364 results on '"Sultana, J"'
Search Results
2. Piglet Mortality and its Management
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Sultana, J. Razia, Vidya, B., Sushma, K., and Raghunandan, T.
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- 2017
- Full Text
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3. Prevalence and associated risk factors of hypertension among pregnant women in rural areas of Dibrugarh District, Assam
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Jurimoni Gogoi, Sultana J. Ahmed, and Parthajyoti Neog
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dibrugarh ,hypertension ,pregnant women ,rural areas ,Medicine - Abstract
Context: Hypertension is one of the most common medical disorders complicating pregnancies and complicates 5 to 10% of all pregnancies. Aims: To estimate the prevalence of hypertension among pregnant women and to determine the associated obstetric risk factors of hypertension among them in rural areas of Dibrugarh district, Assam. Settings and Design: Community-based cross-sectional study. Materials and Methods: The present study was conducted on pregnant women of villages under two health blocks at that point of time from May 2017 to April 2018. The sample size was calculated to be 384. The estimated number of pregnant women in each block was noted, and the pregnant women to be included from each block and from each sub-centre was determined by proportional allocation. Data were collected by house-to-house survey in the villages of the respective sub-centre. A pre-designed and pre-tested proforma was used to collect the data. Statistical Analysis Used: Data were analysed using Chi-square test, Fisher’s exact test, and logistic regression. Results: A total of 384 pregnant women gave consent for participation. The prevalence of hypertension in pregnancy was 9.1%. Among the obstetric factors, multigravidity, multiparity, period of gestation >20 weeks, history of hypertension in previous pregnancy, and history of prior still birth were statistically significant risk factors of hypertension in pregnancy. Logistic regression analysis showed period of gestation >20 weeks to be independent predictor of hypertension in pregnancy. Conclusion: The awareness of obstetric risk factors for hypertension in pregnancy may give ways for prevention in this population.
- Published
- 2024
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- View/download PDF
4. Impact of Small Anaerobic Digester on Household Economy of Bangladeshi Livestock Farmers
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N. Sultana, J. S. Khanam, K. S. Huque, B. K. Roy, N. Huda and M. K. Alam
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manure, bio-digester, ch4-emission, power generation, household economy ,Environmental effects of industries and plants ,TD194-195 ,Science (General) ,Q1-390 - Abstract
An extensive survey was performed covering all the regions of the country to find out the overall impacts of bio-digester on the economy of livestock farmers. Five districts were selected; ten farmers with having bio-digester of 3.2 m3 on average and ten farmers who have no bio-digester were selected from each district. Through direct interviewing and farm monitoring, all farm characteristics, i.e., diurnal biogas production, power generation, cooking time, income and expenditures, farmer’s gross earnings, and manure management practices data were collected accordingly. Descriptive statistics and student t-test was made to express the comparison response of the farms by using XL and SPSS software. It was observed that the owners of anaerobic digesters earned significantly (p < 0.001) more than the traditional farmers by selling animals and biogas (1715 & 306; 1146 & 0.00 USD, respectively). Not only that, by selling milk and fresh manure, the owners of bio-digester harvested more (p < 0.05) annual income than non-bio-digester farmers (4162, 3408 & 60.91, 44.63 USD, respectively). Though the expenditure of farmers having digester was high, but in a single fiscal year, they earned more (p < 0.05) profit than the conventional farmers (USD 4329 & 2842, respectively). However, owners of bio-digester used 67.2 % of their produced manure for gas production. Regarding storing manure as biomass and using it for cooking purposes significant difference (p < 0.001) was observed that was also reflected in the total manure management system of a farm. The farmers having no bio-digester stored 71.95% of their total manure in solid form, whereas the farmers who had bio-digester only stored 20.4% of their manure, which made a significant (p < 0.001) difference. From the biogas chamber, in an average one farmer used a gas stove for 4-5 hours and a gas lamp for 6-8 hours, which saved at least the expenditure of 18 USD per month/household. The notable thing was that the bio-digester alone contributed 7% to those farmers’ gross economy by producing gas. It can be recommended that the rural householders could generate power by installing bio-digester and turn a small bio-digester as a beneficial avenue of their household economy.
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- 2024
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5. Evaluation of IL-4 and IL-13 Single Nucleotide Polymorphisms and Their Association With Childhood Asthma and Its Severity: A Hospital-Based Case-Control Study
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Deka, Himamoni, primary, Siddique, Mir A, additional, Ahmed, Sultana J, additional, Mahanta, Pranabika, additional, and Mahanta, Putul, additional
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- 2024
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6. The Statistics of the Prompt-to-Afterglow GRB Flux Ratios and the Supercritical Pile GRB Model
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Kazanas, D., Racusin, J. L., Sultana, J., and Mastichiadis, A.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the statistics of the ratio, ${\mathrm R}$, between the prompt and afterglow "plateau" fluxes of GRB. This we define as the ratio between the mean prompt energy flux in the {\em Swift} BAT and the {\em Swift} XRT, immediately following the steep transition between these two states and the beginning of the afterglow stage referred to as the "plateau". Like the distribution of other GRB observables, the histogram of ${\mathrm R}$ is close to log-normal, with maximum at ${\mathrm R = R}_{\rm m} \simeq 2,000$, FWHM of about 2 decades and with the entire distribution spanning about 6 decades in the value of ${\mathrm R}$. We note that the peak of the distribution is close to the proton-to-electron mass ratio $({\mathrm R}_{\rm m} \simeq m_p/m_e = 1836)$, as proposed by us earlier, on the basis of a specific model for the conversion of the GRB blast wave kinetic energy into radiation, before any similar analysis were made. It therefore appears that, in addition to the values of the energy of peak luminosity ${E_{\rm pk}\sim m_{e} c^2}$, GRB present us with one more quantity with an apparently characteristic value. The fact that the values of both these quantities (i.e. $E_{\rm pk}$ and ${\mathrm R}$) comply with those implied by the same specific model devised to account for an altogether different issue, namely the efficient conversion of the GRB blast wave kinetic energy into radiation, argues favorably for its underlying assumptions., Comment: 8 pages, 5 figures, to be published in the proceedings of the 10th INTEGRAL Workshop: "A Synergistic View of the High Energy Sky", taken place in September 2014 in Annapolis, Maryland
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- 2015
7. Prevalence and associated risk factors of hypertension among pregnant women in rural areas of Dibrugarh District, Assam.
