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Abstract Riccia sorocarpa Bisch., commonly known as common crystalwort, is a plant belonging to the Marchantiales order with a cosmopolitan distribution among a wide range of habitats: fields, gardens, waste ground, on paths, cliff tops, and thin soil over rocks or by water bodies. However, research into the genetic aspects of this species is limited. In this study, the chromosome-scale telomere-to-telomere genome of R. sorocarpa was assembled exclusively by Oxford Nanopore long-read sequencing and Pore-C technology. A high-quality chromosomal-scale assembly was obtained with a final genome size of 376.690 Mbp, contig N50 of 49.132 Mbp and 97.02% of the assembled contigs associated with the eight chromosomes. Genome assembly completeness was confirmed by BUSCO analysis accounting 91.8%. Among 27,626 total genes, 23,562 (85.29%) were functionally annotated. Moreover, collinearity of Marchantiales was analyzed as well as gene family evolution and DNA methylation profile. The availability of this genome, which is the second telomere-to-telomere liverwort assembly, opens up new avenues for in-depth analysis of R. sorocarpa genetic diversity and genomic characteristics.

This paper investigates Neutrosophic Linear Programming (NLP) and focuses on one of the most suitable approaches to solve it, which is called the Simplex-based model. This type of method, inspired by the classic Simplex algorithm, is in search of an optimal basic neutrosophic feasible solution, and several attractive models of it have been proposed in recent years. However, due to neutrosophic logic considers three dimensions of a problem, using a direct generalization of the simplex algorithm (which has been done in existing methods), the computational volume is greatly increased even for the small problems, and as a result, the use of these models in real-world issues will be questioned. To solve this gap, we consider NLP and propose an effective, simple model that can significantly reduce computational tasks and address these deficits in the mentioned models. Some numerical experiments with the comparison results are provided to explain the efficiency and superiority of the proposed approach.

Infertility is a condition of the reproductive system, which is expressed in the absence of clinical pregnancy after 12 months of regular sexual activity without contraception. Despite the achievements of reproductive medicine, the problem of infertile marriage is far from being resolved. Restoring fertility in married couples requires rapid development of medical technologies in the field of reproductive medicine. Currently, cystectomies and myomectomies of various localizations are performed endoscopically. The undoubted advantages of laparoscopic operations are a decrease in the severity of pain syndrome, shortening the period of hospital stay after surgical treatment, and early activation of patients, as well as improvement the quality of care and increase the likelihood of spontaneous pregnancy. Aim of the study was to evaluate the effectiveness of endovideosurgical treatment of patients with various forms of infertility in a gynecological hospital. Material and methods. A statistical review of the medical documentation of the gynecological department of the Simferopol City Clinical Maternity Hospital No. 1 for 2020 was performed, data from 105 women of reproductive age (from 22 to 43 years) who underwent surgical treatment for infertility were analyzed. The patients were divided into six groups according to nosological units. The results and discussion. 47 women (44.76 %) became pregnant. In group 1 (N97.0, n = 20), 11 (55 %) became pregnant, in group 2 (n = 41), 18 (43.9 %) became pregnant. In group 3 (N97.2, n = 2), pregnancy did not occur (0 %). In group 4 (N97.3, n = 1), pregnancy did not occur after surgical treatment (0 %). In group 5 (N97.8, n = 8), two patients became pregnant (25 %). In group 6 (N97.8, n = 33), 16 (48.5 %) became pregnant. Conclusions. A positive relationship between surgical treatment of patients with various causes of infertility and the frequency of pregnancy in the natural cycle was revealed, which indicates the need for endoscopic diagnostic and therapeutic procedures to restore fertility.

Chronic kidney disease (CKD) emerges as a global health problem with high morbidity and mortality rates, and it induces other diseases. Patients often fail to notice these diseases because there are no obvious symptoms during the earlier stage of CKD. Earlier diagnosis of CKD allows them to receive early medical intervention to improve the disease progression and outcome. Earlier stratification of CKD can affect the health care provided to patients through various options, such as kidney transportation, hemodialysis, or pharmacological care in milder cases. Recently, deep learning (DL) and machine learning (ML) approaches have gained significance in the domain of medical diagnoses due to their high prediction accuracy. DL and ML approaches can successfully aid physicians in achieving these goals due to their accurate and fast detection performance. The performance of the proposed technique mainly depends on selecting the suitable algorithms and appropriate features. Thus, the study introduces an Eurygasters Optimization Algorithm with an Ensemble DL CKD detection (EOAEDL-CKDD) method. The EOAEDL-CKDD method aims to detect and classify the presence of CKD using feature selection and hyperparameter tuning strategies. The EOAEDL-CKDD method applies a min-max scalar to convert the data into a uniform format to achieve this. The EOAEDL-CKDD technique exploits EOA to select features. This is followed by an ensemble of long short-term memory (LSTM), bidirectional gated recurrent unit (BiGRU), and bidirectional LSTM (BiLSTM) models that are used for the CKD detection process. Finally, a shuffled frog leap algorithm (SFLA) based hyperparameter selection process is carried out to choose the ensemble models' hyperparameter values optimally. The empirical assessment of the EOAEDL-CKDD method is tested on the benchmark CKD dataset. The experimental values highlighted that the EOAEDL-CKDD technique gains an optimal detection rate compared to existing models.

