hong, Jong Woo, Han, Ji Hyun, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Kayoung, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Kim, Tae Hyun, Moon, Seok Woo, Park, Jae Young, Park, Joon Hyuk, Byun, Seonjeong, Suh, Seung Wan, Seo, Ji Young, So, Yoonseop, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Kyoung Hwan, Lee, Dong Young, Lee, Dong-Woo, Lee, Seok Bum, Lee, Jung Jae, Lee, Ju Ri, Jeong, Hyeon, Jeong, Hyun-Ghang, Jhoo, Jin Hyeong, Han, Ji Won, and Kim, Ki Woong

Subjects
Longitudinal study, Violation, business.industry, Incidence, Incidence (epidemiology), Cognition, Population based, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Accident, Memory, medicine, Dementia, Original Article, 030212 general & internal medicine, Adverse effect, Prospective cohort study, Memory test, business, 030217 neurology & neurosurgery, Biological Psychiatry, Driving, Demography
Abstract

Objective This study estimated the incidence of driving-related adverse events and examined the association of cognitive function with the risk of future driving-related adverse events in the elderly Korean male population.Methods We analyzed 1,172 male drivers aged 60 years or older in the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD). Using the data from Korean National Police Agency, we classified the participants into three groups: safe driving (drove for 2 years after baseline without a traffic accident or repeated violations), driving cessation (stopped driving), and risky driving (one or more traffic accidents or repeated violations). We estimated the incidences of driving cessation and risky driving, and examined the effect of cognitive function on their risks.Results The incidence of driving cessation and risky driving in the Korean male drivers aged 60 years or older was 19.3 and 69.9 per 1,000 person-years respectively and increased in the late 80s. Drivers with better baseline Word List Memory Test scores showed less risky driving (OR=0.94, p=0.039).Conclusion Driving-related adverse events increased in late 80s, and better memory function was protective against these events.

Published
2020

22. The impact of the COVID-19 pandemic on depression in community-dwelling older adults: a prospective cohort study

Author

Oh, Dae Jong, primary, Yang, Hee Won, additional, Suh, Seung Wan, additional, Byun, Seonjeong, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, and Kim, Ki Woong, additional

Published
2021
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23. Development and validation of cerebral white matter hyperintensity probability map of elderly Koreans

Author

Kim, Jun Sung, primary, Lee, Subin, additional, Kim, Grace Eun, additional, Oh, Dae Jong, additional, Moon, Woori, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, Byun, Seonjeong, additional, Suh, Seung Wan, additional, Choi, Yu Yong, additional, Choi, Kyu Yeong, additional, Lee, Kun Ho, additional, Kim, Jae Hyoung, additional, and Kim, Ki Woong, additional

Published
2021
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24. Mood disorders increase mortality mainly through dementia: A community-based prospective cohort study

Author

An, Hoyoung, primary, Yang, Hee Won, additional, Oh, Dae Jong, additional, Lim, Eunji, additional, Shin, Jin, additional, Moon, Dong Gyu, additional, Suh, Seung Wan, additional, Byun, Seonjeong, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, and Kim, Ki Woong, additional

Published
2021
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26. Mood disorders increase mortality mainly through dementia: A community-based prospective cohort study.

Author

An, Hoyoung, Yang, Hee Won, Oh, Dae Jong, Lim, Eunji, Shin, Jin, Moon, Dong Gyu, Suh, Seung Wan, Byun, Seonjeong, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, and Jhoo, Jin Hyeong

Subjects
DEMENTIA risk factors, STRUCTURAL equation modeling, ANALYSIS of variance, INTERVIEWING, RISK assessment, DEMENTIA, MENTAL depression, SURVIVAL analysis (Biometry), RESEARCH funding, LONGITUDINAL method, PROPORTIONAL hazards models, COMORBIDITY
Abstract

