566 results on '"Suhasini, P."'
Search Results
2. Artificial neural networks-based improved Levenberg–Marquardt neural network for energy efficiency and anomaly detection in WSN
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Revanesh, M., Gundal, Sheetal S., Arunkumar, J. R., Josephson, P. Joel, Suhasini, S., and Devi, T. Kalavathi
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- 2024
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3. Insight Into Aetiology and Severity of Hemolysis Associated with Immunoproteins on Red Cell Surface in Direct Antiglobulin Test Positive Auto-immune Hemolytic Anemia
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Sil, Suhasini, Kaur, Daljit, Negi, Gita, Jain, Ashish, and Nath, Uttam Kumar
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- 2024
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4. Ethylene-vinyl acetate binder-based carbon-supported Pt Anode empowered by potassium borohydride fuel for direct borohydride fuel cells: defining strategies to achieve ambient long-endurance performance
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Verma, Vaibhav, Choudhury, Suhasini Roy, Choudhury, Suman Roy, and Ganesan, Vellaichamy
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- 2024
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5. An effective approach in learning clinical biochemistry-Case Based Learning
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Suhasini, P., Joshi, K.P., Swaroopachary, R.S., Yamini, D., and Sarma, D.V.H.S.
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- 2017
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6. Anticlastogenic activity of ethanolic extract of Lagenaria siceraria fruit (ELSF) against cyclophosphamide induced genotoxicity in mice
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Kolure, Rajini, Penumallu, Naveen Reddy, Thakur, Sneha, De, Somnath, Boddu, Suhasini, Vinaitheerthan, Nachammai, Godela, Ramreddy, and Santhepete Nanjundaiah, Manjula
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- 2024
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7. Perception towards professionalism among Indian dental educators and residents – A descriptive study
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Kathleen Manuela D’Souza, Suresh Chari, Suhasini Nagda, Chinmay Shah, and Fhelen D. da Costa
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dental education ,dental ethics ,dental professionalism ,Dentistry ,RK1-715 - Abstract
Background: Lack of professional integrity among dental students can greatly impact the safety of future patients. Currently, there are no established learning outcomes for dental professionalism. Aim: The aim of the study is to assess the perceptions of Indian educators (DE) and residents (DR) towards the attributes and methods to learn/teach dental professionalism. Materials and Methods: A cross-sectional descriptive study was conducted among Indian DE and DR from April 1, 2022, to July 31, 2022. A 31-item questionnaire was developed to evaluate the demographic data, perceptions of learning/teaching methods, and attributes of professionalism. The sample size was calculated to 446 subjects. Descriptive statistics were carried out. Results: Of the 428 participants, 287 were DE and 141 were DR. Most participants are aware of the attributes and have a positive attitude toward professionalism. Role modeling and mentoring were the most effective ways to learn professionalism. About 97.9% of DE and 97.9% of DR felt it was important to teach dental students about professionalism. About 85.7% of DE and 73% of DR felt the need for an additional program in the current BDS curriculum. Most participants selected contact with role model teachers, clinical experience with patients, and discussion with peers as methods by which they learned dental professionalism. Conclusion: The majority of the participants are aware and have a positive attitude toward dental professionalism.
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- 2024
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8. Clinical pattern of vernal keratoconjunctivitis in children – A cross-sectional study
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Roopa K, Ramalakshmi Badugu, SreeLakshmi Pallamreddy, and Suhasini J
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allergic disease ,itching ,papillae ,vernal keratoconjunctivitis ,Medicine - Abstract
Background: Vernal keratoconjunctivitis (VKC), a chronic and bilateral allergic eye condition, predominantly affects young males and is more prevalent in hot, humid regions with high allergen exposure. It manifests with itching, light sensitivity, burning sensations, and tearing. The three main clinical forms include limbal or bulbar, palpebral or tarsal, and mixed presentations. Aims and Objectives: This study aimed to describe the clinical patterns of VKC in children at a tertiary care hospital in Andhra Pradesh. Materials and Methods: This cross-sectional observational study was conducted in a hospital setting at the Department of Ophthalmology, SV Medical College in Tirupati, Andhra Pradesh, between January 2021 and January 2022. Ninety children aged 5–12 years with symptoms of allergic conjunctivitis were enrolled in the study. The Bonini grading system was used to grade the severity of the disease based on clinical manifestations at the time of initial presentation. Results: Mean age of disease onset was 8.6±2.3 years, with a male-to-female ratio (M: F) of 2.1:1. The majority of the subjects experienced seasonal occurrence 69 (77.0%), whereas 21 (23%) had perennial occurrence. The commonly reported symptoms included itching (83%), redness (73%), watering (73%), and discharge (47%). A significant number of patients (60, 69%) had a mixed type of disease that affected both the tarsal and bulbar conjunctiva. Conclusion: VKC predominantly affects young males, displaying a seasonal distribution and showing less allergic association, consistent with patterns observed in other tropical regions. Most patients had mild VKC at presentation, and a mixed-form pattern was most frequently observed.
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- 2024
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9. Identifying Contributing Factors Associated With Dental Adverse Events Through a Pragmatic Electronic Health Record-Based Root Cause Analysis.
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Kalenderian, Elsbeth, Bangar, Suhasini, Yansane, Alfa, Tran, Duong, Sedlock, Emily, Xiao, Yan, Urata, Janelle, Olson, Greg, Franklin, Amy, Kookal, Krishna, Ibarra-Noriega, Ana, Tungare, Sayali, Tokede, Oluwabunmi, Spallek, Heiko, White, Joel, and Walji, Muhammad
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Humans ,Electronic Health Records ,Medical Errors ,Root Cause Analysis - Abstract
OBJECTIVE: This study assessed contributing factors associated with dental adverse events (AEs). METHODS: Seven electronic health record-based triggers were deployed identifying potential AEs at 2 dental institutions. From 4106 flagged charts, 2 reviewers examined 439 charts selected randomly to identify and classify AEs using our dental AE type and severity classification systems. Based on information captured in the electronic health record, we analyzed harmful AEs to assess potential contributing factors; harmful AEs were defined as those that resulted in temporary moderate to severe harm, required hospitalization, or resulted in permanent moderate to severe harm. We classified potential contributing factors according to (1) who was involved (person), (2) what were they doing (tasks), (3) what tools/technologies were they using (tools/technologies), (4) where did the event take place (environment), (5) what organizational conditions contributed to the event? (organization), (6) patient (including parents), and (7) professional-professional collaboration. A blinded panel of dental experts conducted a second review to confirm the presence of an AE. RESULTS: Fifty-nine cases had 1 or more harmful AEs. Pain occurred most frequently (27.1%), followed by nerve injury (16.9%), hard tissue injury (15.2%), and soft tissue injury (15.2%). Forty percent of the cases were classified as temporary not moderate to severe harm. Person (training, supervision, and fatigue) was the most common contributing factor (31.5%), followed by patient (noncompliance, unsafe practices at home, low health literacy, 17.1%), and professional-professional collaboration (15.3%). CONCLUSIONS: Pain was the most common harmful AE identified. Person, patient, and professional-professional collaboration were the most frequently assessed factors associated with harmful AEs.