Often premature birth is accompanied by preterm premature rupture of membranes (PPROM). PPROM is a complication of the course of pregnancy in 2–3 % cases and is the most common in premature birth. As a rule, the protocols for the management of such patients vary greatly and are mainly individual. In practical obstetrics, there is an urgent need to decide whether the risk of complications resulting from previous PPROM exceeds the risk of intrauterine infection. Of course, the need for further research in this area is necessary, which will help to choose the tactics of the maximum allowable period that would be optimal for reducing perinatal morbidity and mortality, as well as to identify factors that improve the prognosis for the mother and fetus. The review analyzes and summarizes the results of studies on PRPO in premature pregnancy complicated by chorioamnionitis. The advantages and disadvantages of various approaches in the management of such patients are considered. The modern medical literature presented in eLibrary and CyberLeninka electronic libraries, PubMed database of medical and biological publications has been studied.

The lithologic-facial, mineralogical, petrographic, and lithogeochemical studies of Visean terrigenous sediments in the borehole section at the Bashkirian arch were carried out to clarify the sources of matter and sedimentation conditions. Terrigenous rocks of the Radayevsky and Bobrikovsky horizons are characterized by predominantly good sorting and pelletization of clastic material. A significant distance from the source of drifting is assumed. Terrigenous rocks of these horizons are sediments of the first and second sedimentation cycles. The rocks of the Tula horizon are characterized by average sorting and pelletization, which indicates the proximity of the drift source to the sedimentation basin. They are rocks of the first sedimentation cycle. The source of clastic material for the Radayevsky and Tula horizons was found to be rocks of acidic composition. For the beaver horizon, the acidic and the main source of drift was established. It is assumed that sedimentation of rocks occurred in coastal-marine conditions on the passive continental margin, with the inflow of clastic material from the inner parts of the East European Platform, due to overwashing of the early accumulated terrigenous rocks of the Devonian and Proterozoic, as well as destruction of the basement ledges, which were activated in the Early Visean time during the manifestation of folding. The presence of basic rocks in the Bobrikovsky horizon may indicate that the material came from the orogen.

Pregnancy in the uterus rudimentary horn (PURH) is a rare form of ectopic pregnancy that develops in women suffering from abnormalities in the development of growth and fusion of the Mullerian paramesonephral ducts. A literature search was conducted in the Web of Science, eLIBRARY.ru, Scopus, PubMed/MEDLINE databases using key words “ectopic pregnancy”, “anomaly”, “complication”, “rudimentary uterine horn”, “diagnosis”, “management”. We selected articles published from 2014 to 2022. A methodological filter was not used to exclude the omission of suitable articles. The study included full-text papers and literary reviews on the subject under study, articles that are not directly related to the topic of PURH were excluded. In order to avoid the inclusion of duplicate publications in the literature review, if two papers by the same authors were found, the study period of each author was studied, and if the dates coincided, the most recent publication was selected. Usually, the PURH is overlooked and can lead to such a formidable complication as hemoperitoneum. Diagnosis and treatment of PURH remains a difficult task. Many women with rudimentary uterine horn have an acute rupture of the uterus during pregnancy. Early diagnosis is the key to successful treatment. Clinicians of various specialties should maintain a high degree of vigilance to prevent morbidity associated with this life-threatening condition.

In pea (Pisum sativum L.), alleles of the Sym2 gene determine the specificity of the interaction with nodule bacteria (rhizobia). The Sym2A allele present in landraces from Afghanistan provides higher selectiveness toward rhizobia than the Sym2E allele present in European cultivars. Rhizobial strains possessing the nodX gene can interact with both Sym2A and Sym2E peas, while strains lacking nodX can interact only with Sym2E peas. Here, we studied the previously obtained introgression line A33.18 bearing Sym2A in a homozygous state in the genome of the European pea cultivar ‘Rondo’. A33.18 has proved its high selectiveness in pot experiments. Genome sequencing has shown that A33.18 possesses an 18.2 Mb region inherited from Afghanistan pea with 63 genes, including 5 receptor kinase genes, among which was the Sym2 candidate gene LykX. In a field experiment, under inoculation with the nodX+ strain TOM, over 95% of nodules of A33.18 contained TOM, as opposed to less than 8% of nodules containing TOM in the parental European cultivar ‘Rondo’. Thus, introgression of Sym2A enabled peas to interact specifically with the nodX+ strain, favoring the formation of nodules by the strain from the inoculum and protecting peas from the indigenous soil microbiota.

