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139 results on '"Sui, Bing-Dong"'

5. Integrating network pharmacology and experimental validation reveals therapeutic effects of D-mannose on NAFLD through mTOR suppression

Author

Zhang, Sha, primary, Gao, Ying-Feng, additional, Zhang, Kai, additional, Deng, Guo-Rong, additional, He, Guang-Xiang, additional, Gao, Ping-Ping, additional, Yu, Yi-Kang, additional, Yuan, Yuan, additional, Xing, Shu-Juan, additional, Zhao, Na, additional, Zhang, Hong, additional, Di-Wu, Yong-Chang, additional, Liu, Yi-Han, additional, Sui, Bing-Dong, additional, Li, Zhe, additional, Ma, Jing, additional, and Zheng, Chen-Xi, additional

Published
2024
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9. Beige adipose tissue-derived extracellular vesicles: a potent metabolic regulator and a novel remedy for nonalcoholic fatty liver disease

Author

Zhang, Kai, primary, Zhang, Sha, additional, Sui, Bing-Dong, additional, Yuan, Yuan, additional, Liu, Lu, additional, Ying, Si-Qi, additional, Li, Cheng-Han, additional, Zhang, Kai-Chao, additional, Xing, Shu-Juan, additional, Yang, Zhi-Wei, additional, Sun, Yang, additional, Yu, Li-Juan, additional, Liu, Jin, additional, Jin, Yan, additional, Zheng, Chen-Xi, additional, and Kong, Liang, additional

Published
2024
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12. Harnessing mesenchymal aggregation for engineered organ‐level regeneration: Recent progress and perspective.

Author

Zheng, Chen‐Xi, Sui, Bing‐Dong, and Jin, Yan

Subjects
REGENERATION (Biology), CYTOLOGY, CELL aggregation, MESENCHYMAL stem cells, TISSUE engineering, STEM cells
Abstract

Stem cells, especially mesenchymal progenitors or mesenchymal stem cells (MSCs), possess an intrinsic property to form compact spheroid‐like assemblies, a phenomenon known as cell aggregation. In recent years, a growing body of researches have uncovered that this is a cross‐species conserved developmental event essential for initiating organogenesis in a variety of organs. Moreover, the self‐assembly property also contributes to the regenerative capacities of MSC aggregates in vivo with broad range of applications in tissue engineering. In this review, the principles of self‐assembled mesenchymal aggregation and its involvement in physiological organogenesis, as well as the construction approaches of engineering MSC aggregates and its application for organ regeneration are discussed. The authors aim to provide a speculative overview of the current understanding and the recent findings of cell aggregation, from both the developmental and the engineering perspectives, and thus offer insights into the understanding of stem cell biology and the establishment of novel organ regeneration strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Mesenchymal Stem Cell Aggregation‐Released Extracellular Vesicles Induce CD31+EMCN+ Vessels in Skin Regeneration and Improve Diabetic Wound Healing (Adv. Healthcare Mater. 20/2023)

Author

Liu, Lu, primary, Zheng, Chen‐Xi, additional, Zhao, Na, additional, Zhu, Ting, additional, Hu, Cheng‐Biao, additional, Zhang, Nan, additional, Chen, Ji, additional, Zhang, Kai‐Chao, additional, Zhang, Sha, additional, Liu, Jie‐Xi, additional, Zhang, Kai, additional, Jing, Huan, additional, Sui, Bing‐Dong, additional, Jin, Yan, additional, and Jin, Fang, additional

Published
2023
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17. Mesenchymal Stem Cell Aggregation‐Released Extracellular Vesicles Induce CD31 + EMCN + Vessels in Skin Regeneration and Improve Diabetic Wound Healing

Author

Liu, Lu, primary, Zheng, Chen‐Xi, additional, Zhao, Na, additional, Zhu, Ting, additional, Hu, Cheng‐Biao, additional, Zhang, Nan, additional, Chen, Ji, additional, Zhang, Kai‐Chao, additional, Zhang, Sha, additional, Liu, Jie‐Xi, additional, Zhang, Kai, additional, Jing, Huan, additional, Sui, Bing‐Dong, additional, Jin, Yan, additional, and Jin, Fang, additional

Published
2023
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30. Sympathetic Neurostress Drives Osteoblastic Exosomal MiR‐21 Transfer to Disrupt Bone Homeostasis and Promote Osteopenia