- Author
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Gogoi, Jurimoni, Ahmed, Sultana J., and Neog, Parthajyoti
- Subjects
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HYPERTENSION in pregnancy , *STILLBIRTH , *HYPERTENSION risk factors , *PREGNANT women , *RURAL women - Abstract
Context: Hypertension is one of the most common medical disorders complicating pregnancies and complicates 5 to 10% of all pregnancies. Aims: To estimate the prevalence of hypertension among pregnant women and to determine the associated obstetric risk factors of hypertension among them in rural areas of Dibrugarh district, Assam. Settings and Design: Community-based cross-sectional study. Materials and Methods: The present study was conducted on pregnant women of villages under two health blocks at that point of time from May 2017 to April 2018. The sample size was calculated to be 384. The estimated number of pregnant women in each block was noted, and the pregnant women to be included from each block and from each sub-centre was determined by proportional allocation. Data were collected by house-to-house survey in the villages of the respective sub-centre. A pre-designed and pre-tested proforma was used to collect the data. Statistical Analysis Used: Data were analysed using Chi-square test, Fisher's exact test, and logistic regression. Results: A total of 384 pregnant women gave consent for participation. The prevalence of hypertension in pregnancy was 9.1%. Among the obstetric factors, multigravidity, multiparity, period of gestation >20 weeks, history of hypertension in previous pregnancy, and history of prior still birth were statistically significant risk factors of hypertension in pregnancy. Logistic regression analysis showed period of gestation >20 weeks to be independent predictor of hypertension in pregnancy. Conclusion: The awareness of obstetric risk factors for hypertension in pregnancy may give ways for prevention in this population. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Tunable localized surface plasmon graphene metasurface for multiband superabsorption and terahertz sensing
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Islam, M.S., Sultana, J., Biabanifard, M., Vafapour, Z., Nine, M.J., Dinovitser, A., Cordeiro, C.M.B., Ng, B.W.-H., and Abbott, D.
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- 2020
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9. Survival of Hospitalized COVID-19 Patients in Northern Italy: A Population-Based Cohort Study by the ITA-COVID-19 Network
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Ferroni E, Giorgi Rossi P, Spila Alegiani S, Trifirò G, Pitter G, Leoni O, Cereda D, Marino M, Pellizzari M, Fabiani M, Riccardo F, Sultana J, and Massari M
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covid-19 ,survival ,cohort study ,hospitalized patients ,italy ,Infectious and parasitic diseases ,RC109-216 - Abstract
Eliana Ferroni,1 Paolo Giorgi Rossi,2 Stefania Spila Alegiani,3 Gianluca Trifirò,4 Gisella Pitter,1 Olivia Leoni,5 Danilo Cereda,5 Massimiliano Marino,2 Michele Pellizzari,1 Massimo Fabiani,6 Flavia Riccardo,6 Janet Sultana,4 Marco Massari3 On behalf of The ITA-COVID Working Group1Azienda Zero of the Veneto Region, Padua, Italy; 2Azienda Unità Sanitaria Locale – IRCCS, Reggio Emilia, Italy; 3National Center for Drug Research and Evaluation, Istituto Superiore Di Sanità, Rome, Italy; 4Department of Biomedical and Dental Sciences and Morphofunctional Imaging – University of Messina, Messina, Italy; 5Department of Health of Lombardy Region, Milan, Italy; 6Department of Infectious Diseases, Istituto Superiore Di Sanità, Rome, ItalyCorrespondence: Stefania Spila AlegianiIstituto Superiore Di Sanità, Viale Regina Elena, 299, Rome 00161, ItalyTel +39 0649904249Fax +39 0649904248Email stefania.spila@iss.itPaolo Giorgi RossiAzienda Unità Sanitaria Locale – IRCCS, Reggio Emilia, via Amendola 2, Reggio Emilia 42122, ItalyTel +39 0522335490Email paolo.giorgirossi@ausl.re.itIntroduction: COVID-19 case fatality rate in hospitalized patients varies across countries and studies. Reliable estimates, specific for age, sex, and comorbidities, are needed to monitor the epidemic, to compare the outcome in different settings, and to correctly design trials for COVID-19 interventions. The aim of this study was to provide population-based survival curves of hospitalized COVID-19 patients.Materials and Methods: A cohort study was conducted in three areas of Northern Italy, heavily affected by SARS-CoV-2 infection (Lombardy and Veneto Regions, and Reggio Emilia province), using a loco-regional COVID-19 surveillance system, linked to hospital discharge databases. We included all patients testing positive for SARS-CoV-2 RNA by RT-PCR on nasopharyngeal/throat swab samples who were hospitalized from 21 February to 21 April 2020. Kaplan–Meier survival estimates were calculated at 14 and 30 days for death in any setting, stratifying by age, sex, and the Charlson Index.Results: Overall, 42,926 hospitalized COVID-19 patients were identified. Patients’ median age was 69 years (IQR: 57– 79), 62.6% were males, and 6.0% had a Charlson Index ≥ 3. Survival curves showed that 22.0% (95% CI 21.6– 22.4) of patients died within 14 days and 27.6% (95% CI 27.2– 28.1) within 30 days from hospitalization. Survival was higher in younger patients and in females. The negative impact of comorbidities on survival was more pronounced in younger age groups.Conclusion: The high fatality rate observed in the study (28% at 30 days) suggests that studies should focus on death as primary endpoint during a follow-up of at least one month.Keywords: COVID-19, survival, cohort study, hospitalized patients, Italy
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- 2020
10. Protein disulphide isomerase (PDI) is protective against amyotrophic lateral sclerosis (ALS)-related mutant Fused in Sarcoma (FUS) in in vitro models
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Parakh, S., Perri, E. R., Vidal, M., Sultana, J., Shadfar, S., Mehta, P., Konopka, A., Thomas, C. J., Spencer, D. M., and Atkin, J. D.
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- 2021
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11. Editorial: Overcoming boundaries in public health: Advances in international and global health
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Antonazzo, I, Sultana, J, Ferrara, P, Antonazzo I. C., Sultana J., Ferrara P., Antonazzo, I, Sultana, J, Ferrara, P, Antonazzo I. C., Sultana J., and Ferrara P.