One of the priority goals of sustainable socio-economic development for the period up to 2030 is providing food for the planet’s population. This entails an increase in the output of mineral fertilizers and, consequently, an increase in the quantities of solid industrial waste. Phosphogypsum, a by-product of phosphate fertilizer production from apatite ore, is one example of such waste. The problem of solid industrial waste recycling is urgent. The present study examines the process of converting calcium sulfate, in the form of a reagent, and phosphogypsum into a composite material of calcium sulfate/sulfide. An environmentally friendly material, sucrose, is used as a reducing agent. Reduced phosphogypsum (as well as calcium sulfate) luminescence is suggested to be associated with the formation of a CaS/CaSO4 composite material. The synthesized materials are characterized by X-ray phase analysis, X-ray photoelectron spectroscopy, elemental analysis, and calcium sulfide qualitative and quantitative content in the samples. It is shown that in the reduction process at the phase contact point, crystal grids are formed with a significant number of defects, which contributes to the convergence of some of the energy levels of the calcium cation and sulfide anion, facilitating the transitions of electrons from the valence zone to the core zone and the formation of luminescence centers (cross-luminescence). Both samples of reduced phosphogypsum and alkaline earth metal sulfates are found to exhibit luminescence properties under ultraviolet radiation. The data obtained open up broad prospects for the use of solid industrial waste for the synthesis of new materials.

Relevance. Relationship with the Takata formation of diamond reservoir rocks and previously discovered deposits and the presence of prospects for discovering new ones in the zone of the forward folds of the Urals. Aim. To reconstruct the conditions of sedimentation and composition of rocks, the source of the removal of terrigenous rocks of the Takata formation based on the results of studying the "Yuzhnaya Rassolnaya" section. Objects. Terrigenous rocks of the Takata formation in the "Yuzhnaya Rassolnaya" section located in the western part of the alluvial diamond deposit "Yuzhnaya Rassolnaya" in the Krasnovishersky district of the Perm Territory. Methods. Lithofacies analysis, petrographic study of thin sections in transmitted light using crossed nicol methods, determination of the content of rock-forming oxides by X-ray fluorescence on an S8 Tiger (Bruker) spectrometer, analysis of rock-forming elements on glassy disks. Impurity and microimpurity elements (with a content of

The article presents the results of metallographic and tribological tests on GX120MnCr13 cast steel that was previously subjected to heat treatment (including solution treatment from 1100°C and isothermal holding at 250, 400, and 600°C for 100 hours). The temperatures of the isothermal holding process were selected in order to reflect the possible working conditions of the cast elements that can be made of this cast steel. Wear tests were carried out under dry friction conditions using the ball-on-disc method using a ZrO2 ball as a counter-sample. The tests were carried out with a load of 5 N. The influence of the long-term isothermal holding process on the microstructure of the tested cast steel was analysed by light and scanning microscopy; however, abrasion marks were also examined using a confocal microscope. Based on the tests conducted, it was found that in the microstructures of the sample after solution treatment and samples that were held in isothermal condition at 250 and 400°C, the grain boundary areas were enriched in Mn and Cr compared to the areas inside the grains. Pearlite appeared in the sample that was heated (or held in isothermal holding) at 600°C; its share reached 41.6%. The presence of pearlite in the austenitic matrix increased the hardness to 351.4 HV 10. The hardness of the remaining tested samples was within a range of 221.8–229.1 HV 10. Increasing the hardness of the tested cast steel directly resulted in a reduction in the degree of wear as well as the volume, area, and width of the abrasion marks. A microscopic analysis of the wear marks showed that the dominant process of the abrasive wear of the tested friction pair was the detachment and displacement of the tested material through the indentation as a result of the cyclical impact of the counter-sample.