Author

Hu, Cheng‐Hu, primary, Sui, Bing‐Dong, additional, Liu, Jin, additional, Dang, Lei, additional, Chen, Ji, additional, Zheng, Chen‐Xi, additional, Shi, Songtao, additional, Zhao, Na, additional, Dang, Min‐Yan, additional, He, Xiao‐Ning, additional, Zhang, Li‐Qiang, additional, Gao, Ping‐Ping, additional, Chen, Nan, additional, Kuang, Hui‐Juan, additional, Chen, Kai, additional, Xu, Xiao‐Lin, additional, Yu, Xiao‐Rui, additional, Zhang, Ge, additional, and Jin, Yan, additional

Published
2021
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31. Additional file 1 of Glycemic control by umbilical cord-derived mesenchymal stem cells promotes effects of fasting-mimicking diet on type 2 diabetic mice

Author

Zhao, Na, Gao, Ying-Feng, Bao, Lei, Lei, Jing, An, Huan-Xiao, Pu, Feng-Xing, Cheng, Rui-Ping, Chen, Ji, Ni, Hua, Sui, Bing-Dong, Ji, Fan-Pu, and Hu, Cheng-Hu

Abstract

Additional file 1: Figure S1. Glucose homeostasis in control and DIO mice. (a, b): Glucose tolerance was assessed by IPGTT. AUC above baseline was calculated as an index of glucose tolerance. (c-e): ELISA analyzed the levels of HbA1c, Hb and serum insulin. (f): weight gain after 16 weeks of HFD. The data are expressed as mean values ± SD. n=6 mice per group. *P < 0.05, **P < 0.01, ***P< 0.001. Figure S2. The identification of UC-MSCs. (a): Flow Cytometry results determining the UC-MSCs phenotype. UC-MSCs were stained with FITC-labeled CD14, CD19, CD73, HLA-DR and PE-labeled, CD34, CD45, CD90, CD105. Figure S3. Histomorphological changes of liver, skin and visceral fat. (a): Liver steatosis were analyzed through staining with Oil Red O (Scale bar, 200 μm). (b): H&E staining of skin (Scale bar, 1 mm). (c): H&E staining of visceral fat (Scale bar, 100 μm). Figure S4. Histomorphological changes of liver, skin and visceral fat. (a): Liver steatosis were analyzed through staining with Oil Red O (Scale bar, 200 μm). (b): H&E staining of skin (Scale bar, 1 mm). (c): H&E staining of visceral fat (Scale bar, 100 μm). Figure S5. The effect of UC-MSCs combined with FMD on blood glucose and body weight in db/db mice. (a-c): Blood glucose and body weight were determined after fasting 6h at sacrificed. The data are expressed as mean values ± SD. n=6 mice per group. *P < 0.05, **P < 0.01, ***P< 0.001.

Published
2021
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35. Sympathetic Neurostress Drives Osteoblastic Exosomal MiR‐21 Transfer to Disrupt Bone Homeostasis and Promote Osteopenia.

Author

Hu, Cheng‐Hu, Sui, Bing‐Dong, Liu, Jin, Dang, Lei, Chen, Ji, Zheng, Chen‐Xi, Shi, Songtao, Zhao, Na, Dang, Min‐Yan, He, Xiao‐Ning, Zhang, Li‐Qiang, Gao, Ping‐Ping, Chen, Nan, Kuang, Hui‐Juan, Chen, Kai, Xu, Xiao‐Lin, Yu, Xiao‐Rui, Zhang, Ge, and Jin, Yan

Subjects
*MICRORNA, *EXOSOMES, *OSTEOPENIA, *EXTRACELLULAR vesicles, *BONE remodeling, *PSYCHOLOGICAL stress
Abstract

