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Background and objectives: As microbes are developing resistance to antibiotics, natural, botanical drugs or traditional herbal medicine are presently being studied with an eye of great curiosity and hope. Hence, complementary and alternative treatments for uncomplicated pelvic inflammatory disease (uPID) are explored for their efficacy. Therefore, this study determined the therapeutic efficacy and safety of Sesamum indicum Linn seeds with Rosa damascena Mill Oil in uPID with standard control. Additionally, we analyzed the data with machine learning. Materials and methods: We included 60 participants in a double-blind, doubledummy, randomized standard-controlled study. Participants in the Sesame and Rose oil group (SR group) (n = 30) received 14 days course of black sesame powder (5 gm) mixed with rose oil (10 mL) per vaginum at bedtime once daily plus placebo capsules orally. The standard group (SC), received doxycycline 100 mg twice and metronidazole 400 mg thrice orally plus placebo per vaginum for the same duration. The primary outcome was a clinical cure at post-intervention for visual analogue scale (VAS) for lower abdominal pain (LAP), and McCormack pain scale (McPS) for abdominal-pelvic tenderness. The secondary outcome included white blood cells (WBC) cells in the vaginal wet mount test, safety profile, and health-related quality of life assessed by SF-12. In addition, we used AdaBoost (AB), Naïve Bayes (NB), and Decision Tree (DT) classifiers in this study to analyze the experimental data. Results: The clinical cure for LAP and McPS in the SR vs SC group was 82.85% vs 81.48% and 83.85% vs 81.60% on Day 15 respectively. On Day 15, pus cells less than 10 in the SR vs SC group were 86.6% vs 76.6% respectively. No adverse effects were reported in both groups. The improvement in total SF-12 score on Day 30 for the SR vs SC group was 82.79% vs 80.04% respectively. In addition, our Naive Bayes classifier based on the leave-one-out model achieved the maximum accuracy (68.30%) for the classification of both groups of uPID. Conclusion: We concluded that the SR group is cost-effective, safer, and efficacious for curing uPID. Proposed alternative treatment (test drug) could be a substitute of standard drug used for Female genital tract infections. [ABSTRACT FROM AUTHOR]

Context • Pelvic organ prolapse (POP) is a leading health problem, in which pelvic organs—the uterus, bladder, and rectum—bulge from the vagina, causing bladder and bowel dysfunction. Uterovaginal prolapse (UVP), Nutual-Rahim, affects more than 50% of parous women (women who have had children), especially those above 60 years of age. Objective • The current case study intended to evaluate the benefits of a holistic Unani treatment in ameliorating POP symptoms, healing decubitus ulcers, preventing further prolapse, improving quality of life, and maintaining social independence. Design • The research team developed a case report. Setting • The study took place at the National Institute of Unani Medicine in Bengaluru, Karnataka, India. Participant • The participant was a 70 year-old female patient at the Institute with backache, spotting from the vagina, foul-smelling vaginal discharge, general weakness, and fourth-degree UVP with multiple decubitus ulcers. Intervention • The participant orally received Majun Moocharus, 7 g twice daily for 60 days,and took sitz baths (Abzan) once daily for 20 minutes for 60 days, which used a medicated decoction of 3g of alum (phitkari ) and 10 g each of a medicated decoction (Joshanda) of nutgalls from the Aleppo oak, Quercus infectoria (Mazu), root of lemon grass Andropogan jwarancusa (Izkhar), and pomegranate rind from Punica granatum (Post anar). She also used vaginal tampons (Hamul) which each used 2g of the same medicinal powder with 10 ml of rose oil and which was inserted into her vagina once per day for 60 days, in combination with pelvic-floor-muscle exercises. Results • The ulcers were healed within a week. The monthly follow-ups for ten months showed no cervical descent or symptoms associated with it. Conclusions • The current case study found that a fourth-grade UVP can be managed effectively with Unani medications. The participant’s ulcers were healed, her clinical symptoms of UVP were reduced, and her quality of life improved. Clinical trials are recommended with large sample sizes to create a higher level of evidence for the efficacy of the Unani medicine. [ABSTRACT FROM AUTHOR]