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- 2022
12. Overview of the European post-authorisation study register post-authorization studies performed in Europe from September 2010 to December 2018
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Sultana, J, Crisafulli, S, Almas, M, Antonazzo, I, Baan, E, Bartolini, C, Bertuccio, M, Bonifazi, F, Capuano, A, Didio, A, Ehrenstein, V, Felisi, M, Ferrajolo, C, Fontana, A, Francisca, R, Fourrier-Reglat, A, Fortuny, J, Gini, R, Hyeraci, G, Hoeve, C, Kontogiorgis, C, Isgro, V, Lalagkas, P, L'Abbate, L, Layton, D, Landi, A, Narduzzi, S, Roque Pereira, L, Poulentzas, G, Rafaniello, C, Roberto, G, Scondotto, G, Sportiello, L, Toma, M, Toussi, M, Verhamme, K, Volpe, E, Trifiro, G, Sultana J., Crisafulli S., Almas M., Antonazzo I. C., Baan E., Bartolini C., Bertuccio M. P., Bonifazi F., Capuano A., Didio A., Ehrenstein V., Felisi M., Ferrajolo C., Fontana A., Francisca R., Fourrier-Reglat A., Fortuny J., Gini R., Hyeraci G., Hoeve C., Kontogiorgis C., Isgro V., Lalagkas P. -N., L'Abbate L., Layton D., Landi A., Narduzzi S., Roque Pereira L., Poulentzas G., Rafaniello C., Roberto G., Scondotto G., Sportiello L., Toma M., Toussi M., Verhamme K., Volpe E., Trifiro G., Sultana, J, Crisafulli, S, Almas, M, Antonazzo, I, Baan, E, Bartolini, C, Bertuccio, M, Bonifazi, F, Capuano, A, Didio, A, Ehrenstein, V, Felisi, M, Ferrajolo, C, Fontana, A, Francisca, R, Fourrier-Reglat, A, Fortuny, J, Gini, R, Hyeraci, G, Hoeve, C, Kontogiorgis, C, Isgro, V, Lalagkas, P, L'Abbate, L, Layton, D, Landi, A, Narduzzi, S, Roque Pereira, L, Poulentzas, G, Rafaniello, C, Roberto, G, Scondotto, G, Sportiello, L, Toma, M, Toussi, M, Verhamme, K, Volpe, E, Trifiro, G, Sultana J., Crisafulli S., Almas M., Antonazzo I. C., Baan E., Bartolini C., Bertuccio M. P., Bonifazi F., Capuano A., Didio A., Ehrenstein V., Felisi M., Ferrajolo C., Fontana A., Francisca R., Fourrier-Reglat A., Fortuny J., Gini R., Hyeraci G., Hoeve C., Kontogiorgis C., Isgro V., Lalagkas P. -N., L'Abbate L., Layton D., Landi A., Narduzzi S., Roque Pereira L., Poulentzas G., Rafaniello C., Roberto G., Scondotto G., Sportiello L., Toma M., Toussi M., Verhamme K., Volpe E., and Trifiro G.
- Abstract
Background: The European post-authorisation study (EU PAS) register is a repository launched in 2010 by the European Medicines Agency (EMA). All EMA-requested PAS, commonly observational studies, must be recorded in this register. Multi-database studies (MDS) leveraging secondary data have become an important strategy to conduct PAS in recent years, as reflected by the type of studies registered in the EU PAS register. Objectives: To analyse and describe PAS in the EU PAS register, with focus on MDS. Methods: Studies in the EU PAS register from inception to 31st December 2018 were described concerning transparency, regulatory obligations, scope, study type (e.g., observational study, clinical trial, survey, systematic review/meta-analysis), study design, type of data collection and target population. MDS were defined as studies conducted through secondary use of >1 data source not linked at patient-level. Data extraction was carried out independently by 14 centres with expertise in pharmacoepidemiology, using publicly available information in the EU PAS register including study protocol, whenever available, using a standardised data collection form. For validation purposes, a second revision of key fields for a 15% random sample of studies was carried out by a different centre. The inter-rater reliability (IRR) was then calculated. Finally, to identify predictors of primary data collection-based studies/versus those based on secondary use of healthcare databases) or MDS (vs. non-MDS), odds ratios (OR) and 95% confidence intervals (CI) were calculated fitting univariate logistic regression models. Results: Overall, 1426 studies were identified. Clinical trials (N = 30; 2%), systematic reviews/meta-analyses (N = 16; 1%) and miscellaneous study designs (N = 46; 3%) were much less common than observational studies (N = 1227; 86%). The protocol was available for 63% (N = 360) of 572 observational studies requested by a competent authority. Overall, 36% (N = 446) of ob
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- 2022
13. Assessing intravitreal anti-VEGF drug safety using real-world data: methodological challenges in observational research
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Scondotto, G, Crisafulli, S, Antonazzo, I, Virgili, G, Trifiro, G, Sultana, J, Scondotto G., Crisafulli S., Antonazzo I. C., Virgili G., Trifiro G., Sultana J., Scondotto, G, Crisafulli, S, Antonazzo, I, Virgili, G, Trifiro, G, Sultana, J, Scondotto G., Crisafulli S., Antonazzo I. C., Virgili G., Trifiro G., and Sultana J.
- Abstract
Introduction: It is generally acknowledged that the ocular safety profile of intravitreal anti-VEGF drugs is acceptable, while the burden of systemic safety of these intravitreal agents is still being debated. The evaluation of the systemic safety of these drugs using real-world data (RWD), such as spontaneous reporting systems (SRS), electronic medical records (EMRs) and claims databases has several advantages, including the capture of outcomes among real-world populations over long observation periods. Nevertheless, there is a relatively small body of research exploring the post-marketing safety of these drugs. Areas covered: The aim of this scoping review is to outline and discuss some of the methodological challenges to be faced when investigating the systemic safety of intravitreal anti-VEGF drugs using different sources of RWD. Expert opinion: Such challenges include the selection of the most suitable data source, taking into account how well drug utilization is captured and whether the outcomes and covariates of interest can be captured. The strengths and limitations of some analytic methods that can be used to quantify risk, such as the intention-to-treat approach and the as-treated approach, complement each other, and using these together provides a more balanced analysis.