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- 2023
10. Pre-pregnancy Weight and Racial-Ethnic Disparities in Pregnancy-Associated Conditions in the State of Georgia: A Population-Based Study
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Ramisetty-Mikler, Suhasini, Willis, Angelique, and Tiwari, Chetan
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- 2024
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11. Unlocking the potential of Kodo millet: reviving an indigenous super grain for tomorrow's nutrition
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Jeeva, G., Suhasini, B., Pramitha, Lydia, Jency, J. Poornima, Joshi, Pabitra, Ravikesavan, R., and Elango, Dinakaran
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- 2024
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12. High expression of CD9 and Epidermal Growth Factor Receptor promotes the development of tongue cancer
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Suhasini, P. C., Bhat, Vadisha, Shetty, Shilpa S, Shetty, Praveen Kumar, Roopashree, P. G., and Kumari, N. Suchetha
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- 2024
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13. Study On Spatial Variations of Surface Water Quality Vulnerable Zones in Baitarani River Basin, Odisha, India
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Abhijeet Das, J. Jerlin Regin, A. Suhasini and K. Baby Lisa
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water quality, baitarani river, entropy, topsis, pollution, anthropogenic activities ,Environmental effects of industries and plants ,TD194-195 ,Science (General) ,Q1-390 - Abstract
The stated goal of the research is to investigate the surface water quality of the Baitarani River in Odisha to ascertain its compatibility for various uses. Large, complex datasets generated during the one-year (2021-2022) monitoring program were collected from 13 locations and encompassed 22 parameters. To examine temporal and spatial fluctuations in and to interpret these datasets, MCDMs like TOPSIS and the Entropy-based Water Quality Index (EWQI) were utilized. The physical and chemical outcomes of the current experiment were compared to WHO standards. According to the analysis’s results, turbidity and total coliform (TC) are indicators that have a greater impact on water quality in all locations during both seasons and are directly linked to home and agricultural non-point source pollution. As per EWQI interpretation, 30.77 % of the observations in PRM and POM fall under the poor category. The findings showed how anthropogenic activities have harmed St. 8, 11, 12, and 13 and require effective management. A quantifiable approach was also carried out to decide the efficacy of TOPSIS. Farming attributes, including SAR, % Na, RSC, MR, KI, and PI, were estimated to delineate the agriculturally practicable zones. This work can offer a reference database for the betterment of water quality.
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- 2024
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14. Translating periodontal data to knowledge in a learning health system
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Tokede, Bunmi, Yansane, Alfa, White, Joel, Bangar, Suhasini, Mullins, Joanna, Brandon, Ryan, Gantela, Swaroop, Kookal, Krishna, Rindal, Donald, Lee, Chun-Teh, Lin, Guo-Hao, Spallek, Heiko, Kalenderian, Elsbeth, and Walji, Muhammad
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Biomedical and Clinical Sciences ,Dentistry ,Clinical Research ,Dental/Oral and Craniofacial Disease ,Prevention ,Infectious Diseases ,Oral and gastrointestinal ,Good Health and Well Being ,Dental Informatics ,Humans ,Learning Health System ,Periodontal Diseases ,Periodontitis ,Population Health ,Tooth Loss ,  ,Clinical outcomes ,big data ,decision making ,dental informatics ,epidemiology ,population health - Abstract
BackgroundA learning health system (LHS) is a health system in which patients and clinicians work together to choose care on the basis of best evidence and to drive discovery as a natural outgrowth of every clinical encounter to ensure the right care at the right time. An LHS for dentistry is now feasible, as an increased number of oral health care encounters are captured in electronic health records (EHRs).MethodsThe authors used EHRs data to track periodontal health outcomes at 3 large dental institutions. The 2 outcomes of interest were a new periodontitis case (for patients who had not received a diagnosis of periodontitis previously) and tooth loss due to progression of periodontal disease.ResultsThe authors assessed a total of 494,272 examinations (new periodontitis outcome: n = 168,442; new tooth loss outcome: n = 325,830), representing a total of 194,984 patients. Dynamic dashboards displaying performance on both measures over time allow users to compare demographic and risk factors for patients. The incidence of new periodontitis and tooth loss was 4.3% and 1.2%, respectively.ConclusionsPeriodontal disease, diagnosis, prevention, and treatment are particularly well suited for an LHS model. The results showed the feasibility of automated extraction and interpretation of critical data elements from the EHRs. The 2 outcome measures are being implemented as part of a dental LHS. The authors are using this knowledge to target the main drivers of poorer periodontal outcomes in a specific patient population, and they continue to use clinical health data for the purpose of learning and improvement.Practical implicationsDental institutions of any size can conduct contemporaneous self-evaluation and immediately implement targeted strategies to improve oral health outcomes.
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- 2022
15. Using the left Gram matrix to cluster high dimensional data
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Rahman, Shahina, Johnson, Valen E., and Rao, Suhasini Subba
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Statistics - Machine Learning ,Computer Science - Machine Learning - Abstract
For high dimensional data, where P features for N objects (P >> N) are represented in an NxP matrix X, we describe a clustering algorithm based on the normalized left Gram matrix, G = XX'/P. Under certain regularity conditions, the rows in G that correspond to objects in the same cluster converge to the same mean vector. By clustering on the row means, the algorithm does not require preprocessing by dimension reduction or feature selection techniques and does not require specification of tuning or hyperparameter values. Because it is based on the NxN matrix G, it has a lower computational cost than many methods based on clustering the feature matrix X. When compared to 14 other clustering algorithms applied to 32 benchmarked microarray datasets, the proposed algorithm provided the most accurate estimate of the underlying cluster configuration more than twice as often as its closest competitors.
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- 2022
16. Inverse covariance operators of multivariate nonstationary time series
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Krampe, Jonas and Rao, Suhasini Subba
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Mathematics - Statistics Theory ,Statistics - Methodology - Abstract
For multivariate stationary time series many important properties, such as partial correlation, graphical models and autoregressive representations are encoded in the inverse of its spectral density matrix. This is not true for nonstationary time series, where the pertinent information lies in the inverse infinite dimensional covariance matrix operator associated with the multivariate time series. This necessitates the study of the covariance of a multivariate nonstationary time series and its relationship to its inverse. We show that if the rows/columns of the infinite dimensional covariance matrix decay at a certain rate then the rate (up to a factor) transfers to the rows/columns of the inverse covariance matrix. This is used to obtain a nonstationary autoregressive representation of the time series and a Baxter-type bound between the parameters of the autoregressive infinite representation and the corresponding finite autoregressive projection. The aforementioned results lay the foundation for the subsequent analysis of locally stationary time series. In particular, we show that smoothness properties on the covariance matrix transfer to (i) the inverse covariance (ii) the parameters of the vector autoregressive representation and (iii) the partial covariances. All results are set up in such a way that the constants involved depend only on the eigenvalue of the covariance matrix and can be applied in the high-dimensional settings with non-diverging eigenvalues.