Malaria is a major international public health problem. The risk of acquiring malaria varies depending on the intensity of transmission and adherence to mosquito precautions and prophylaxis recommendations. Severe malaria can cause significant multiorgan dysfunction, including acute kidney injury (AKI). Intravenous artesunate is the treatment of choice for severe malaria in non-endemic areas. One of the possible events connected with the lifesaving effects of artemisins is post-artesunate haemolysis (PADH), which may be potentially dangerous and under-recognised. We present a case of a seafarer with severe Plasmodium falciparum malaria complicated with AKI and PADH, with a good response to steroid treatment. This case highlights the need for malaria prophylaxis in business travellers, e.g., seafarers to malara-endemic regions, and close supervision of patients with malaria even after the completion of antimalarial treatment due to the possibility of late complications.

The indicators of recent years demonstrate stability and high results in milk production at agricultural enterprises. The relevance is confirmed by the fact that milk production and its optimization are key aspects of the economic development of the agricultural sector of Ukraine in the post-war period, because dairy farming is a system-forming branch of agriculture that opens up new opportunities for the formation of promising business development vectors. The purpose of the article is to analyse the problems and prospects of economic aspects of the efficiency of resource use and optimization of milk production in agricultural enterprises of Ukraine in the post-war period. The research used the following methods: induction and deduction, synthesis, theoretical generalization, statistical analysis, comparative analysis, modelling. The links of inconsistency between resources, production of dairy products and the capabilities of enterprises, state policy, the level, and norms of consumption of milk and dairy products by the population in the post-war period are studied. Accordingly, the dynamics of production, export, sales, stages of production, peculiarities of cooperation and import of basic dairy products were considered. A direct connection between the production and consumption of milk, the dependence of the demand and consumption of milk and dairy products on the level of total income of households has been established. Based on this, the work presents a full description of the dairy industry in Ukraine, the volume of milk production in the pre-war period and prospects for development in the post-war period. A systematic study of the market properties of various types of dairy products of Ukraine using SWOT and PEST analysis is given in general. In order to improve the state of the market of milk and dairy products of Ukraine, appropriate proposals have been formulated. The practical value of the work lies in the fact that its results can be used as a basis for the development of technologies for the use of milk production resources in the post-war period, as well as in the work of specialists in the agro-industrial and economic sectors

This study introduces an approach for Multiple Attribute Decision-Making (MADM) that deals with the complexity of Single-Valued Neutrosophic Uncertain Linguistic Variables (SVNULVs). This method is engineered to grasp the interconnectedness of multiple inputs and to meet the diverse requirements for semantic transformations. Due to the shortcomings of existing operational rules in terms of closeness and flexibility, this paper proposes a novel set of operational rules and a ranking process for SVNULVs, integrating the concept of a Linguistic Scale Function (LSF). We propose an innovative operator along with its weighted counterpart to amalgamate SVNULVs, thereby characterizing the dynamics among various inputs through these new operations. Concurrently, we scrutinize and discuss the unique cases and favorable properties of these proposed operators. Building upon this new operator, the paper also unveils a fresh MADM methodology leveraging SVNULVs. To validate the effectiveness of this proposed methodology, an illustrative example is employed, demonstrating the precision of the method and its advantages over existing MADM techniques.

Membrane-bound organelles, such as mitochondria and chloroplasts, have played a crucial role in the evolution of plant cells. In this study, we investigate the presence of heteroplasmy and genomic variation in liverworts, a group of non-vascular plants, using nanopore sequencing technology. We selected four liverwort species representing different lineages: Riccia fluitans , Apopellia endiviifolia , Aneura pinguis , and Scapania undulata . Through nanopore sequencing, we sequenced, assembled, and annotated the organellar genomes of selected liverwort species. The plastid genomes of Riccia fluitans , Apopellia endiviifolia , Aneura pinguis , and Scapania undulata exhibited high conservation with previously published genomes, while the mitogenome of Scapania undulata represents the first report for this species. The analysis of the liverwort organellar genomes revealed conserved gene content, structure, and order. We further investigated heteroplasmy within the liverwort species. The plastome analysis did not detect structural heteroplasmy, which is observed in some angiosperms but seems limited to seed plants. However, in the mitogenomes, we found evidence of heteroplasmy in Aneura pinguis , Apopellia endiviifolia , and Scapania undulata . The heteroplasmic sites in the mitogenomes were mainly represented by substitutions, indels, and short tandem repeat polymorphisms. Some of the identified substitutions resembled RNA editing patterns observed in liverworts. This study highlights the utility of nanopore sequencing for studying organellar genomes and detecting heteroplasmy in liverworts. The findings expand our understanding of organellar genomic variation in non-vascular plants and provide insights into the mechanisms underlying heteroplasmy in liverwort mitogenomes. Further research is needed to explore the functional significance of heteroplasmy and its implications for liverwort evolution and adaptation.