A single-blind double-dummy randomized study was conducted in diagnosed patients (n = 66) to compare the efficacy of Linseeds (Linum usitatissimum L.), Psyllium (Plantago ovata Forssk.), and honey in uncomplicated pelvic inflammatory disease (uPID) with standard drugs using experimental and computational analysis. The pessary group received placebo capsules orally twice daily plus a per vaginum cotton pessary of powder from linseeds and psyllium seeds, each weighing 3 gm, with honey (5 mL) at bedtime. The standard group received 100 mg of doxycycline twice daily and 400 mg of metronidazole TID orally plus a placebo cotton pessary per vaginum at bedtime for 14 days. The primary outcomes were clinical features of uPID (vaginal discharge, lower abdominal pain (LAP), low backache (LBA), and pelvic tenderness. The secondary outcomes included leucocytes (WBCs) in vaginal discharge on saline microscopy and the SF-12 health questionnaire. In addition, we also classified both (pessary and standard) groups using machine learning models such as Decision Tree (DT), Random Forest (RF), Logistic Regression (LR), and AdaBoost (AB). The pessary group showed a higher percentage reduction than the standard group in abnormal vaginal discharge (87.05% vs. 77.94%), Visual Analogue Scale (VAS)-LAP (80.57% vs. 77.09%), VAS-LBA (74.19% vs. 68.54%), McCormack pain scale (McPS) score for pelvic tenderness (75.39% vs. 67.81%), WBC count of vaginal discharge (87.09% vs. 83.41%) and improvement in SF-12 HRQoL score (94.25% vs. 86.81%). Additionally, our DT 5-fold model achieved the maximum accuracy (61.80%) in the classification. We propose that the pessary group is cost-effective, safer, and more effective as standard drugs for treating uPID and improving the HRQoL of women. Aucubin, Plantamajoside, Herbacetin, secoisolariciresinol diglucoside, Secoisolariciresinol Monoglucoside, and other various natural bioactive molecules of psyllium and linseeds have beneficial effects as they possess anti-inflammatory, antioxidant, antimicrobial, and immunomodulatory properties. The anticipated research work is be a better alternative treatment for genital infections. [ABSTRACT FROM AUTHOR]

Objectives. Abnormal vaginal discharge (Sayalan al-Rahim) is a common public health problem that significantly disrupts the health-related quality of life (HRQoL). Syndromic management infers the concurrent treatment of two or more infections. Hence, a comparative, single-blind study was planned to determine the efficacy of Acacia (Acacia nilotica Linn.) pod's sitz bath (Abzan) plus vaginal pessary (Farzaja) vs. placebo in abnormal vaginal discharge syndromic management, its associated symptoms, and women's HRQoL. Methods. Diagnosed patients (n = 66) were randomly divided into Acacia (n = 33) and placebo (n = 33) group. Acacia group received Sitz bath with Acacia pod powder (30g) solution followed by vaginal cotton pessary (5 ml of the same solution) once daily for 10 days. The placebo group received palm sugar powder (30g) solution for Sitz bath plus vaginal cotton pessary same as the Acacia group. Primary outcomes included clinical cure assessed with VAS for symptoms and Modified McCormack Pain Scale (McPS) for pelvic tenderness. The secondary outcomes included were the EQ-5D-5 L questionnaire, TSQM questionnaire, sachet count, and microbiological cure. Overall, therapeutic cure included clinical and microbiological cure after treatment. Results. The overall therapeutic cure for bacterial vaginosis, cervicitis, and uncomplicated pelvic inflammatory disease was 100% (n = 7/7), 45.45% (n = 10/22), and 71.42% (n = 5/7), respectively, in the Acacia group, while in the placebo group none of the patients had responded. The VAS score for symptoms was significantly reduced in Acacia than in the placebo group. At each follow-up, the improvement in the EQ-5D-5 L level of HRQoL was significantly higher in the Acacia group than in the placebo group. Conclusion. Acacia would be an effective and safe alternative in syndromic management of abnormal vaginal discharge, associated symptoms, and improved women's HRQoL. Trial registration. This trial was registered in the Clinical Trials Registry of Indian Trials Website and given the identification no. CTRI/2018/02/012175 (dated: 27/02/2018). [ABSTRACT FROM AUTHOR]