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- 2022
17. Sirka: An alternative to the formalin fixative
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Suhasini P Gotur, Nagaraju Kamarthi, and Vijay Wadhwan
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fixative ,formalin ,sirka ,vinegar ,Pathology ,RB1-214 ,Microbiology ,QR1-502 - Abstract
Formalin fixation is the most essential step of routine histopathology practice. During the last few years, various fixatives have been developed for use in histopathology practice as an alternative to formalin, to overcome its side effects on health. Here we have demonstrated an interesting and novel idea of using sirka or sugar cane vinegar as an alternative to the formalin with the adequate result.
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- 2024
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18. SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation
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Huixin Xu, Guillaume P. Dugué, Yasmine Cantaut-Belarif, François-Xavier Lejeune, Suhasini Gupta, Claire Wyart, and Maria K. Lehtinen
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SCO-spondin/SSPO ,Subcommissural organ (SCO) ,Reissner’s fiber ,Cerebrospinal fluid ,Spinal cord ,Ventricular volume ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Reissner’s fiber (RF) is an extracellular polymer comprising the large monomeric protein SCO-spondin (SSPO) secreted by the subcommissural organ (SCO) that extends through cerebrospinal fluid (CSF)-filled ventricles into the central canal of the spinal cord. In zebrafish, RF and CSF-contacting neurons (CSF-cNs) form an axial sensory system that detects spinal curvature, instructs morphogenesis of the body axis, and enables proper alignment of the spine. In mammalian models, RF has been implicated in CSF circulation. However, challenges in manipulating Sspo, an exceptionally large gene of 15,719 nucleotides, with traditional approaches has limited progress. Here, we generated a Sspo knockout mouse model using CRISPR/Cas9-mediated genome-editing. Sspo knockout mice lacked RF-positive material in the SCO and fibrillar condensates in the brain ventricles. Remarkably, Sspo knockout brain ventricle sizes were reduced compared to littermate controls. Minor defects in thoracic spine curvature were detected in Sspo knockouts, which did not alter basic motor behaviors tested. Altogether, our work in mouse demonstrates that SSPO and RF regulate ventricle size during development but only moderately impact spine geometry.
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- 2023
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19. Revolutionizing Gastrointestinal Disorder Management: Cutting-Edge Advances and Future Prospects
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Chahat Suri, Babita Pande, Tarun Sahu, Lakkakula Suhasini Sahithi, and Henu Kumar Verma
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gastrointestinal disorders ,management ,theraputics ,diagnosis ,artificial intelligence ,Medicine - Abstract
In recent years, remarkable strides have been made in the management of gastrointestinal disorders, transforming the landscape of patient care and outcomes. This article explores the latest breakthroughs in the field, encompassing innovative diagnostic techniques, personalized treatment approaches, and novel therapeutic interventions. Additionally, this article emphasizes the use of precision medicine tailored to individual genetic and microbiome profiles, and the application of artificial intelligence in disease prediction and monitoring. This review highlights the dynamic progress in managing conditions such as inflammatory bowel disease, gastroesophageal reflux disease, irritable bowel syndrome, and gastrointestinal cancers. By delving into these advancements, we offer a glimpse into the promising future of gastroenterology, where multidisciplinary collaborations and cutting-edge technologies converge to provide more effective, patient-centric solutions for individuals grappling with gastrointestinal disorders.
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- 2024
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20. Graphical models for nonstationary time series
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Basu, Sumanta and Rao, Suhasini Subba
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Mathematics - Statistics Theory ,62M10 - Abstract
We propose NonStGM, a general nonparametric graphical modeling framework for studying dynamic associations among the components of a nonstationary multivariate time series. It builds on the framework of Gaussian Graphical Models (GGM) and stationary time series Gaussian Graphical model (StGM), and complements existing works on parametric graphical models based on change point vector autoregressions (VAR). Analogous to StGM, the proposed framework captures conditional noncorrelations (both intertemporal and contemporaneous) in the form of an undirected graph. In addition, to describe the more nuanced nonstationary relationships among the components of the time series, we introduce the new notion of conditional nonstationarity/stationarity and incorporate it within the graph architecture. This allows one to distinguish between direct and indirect nonstationary relationships among system components, and can be used to search for small subnetworks that serve as the "source" of nonstationarity in a large system. Together, the two concepts of conditional noncorrelation and nonstationarity/stationarity provide a parsimonious description of the dependence structure of the time series.
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- 2021
21. A prediction perspective on the Wiener-Hopf equations for time series
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Rao, Suhasini Subba and Yang, Junho
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Mathematics - Statistics Theory ,Electrical Engineering and Systems Science - Signal Processing ,Statistics - Methodology - Abstract
The Wiener-Hopf equations are a Toeplitz system of linear equations that naturally arise in several applications in time series. These include the update and prediction step of the stationary Kalman filter equations and the prediction of bivariate time series. The celebrated Wiener-Hopf technique is usually used for solving these equations and is based on a comparison of coefficients in a Fourier series expansion. However, a statistical interpretation of both the method and solution is opaque. The purpose of this note is to revisit the (discrete) Wiener-Hopf equations and obtain an alternative solution that is more aligned with classical techniques in time series analysis. Specifically, we propose a solution to the Wiener-Hopf equations that combines linear prediction with deconvolution. The Wiener-Hopf solution requires the spectral factorization of the underlying spectral density function. For ease of evaluation it is often assumed that the spectral density is rational. This allows one to obtain a computationally tractable solution. However, this leads to an approximation error when the underlying spectral density is not a rational function. We use the proposed solution with Baxter's inequality to derive an error bound for the rational spectral density approximation.
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- 2021
22. SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation
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Xu, Huixin, Dugué, Guillaume P., Cantaut-Belarif, Yasmine, Lejeune, François-Xavier, Gupta, Suhasini, Wyart, Claire, and Lehtinen, Maria K.
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- 2023
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23. Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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Rodina, Anna, Xu, Chao, Digwal, Chander S., Joshi, Suhasini, Patel, Yogita, Santhaseela, Anand R., Bay, Sadik, Merugu, Swathi, Alam, Aftab, Yan, Pengrong, Yang, Chenghua, Roychowdhury, Tanaya, Panchal, Palak, Shrestha, Liza, Kang, Yanlong, Sharma, Sahil, Almodovar, Justina, Corben, Adriana, Alpaugh, Mary L., Modi, Shanu, Guzman, Monica L., Fei, Teng, Taldone, Tony, Ginsberg, Stephen D., Erdjument-Bromage, Hediye, Neubert, Thomas A., Manova-Todorova, Katia, Tsou, Meng-Fu Bryan, Young, Jason C., Wang, Tai, and Chiosis, Gabriela
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- 2023
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24. Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution
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Fame, Ryann M., Kalugin, Peter N., Petrova, Boryana, Xu, Huixin, Soden, Paul A., Shipley, Frederick B., Dani, Neil, Grant, Bradford, Pragana, Aja, Head, Joshua P., Gupta, Suhasini, Shannon, Morgan L., Chifamba, Fortunate F., Hawks-Mayer, Hannah, Vernon, Amanda, Gao, Fan, Zhang, Yong, Holtzman, Michael J., Heiman, Myriam, Andermann, Mark L., Kanarek, Naama, Lipton, Jonathan O., and Lehtinen, Maria K.