Introduction. Uterine artery embolization (UAE) is an effective minimally invasive manipulation that has been widely applied in obstetric and gynecological practice. The expediency of using this method of surgical treatment in patients with reproductive plans is still controversial. The main clinicians' concerns are the risk of developing local endometrial ischemia able to lead to habitual miscarriage, premature birth and pathological placentation as well as decreased ovarian reserve due to impaired adequate ovarian blood supply.Aim: to analyze the literature data regarding UAE effect on reproductive function.Materials and Methods. The search for literature was carried out in databases Web of Science, eLibrary, Scopus, PubMed/MEDLINE. We selected articles for the years 1995–2023 devoted to assessing UAE influence on reproductive function. The articles were searched by the keywords "embolization", "uterine arteries", "reproductive function", "prognosis", "assessment". No methodological filter was used to exclude the omission of suitable articles. The study included full-text sources and literary reviews on the subject under study. Articles that are not directly related to the subject UAE were excluded from the review. In order to avoid the inclusion of duplicate publications if two same author studies were found, the study period of each author was assessed, and if publication dates coincided, the most recent publication was selected.Results. Based on the review of domestic and foreign literature sources over recent years, it can be concluded that there are restrictions on the frequency and outcomes of pregnancy in such cohort of patients who underwent UAE. Many patients included in existing studies and case reports have variable factors complicating direct analysis or comparison such as age of patients, previous spontaneous abortions, previous uterine surgery, different techniques and professional training of X-ray endovascular surgeons, uncertainty of a woman regarding further reproductive plans and other forms of infertility, which can also distort research results. In addition, the most well-controlled studies often have small patients sample sizes not allowing to obtain meaningful clinical information from thereof.Conclusion. Pregnancy is possible in women after UAE, and many of these pregnancies proceed without complications and lead to successful childbirth. The actual fertility rate after UAE remains uncertain, but is approaching 38.3 % based on the available published results.

A rare clinical case of successful treatment of an interrupted ovarian pregnancy (ОР), the incidence of which is 0.4– 1.3 % of all ectopic pregnancies (ЕР), is described. The exact etiopathogenetic mechanism of OP development is still unknown. The rupture of OP mainly occurs in the first trimester of pregnancy 91.0 %, in the second trimester it is 5.3 %, and in the third it’s 3.7 %. Untimely diagnosis of EP in the ovaries can be fatal with massive bleeding and is associated with the risk of ovariectomy with a subsequent decrease in fertility in patients of reproductive age. It is very difficult to diagnose OP. Differential diagnosis should be carried out with interrupted tubal pregnancy, rupture of the ovarian cyst, as well as with torsion of the ovarian cyst. The article presents the results of a pathomorphological study confirming the diagnosis and adequacy of the performed therapeutic measures. The algorithm of OP diagnosis, justification and decision- making on the method of patient’s management and treatment are shown. The presented clinical case will allow physicians of various specialties to know about this EP rare form, to suspect and successfully diagnose OP in the early stages of gestation, which will avoid severe, and sometimes life-threatening, complications or reduce their development.

Currently, one of the most important problems of environmental protection is the deep and complex processing of mineral raw materials. This problem is especially relevant when processing substandard ores and production waste, one of which is phosphogypsum. This study examines the process of CaSO4/CaS composite material formation during the reduction of phosphogypsum with citric acid. The composite structure formation mechanism is proposed. The resulting materials are characterized using various methods, including X-ray diffraction (XRD), transmission electron microscopy, the Scherrer method, thermogravimetric analysis (TGA), and FT-IR spectroscopy. The reduced sample emits orange radiation in the range of 500–750 nm with a quantum yield of 0.17. Experimental results showed that the sample decomposition process in the solid state consisted of two components with a predominant contribution from the long-lived component (~46 ns). The optimal conditions for producing luminescent materials by reducing phosphogypsum with citric acid were determined: a heat treatment temperature of 1073 K, a holding time of 60 min, and a reducing agent mole fraction of 37%. It was found that an increase in temperature with a simultaneous decrease in heat treatment time, as well as a decrease in temperature with a simultaneous increase in heat treatment time, led to a decrease in the luminescent properties of the synthesized material compared to optimal values. The results can be used to develop technology for recycling large-tonnage waste from the chemical industry into luminescent materials.