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- 2022
14. Can information on functional and cognitive status improve short-term mortality risk prediction among community-dwelling older people? A cohort study using a UK primary care database
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Sultana J, Fontana A, Giorgianni F, Basile G, Patorno E, Pilotto A, Molokhia M, Stewart R, Sturkenboom M, and Trifirò G
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elderly ,frailty ,database ,mortality ,Infectious and parasitic diseases ,RC109-216 - Abstract
Janet Sultana,1,2 Andrea Fontana,3 Francesco Giorgianni,1 Giorgio Basile,1 Elisabetta Patorno,4 Alberto Pilotto,5 Mariam Molokhia,6 Robert Stewart,7 Miriam Sturkenboom,2 Gianluca Trifirò1,2 1Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy; 2Department of Medical Informatics, Erasmus University Medical Centre, Rotterdam, the Netherlands; 3Unit of Biostatistics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; 4Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA; 5Geriatrics Unit, Department of Geriatric Care, Ortho Geriatrics and Rehabilitation, Frailty Area, E.O. Galliera Hospital, Genova, Italy; 6Department of Primary Care and Public Health Sciences, King’s College, London, UK; 7Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience King’s College London, UK Background: Functional and cognitive domains have rarely been evaluated for their prognostic value in general practice databases. The aim of this study was to identify functional and cognitive domains in The Health Improvement Network (THIN) and to evaluate their additional value for the prediction of 1-month and 1-year mortality in elderly people.Materials and methods: A cohort study was conducted using a UK nationwide general practitioner database. A total of 1,193,268 patients aged 65 years or older, of whom 15,300 had dementia, were identified from 2000 to 2012. Information on mobility, dressing and accommodation was recorded frequently enough to be analyzed further in THIN. Cognition data could not be used due to very poor recording of data in THIN. One-year and 1-month mortality was predicted using logistic models containing variables such as age, sex, disease score and functionality status.Results: A significant but moderate improvement in 1-year and 1-month mortality prediction in elderly people was observed by adding accommodation to the variables age, sex and disease score, as the c-statistic (95% confidence interval [CI]) increased from 0.71 (0.70–0.72) to 0.76 (0.75–0.77) and 0.73 (0.71–0.75) to 0.79 (0.77–0.80), respectively. A less notable improvement in the prediction of 1-year and 1-month mortality was observed in people with dementia.Conclusion: Functional domains moderately improved the accuracy of a model including age, sex and comorbidities in predicting 1-year and 1-month mortality risk among community-dwelling older people, but they were much less able to predict mortality in people with dementia. Cognition could not be explored as a predictor of mortality due to insufficient data being recorded. Keywords: elderly, frailty, database, mortality
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- 2017
15. Unsuspected Paraganglioma—Infratemporal Fossa
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Nikhat Sultana J, Shekhar R. Gurrala, Lakshman K. Kommula, and Gnana R. Boola
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paraganglionoma ,infratemporal fossa ,undiagnosed catecholamine secreting tumor ,Anesthesiology ,RD78.3-87.3 - Abstract
Paraganglioma of the infratemporal fossa is exceedingly rare, with no more than a handful of documented cases. Undiagnosed paraganglioma poses a great challenge. We present a 39-year-old hypertensive female, who presented with giddiness and headache for 3 months and four episodes of syncope over 3 months. CT and MRI revealed an enhancing infratemporal region space-occupying mass close proximity to petrous carotid artery. Intraoperatively, the patient had hemodynamic instability (tachycardia and hypertension) when the mass was surgically manipulated. Diagnosis of paraganglioma was suspected, based on hemodynamic instability, which was later confirmed by histopathology. Undiagnosed paraganglioma pose a great challenge to the anesthetic management. Low-threshold of suspicion has to be there to avoid significant morbidity and mortality.
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- 2020
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16. Overweight and obesity in early adolescents and its relation to dietary habit and physical activity: A study in Dibrugarh town
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Saikia, Dimpymoni, Ahmed, Sultana J., Saikia, Hiranya, and Sarma, Ratna
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- 2016
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17. Medication is an additional source of phosphate intake in chronic kidney disease patients
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Sultana, J., Musazzi, U.M., Ingrasciotta, Y., Giorgianni, F., Ientile, V., Fontana, A., Minghetti, P., Perrotta, M., Santoro, D., Savica, V., and Trifirò, G.
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- 2015
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18. AIR QUALITY OF DHAKA CITY: A CASE OF VEHICULAR POLLUTION
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Azad, K., primary, Sultana, J., additional, and Akter, J., additional
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- 2022
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19. Systemic Administration of Porphyromonas Gingivalis Lipopolysaccharide Induces Glial Activation and Depressive-Like Behavior in Rats.
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Mamunur, Rahman, Sadayuki Hashioka, Azis, Ilhamuddin A., Jaya, Muhammad A., Jerin, Sultana J. F., Kaori Kimura-Kataoka, Junko Fujihara, Ken Inoue, Masatoshi Inagaki, and Haruo Takeshita
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PORPHYROMONAS gingivalis ,PERIODONTITIS ,GLIAL fibrillary acidic protein ,SPRAGUE Dawley rats ,HIPPOCAMPUS (Brain) ,MENTAL depression - Abstract
Background: Periodontitis is one of the most common chronic inflammatory disorders in adults. Although clinical studies have suggested a causal relationship between periodontitis and major depression (MD), the biological mechanisms by which periodontitis instigates MD are unknown. We investigated whether a systemic administration of lipopolysaccharide (LPS) from Porphyromonas gingivalis (Pg), a major Gram-negative pathogen of periodontitis, causes depressive-like behavior and glial activation in the hippocampus and the prefrontal cortex (PFC), which are MD-related brain regions. Materials and Methods: Eight-week-old male Sprague Dawley rats were randomly divided into a behavioral test group and an immunohistochemistry group. The rats in each group were further assigned to the sham injection (saline) and Porphyromonas gingivalis-lipopolysaccharide (Pg-LPS) injection protocols. The rats received an intraperitoneal injection of saline or Pg-LPS with gradually increasing doses (day 1: 0.5, day 2: 0.5, day 3: 0.75, day 4: 0.75, day 5: 1.0, day 6: 1.0, and day 7: 1.0 mg/kg of body weight) for seven consecutive days. After the systemic administration, the behavior test group underwent the forced swimming test (FST) and Y-maze test. For the immunohistochemistry group, we quantified the immunoreactivity for microglial Iba-1 (ionized calcium-binding adapter molecule 1) and astrocytic glial fibrillary acidic protein (GFAP) in the hippocampus (dentate gyrus [DG], cornu ammonis [CA1 and CA3]) and PFC (prelimbic [PrL] and the infralimbic [IL]) areas. Results: The FST immobility time in the Pg-LPS group was significantly longer than that in the sham group. In the Y-maze test, a significant decline in spontaneous alternation behavior was observed in the Pg-LPS group compared to the sham group. The peripheral administration of Pg-LPS significantly increased the immunoreactivity for Iba-1 in the CA3 and PrL. Pg-LPS injection significantly increased the immunoreactivity for GFAP in the DG, CA1, and CA3. Conclusions: The major result of this study is that a repeated systemic administration of Pg-LPS caused depressive-like behavior and both microglial and astrocytic activation in rats. This finding may comprise biological evidence of a causal relationship between periodontitis and MD. [ABSTRACT FROM AUTHOR]
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- 2023
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20. 3D Printed Terahertz Antiresonant Fibers for Controllable Guiding Properties
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Sultana, J., primary, Islam, M. S., additional, Cordeiro, C. M. B., additional, Habib, M. S., additional, Dinovitser, A., additional, Kaushik, M., additional, Ng, B. W.-H., additional, and Abbott, D., additional
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- 2022
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21. What can real world evidence contribute to regulatory science in pre and post marketing setting?