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- 2023
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25. RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells
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Herrejon Chavez, Florisela, Luo, Hanzhi, Cifani, Paolo, Pine, Alli, Chu, Eren L., Joshi, Suhasini, Barin, Ersilia, Schurer, Alexandra, Chan, Mandy, Chang, Kathryn, Han, Grace Y. Q., Pierson, Aspen J., Xiao, Michael, Yang, Xuejing, Kuehm, Lindsey M., Hong, Yuning, Nguyen, Diu T. T., Chiosis, Gabriela, Kentsis, Alex, Leslie, Christina, Vu, Ly P., and Kharas, Michael G.
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- 2023
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26. Smart explainable artificial intelligence for sustainable secure healthcare application based on quantum optical neural network
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Suhasini, S., Tatini, Narendra Babu, Arslan, Farrukh, Bansal, Sushil Kumar, Babu, Suresh, and Umaralievich, Mekhmonov Sultonali
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- 2023
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27. The importance of rapid assessment tools in evaluating mental health in emergency departments among patients with chronic diseases
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Aditya Lal Vallath, Barath Prashanth Sivasubramanian, Diviya Bharathi Ravikumar, Akshita Lalendran, Suhasini Krishnan, Sudeshna Samanta, Snigda Banerjee, Tania Das, Ritwick Kundu, Vyom Richharia, Ravisha More, Mishika Khithani, Sahana Nazimudeen, Sasidhar Gunturu, and Indraneel Dasgupta
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mental health ,CLOX-1 ,six-item screener ,WHO well-being index ,emergency department ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundRapid screening tools such as the WHO well-being Index (WWBI), Six-item screener (SIS), and the CLOX-1 test can be used to assess overall mental health and cognition, respectively. We sought to evaluate mental health with cognition in individuals with chronic diseases and stable vital signs presenting to the Emergency Department (ED).MethodsAn observational study in the ED with 279 participants was conducted.ResultsChronic diseases were more prevalent among 51–70 years (43.4%) and diabetes was most common (58.8%). Fever (22.6%) and GI bleeding (32.6%) presentation were high. Participants with low WWBI had low SIS compared to the ones with higher scores (83.3% vs. 17.7%, p
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- 2024
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28. Caries Risk Documentation And Prevention: eMeasures For Dental Electronic Health Records.
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Bangar, Suhasini, Neumann, Ana, White, Joel, Yansane, Alfa, Johnson, Todd, Olson, Gregory, Kumar, Shwetha, Kookal, Krishna, Kim, Aram, Obadan-Udoh, Enihomo, Mertz, Elizabeth, Simmons, Kristen, Mullins, Joanna, Brandon, Ryan, Walji, Muhammad, and Kalenderian, Elsbeth
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Dental Caries Susceptibility ,Documentation ,Electronic Health Records ,Humans ,Risk Assessment - Abstract
BACKGROUND: Longitudinal patient level data available in the electronic health record (EHR) allows for the development, implementation, and validations of dental quality measures (eMeasures). OBJECTIVE: We report the feasibility and validity of implementing two eMeasures. The eMeasures determined the proportion of patients receiving a caries risk assessment (eCRA) and corresponding appropriate risk-based preventative treatments for patients at elevated risk of caries (appropriateness of care [eAoC]) in two academic institutions and one accountable care organization, in the 2019 reporting year. METHODS: Both eMeasures define the numerator and denominator beginning at the patient level, populations specifications, and validated the automated queries. For eCRA, patients who completed a comprehensive or periodic oral evaluation formed the denominator, and patients of any age who received a CRA formed the numerator. The eAoC evaluated the proportion of patients at elevated caries risk who received the corresponding appropriate risk-based preventative treatments. RESULTS: EHR automated queries identified in three sites 269,536 patients who met the inclusion criteria for receiving a CRA. The overall proportion of patients who received a CRA was 94.4% (eCRA). In eAoC, patients at elevated caries risk levels (moderate, high, or extreme) received fluoride preventive treatment ranging from 56 to 93.8%. For patients at high and extreme risk, antimicrobials were prescribed more frequently site 3 (80.6%) than sites 2 (16.7%) and 1 (2.9%). CONCLUSION: Patient-level data available in the EHRs can be used to implement process-of-care dental eCRA and AoC, eAoC measures identify gaps in clinical practice. EHR-based measures can be useful in improving delivery of evidence-based preventative treatments to reduce risk, prevent tooth decay, and improve oral health.
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- 2022
29. Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution
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Ryann M. Fame, Peter N. Kalugin, Boryana Petrova, Huixin Xu, Paul A. Soden, Frederick B. Shipley, Neil Dani, Bradford Grant, Aja Pragana, Joshua P. Head, Suhasini Gupta, Morgan L. Shannon, Fortunate F. Chifamba, Hannah Hawks-Mayer, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Mark L. Andermann, Naama Kanarek, Jonathan O. Lipton, and Maria K. Lehtinen
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Science - Abstract
Abstract Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can modulate brain states via regulation of cerebrospinal fluid (CSF) composition. Here, we developed a platform to analyze diurnal variations in male mouse ChP and CSF. Ribosome profiling of ChP epithelial cells revealed diurnal translatome differences in metabolic machinery, secreted proteins, and barrier components. Using ChP and CSF metabolomics and blood-CSF barrier analyses, we observed diurnal changes in metabolites and cellular junctions. We then focused on transthyretin (TTR), a diurnally regulated thyroid hormone chaperone secreted by the ChP. Diurnal variation in ChP TTR depended on Bmal1 clock gene expression. We achieved real-time tracking of CSF-TTR in awake Ttr mNeonGreen mice via multi-day intracerebroventricular fiber photometry. Diurnal changes in ChP and CSF TTR levels correlated with CSF thyroid hormone levels. These datasets highlight an integrated platform for investigating diurnal control of brain states by the ChP and CSF.
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- 2023
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30. Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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Anna Rodina, Chao Xu, Chander S. Digwal, Suhasini Joshi, Yogita Patel, Anand R. Santhaseela, Sadik Bay, Swathi Merugu, Aftab Alam, Pengrong Yan, Chenghua Yang, Tanaya Roychowdhury, Palak Panchal, Liza Shrestha, Yanlong Kang, Sahil Sharma, Justina Almodovar, Adriana Corben, Mary L. Alpaugh, Shanu Modi, Monica L. Guzman, Teng Fei, Tony Taldone, Stephen D. Ginsberg, Hediye Erdjument-Bromage, Thomas A. Neubert, Katia Manova-Todorova, Meng-Fu Bryan Tsou, Jason C. Young, Tai Wang, and Gabriela Chiosis
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Science - Abstract
Abstract Systems-level assessments of protein-protein interaction (PPI) network dysfunctions are currently out-of-reach because approaches enabling proteome-wide identification, analysis, and modulation of context-specific PPI changes in native (unengineered) cells and tissues are lacking. Herein, we take advantage of chemical binders of maladaptive scaffolding structures termed epichaperomes and develop an epichaperome-based ‘omics platform, epichaperomics, to identify PPI alterations in disease. We provide multiple lines of evidence, at both biochemical and functional levels, demonstrating the importance of these probes to identify and study PPI network dysfunctions and provide mechanistically and therapeutically relevant proteome-wide insights. As proof-of-principle, we derive systems-level insight into PPI dysfunctions of cancer cells which enabled the discovery of a context-dependent mechanism by which cancer cells enhance the fitness of mitotic protein networks. Importantly, our systems levels analyses support the use of epichaperome chemical binders as therapeutic strategies aimed at normalizing PPI networks.