This study aimed to investigate the physical, mechanical, corrosion, and tribological properties of Cu-based composites with varying zirconium diboride content. The composites were successfully consolidated using spark plasma sintering (SPS) at temperatures of 850 °C and 950 °C and a pressure of 35 MPa. The effect of the ZrB2 content and the sintering temperature on the properties of the Cu-based composites was investigated. Scanning electron microscopy (SEM), electron backscatter diffraction (EBSD), and X-ray diffraction were used to analyse microstructure evolution in copper matrix composites. Microhardness tests were used to evaluate mechanical properties. Wear behaviour was evaluated using a ball-on-disc method. Corrosion properties were estimated on electrochemical tests, such as potentiodynamic polarisation. The results demonstrated an enhancement in the density and porosity of the composites as the sintering temperature increased. A uniform dispersion of ZrB2 was observed in the copper matrix for all composites. With an increase in the content of the ZrB2 reinforcement phase, there was an increase in microhardness and an improvement in the wear resistance of the sintered composites. A reduction in densification and corrosion resistance of Cu-based composites was observed with increasing ZrB2 content.

IntroductionDNA methylation plays major roles in the epigenetic regulation of gene expression, transposon and transcriptional silencing, and DNA repair, with implications in developmental processes and phenotypic plasticity. Relevantly for woody species, DNA methylation constitutes a regulative layer in cell wall dynamics associated with xylogenesis. The use of methyltransferase and/or demethylase inhibitors has been proven informative to shed light on the methylome dynamics behind the regulation of these processes.MethodsThe present work employs the cytidine analog zebularine to inhibit DNA methyltransferases and induce DNA hypomethylation in Salix purpurea plantlets grown in vitro and in soil. An integrative approach was adopted to highlight the effects of zebularine on proteomic dynamics, revealing age-specific (3 weeks of in vitro culture and 1 month of growth in soil) and tissue-specific (stem and root) effects.Results and discussionAfter 3 weeks of recovery from zebularine treatment, a decrease of 5-mC levels was observed in different genomic contexts in the roots of explants that were exposed to zebularine, whereas a functionally heterogeneous subset of protein entries was differentially accumulated in stem samples, including entries related to cell wall biosynthesis, tissue morphogenesis, and hormonal regulation. Significant proteomic remodeling was revealed in the development from in vitro to in-soil culture, but no significant changes in 5-mC levels were observed. The identification of tissue-specific proteomic hallmarks in combination with hypomethylating agents provides new insights into the role of DNA methylation and proteome in early plant development in willow species. Proteomic data are available via ProteomeXchange with identifier PXD045653. WGBS data are available under BioProject accession PRJNA889596.

Vaginal delivery after a Caesarean section remains a controversial topic: there is a lack of reliable data to help doctors and women in labour to determine the best option for delivery during subsequent pregnancy. The review analyzed and summarized the results of the studies devoted to childbirth of pregnant women with scars on the uterus, considered the advantages and disadvantages of vaginal childbirth and repeat Caesarean section, the frequency of complications in the attempt of vaginal childbirth in women with scars on the uterus has been assessed. The modern medical literature available in open sources has been studied: Russian-language scientifc electronic libraries eLibrary and CyberLeninka, Englishlanguage database of medical and biological publications PubMed. It is necessary to consider the data of anamnesis and clinical-instrumental data when choosing the best management tactics of pregnancy and delivery for women with scars on the uterus. Attempting to deliver vaginally helps to reduce maternal and neonatal morbidity, and a large number of studies on this issue should help to reduce the number of unwarranted repeat Caesarean sections. Vaginal delivery after a Caesarean section is an opportunity to avoid severe abdominal surgery and negative consequences associated with repeated Caesarean sections.

Future communication systems and networks, namely smart networks, are becoming the foundation of the human-centric Internet. They provide an energy-efficient and high-performance infrastructure where NGI (Next Generation Internet) and other digital services can be developed and deployed. The development of new services provided to the end user led to the technology of providing a network as a service NaaS (Network as a Service) implementation, which should be an intelligent, decentralized and highly automated network. The architecture of the intelligent network is already software-defined and provides functions that highly exceed the connectivity capabilities: multi-service and mobile edge computing will allow data to be stored and processed locally at the edges of the network to guarantee quick response and efficient use of network resources. But assignment the required amount of computing resources and determining their location remains an incompletely resolved issue. This paper proposes a method of dynamic reconfiguration of computing resources to support NaaS technology. The method allows you to manage the placement and determination of the required amount of network functions resources to optimize the amount of computing resources allocated to the network function in the telecom operator infrastructure, and also binds the performance of the network virtualized function with the amount of resources assigned to it, takes into account the hybridity of the communications environment.