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Martini, N, Sultana, J, Addis, ., Braga, M, Corrao, G, Campomori, A, Capuano, A, Gini, R, Mazzaglia, G, Patarnello, F, Petrini, C, Pierini, A, Pippo, L, Popoli, P, Russo, P, Scondotto, G, Trifirò, G, Martini, N., Sultana, J., Braga, M., Corrao, G., Campomori, A., Capuano, A., Gini, R., Mazzaglia, G., Patarnello, F., Petrini, C., Pierini, A., Pippo, L., Popoli, P., Russo, P., Scondotto, G., Trifirò, G., Martini, N, Sultana, J, Addis, ., Braga, M, Corrao, G, Campomori, A, Capuano, A, Gini, R, Mazzaglia, G, Patarnello, F, Petrini, C, Pierini, A, Pippo, L, Popoli, P, Russo, P, Scondotto, G, Trifirò, G, Martini, N., Sultana, J., Braga, M., Corrao, G., Campomori, A., Capuano, A., Gini, R., Mazzaglia, G., Patarnello, F., Petrini, C., Pierini, A., Pippo, L., Popoli, P., Russo, P., Scondotto, G., and Trifirò, G.
- Published
- 2020
22. RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia-an international Delphi consensus.
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O'Brien, JT, Chouliaras, L, Sultana, J, Taylor, J-P, Ballard, C, RENEWAL Study Group, O'Brien, JT, Chouliaras, L, Sultana, J, Taylor, J-P, Ballard, C, and RENEWAL Study Group
- Abstract
Drug repositioning and repurposing has proved useful in identifying new treatments for many diseases, which can then rapidly be brought into clinical practice. Currently, there are few effective pharmacological treatments for Lewy body dementia (which includes both dementia with Lewy bodies and Parkinson's disease dementia) apart from cholinesterase inhibitors. We reviewed several promising compounds that might potentially be disease-modifying agents for Lewy body dementia and then undertook an International Delphi consensus study to prioritise compounds. We identified ambroxol as the top ranked agent for repurposing and identified a further six agents from the classes of tyrosine kinase inhibitors, GLP-1 receptor agonists, and angiotensin receptor blockers that were rated by the majority of our expert panel as justifying a clinical trial. It would now be timely to take forward all these compounds to Phase II or III clinical trials in Lewy body dementia.
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- 2022
23. Inertia in Friedmann Universes with variable Λ
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Sultana, J. and Kazanas, D.
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- 2015
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24. All-cause mortality and antipsychotic use among elderly persons with high baseline cardiovascular and cerebrovascular risk: a multi-center retrospective cohort study in Italy
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Sultana J., Giorgianni F., REA, FEDERICO, Lucenteforte E., Lombardi N., Mugelli A., Vannacci A., Liperoti R., Kirchmayer U., Vitale C., Chinellato A., Roberto G., Corrao G., Trifiro G., Agabiti N., Bartolini C., Bernabei R., Bettiol A., Bonassi S., Caputi A. P., Cascini S., Cipriani F., Davoli M., Fini M., Gini R., Lapi F., Onder G., Sorge C., Tari M., Vetrano D. L., Sultana, J, Giorgianni, F, Rea, F, Lucenteforte, E, Lombardi, N, Mugelli, A, Vannacci, A, Liperoti, R, Kirchmayer, U, Vitale, C, Chinellato, A, Roberto, G, Corrao, G, Trifiro, G, Agabiti, N, Bartolini, C, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Cipriani, F, Davoli, M, Fini, M, Gini, R, Lapi, F, Onder, G, Sorge, C, Tari, M, and Vetrano, D
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Male ,Pediatrics ,medicine.medical_treatment ,Toxicology ,030226 pharmacology & pharmacy ,Cohort Studies ,Antipsychotic ,0302 clinical medicine ,Retrospective Studie ,Risk Factors ,Cardiovascular Disease ,80 and over ,Antipsychotics ,Medicine ,Drug Interactions ,Aged, 80 and over ,Incidence ,Incidence (epidemiology) ,General Medicine ,Italy ,Cardiovascular Diseases ,030220 oncology & carcinogenesis ,Cerebrovascular Disorder ,Female ,cohort study ,drug interactions ,elderly ,mortality ,Antipsychotic Agents ,Human ,Cohort study ,medicine.medical_specialty ,03 medical and health sciences ,Elderly persons ,Humans ,Cerebrovascular risk ,Proportional Hazards Models ,Retrospective Studies ,Aged ,Pharmacology ,drug interaction ,urogenital system ,business.industry ,Proportional hazards model ,Settore MED/09 - MEDICINA INTERNA ,Retrospective cohort study ,equipment and supplies ,Cerebrovascular Disorders ,Antipsychotic Agent ,Proportional Hazards Model ,Cohort Studie ,business ,All cause mortality - Abstract
Background: Little is known about the comparative risk of death with atypical or conventional antipsychotics (APs) among persons with cardiovascular or cerebrovascular disease (CCD). Research design and methods: A cohort study was conducted using five Italian claims databases. New atypical AP users with CCD aged ≥65 (reference) were matched to new conventional AP users. Mortality per 100 person-years (PYs) and hazard ratios (HR), estimated using Cox models, were reported. Incidence and risk of death were estimated for persons having drug–drug interactions. Outcome occurrence was evaluated 180 days after AP initiation. Results: Overall 24,711 and 27,051 elderly new conventional and atypical AP users were identified. The mortality rate was 51.3 and 38.5 deaths per 100 PYs for conventional and atypical AP users. Mortality risk was 1.33 (95%CI: 1.27–1.39) for conventional APs. There was no increased mortality risk with single drug–drug interactions (DDIs) vs. no DDI. AP users with ≥1 DDI had a 29% higher mortality risk compared to no DDI in the first 90 days of treatment (HR: 1.29 (95% CI: 1.00–1.67)). Conclusions: Conventional APs had a higher risk of death than atypical APs among elderly persons with CCD. Having ≥1 DDI was associated with an increased risk of death.