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- 2023
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31. RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells
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Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Eren L. Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y. Q. Han, Aspen J. Pierson, Michael Xiao, Xuejing Yang, Lindsey M. Kuehm, Yuning Hong, Diu T. T. Nguyen, Gabriela Chiosis, Alex Kentsis, Christina Leslie, Ly P. Vu, and Michael G. Kharas
- Subjects
Science - Abstract
Abstract Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are essential for long-term repopulation after secondary transplantation. Here, using a conditional knockout mouse model, we revealed that the RNA-binding protein SYNCRIP is required for maintenance of blood homeostasis especially after regenerative stress due to defects in HSCs and progenitors. Mechanistically, we find that SYNCRIP loss results in a failure to maintain proteome homeostasis that is essential for HSC maintenance. SYNCRIP depletion results in increased protein synthesis, a dysregulated epichaperome, an accumulation of misfolded proteins and induces endoplasmic reticulum stress. Additionally, we find that SYNCRIP is required for translation of CDC42 RHO-GTPase, and loss of SYNCRIP results in defects in polarity, asymmetric segregation, and dilution of unfolded proteins. Forced expression of CDC42 recovers polarity and in vitro replating activities of HSCs. Taken together, we uncovered a post-transcriptional regulatory program that safeguards HSC self-renewal capacity and blood homeostasis.
- Published
- 2023
- Full Text
- View/download PDF
32. Flexural response of concurrently 3D printed sandwich composite
- Author
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S, Bharath H, Bonthu, Dileep, Gururaja, Suhasini, Prabhakar, Pavana, and Doddamani, Mrityunjay
- Subjects
Physics - Applied Physics - Abstract
Among many lightweight materials used in marine applications, sandwich structures with syntactic foam core are promising because of lower water uptake in foam core amid face-sheets damage. HDPE (high-density polyethylene) filament is used to 3D print sandwich skin, and glass microballoon (GMB) reinforced HDPE syntactic foam filaments are used for the core. The optimized parameters are used to prepare blends of 20, 40, and 60 volume % of GMB in HDPE. These foamed blends are extruded in filament form to be subsequently used in commercially available fused filament fabrication (FFF) based 3D printers. The defect-free syntactic foam core sandwich composites are 3D printed concurrently for characterizing their flexural behavior. The printed HDPE, foam cores, and sandwiches are tested under three-point bending mode. The addition of GMB increases both specific modulus and strength in sandwich composites and is highest for the sandwich having a core with 60 volume % of GMB. The flexural strength, fracture strength, and strain of foam core sandwiches registered superior response than their respective cores. The experimental results are found in good agreement compared with theoretical predictions. Finally, the failure mode of the printed sandwich is also discussed.
- Published
- 2020
- Full Text
- View/download PDF
33. Spectral methods for small sample time series: A complete periodogram approach
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Das, Sourav, Rao, Suhasini Subba, and Yang, Junho
- Subjects
Mathematics - Statistics Theory - Abstract
The periodogram is a widely used tool to analyze second order stationary time series. An attractive feature of the periodogram is that the expectation of the periodogram is approximately equal to the underlying spectral density of the time series. However, this is only an approximation, and it is well known that the periodogram has a finite sample bias, which can be severe in small samples. In this paper, we show that the bias arises because of the finite boundary of observation in one of the discrete Fourier transforms which is used in the construction of the periodogram. Moreover, we show that by using the best linear predictors of the time series over the boundary of observation we can obtain a "complete periodogram" that is an unbiased estimator of the spectral density. In practice, the "complete periodogram" cannot be evaluated as the best linear predictors are unknown. We propose a method for estimating the best linear predictors and prove that the resulting "estimated complete periodogram" has a smaller bias than the regular periodogram. The estimated complete periodogram and a tapered version of it are used to estimate parameters, which can be represented in terms of the integrated spectral density. We prove that the resulting estimators have a smaller bias than their regular periodogram counterparts. The proposed method is illustrated with simulations and real data.
- Published
- 2020
34. Reconciling the Gaussian and Whittle Likelihood with an application to estimation in the frequency domain
- Author
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Rao, Suhasini Subba and Yang, Junho
- Subjects
Mathematics - Statistics Theory - Abstract
In time series analysis there is an apparent dichotomy between time and frequency domain methods. The aim of this paper is to draw connections between frequency and time domain methods. Our focus will be on reconciling the Gaussian likelihood and the Whittle likelihood. We derive an exact, interpretable, bound between the Gaussian and Whittle likelihood of a second order stationary time series. The derivation is based on obtaining the transformation which is biorthogonal to the discrete Fourier transform of the time series. Such a transformation yields a new decomposition for the inverse of a Toeplitz matrix and enables the representation of the Gaussian likelihood within the frequency domain. We show that the difference between the Gaussian and Whittle likelihood is due to the omission of the best linear predictions outside the domain of observation in the periodogram associated with the Whittle likelihood. Based on this result, we obtain an approximation for the difference between the Gaussian and Whittle likelihoods in terms of the best fitting, finite order autoregressive parameters. These approximations are used to define two new frequency domain quasi-likelihoods criteria. We show that these new criteria can yield a better approximation of the spectral divergence criterion, as compared to both the Gaussian and Whittle likelihoods. In simulations, we show that the proposed estimators have satisfactory finite sample properties.
- Published
- 2020
35. Photocatalytic efficacy of Magnesium oxide nanoparticles in dye Degradation: A sustainable One-Pot synthesis utilizing Syzygium samarangense L. Extract
- Author
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K.M. Rajeshwari, M.R. Suhasini, S. Bindya, A.B. Hemavathi, Nemat Ali, Raghavendra G. Amachawadi, Chandan Shivamallu, Raghavendra L.S. Hallur, Sanjay S. Majani, and Shiva Prasad Kollur
- Subjects
Syzygium Samarangense leaves ,MgO NPs ,Photocatalytic degradation ,Methylene blue ,Congo red ,Chemistry ,QD1-999 - Abstract
Efficient degradation of organic pollutants is a pressing environmental concern. In our current study, we propose a novel photocatalytic solution to address this challenge, harnessing the potential of advanced nanomaterials to enhance pollutant removal rates. The present work reports the synthesis of Magnesium Oxide (MgO) nanoparticles via a green technique using an aqueous extract of Syzygium samarangense leaves. The role of reducing and capping agents in the process was owned by Syzygium samarangense leaf extract. The green synthesized MgO nanoparticles (MgO NPs) were characterized for their structural, morphology, and optical details using various analytical techniques. The formation of metal oxide in the sample was evident from a strong absorbance peak at 264 nm, and the calculated Eg value of 5.5 eV. The high crystallinity of the prepared NPs was authenticated by PXRD analysis with a cubic structure of calculated average crystalline size of 18 nm. Both leaf extract and the prepared MgO NPs were subjected to FTIR analysis, and the action of phytochemicals was affirmed by the absence of major band in MgO NPs spectrum. Precursor and agglomerated morphology were confirmed on SEM analysis. The prepared sample were utilized to perform degradation of Methylene blue (MB) and congo red (CR) dyes through photocatalysis under UV irradiation. The results affirm the decrement in absorbance with the increment of irradiation time. The affirmed decrement was put forth to study the kinetics of the degradation reaction, and the results was best aligned with 1st kinetic equation with R2 value of 0.9850 and 0.976 for MB and CR dye, respectively. The same results were utilized to study the effect of dye dosage, catalyst concentration, pH level, and presence of different scavengers. All the results found compelling and suggest the prepared MgO NPs as a potent candidate for photocatalytic dye degradation of MB and CR.