Extraskeletal Myxoid Chondrosarcoma (EMC) is a rare malignant soft tissue sarcoma with uncertain differentiation, most often seen in males. The incidence is 3% of all soft tissue tumour with limited literature available on its cytological features. EMC may arise from lower extremities, upper extremities, retroperitoneum, pelvis, and buttocks. This case report was an effort to understand the role of Fine Needle Aspiration Cytology (FNAC), histopathology and immunochemistry in the diagnosis of EMC. Authors hereby report a case of a 70-year-old male patient with slow-growing soft tissue swelling on the back just behind the right shoulder who was referred for FNAC. Patient complete history and clinical findings were recorded. Radiological images were suggestive of malignant soft tissue neoplasm with no involvement of underlining bone. FNAC reveled tumour cells which appeared monotonous and they were seen in a myxoid stroma background. Subsequently, the excised lesion was sent for histopathological examination and the report revealed the presence of abundant chondromyxoid matrix material within which were found numerous elongated spindly shaped cells. These cells had moderately pleomorphic elongated nuclei with focal solid fibrocollagenous areas along intersecting fascicles of the moderately pleomorphic spindly cell. Few of these cells had multilobulated bizarre nuclei with nuclear inclusions. Immunohistochemical stains showed diffuse positivity for S-100, vimentin, and focally positive for Epithelial Membrane Antigen (EMA). The FNAC, histopathology and immunohistochemical features confirm the diagnosis of EMC on right shoulder. It's a rare tumour whose diagnosis is made depending on history, clinical location, growth pattern, histopathology, and immunohistochemistry. [ABSTRACT FROM AUTHOR]

Objectives: To compare the efficacy of Unani formulations and Hijama Bila Shart in Tashanuji Usr al-Tamth (spasmodic dysmenorrhea). Materials and Methods: Diagnosed patients (n=40) were randomly allocated in 2 groups (A and B). Group A (n=20) received 200 mL Joshanda (decoction) of Post Amaltas (7 g), Badiyan (5 g), and Pudina Khushk (5 g) and 6 g Sufuf (Tukhm Kharpaza (5 g), Hulba (3 g), Hab ul Qilt (3 g), and Maghz Tukhm Bakayan (1 g), twice daily, 2 days before the onset of menstruation and continued for 3 days of menstrual cycle and Hijama bila Shart (dry cupping) were applied over the suprapubic region on day 1 to day 3 of the menstrual cycle in Group B (n=20) for three consecutive cycles. The primary outcome included a Verbal Rating Scale (VRS) for the severity of pain at baseline and at each follow-up. The secondary outcome included a multidimensional scoring system WaLIDD (working ability, location, intensity, days of pain, dysmenorrhea) score at baseline and post-intervention (4th cycle). With a 5% level of significance, the data was statistically analyzed. Results: In both groups significant pain relief was noted at each follow-up from baseline. Cupping therapy was more effective than oral medication. The mean WaLIDD score of group A and group B comparison at baseline [8.85±1.23 and 8.20±1.40] and post-intervention [4.10±2.69 and 4.20±2.40] was statistically not significant (p>0.05). However, the intragroup comparison showed significant differences in both groups. No side effects of drugs were noted. Conclusion: Both groups were effective, safe and cost-effective, in pain management of Tashanuji Usr al-Tamth. However, further randomized standard controlled trials in large samples are recommended. [ABSTRACT FROM AUTHOR]

Objectives: This study was conducted to evaluate the efficacy of preparations of certain Unani herbs o n Lequesne Algo‑Functional Index of knee osteoarthritis (OA). Materials and Methods: A prospective, pre‑ and post test evaluation study was conducted on 20 diagnosed patients of OA recruited from the Nizamia General Hospital, Hyderabad. Internally, a combination (formula) of Unani herbs was administered, which was as follows: 3.5 g powder of Asarun (2 g), Tukhme karafs (2 g), and Filfil daraz (3 g) was administered internally twice daily. Externally, the concoction of Gule baboona (20 g) and Gule tesu (40 g) made in 1 l water was poured over the affected knee, daily once for 40 days. The primary outcome was to assess the efficacy of Unani test drugs with the modified Lequesne Algo‑Functional Index for knee OA. Results: The mean percentage reduction of Lequesne Algo‑Functional Index score was 71.09%. The mean and standard deviation was 10.55 (1.70) and 3.05 (2.30) before treatment and after treatment, respectively. The pre‑ and post test evaluation showed reduction in Lequesne Algo‑Functional Index score (P < 0.0001). Conclusion: In this study, the Unani treatment module was found to be effective in reducing the severity of disease in patients with osteoarthritis of knees. [ABSTRACT FROM AUTHOR]