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- 2019
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25. Effect of dietary Chromium, vitamin E and Selenium supplementation on biochemical and physiological parameters of Holstein Friesian cows under heat stress
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RAGHUNANDAN, T, primary, SULTANA, J RAZIA, additional, CHANDRA, A SARAT, additional, PRAKASH, M GNANA, additional, VENKATESWARLU, M, additional, and RAMANA, D B V, additional
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- 2022
- Full Text
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26. Studying the comparative performance of p-CuO/n-Si thin film hetero-junction solar cells grown by chemical bath deposition and vapor liquid solid processes
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Sultana, J., primary, Paul, S., additional, Karmakar, A., additional, and Chattopadhyay, S., additional
- Published
- 2016
- Full Text
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27. Role of healthcare databases and registries for surveillance of orphan drugs in the real-world setting: the Italian case study
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Crisafulli, S, Sultana, J, Ingrasciotta, Y, Addis, A, Cananzi, P, Cavagna, L, Conter, V, D'Angelo, G, Ferrajolo, C, Mantovani, L, Pastorello, M, Scondotto, S, Trifiro, G, Crisafulli S., Sultana J., Ingrasciotta Y., Addis A., Cananzi P., Cavagna L., Conter V., D'Angelo G., Ferrajolo C., Mantovani L., Pastorello M., Scondotto S., Trifiro G., Crisafulli, S, Sultana, J, Ingrasciotta, Y, Addis, A, Cananzi, P, Cavagna, L, Conter, V, D'Angelo, G, Ferrajolo, C, Mantovani, L, Pastorello, M, Scondotto, S, Trifiro, G, Crisafulli S., Sultana J., Ingrasciotta Y., Addis A., Cananzi P., Cavagna L., Conter V., D'Angelo G., Ferrajolo C., Mantovani L., Pastorello M., Scondotto S., and Trifiro G.
- Abstract
Introduction: Orphan drugs are medicines intended to treat, prevent, or diagnose a rare and serious condition. The collection of pre-marketing safety and efficacy data for orphan drugs is very challenging for several reasons related to the rarity of the diseases. This highlights the need for robust post-marketing evidence generation. Real-world data sources, such as claims databases, electronic healthcare records, and disease and drug registers, have an important role in studying orphan drugs. The availability and usefulness of such resources vary from country to country. Areas covered: A detailed description of the available real-world data sources and their contribution to generating post-marketing evidence on orphan drug benefit-risk profile in Italy is provided. Expert opinion: Despite their considerable potential for rare disease research, the available Italian data sources are currently under-used and require further harmonization of data collection. The establishment of large structured and integrated nationwide data sources, tailored to respond to both research as well as regulatory requirements, is necessary to provide clinically useful information on orphan drugs as well. Such data sources should also be more accessible at the loco-regional, national and international level.
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- 2019
28. All-cause mortality and antipsychotic use among elderly persons with high baseline cardiovascular and cerebrovascular risk: a multi-center retrospective cohort study in Italy
- Author
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Sultana, J, Giorgianni, F, Rea, F, Lucenteforte, E, Lombardi, N, Mugelli, A, Vannacci, A, Liperoti, R, Kirchmayer, U, Vitale, C, Chinellato, A, Roberto, G, Corrao, G, Trifiro, G, Agabiti, N, Bartolini, C, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Cipriani, F, Davoli, M, Fini, M, Gini, R, Lapi, F, Onder, G, Sorge, C, Tari, M, Vetrano, D, Sultana J., Giorgianni F., REA, FEDERICO, Lucenteforte E., Lombardi N., Mugelli A., Vannacci A., Liperoti R., Kirchmayer U., Vitale C., Chinellato A., Roberto G., Corrao G., Trifiro G., Agabiti N., Bartolini C., Bernabei R., Bettiol A., Bonassi S., Caputi A. P., Cascini S., Cipriani F., Davoli M., Fini M., Gini R., Lapi F., Onder G., Sorge C., Tari M., Vetrano D. L., Sultana, J, Giorgianni, F, Rea, F, Lucenteforte, E, Lombardi, N, Mugelli, A, Vannacci, A, Liperoti, R, Kirchmayer, U, Vitale, C, Chinellato, A, Roberto, G, Corrao, G, Trifiro, G, Agabiti, N, Bartolini, C, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Cipriani, F, Davoli, M, Fini, M, Gini, R, Lapi, F, Onder, G, Sorge, C, Tari, M, Vetrano, D, Sultana J., Giorgianni F., REA, FEDERICO, Lucenteforte E., Lombardi N., Mugelli A., Vannacci A., Liperoti R., Kirchmayer U., Vitale C., Chinellato A., Roberto G., Corrao G., Trifiro G., Agabiti N., Bartolini C., Bernabei R., Bettiol A., Bonassi S., Caputi A. P., Cascini S., Cipriani F., Davoli M., Fini M., Gini R., Lapi F., Onder G., Sorge C., Tari M., and Vetrano D. L.
- Abstract
Background: Little is known about the comparative risk of death with atypical or conventional antipsychotics (APs) among persons with cardiovascular or cerebrovascular disease (CCD). Research design and methods: A cohort study was conducted using five Italian claims databases. New atypical AP users with CCD aged ≥65 (reference) were matched to new conventional AP users. Mortality per 100 person-years (PYs) and hazard ratios (HR), estimated using Cox models, were reported. Incidence and risk of death were estimated for persons having drug–drug interactions. Outcome occurrence was evaluated 180 days after AP initiation. Results: Overall 24,711 and 27,051 elderly new conventional and atypical AP users were identified. The mortality rate was 51.3 and 38.5 deaths per 100 PYs for conventional and atypical AP users. Mortality risk was 1.33 (95%CI: 1.27–1.39) for conventional APs. There was no increased mortality risk with single drug–drug interactions (DDIs) vs. no DDI. AP users with ≥1 DDI had a 29% higher mortality risk compared to no DDI in the first 90 days of treatment (HR: 1.29 (95% CI: 1.00–1.67)). Conclusions: Conventional APs had a higher risk of death than atypical APs among elderly persons with CCD. Having ≥1 DDI was associated with an increased risk of death.
- Published
- 2019
29. Effect of Supplemental Chromium, Vitamin E and Selenium on Biochemical and Physiological Parameters of Holstein Friesian Calves under Heat Stress
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Sultana, J. Razia, primary, Chandra, A. Sarat, additional, Ramana, D.B.V., additional, Raghunandan, T., additional, Prakash, M. Gnana, additional, and Venkateswarlu, M., additional
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- 2021
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30. Hormonal regulations in insect metamorphosis: A review
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Sultana, J, primary, Rahman, MM, additional, and Haque, MA, additional
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- 2021
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31. The Role of European Healthcare Databases for Post-Marketing Drug Effectiveness, Safety and Value Evaluation: Where Does Italy Stand?