- Published
- 2023
- Full Text
- View/download PDF
36. Assessing the completeness of periodontal disease documentation in the EHR: a first step in measuring the quality of care.
- Author
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Mullins, Joanna, Yansane, Alfa, Kumar, Shwetha, Bangar, Suhasini, Neumann, Ana, Johnson, Todd, Olson, Gregory, Kookal, Krishna, Sedlock, Emily, Kim, Aram, Mertz, Elizabeth, Brandon, Ryan, Simmons, Kristen, White, Joel, Kalenderian, Elsbeth, and Walji, Muhammad
- Subjects
Dental quality measures (DQMs) ,EHR ,Periodontal disease ,Periodontal risk assessment ,Quality ,Value ,Documentation ,Electronic Health Records ,Humans ,Patient Compliance ,Periodontal Diseases - Abstract
BACKGROUND: Our objective was to measure the proportion of patients for which comprehensive periodontal charting, periodontal disease risk factors (diabetes status, tobacco use, and oral home care compliance), and periodontal diagnoses were documented in the electronic health record (EHR). We developed an EHR-based quality measure to assess how well four dental institutions documented periodontal disease-related information. An automated database script was developed and implemented in the EHR at each institution. The measure was validated by comparing the findings from the measure with a manual review of charts. RESULTS: The overall measure scores varied significantly across the four institutions (institution 1 = 20.47%, institution 2 = 0.97%, institution 3 = 22.27% institution 4 = 99.49%, p-value 80%). CONCLUSION: Our results demonstrate the feasibility of developing automated data extraction scripts using structured data from EHRs, and successfully implementing these to identify and measure the periodontal documentation completeness within and across different dental institutions.
- Published
- 2021
37. A compendium of late-onset darier with an unusual report
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Bhavni Oberoi, Suhasini Chand, Divya Shelly, and Reetu Agarwal
- Subjects
comedonal ,darier ,genetic disorder ,late onset ,Dermatology ,RL1-803 - Abstract
Darier disease is an autosomal dominant inherited skin disorder with complete penetrance and variable expressivity due to mutation in the ATP 2A2 gene. It usually develops from childhood and persists through adolescence. Late onset of this genodermatosis has been infrequently reported and found to have minimal findings compared to the classical cases. Classical disease presents with greasy keratotic yellowish-brown papules over the seborrheic areas with palmar pits and nail changes. We hereby report a case of late onset comedonal darier disease with extensive hypopigmented lesions, involvement of palms and nails which is rarely reported in this setting. A thorough review of literature was done and a compendium prepared of late onset darier and no other case report was found to have such extensive involvement as the case reported. It will be interesting to compare more such late onset cases to see if they have a common pattern which can suggest them to be a separate entity from the classical darier.
- Published
- 2023
- Full Text
- View/download PDF
38. Measuring sealant placement in children at the dental practice level.
- Author
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Kumar, Shwetha, Yansane, Alfa, Neumann, Ana, Johnson, Todd, Olson, Gregory, Bangar, Suhasini, Kookal, Krishna, Kim, Aram, Obadan-Udoh, Enihomo, Mertz, Elizabeth, Simmons, Kristen, Mullins, Joanna, White, Joel, Kalenderian, Elsbeth, and Walji, Muhammad
- Subjects
Caries risk ,dental quality measures ,dental sealants ,electronic measures ,Adolescent ,Child ,Dental Caries ,Humans ,Pit and Fissure Sealants - Abstract
BACKGROUND: Although sealants are an established and recommended caries-preventive treatment, many children still fail to receive them. In addition, research has shown that existing measures underestimate care by overlooking the sealable potential of teeth before evaluating care. To address this, the authors designed and evaluated 3 novel dental electronic health record-based clinical quality measures that evaluate sealant care only after assessing the sealable potential of teeth. METHODS: Measure I recorded the proportion of patients with sealable teeth who received sealants. Measure II recorded the proportion of patients who had at least 1 of their sealable teeth sealed. Measure III recorded the proportion of patients who received sealant on all of their sealable teeth. RESULTS: On average, 48.1% of 6- through 9-year-old children received 1 or more sealants compared with 32.4% of 10- through 14-year-olds (measure I). The average measure score decreased for patients who received sealants for at least 1 of their sealable teeth (measure II) (43.2% for 6- through 9-year-olds and 28.4% for 10- through 14-year-olds). Fewer children received sealants on all eligible teeth (measure III) (35.5% of 6- through 9-year-olds and 21% of 10- through 14-year-olds received sealant on all eligible teeth). Among the 48.5% who were at elevated caries risk, the sealant rates were higher across all 3 measures. CONCLUSIONS: A valid and actionable practice-based sealant electronic measure that evaluates sealant treatment among the eligible population, both at the patient level and the tooth level, has been developed. PRACTICAL IMPLICATIONS: The measure developed in this work provides practices with patient-centered and actionable sealant quality measures that aim to improve oral health outcomes.
- Published
- 2020
39. Meta-analysis Provides Weak Evidence for an Effect of Mindfulness on Neural Activity Related to Error-Processing in Healthy Individuals Only
- Author
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Osborn, Melissa, Shankar, Suhasini, Szymanski, Oliver, Gunningham, Kate, Caldwell, Bridget, Perera, Magelage Prabhavi N., Michael, Jessica, Wang, Michael, Fitzgerald, Paul B., and Bailey, Neil W.
- Published
- 2022
- Full Text
- View/download PDF
40. An Efficient Route Optimization Using Ticket-ID Based Routing Management System (T-ID BRM)
- Author
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Venkatasubramanian, S., Suhasini, A., and Vennila, C.