Introduction: Greco-Arabic Medicine imparts vast knowledge regarding diseases afflicting different systems. Urinary incontinence (UI) is involuntary leakage of urine. It is an undiagnosed, under-reported, and frequently untreated medical condition that greatlyaffects the quality of life of women in any age. Therefore, a literary search in classical literature of Greco-Arabic medicine for UI was explored to implement in current era. Material and Methods: Meticulous literature search was carried out to comprehend the concept of urinary incontinence described in ancient Unani literature. The classical Greco-Arabic medicine texts were searched. Further, browsing of PubMed/Google Scholar and other websites was carried by searching complementary and alternative treatment for urinary incontinence and herbal remedies useful in urinary incontinence. Results: The causes of urinary incontinence described in Greco-Arabic texts are abnormal temperament of body or bladder, dislocation of vertebrae, pregnancy, diuretic, laxity of musculature of bladder, diseases of surrounding structure such as uterine inflammation, omphalitis, constipation, etc. The principle treatment is treating the cause viz., the temperament is corrected by diet and herbs in abnormal temperament, and elimination of morbid humour is required in dominance of humour. Further, web search showed that herbs are useful in Urinary diseases. However, evidences are weak. Conclusion: The classical Greco-Arabic texts are enriched with important information. Thus documentation and preservation of the traditional knowledge is required so that it can still be conserved for future research in pharmaceuticals and drug discovery. [ABSTRACT FROM AUTHOR]

Introduction: Greco-Arabic Medicine imparts vast knowledge regarding diseases afflicting different systems. Urinary incontinence (UI) is involuntary leakage of urine. It is an undiagnosed, under-reported, and frequently untreated medical condition that greatlyaffects the quality of life of women in any age. Therefore, a literary search in classical literature of Greco-Arabic medicine for UI was explored to implement in current era. Material and Methods: Meticulous literature search was carried out to comprehend the concept of urinary incontinence described in ancient Unani literature. The classical Greco-Arabic medicine texts were searched. Further, browsing of PubMed/Google Scholar and other websites was carried by searching complementary and alternative treatment for urinary incontinence and herbal remedies useful in urinary incontinence. Results: The causes of urinary incontinence described in Greco-Arabic texts are abnormal temperament of body or bladder, dislocation of vertebrae, pregnancy, diuretic, laxity of musculature of bladder, diseases of surrounding structure such as uterine inflammation, omphalitis, constipation, etc. The principle treatment is treating the cause viz., the temperament is corrected by diet and herbs in abnormal temperament, and elimination of morbid humour is required in dominance of humour. Further, web search showed that herbs are useful in Urinary diseases. However, evidences are weak. Conclusion: The classical Greco-Arabic texts are enriched with important information. Thus documentation and preservation of the traditional knowledge is required so that it can still be conserved for future research in pharmaceuticals and drug discovery. [ABSTRACT FROM AUTHOR]

Objective: The aim was to investigate and compare the efficacy of oleo-gum-resin of root of Cyperus scariosus and Boswellia serrata with placebo in improving health-related quality-of-life (HRQOL) in women with stress urinary incontinence (SUI). Materials and Methods: A parallel, randomized placebo-controlled, single-blind, pre- and post-test trial was conducted in the National Institute of Unani Medicine Hospital. The patients (n = 60) were randomly allocated to either test (n = 30) or control group (n = 30). In the test and placebo group, an equal quantity of C. scariosus and B. serrata (4 g powder in two divided doses) plus pelvic floor muscle training (PFMT) and placebo plus PFMT, respectively, was given for 8 weeks. The outcome was to assess HRQOL by International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). Mann-Whitney, Wilcoxon matched paired, Chi-square or Fisher exact tests were used to analyze the results. Results: The mean ICIQ-SF score in the test and control group at baseline was 10.2 ± 0.96 and 10.13 ± 0.89, respectively. At post-intervention, statistically significant improvement was recorded in the ICIQ-SF scores between groups. In addition, within the group comparison was statistically significant in both groups at each follow-up. The percentage improvement from baseline at 12 weeks was 70% and 53% in the test and control groups, respectively. No adverse effects were noted. Conclusion: The test group yielded a more positive effect with regards to improvement in HRQOL than the control group in women with SUI. Hence, test drugs plus PFMT appear to be a better alternative than PFMT alone. [ABSTRACT FROM AUTHOR]

