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Breast cancer is the leading cancer type among women globally. Since breast cancer has a high survival rate, most survivors are likely to return to work (RTW). In recent years, breast cancer cases have risen significantly in younger age groups. As self-efficacy is an important factor in the success of RTW, this study performed a translation and cross-cultural adaptation of the Chinese version of the Return-To-Work Self-Efficacy Scale (CRTWSE-19) and examined its psychometric properties in patients with breast cancer. This validation study followed standard guidelines, including forward translation, back translation, cross-cultural adaptation, and psychometric testing. The results of this study show that the CRTWSE-19 met reliability standards, including high internal reliability for the total scores and subscales. An exploratory factor analysis of 19 items extracted 3 factors showing consistency with the original version of the RTWSE-19. Criterion validity was demonstrated by comparing subdomains with the Fear of Cancer Recurrence Inventory. Furthermore, the known-group validity was studied by comparing mean scores among the unemployed group and the employed group. We conclude that the CRTWSE-19 has very good screening accuracy and is able to discriminate between working and unemployed populations. It can facilitate health care professionals in triaging, planning, and evaluating interventions in clinical practice.

Figure S1. Multidimensional scaling (MDS) analysis of broad library-wise trends. No major trends were observed related to infection type or time post-infection. Figure S2. Elbow plot used to define appropriate number of clusters for k-means clustering. Figure S3. Expression of selected genes in the RIG-I-like receptor signaling pathway analyzed by real-time PCR. Figure S4. The interaction network between inversely regulated miRNAs and mRNAs enriched in RIG-I like receptor signaling pathway at 6-h post-infection in H5N1 virus-infected cells. (DOCX 3058 kb)

Table S1. Sequencing statistics of mRNA transcriptomes. Table S2. Significantly enriched Gene Ontology terms in response to H5N1 virus infection. Table S3. Sequencing statistics of miRNA transcriptomes. Table S4. MiRNAs and their target mRNAs in RIG-I like receptor signaling pathway. (DOCX 41 kb)

Table S1. Sequencing statistics of mRNA transcriptomes. Table S2. Significantly enriched Gene Ontology terms in response to H5N1 virus infection. Table S3. Sequencing statistics of miRNA transcriptomes. Table S4. MiRNAs and their target mRNAs in RIG-I like receptor signaling pathway. (DOCX 41 kb)