Background. Conducting clinical studies to determine the factors determining the aseptic instability of knee joint endoprosthesis components is an urgent issue in modern orthopedics. The aim of the study was to determine some clinical factors of aseptic instability of knee joint endoprosthesis components. Materials and methods. Comprehensive research was conducted on 285 patients who underwent primary knee arthroplasty between 2010 and 2021, including 85 patients with clinical and radiological signs of aseptic instability of knee arthroplasty components (AIKAC). Also, 200 patients made up a control group with no signs of AIKAC instability observed. Clinical research methods included general, and special orthopedic methods of studying local changes in the knee joint. They included measurement of body mass index (BMI), overloading of the knee joint due to work, previous surgical interventions and early postoperative complications of primary arthroplasty, and presence of angular deformities in the knee joint. For the clinical assessment of the knee joint of patients after knee arthroplasty, we used our own point assessment of the state of the knee joint. Results. It was determined that significant factors for the development of instability of components of the knee joint endoprosthesis are both directly related to the patient (increase in BMI, difficult working conditions, the presence of operative interventions on the knee joint), and factors related to errors du­ring the primary total arthroplasty (residual deformities of the knee joint and early postoperative complications). Conclusions. We determined important factors of aseptic instability of the knee joint in the patients after arthroplasty. Taking into account the results of this study will improve the diagnosis and treatment of aseptic instability of the knee joint.

Recent years have been marked by a significant increase in interest in solving nonlinear equations that arise in various fields of natural science. This trend is associated with the creation of a new method of mathematical physics. The present study is devoted to the analysis of the propagation of m-nonlinear viscoelastic waves equations in an unbounded domain. The physical properties are determined by the equations of the linear theory of viscoelasticity. This article shows the main effect and interaction between the different weak and strong damping terms on the behavior of solutions. We found, under a novel condition on the kernel functions, an energy decay rate by using an appropriate energy estimates.

The synthesis of stereochemically pure oximes, amines, saturated and unsaturated cyanomethyl compounds, and methylaminomethyl compounds at the C9 position in 3-hydroxy-N-phenethyl-5-phenylmorphans provided μ-opioid receptor (MOR) agonists with varied efficacy and potency. One of the most interesting compounds, (2-((1S,5R,9R)-5-(3-hydroxyphenyl)-2-phenethyl-2-azabicyclo[3.3.1]nonan-9-yl)acetonitrile), was found to be a potent partial MOR agonist (EC50 = 2.5 nM, %Emax = 89.6%), as determined in the forskolin-induced cAMP accumulation assay. Others ranged in potency and efficacy at the MOR, from nanomolar potency with a C9 cyanomethyl compound (EC50 = 0.85 nM) to its totally inactive diastereomer, and three compounds exhibited weak MOR antagonist activity (the primary amine 3, the secondary amine 8, and the cyanomethyl compound 41). Many of the compounds were fully efficacious; their efficacy and potency were affected by both the stereochemistry of the molecule and the specific C9 substituent. Most of the MOR agonists were selective in their receptor interactions, and only a few had δ-opioid receptor (DOR) or κ-opioid receptor (KOR) agonist activity. Only one compound, a C9-methylaminomethyl-substituted phenylmorphan, was moderately potent and fully efficacious as a KOR agonist (KOR EC50 = 18 nM (% Emax = 103%)).

Recent data suggest that 3,4-methylenedioxypyrovalerone (MDPV) has neurotoxic effects; however, the cognitive and neurochemical consequences of MDPV self-administration remain largely unexplored. Furthermore, despite the fact that drug preparations that contain MDPV often also contain caffeine, little is known regarding the toxic effects produced by the co-use of these two stimulants. The current study investigated the degree to which self-administered MDPV or a mixture of MDPV+caffeine can produce deficits in recognition memory and alter neurochemistry relative to prototypical stimulants. Male Sprague Dawley rats were provided 90 min or 12 h access to MDPV, MDPV+caffeine, methamphetamine, cocaine, or saline for 6 weeks. Novel object recognition (NOR) memory was evaluated prior to any drug self-administration history and 3 weeks after the final self-administration session. Rats that had 12 h access to methamphetamine and those that had 90 min or 12 h access to MDPV+caffeine exhibited significant deficits in NOR, whereas no significant deficits were observed in rats that self-administered cocaine or MDPV. Striatal monoamine levels were not systematically affected. These data demonstrate synergism between MDPV and caffeine with regard to producing recognition memory deficits, highlighting the importance of recapitulating the manner in which drugs are used (e.g., in mixtures containing multiple stimulants, binge-like patterns of intake).

The article presents the results of endovascular diagnosis and treatment of 76 women suffering from migraine cefalgia, which as a result of the survey also identified signs of a congenital disease. The failure of the ovarian vein valve apparatus and reversed blood flow on them with the formation of pelvic full-volume was detected in 100 % of cases. The results of the endovascular correction of pelvic venous blood flow make it possible to approve about the connection of the congenital syndrome with migraine cefalgia with a high propriety.