Innervation and extracellular vesicle secretion co‐exist in the local tissue microenvironment for message transfer, but whether they are interconnected to regulate organ homeostasis remains unknown. Sympatho‐adrenergic activation is implicated in stress‐induced depression and leads to bone loss, but the mechanisms and therapeutics are incompletely elucidated. Here, it is revealed that sympathetic neurostress through the β1/2‐adrenergic receptor (β1/2‐AR) signaling triggers the transcription response of a microRNA, miR‐21, in osteoblasts, which is transferred to osteoclast progenitors via exosomes for dictating osteoclastogenesis. After confirming that miR‐21 deficiency retards the β1/2‐AR agonist isoproterenol (ISO)‐induced osteopenia, it is shown that the pharmacological inhibition of exosome release by two clinically‐relevant drugs, dimethyl amiloride and omeprazole, suppresses osteoblastic miR‐21 transfer and ameliorates bone loss under both ISO and chronic variable stress (CVS)‐induced depression conditions. A targeted delivery approach to specifically silence osteoblastic miR‐21 is further applied, which is effective in rescuing the bone remodeling balance and ameliorating ISO‐ and CVS‐induced osteopenias. These results decipher a previously unrecognized paradigm that neural cues drive exosomal microRNA communication to regulate organ homeostasis and help to establish feasible strategies to counteract bone loss under psychological stresses. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Mechanosensing by Gli1+ cells contributes to the orthodontic force‐induced bone remodelling.

Author

Liu, An‐Qi, Zhang, Li‐Shu, Chen, Ji, Sui, Bing‐Dong, Liu, Jin, Zhai, Qi‐Ming, Li, Yan‐Jiao, Bai, Meng, Chen, Kai, Jin, Yan, Hu, Cheng‐Hu, and Jin, Fang

Subjects
BONE remodeling, CORRECTIVE orthodontics, PERIODONTAL ligament, BONE cells, TRANSGENIC mice
Abstract

Objectives: Gli1+ cells have received extensive attention in tissue homeostasis and injury mobilization. The aim of this study was to investigate whether Gli1+ cells respond to force and contribute to bone remodelling. Materials and methods: We established orthodontic tooth movement (OTM) model to assess the bone response for mechanical force. The transgenic mice were utilized to label and inhibit Gli1+ cells, respectively. Additionally, mice that conditional ablate Yes‐associated protein (Yap) in Gli1+ cells were applied in the present study. The tooth movement and bone remodelling were analysed. Results: We first found Gli1+ cells expressed in periodontal ligament (PDL). They were proliferated and differentiated into osteoblastic cells under tensile force. Next, both pharmacological and genetic Gli1 inhibition models were utilized to confirm that inhibition of Gli1+ cells led to arrest of bone remodelling. Furthermore, immunofluorescence staining identified classical mechanotransduction factor Yap expressed in Gli1+ cells and decreased after suppression of Gli1+ cells. Additionally, conditional ablation of Yap gene in Gli1+ cells inhibited the bone remodelling as well, suggesting Gli1+ cells are force‐responsive cells. Conclusions: Our findings highlighted that Gli1+ cells in PDL directly respond to orthodontic force and further mediate bone remodelling, thus providing novel functional evidence in the mechanism of bone remodelling and first uncovering the mechanical responsive property of Gli1+ cells. [ABSTRACT FROM AUTHOR]

Published
2020
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47. Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application

Author

Zhao, Pan, primary, Sui, Bing-Dong, additional, Liu, Nu, additional, Lv, Ya-Jie, additional, Zheng, Chen-Xi, additional, Lu, Yong-Bo, additional, Huang, Wen-Tao, additional, Zhou, Cui-Hong, additional, Chen, Ji, additional, Pang, Dan-Lin, additional, Fei, Dong-Dong, additional, Xuan, Kun, additional, Hu, Cheng-Hu, additional, and Jin, Yan, additional

Published
2017
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49. Mesenchymal Stem Cell Aggregation‐Released Extracellular Vesicles Induce CD31+EMCN+Vessels in Skin Regeneration and Improve Diabetic Wound Healing (Adv. Healthcare Mater. 20/2023)

Author

Liu, Lu, Zheng, Chen‐Xi, Zhao, Na, Zhu, Ting, Hu, Cheng‐Biao, Zhang, Nan, Chen, Ji, Zhang, Kai‐Chao, Zhang, Sha, Liu, Jie‐Xi, Zhang, Kai, Jing, Huan, Sui, Bing‐Dong, Jin, Yan, and Jin, Fang

Abstract

Extracellular Vesicles In article number 2300019, Bing‐Dong Sui, Yan Jin, Fang Jin, and co‐workers discover mesenchymal stem cell aggregates secrete angiogenic extracellular vesicles, which exert high efficacy in boosting CD31+EMCN+vessels with adjacent cell proliferation and provide an effective therapy to alleviate non‐healing diabetic wounds.

Published
2023
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