- Published
- 2022
- Full Text
- View/download PDF
41. Thermal-based Zinc-Oxide-Coated Smart Fabric for Thermochromic Applications
- Author
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Mohammed Jabir, P. Guru Gopinath, Suhasini Sathiyamoorthy, K. Jayabal, and Pandiyarasan Veluswamy
- Subjects
thermochromic ,Thin film growth ,fabric coating ,Industrial electrochemistry ,TP250-261 - Abstract
The present study focuses on developing a thermochromic device with a flexible substrate through the coating of cotton fabric with ZnO (Zinc oxide) by solvothermal synthesis technique. Here, ZnO is used as the thermochromic layer for the fabrication work, and it is suitable for textile and wearable applications as it is non-toxic to human skin. This device is designed and fabricated in order to gain better insight into the role of ZnO in thermochromic applications. Here, 3D nanostructures of ZnO are grown on the surface of cotton fabric using a simple and cost-effective solvothermal synthesis approach. The coated fabrics are investigated to determine their structure, morphology, composition, electrical, optical and emissivity properties using an X-ray diffraction (XRD), field-emission scanning electron microscope (FE-SEM), current-voltage (I-V) characteristics, ultraviolet protection factor (UPF) etc. From the morphology study, uniformly packed ZnO nanorods with growth in the c -axis direction are observed. The ZnO nanostructures are known to have excellent UPF when exposed to solar radiation and showed UPF value of 112.48. It is found that coated fabrics have increased electrical conductivity under optical excitations and also enhanced the reflectance. Moreover, based on the emissivity analysis coated ZnO cotton fabric showed the emissivity of 0.95, which is higher and has greater radiation protection than that of bare cotton fabric. Hence, the developed thermochromic device has potential for use in the future in textile and wearable based thermochromic application.
- Published
- 2024
- Full Text
- View/download PDF
42. Rare blood group registry in India-current challenges and future perspectives
- Author
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Suvro Sankha Datta, Suhasini Sil, and Saikat Mandal
- Subjects
rare blood groups ,registry ,immunohematological approach ,blood group genotyping ,India ,Genetics ,QH426-470 - Abstract
Patients who require blood from rare blood group donors present great challenges even to the most advanced healthcare delivery system. It is most challenging to supply blood for a patient with an antibody to an antigen of high prevalence. The blood donor lacking the corresponding antigen would have an occurrence rate of less than one in 1,000. The International Rare Donor Panel was established in 1965, but since then there has been gross underrepresentation of South Asian countries, including India. There are several challenges to starting a rare blood group donor program in India that include technical, logistical, and administrative limitations. But the main limiting factors are poor availability of trained resources, lack of awareness, absence of antibody screening, inadequate number of laboratories with blood group genotyping facilities, and the decentralized nature of blood transfusion services. Despite that, there were several rare blood groups identified by Indian immunohematologists in the recent past. Recently, a transfusion genomic group has been established in collaboration with the clinical transfusion medicine specialists in India under the GUaRDIAN (Genomics for Understanding Rare Disease in India Alliance Network) initiative to address the domain of rare blood group genomics. Similarly, the National Institute of Immunohematology, Mumbai under the directive of the ICMR (Indian Council of Medical Research) has taken a step to start the RDRI (Rare Donor Registry of India). In this context, we explore the current challenges of setting-up a rare blood group registry in India and future goals from a developing nation’s perspective.
- Published
- 2023
- Full Text
- View/download PDF
43. Smart Attendance System Using Machine Learning Algorithms
- Author
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Chowdary, M. Nitin, Sujana, V., Satvika, K., Srinivas, K. Lakshmi, Suhasini, P. S., Howlett, Robert J., Series Editor, Jain, Lakhmi C., Series Editor, Chen, Joy Iong-Zong, editor, Wang, Haoxiang, editor, Du, Ke-Lin, editor, and Suma, V., editor
- Published
- 2022
- Full Text
- View/download PDF
44. Number of Pregnant Women at Four Dental Clinics and the Care They Received: A Dental Quality eMeasure Evaluation
- Author
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Neumann, Ana, Obadan‐Udoh, Enihomo, Bangar, Suhasini, Kumar, Shwetha V, Tokede, Oluwabunmi, Kim, Aram, Yansane, Alfa, Mertz, Elizabeth, Panwar, Sapna, Gharpure, Arti, Kookal, Krisha Kumar, Mullins, Joanna, Even, Joshua B, Simmons, Kristen, White, Joel M, Walji, Muhammad F, and Kalenderian, Elsbeth
- Subjects
Biomedical and Clinical Sciences ,Dentistry ,Health Services ,Prevention ,Dental/Oral and Craniofacial Disease ,Patient Safety ,Clinical Research ,8.1 Organisation and delivery of services ,Health and social care services research ,Reproductive health and childbirth ,Adolescent ,Adult ,Curriculum ,Dental Care ,Dental Clinics ,Electronic Health Records ,Female ,Humans ,Pregnancy ,Prenatal Care ,Quality Improvement ,Young Adult ,dental care ,dental patients ,dentistry ,pregnancy ,pregnant patients ,quality improvement ,dental quality measure ,dental education ,Curriculum and Pedagogy - Abstract
Process-of-care quality measure research can be used to identify gaps in the delivery of dental services to pregnant patients. The aim of this study was to evaluate the types of dental services that pregnant patients received in four dental clinics over five years as documented in the electronic health record (EHR). To accomplish this objective, the authors modified and validated a previously published claims-based dental quality measure for EHR use. After the electronic dental quality measure specifications were defined, the number of pregnant patients was calculated at three academic dental institutions and one large accountable care organization, and the types of dental care services they received over a five-year period (2013-17) were determined. Calibrated reviewers at each institution independently reviewed a sub-sample of patient charts to validate the information obtained from EHR queries, and the concordance between manual chart reviews and EHR query reports was analyzed. Of the 335,078 women aged 15-44 years who received care at the four clinics for the five reporting years, 3.9% (n=13,026) were pregnant. Among these pregnant patients, 48.9% (n=6,366) received a periodic dental examination; 30.0% (n=3,909) received a comprehensive dental exam; and 21.5% (n=2,799) received additional dental services, irrespective of comprehensive or periodic oral evaluations. Overall, the mean proportion of pregnant patients seeking care in these academic dental and group practice clinics was low, but 78.9% of them received either a periodic or comprehensive oral evaluation. Given the importance of oral health care during pregnancy, these findings suggest a need for curriculum development to incorporate prenatal oral health education in the training of dental students.
- Published
- 2019
45. Intertwining Neuropathogenic Impacts of Aberrant Circadian Rhythm and Impaired Neuroregenerative Plasticity in Huntington’s Disease: Neurotherapeutic Significance of Chemogenetics
- Author
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Sowbarnika Ravichandran, Ramalingam Suhasini, Sudhiksha Madheswaran Deepa, Divya Bharathi Selvaraj, Jemi Feiona Vergil Andrews, Viruthachalam Thiagarajan, and Mahesh Kandasamy
- Subjects
Huntington’s disease ,circadian rhythm ,clock genes ,adult neurogenesis ,chemogenetics ,Pathology ,RB1-214 - Abstract
Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by abnormal progressive involuntary movements, cognitive deficits, sleep disturbances, and psychiatric symptoms. The onset and progression of the clinical symptoms have been linked to impaired adult neurogenesis in the brains of subjects with HD, due to the reduced neurogenic potential of neural stem cells (NSCs). Among various pathogenic determinants, an altered clock pathway appears to induce the dysregulation of neurogenesis in neurodegenerative disorders. Notably, gamma-aminobutyric acid (GABA)-ergic neurons that express the vasoactive intestinal peptide (VIP) in the brain play a key role in the regulation of circadian rhythm and neuroplasticity. While an abnormal clock gene pathway has been associated with the inactivation of GABAergic VIP neurons, recent studies suggest the activation of this neuronal population in the brain positively contributes to neuroplasticity. Thus, the activation of GABAergic VIP neurons in the brain might help rectify the irregular circadian rhythm in HD. Chemogenetics refers to the incorporation of genetically engineered receptors or ion channels into a specific cell population followed by its activation using desired chemical ligands. The recent advancement of chemogenetic-based approaches represents a potential scientific tool to rectify the aberrant circadian clock pathways. Considering the facts, the defects in the circadian rhythm can be rectified by the activation of VIP-expressing GABAergic neurons using chemogenetics approaches. Thus, the chemogenetic-based rectification of an abnormal circadian rhythm may facilitate the neurogenic potentials of NSCs to restore the neuroregenerative plasticity in HD. Eventually, the increased neurogenesis in the brain can be expected to mitigate neuronal loss and functional deficits.