Objective: The effects of mood disorders on mortality may be mediated by their effects on the risk of dementia, and interventions to reduce the occurrence of dementia may reduce their overall mortality. This study aimed to investigate the direct effects of depressive and bipolar disorders on the 6-year risk of mortality and also their indirect effects on mortality due to their effect on the risk of dementia. Methods: A total of 5101 Koreans were selected from a community-based prospective cohort study, and 6-year risks of mortality and dementia in participants with depressive and bipolar disorders were estimated by Cox proportional hazard analysis. The direct and indirect effects of depressive and bipolar disorders on the risk of mortality were estimated using structural equation modeling. Results: The depressive and bipolar disorder groups showed 51% and 85% higher 6-year mortality, and 82% and 127% higher risk of dementia, respectively, compared to euthymic controls. The effects of depressive and bipolar disorders on mortality were mainly mediated by their effects on the risk of dementia in a structural equation model. The direct effects of each mood disorder on mortality were not significant. Conclusion: Both depressive and bipolar disorders increased the risks of mortality and dementia, and the effects of mood disorders on mortality were mainly mediated through dementia. As dementia occurs later in life than mood disorders, measures to prevent it may effectively reduce mortality in individuals with a history of mood disorders, as well as being more feasible than attempting to control other causes of death. [ABSTRACT FROM AUTHOR]

Published
2022
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27. A 9-Year Comparison of Dementia Prevalence in Korea: Results of NaSDEK 2008 and 2017

Author

Suh, Seung Wan, primary, Kim, You Joung, additional, Kwak, Kyung Phil, additional, Kim, Kiwon, additional, Kim, Moon-Doo, additional, Kim, Byung-Soo, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Moon, Seok Woo, additional, Park, Kyung Won, additional, Park, Jong-Il, additional, Park, Joon Hyuk, additional, Bae, Jae Nam, additional, Seo, Jiyeong, additional, Seong, Su Jeong, additional, Son, Sang Joon, additional, Shin, Il-Seon, additional, Ryu, Seung-Ho, additional, Lee, Kang Joon, additional, Lee, Nam-Jin, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Chang Uk, additional, Chang, Sung Man, additional, Jeong, Hyun-Ghang, additional, Cho, Maeng Je, additional, Cho, Seong-Jin, additional, Jhoo, Jin Hyeong, additional, Choe, Young Min, additional, Han, Ji Won, additional, and Kim, Ki Woong, additional

Published
2021
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28. Construction and validation of a cerebral white matter hyperintensity probability map of older Koreans

Author

Kim, Jun Sung, primary, Lee, Subin, additional, Kim, Grace Eun, additional, Oh, Dae Jong, additional, Moon, Woori, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, Byun, Seonjeong, additional, Suh, Seung Wan, additional, Choi, Yu Yong, additional, Choi, Kyu Yeong, additional, Lee, Kun Ho, additional, Kim, Jae Hyoung, additional, and Kim, Ki Woong, additional

Published
2021
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33. Additional file 1 of Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study

Author

Röhr, Susanne, Pabst, Alexander, Riedel-Heller, Steffi G., Jessen, Frank, Yuda Turana, Handajani, Yvonne S., Brayne, Carol, Matthews, Fiona E., Stephan, Blossom C. M., Lipton, Richard B., Katz, Mindy J., Cuiling Wang, Guerchet, Maëlenn, Pierre-Marie Preux, Mbelesso, Pascal, Ritchie, Karen, Marie-Laure Ancelin, Carrière, Isabelle, Guaita, Antonio, Davin, Annalisa, Vaccaro, Roberta, Kim, Ki Woong, Han, Ji Won, Suh, Seung Wan, Shahar, Suzana, Normah C. Din, Vanoh, Divya, Boxtel, Martin Van, Köhler, Sebastian, Ganguli, Mary, Jacobsen, Erin P., Snitz, Beth E., Anstey, Kaarin J., Cherbuin, Nicolas, Kumagai, Shuzo, Sanmei Chen, Narazaki, Kenji, Tze Pin Ng, Gao, Qi, Xinyi Gwee, Brodaty, Henry, Kochan, Nicole A., Trollor, Julian, Lobo, Antonio, López-Antón, Raúl, Santabárbara, Javier, Crawford, John D., Lipnicki, Darren M., and Perminder S. Sachdev

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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34. Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study

Author

Suh, Seung Wan, primary, Han, Ji Won, additional, Han, Ji Hyun, additional, Bae, Jong Bin, additional, Moon, Woori, additional, Kim, Hye Sung, additional, Oh, Dae Jong, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Ryu, Seung-Ho, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Byun, Seonjeong, additional, Seo, Jiyeong, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, and Kim, Ki Woong, additional

Published
2020
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36. Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: A COSMIC study