Background and objectives: Infertility is a state of inability to conceive after unprotected intercourse for 1 year; it involves 1 in 6 couples in England. It is a complex problem with an incidence of 10%-15% and of these, 14% of infertilities are due to a tubal factor. The incidence of unilateral tubal blockage is 33%. Pregnancy can occur in unilateral tubal blockage. In the Unani system of medicine, many herbal drugs are used empirically for enhancing fertility. This case report was an effort to understand the role of Unani formulations in conception. This patient had unilateral tubal blockage and she was also resistant to clomiphene citrate. Location: This study was performed in the Outpatient Department of the National Institute of Unani Medicine, Bangalore, India. Interventions: A 25-year-old female patient with primary infertility for 2½ years was diagnosed with unilateral tubal blockage. She was given Unani treatment with Hab hamal 1 tablet t.i.d. for 5 days from the seventh day of the menstrual cycle, Majoon hamal amberi alvi khani 5 g, and Majoon supari pak 5 g b.i.d. for 1 month from the seventh day of menstrual cycle for two consecutive cycles. Outcome measures: The main outcome measure was to observe the conception in the patient. Results and conclusions: The patient conceived within 2 months of the treatment. These formulations might have assisted in conception as they are considered to have uterine tonic, vitalizer, and aphrodisiac properties in Unani medicine. Some of these drugs have been pharmacologically proved to assist in conception, such as Crocus sativus Linn, which is reported to improve fertility that may be attributed to crocetin and/or flavonoids. It is also reported that oysters, which contain zinc and calcium, might have been helped in enhancing fertility. [ABSTRACT FROM AUTHOR]

The study objectives were to interview the relationship between the E-Recruitment and E-Selection process in the Information Technology (IT) MNC Companies in Hyderabad. E-Recruitment primary process starts with identify the job needs, Job analysis, job specification, job description, attracting the applicants to apply for the job screening the profile of the job applicants or seekers and interview the application according to the needs of the organization. The process of E-Recruitment process is length in the 2000 to 2010 due to manual process. After 2010 onwards, the process of the recruitment easier by adopting the E-Recruitment strategies for the Information Technology. At present in 2020 onwards, the recruitment process become must be easier by involving the Artificial Intelligence (AI) in the ERecruitment process. The E-Recruitment and E-Selection process is work together for the effective function of the EHuman resource management. The research is based on the two independent variables E-Recruitment process and Eselection process on the dependent variable E-Human resource management process with the special study on the Information Technology companies i.e., Multinational Companies (MNC) located in the capital of Telangana, Hyderabad. The scholar collected the research data from the employees working in software companies in Hyderabad. The scholar prepared the questionnaries was using five-point Likert scale. The scholar uses the reliability test, validity test and factor analysis test to find the relationship between the e-recruitment and e-selection process on e-hrm process in IT MNC companies in Hyderabad from 190 samples. [ABSTRACT FROM AUTHOR]

Introduction: To compare the efficacy of two polyherbal Unani formulations in gestational urinary tract infections (GUTIs). Materials and Methods: A prospective, randomized, comparative trial was conducted at Nizamia Tibbia College. Group A (n = 20) received mucilage of Althaea officinalis L. (5 ml) with 2.5 g powder of Sphaeranthus indicus L., Euphorbia hypericifolia L., Tribulus terrestris L., and Sharbat Anar shireen (Punica granatum) 10 ml, whereas Group B (n = 20) received 2.5 g powder of Citrullus vulgaris seeds L., Cucumis melo L. seed, and S. indicus L. orally twice daily after meals for 3 consecutive months. The primary outcome included cured measured as negative urine culture and alleviation of GUTIs symptoms. The secondary outcomes included the absence of pus cell in urine analysis, Apgar score, prevention of complication of GUTIs, and perinatal outcome. The results were analyzed with chi-square, Fisher exact test and student t-test with alpha 0.05. Results: The cure rate in Groups A and B was similar with 50% response. Both groups were equally effective in relieving the GUTIs symptoms (P < 0.001), Apgar score was >7, good perinatal outcome with no preterm labor, and intrauterine growth retardation. No maternal and fetal adverse effects were noted. Conclusion: Both groups were equally effective for the treatment of GUTIs without any maternal and fetal adverse effects. [ABSTRACT FROM AUTHOR]