Introduction. Aortic dissection (AD) is a rare and extremely dangerous pathology in obstetrics and gynecology. AD frequency in pregnant women comprises only 14.5 cases per 1 million subjects and leads to maternal death in 30 % cases. AD is characterized by the difficulty in performing differential diagnostics.Aim: to describe a clinical case demonstrating the difficulties in timely AD diagnostics and treatment during delivery.Materials and Methods. A rare clinical case of asymptomatic AD resulting in death of the woman in labor is presented after assessing the patient medical history, the conclusion of the pathoanatomical examination and the protocol of the mortality review.Results. The presented AD clinical case in labor with subtle clinical symptoms demonstrate the extreme difficulty of timely diagnostics of this pathology for practitioners, which inevitably resulted in maternal mortality.Conclusion. AD during pregnancy and labor is the condition with extremely rare and difficult diagnostics, high probability of maternal and perinatal mortality, which should be known and remembered by obstetrician-gynecologists.

One of the priority goals of sustainable socio-economic development for the period up to 2030 is providing food for the planet's population. This entails an increase in the output of mineral fertilizers and, consequently, an increase in the quantities of solid industrial waste. Phosphogypsum, a by-product of phosphate fertilizer production from apatite ore, is one example of such waste. The problem of solid industrial waste recycling is urgent. The present study examines the process of converting calcium sulfate, in the form of a reagent, and phosphogypsum into a composite material of calcium sulfate/sulfide. An environmentally friendly material, sucrose, is used as a reducing agent. Reduced phosphogypsum (as well as calcium sulfate) luminescence is suggested to be associated with the formation of a CaS/CaSO4 composite material. The synthesized materials are characterized by X-ray phase analysis, X-ray photoelectron spectroscopy, elemental analysis, and calcium sulfide qualitative and quantitative content in the samples. It is shown that in the reduction process at the phase contact point, crystal grids are formed with a significant number of defects, which contributes to the convergence of some of the energy levels of the calcium cation and sulfide anion, facilitating the transitions of electrons from the valence zone to the core zone and the formation of luminescence centers (cross-luminescence). Both samples of reduced phosphogypsum and alkaline earth metal sulfates are found to exhibit luminescence properties under ultraviolet radiation. The data obtained open up broad prospects for the use of solid industrial waste for the synthesis of new materials. [ABSTRACT FROM AUTHOR]

Abstract Low‐efficacy mu‐opioid receptor (MOR) agonists represent promising therapeutics, but existing compounds (e.g., buprenorphine, nalbuphine) span a limited range of low MOR efficacies and have poor MOR selectivity. Accordingly, new and selective low‐efficacy MOR agonists are of interest. A novel set of chiral C9‐substituted phenylmorphans has been reported to display improved MOR selectivity and a range of high‐to‐low MOR efficacies under other conditions; however, a full opioid receptor binding profile for these drugs has not been described. Additionally, studies in mice will be useful for preclinical characterization of these novel compounds, but the pharmacology of these drugs in mice has also not been examined. Accordingly, the present study characterized the binding selectivity and in vitro efficacy of these compounds using assays of opioid receptor binding and ligand‐stimulated [35S]GTPɣS binding. Additionally, locomotor effects were evaluated as a first step for in vivo behavioral assessment in mice. The high‐efficacy MOR agonist and clinically effective antidepressant tianeptine was included as a comparator. In binding studies, all phenylmorphans showed improved MOR selectivity relative to existing lower‐efficacy MOR agonists. In the ligand‐stimulated [35S]GTPɣS binding assay, seven phenylmorphans had graded levels of sub‐buprenorphine MOR efficacy. In locomotor studies, the compounds again showed graded efficacy with a rapid onset and ≥1 h duration of effects, evidence for MOR mediation, and minor sex differences. Tianeptine functioned as a high‐efficacy MOR agonist. Overall, these in vitro and in vivo studies support the characterization of these compounds as MOR‐selective ligands with graded MOR efficacy and utility for further behavioral studies in mice.

This article traces the history of US and Soviet reconnaissance satellites during the Cold War. It fills the gap in historiography of the Space Race that has inadequately studied military space programs and focused largely on civilian spaceflight, with the Apollo Moon landings being a prime example. It argues that the military satellites employed by both the US and Soviets offered unprecedented amounts of information on the other side and eliminated the issue of lacking intelligence that characterized the early Cold War. This in turn allowed for a more peaceful coexistence between these two ideologically opposed superpowers. Spy satellites allowed for a better assessment of the other side’s military strength, created a system of early warning for nuclear attacks, and offered a non-invasive way of verifying arms control treaties. These reconnaissance satellites and their successors play this important role up to this day.