Author

Roehr, Susanne, primary, Pabst, Alexander, additional, Riedel-Heller, Steffi G., additional, Jessen, Frank, additional, Turana, Yuda, additional, Handajani, Yvonne S., additional, Brayne, Carol, additional, Matthews, Fiona E., additional, Stephan, Blosso C.M., additional, Lipton, Richard B., additional, Katz, Mindy J., additional, Wang, Cuiling, additional, Guerchet, Maëlenn, additional, Preux, Pierre-Marie, additional, Mbelesso, Pascal, additional, Ritchie, Karen, additional, Ancelin, Marie-Laure, additional, Carrière, Isabelle, additional, Guaita, Antonio, additional, Davin, Annalisa, additional, Vaccaro, Roberta, additional, Kim, Ki Woong, additional, Han, Ji Won, additional, Suh, Seung Wan, additional, Shahar, Suzana, additional, Din, Normah C., additional, Vanoh, Divya, additional, van Boxtel, Martin, additional, Köhler, Sebastian, additional, Ganguli, Mary, additional, Jacobsen, Erin P., additional, Snitz, Beth E., additional, Anstey, Kaaren J., additional, Cherbuin, Nicolas, additional, Kumagai, Shuzo, additional, Chen, Sanmei, additional, Narazaki, Kenji, additional, Ng, Tze Pin, additional, Gao, Qi, additional, Gwee, Xin Yi, additional, Brodaty, Henry, additional, Kochan, Nicole A., additional, Trollor, Julian, additional, Lobo, Antonio, additional, López-Antón, Raúl, additional, Santabárbara, Javier, additional, Crawford, John D., additional, Lipnicki, Darren M., additional, and Sachdev, Perminder S., additional

Published
2020
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38. Loss of Functional Dentition is Associated with Cognitive Impairment

Author

Han, Ji Hyun, primary, Lee, Hyo-Jung, additional, Han, Ji Won, additional, Suh, Seung Wan, additional, Lee, Ju Ri, additional, Byun, Seonjeong, additional, Kim, Keun Suh, additional, Kim, Sung Yeol, additional, Lee, Jung-Tae, additional, Yoo, Eunha, additional, Chang, Na-Hee, additional, Kim, Tae Hui, additional, and Kim, Ki Woong, additional

Published
2020
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40. Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia

Author

Lee, Dongyun, primary, Kim, Bong-Jo, additional, Han, Ji Won, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Kayoung, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hyun, additional, Moon, Seok Woo, additional, Park, Jae Young, additional, Park, Joon Hyuk, additional, Byun, Seonjeong, additional, Suh, Seung Wan, additional, Seo, Ji Young, additional, So, Yoonseop, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Kyoung Hwan, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Ju Ri, additional, Jeong, Hyeon, additional, Jeong, Hyun-Ghang, additional, Jhoo, Jin Hyeong, additional, Han, Kyuhee, additional, Hong, Jong Woo, additional, Bae, Jong Bin, additional, and Kim, Ki Woong, additional

Published
2020
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44. Anhedonia and Dysphoria Are Differentially Associated with the Risk of Dementia in the Cognitively Normal Elderly Individuals: A Prospective Cohort Study

Author

Lee, Ju Ri, primary, Suh, Seung Wan, additional, Han, Ji Won, additional, Byun, Seonjeong, additional, Kwon, Soon Jai, additional, Lee, Kyoung Hwan, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Ryu, Seung-Ho, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Lee, Dong-Woo, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, and Kim, Ki Woong, additional

Published
2019
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45. Short Average Duration of NREM/REM Cycle Is Related to Cognitive Decline in an Elderly Cohort: An Exploratory Investigation

Author

Suh, Seung Wan, primary, Han, Ji Won, additional, Lee, Ju Ri, additional, Byun, Seonjeong, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Ryu, Seung-Ho, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Seo, Jiyeong, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, Yoon, In Young, additional, and Kim, Ki Woong, additional

Published
2019
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47. Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment

Author

Jang, Soomin, primary, Han, Ji Won, additional, Shin, Jiyoon, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Kayoung, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hyun, additional, Moon, Seok Woo, additional, Park, Jae Young, additional, Park, Joon Hyuk, additional, Byun, Seonjeong, additional, Suh, Seung Wan, additional, Seo, Jiyeong, additional, So, Yoonseop, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Kyoung Hwan, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Ju Ri, additional, Jeong, Hyeon, additional, Jeong, Hyun-Ghang, additional, Jhoo, Jin Hyeong, additional, Han, Kyuhee, additional, Hong, Jong Woo, additional, and Kim, Ki Woong, additional

Published
2019
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