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Trifirò, G, Gini, R, Barone-Adesi, F, Beghi, E, Cantarutti, A, Capuano, A, Carnovale, C, Clavenna, A, Dellagiovanna, M, Ferrajolo, C, Franchi, M, Ingrasciotta, Y, Kirchmayer, U, Lapi, F, Leone, R, Leoni, O, Lucenteforte, E, Moretti, U, Mugelli, A, Naldi, L, Poluzzi, E, Rafaniello, C, Rea, F, Sultana, J, Tettamanti, M, Traversa, G20, Vannacci, A, Mantovani, L, Corrao, G, Trifirò, Gianluca, Trifiro G., Gini R., Barone-Adesi F., Beghi E., Cantarutti A., Capuano A., Carnovale C., Clavenna A., Dellagiovanna M., Ferrajolo C., Franchi M., Ingrasciotta Y., Kirchmayer U., Lapi F., Leone R., Leoni O., Lucenteforte E., Moretti U., Mugelli A., Naldi L., Poluzzi E., Rafaniello C., Rea F., Sultana J., Tettamanti M., Traversa G., Vannacci A., Mantovani L., Corrao G., Trifirò, Gianluca, Gini, Rosa, Barone-Adesi, Francesco, Beghi, Ettore, Cantarutti, Anna, Capuano, Annalisa, Carnovale, Carla, Clavenna, Antonio, Dellagiovanna, Mirosa, Ferrajolo, Carmen, Franchi, Matteo, Ingrasciotta, Ylenia, Kirchmayer, Ursula, Lapi, Francesco, Leone, Roberto, Leoni, Olivia, Lucenteforte, Ersilia, Moretti, Ugo, Mugelli, Alessandro, Naldi, Luigi, Poluzzi, Elisabetta, Rafaniello, Concita, Rea, Federico, Sultana, Janet, Tettamanti, Mauro, Traversa, Giuseppe, Vannacci, Alfredo, Mantovani, Lorenzo, Corrao, Giovanni, Trifirò, G, Gini, R, Barone-Adesi, F, Beghi, E, Cantarutti, A, Capuano, A, Carnovale, C, Clavenna, A, Dellagiovanna, M, Ferrajolo, C, Franchi, M, Ingrasciotta, Y, Kirchmayer, U, Lapi, F, Leone, R, Leoni, O, Lucenteforte, E, Moretti, U, Mugelli, A, Naldi, L, Poluzzi, E, Rafaniello, C, Rea, F, Sultana, J, Tettamanti, M, Traversa, G, Vannacci, A, Mantovani, L, and Corrao, G
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Drug ,Value (ethics) ,Pharmacovigilance, Drug Toxicity, spontaneous reporting ,Databases, Factual ,Drug-Related Side Effects and Adverse Reactions ,National Health Programs ,media_common.quotation_subject ,National Health Program ,MEDLINE ,spontaneous reporting ,Information Storage and Retrieval ,Disease ,Toxicology ,computer.software_genre ,030226 pharmacology & pharmacy ,Pharmacovigilance ,03 medical and health sciences ,Pharmacology ,Pharmacology (medical) ,0302 clinical medicine ,Drug Utilization Review ,Drug Toxicity ,Health care ,Product Surveillance, Postmarketing ,Medicine ,Electronic Health Records ,030212 general & internal medicine ,media_common ,Database ,business.industry ,Health technology ,Italy ,Observational study ,Electronic Health Record ,business ,Drug-Related Side Effects and Adverse Reaction ,computer - Abstract
Enormous progress has been made globally in the use of evidence derived from patients’ clinical information as they access their routine medical care. The value of real-world data lies in their complementary nature compared with data from randomised controlled trials: less detailed information on drug efficacy but longer observational periods and larger, more heterogeneous study populations reflecting clinical practice because individuals are included who would not usually be recruited in trials. Real-world data can be collected in various types of electronic sources, such as electronic health records, claims databases and drug or disease registries. These data sources vary in nature from country to country, according to national healthcare system structures and national policies. In Italy, a growing number of healthcare databases have been used to evaluate post-marketing drug utilisation and safety in the last two decades. The aim of this narrative review is to describe the available Italian sources of real-world data and their contribution to generating post-marketing evidence on drug use and safety. We also discuss the strengths and limitations of the most commonly used Italian healthcare databases in addressing various research questions concerning drug utilisation, comparative effectiveness and safety studies, as well as health technology assessment and other areas.
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- 2018
32. Evidence of intra-familial transmission of Helicobacter pylori by PCR-based RAPD fingerprinting in Bangladesh
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Nahar, S., Kibria, K. M. K., Hossain, Md. E., Sultana, J., Sarker, S. A., Engstrand, L., Bardhan, P. K., Rahman, M., and Endtz, H. P.
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- 2009
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33. Pattern and magnitude of cystic artery variations among Saudis in Aseer Region: Descriptive approach.
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alhazmi, Ahmad, Karkaman, Mohammed Jalwi, Alkhathami, Awdah Abdulrahman, Korkoman, Abdulrahman Jalwi, Korkoman, Sultana J., and Korkoman, Abdullah J.