- Published
- 2022
- Full Text
- View/download PDF
46. MRBSChain a novel scalable medical records binance smart chain framework enabling a paradigm shift in medical records management
- Author
-
Suhasini Monga and Dilbag Singh
- Subjects
Medicine ,Science - Abstract
Abstract Medical records management had always been a challenging in healthcare sector. Traditionally, medical records are handled either manually or electronically that are under the stewardship of hospitals/healthcare institutions. A patient centric approach is the new paradigm where patient is an inherent part of the healthcare ecosystem controlling the access and sharing of his/her personal medical care information. Medical care information requires robust security and privacy. Also there are other issues like confidentiality, interoperability, scalability, cost efficiency and timeliness that need to be addressed. To achieve these objectives, this paper proposes a novel-scalable patient centric yet privacy preserving framework for efficient and secure electronic medical records management. In addition, proposed system generates a unified trusted record and authentication role mapping for enforcing secure access control for medical records using complex encryption algorithms. This paper identifies 13 key performance factors for performance comparison of proposed framework with traditional models. Ethereum and Binance Smart Chain acted as a benchmark platform for performance evaluation of MRBSChain on the basis of three metrics (transaction cost, average block time and deployment cost).At last, a comparative analysis of MRBSChain with other state of art blockchain systems on the basis of execution time is presented in the paper.
- Published
- 2022
- Full Text
- View/download PDF
47. Third-order nonlinear optical responses of Cr3+ ions on La2(WO4)3 nanoparticles for optical limiting applications
- Author
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Karthikeyan, D., Vijayakumar, K., Suhasini, P., Dhanusha, A., and Sabari Girisun, T.C.
- Published
- 2023
- Full Text
- View/download PDF
48. Pectin/PVA and pectin-MgO/PVA films: Preparation, characterization and biodegradation studies
- Author
-
Suhasini M R, Rajeshwari K M, Bindya S, Hemavathi A B, Prashant M. Vishwanath, Asad Syed, Rajalakshmanan Eswaramoorthy, Raghavendra G. Amachawadi, Chandan Shivamallu, Vijay Kumar Chattu, Sanjay S. Majani, and Shiva Prasad Kollur
- Subjects
Pectin-MgO/PVA ,Eco-friendly ,Citrus fruit peel ,Biodegradation ,Food packaging ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
There is a great demand to replace non-renewable materials with eco-friendly renewable materials for many applications in recent times. In the present study, such an attempt was made to substitute synthetic polymer-based films used for food packaging applications with films prepared out of renewable materials derived from waste. The pectin/polyvinyl alcohol (PP) and pectin-MgO/polyvinyl alcohol (PMP) films were prepared and characterized to ascertain their suitability for packaging applications. To improve the mechanical strength and thermal stability of films, MgO nanoparticles were incorporated in situ into the polymer matrix. The pectin used in the study was extracted from citrus fruit peel. The prepared nanocomposite films were evaluated for physico-mechanical properties, water contact angle, thermal stability, crystallinity, morphology, compositional purity and biodegradability. The elongation at break for PP film was 42.24% and for PMP film it was 39.18%. Also, the ultimate modulus in terms of MPa for PP film was 6.8 and for PMP it was 7.9. So, it was found that PMP films have better ductility and modulus than PP films due to the presence of MgO nanoparticles. The spectral studies confirmed the compositional purity of the prepared films. The biodegradation studies revealed that both films could be degraded at ambient conditions at appreciable time span, suggesting them to be a better choice as an environmentally friendly food packaging material.
- Published
- 2023
- Full Text
- View/download PDF
49. Single Stage Reconstruction of Full Thickness Defects of Cheek with Pectoralis Major Myocutaneous Flap Using an Innovative Flap Technique
- Author
-
Kumari, Baswa Mani, Jonathan, G. T., and Gazula, Suhasini
- Published
- 2022
- Full Text
- View/download PDF
50. Tobacco screening and cessation efforts by dental providers: A quality measure evaluation
- Author
-
Neumann, Ana, Kumar, Shwetha, Bangar, Suhasini, Kookal, Krishna Kumar, Spallek, Heiko, Tokede, Oluwabunmi, Simmons, Kristen, Even, Joshua, Mullins, Joanna, Mertz, Elizabeth, Yansane, Alfa, Obadan‐Udoh, Enihomo, White, Joel, Walji, Muhammad, and Kalenderian, Elsbeth
- Subjects
Health Services and Systems ,Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Behavioral and Social Science ,Tobacco Smoke and Health ,Dental/Oral and Craniofacial Disease ,Health Services ,Tobacco ,Prevention ,Substance Misuse ,Clinical Research ,8.1 Organisation and delivery of services ,Health and social care services research ,Good Health and Well Being ,Counseling ,Health Behavior ,Humans ,Mass Screening ,Tobacco Use Cessation ,oral health ,quality improvement ,dental quality measures ,tobacco use cessation ,Dentistry ,Public Health and Health Services ,Public health - Abstract
OBJECTIVES:The purpose of this study was to adapt, test, and evaluate the implementation of a primary care "Preventive care and Screening" meaningful use quality measure for tobacco use, in dental institutions. We determined the percentage of dental patients screened for tobacco use, and the percentage of tobacco users who received cessation counseling. METHODS:We implemented the dental quality measure (DQM), in three dental schools and a large dental accountable care organization. An automated electronic health record (EHR) query identified patients 18 years and older who were screened for tobacco use one or more times within 24 months, and who received cessation counseling intervention if identified as a tobacco user. We evaluated EHR query performance with a manual review of a subsample of charts. RESULTS:Across all four sites, in the reporting calendar year of 2015, a total of 143,675 patients met the inclusion criteria for the study. Within 24 months, including 2014 and 2015 calendar years, percentages of tobacco screening ranged from 79.7 to 99.9 percent, while cessation intervention percentages varied from 1 to 81 percent among sites. By employing DQM research methodology, we identified intervention gaps in clinical practice. CONCLUSIONS:We demonstrated the successful implementation of a DQM to evaluate screening rates for tobacco use and cessation intervention. There is substantial variation in the cessation intervention rates across sites, and these results are a call for action for the dental profession to employ tobacco evidence-based cessation strategies to improve oral health and general health outcomes.
- Published
- 2019
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