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CHOLECYSTECTOMY ,SAUDI Arabians ,ARTERIES ,MILITARY hospitals ,LAPAROSCOPIC surgery ,BLOOD vessels ,CHOLECYSTITIS ,CHOLANGITIS - Abstract
Background: Cystic artery injury is a common complication during laparoscopic cholecystectomy, which transfers laparoscopic surgery to open surgery. If surgery is performed incorrectly, injury to the extra hepatic bile duct or intra-abdominal organs is un-avoidable. The reported rate of changing to open surgery because of blood vessel injuries is approximately 0%-1.9% during laparoscopic cholecystectomy. Aim: To assess the pattern and magnitude of cystic artery variations by laparoscopy among patients undergone laparoscopic cholecystectomy in southern region, Saudi Arabia. Material and Methods: A descriptive approach was used including all patients undergone cholecystectomy procedures in Aseer Central Hospital and Military Hospital in Khamis Mushayt. Anatomic variations of the cystic artery were viewed during laparoscopic or open cholecystectomy procedures and recorded by the surgeon. The course, origin and length of the cystic artery was recorded besides patients' demographic data. Results: The study included 199-cases with ages ranged from 13 to 97 years old and mean age of 47.7 18.6 years old. Exact of 94.5% of the cases were females. As for cystic artery variation, only two cases (1%) recorded abnormality. The abnormality was more among females at middle ages. Conclusions: The study revealed that cystic artery variations recorded among Saudi patients in southern region was very rare as only 2-cases out of about 200-cases were positive for cystic artery variations. [ABSTRACT FROM AUTHOR]
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- 2022
34. Corrigendum to “Tunable localized surface plasmon graphene metasurface for multiband superabsorption and terahertz sensing” [Carbon (2020) 559–567]
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Islam, M.S., primary, Sultana, J., additional, Biabanifard, M., additional, Vafapour, Z., additional, Nine, M.J., additional, Dinovitser, A., additional, Cordeiro, C.M.B., additional, Ng, B.W.-H., additional, and Abbott, D., additional
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- 2021
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35. Knowledge and attitude towards COVID-19 in Bangladesh: Population-level estimation and a comparison of data obtained by phone and online survey methods
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Rahaman Mm, Sultana J, Akter M, Haque A, Bhuiyan Mnh, Mazid At, Usaila F, Majumder K, Sifat S, Nishat Anjum Nourin, Munia Nn, Banu T, Anwarul Karim, Aziz Tt, Orindom Shing Pulock, Mehnaz Q, Barua D, Tamanna N, Uddin Mf, Hayee S, Kuri Ak, Bhowmik M, Mitu Ma, Rashid H, Yeasmin F, Akter S, Tanvir Ahammed, GS Chuwdhury, Sharik N, and Das A
- Subjects
Estimation ,education.field_of_study ,Point (typography) ,Higher education ,business.industry ,Knowledge level ,Population ,Survey methodology ,Phone ,The Internet ,business ,education ,Psychology ,Demography - Abstract
Peoples’ adherence to the guidelines and measures suggested in fighting the ongoing COVID-19 pandemic is partly determined by the Knowledge, Attitude, and Practices (KAP) of the population. In this cross-sectional study, we primarily addressed two key issues. First, we tried to determine whether there is a significant difference in the estimated COVID-19 knowledge level from the online and phone survey methods. Second, we tried to quantify the knowledge and attitude of COVID-19 in Bangladeshi adult population. Data were collected through phone calls (April 14-23, 2020) and online survey (April 18-19, 2020) in Bangladesh. The questionnaire had 20 knowledge questions with each correct response getting one point and incorrect/don’t know response getting no point (maximum total knowledge score 20). Participants scoring >17 were categorized as having good knowledge. The percentages of good knowledge holders were 57.6%, 75.1%, and 95.8% in the phone (n=1426), online non-medical (n=1097), and online medical participants (n=382), respectively. Comparison between phone and online survey showed that, overall, online survey might overestimate knowledge level than that of phone survey, although there was no difference for elderly, poor, and rural people. Male gender, higher education, living in town/urban areas, good financial condition, and use of internet were positively associated with good knowledge. However, higher knowledge was associated with having less confidence in the final control of COVID-19. Our adult population-level estimates showed that only 32.6% (95% CI 30.1-35.2%) had good knowledge. This study provides crucial information that could be useful for the researchers and policymakers to develop effective strategies.
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- 2020
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36. Using the Multidimensional Prognostic Index (MPI) to improve cost-effectiveness of interventions in multimorbid frail older persons: results and final recommendations from the MPI_AGE European Project
- Author
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Cruz-Jentoft, A. J., Daragjati, J., Fratiglioni, L., Maggi, S., Mangoni, A. A., Mattace-Raso, F., Paccalin, M., Polidori, M. C., Topinkova, E., Ferrucci, L., Pilotto, A., Angleman, S. B., Bureau, M. -L., Brunet, T., Cella, A., Custodero, C., Custureri, R., Egberts, A., Durando, M., Ferri, A., Gallina, P., Hoffmann, D., Liuu, E., Madlova, P., Meyer, A., Michalkova, H., Miret-Corchado, C., Montero-Errasquin, B., Musacchio, C., Puntoni, M., Ruxton, K., Sabba, C., Santoni, G., Schulz, R. -J., Simonato, M., Siri, G., Sultana, J., Tap, L., Trifiro, G., Welmer, A. -K., and Internal Medicine
- Subjects
Male ,Aging ,medicine.medical_specialty ,Cost effectiveness ,Cost-Benefit Analysis ,Frail Elderly ,Population ,Psychological intervention ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Multidimensional Prognostic Index ,Risk Factors ,Health care ,Medicine ,media_common.cataloged_instance ,Humans ,030212 general & internal medicine ,Prospective Studies ,European union ,Cognitive decline ,Intensive care medicine ,education ,Comprehensive Geriatric Assessment ,Frailty ,MPI_AGE ,Multimorbidity ,Geriatric Assessment ,media_common ,Aged ,Geriatrics ,Aged, 80 and over ,education.field_of_study ,business.industry ,medicine.disease ,Prognosis ,Hospitalization ,Female ,Independent Living ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Abstract
MPI_AGE is a European Union co-funded research project aimed to use the Multidimensional Prognostic Index (MPI), a validated Comprehensive Geriatric Assessment (CGA)-based prognostic tool, to develop predictive rules that guide clinical and management decisions in older people in different European countries. A series of international studies performed in different settings have shown that the MPI is useful to predict mortality and risk of hospitalization in community-dwelling older subjects at population level. Furthermore, studies performed in older people who underwent a CGA before admission to a nursing home or receiving homecare services showed that the MPI successfully identified groups of persons who could benefit, in terms of reduced mortality, of specific therapies such as statins in diabetes mellitus and coronary artery disease, anticoagulants in atrial fibrillation and antidementia drugs in cognitive decline. A prospective trial carried out in nine hospitals in Europe and Australia demonstrated that the MPI was able to predict not only in-hospital and long-term mortality, but also institutionalization, re-hospitalization and receiving homecare services during the one-year follow-up after hospital discharge. The project also explored the association between MPI and mortality in hospitalized older patients in need of complex procedures such as transcatheter aortic valve implantation or enteral tube feeding. Evidence from these studies has prompted the MPI_AGE Investigators to formulate recommendations for healthcare providers, policy makers and the general population which may help to improve the cost-effectiveness of appropriate health care interventions for older patients.
- Published
- 2020
37. Intravitreal Anti-VEGF Drugs and Signals of Dementia and Parkinson-Like Events: Analysis of the VigiBase Database of Spontaneous Reports
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Sultana, J. (Janet), Scondotto, G. (Giulia), Cutroneo, P.M. (Paola Maria), Morgante, F. (Francesca), Trifirò, G. (Gianluca), Sultana, J. (Janet), Scondotto, G. (Giulia), Cutroneo, P.M. (Paola Maria), Morgante, F. (Francesca), and Trifirò, G. (Gianluca)
- Abstract
Introduction: Since vascular endothelial growth factor (VEGF) regulates several aspects of the central nervous system, particularly in dopaminergic neurons, VEGF inhibitors may be linked to Parkinson-like events and dementia, or variants of these diseases. Two recent case reports have found a potential link between intravitreal anti-VEGF use and Parkinson’s disease (PD) and dementia. Aim: To evaluate disproportionality in a large spontaneous reporting database concerning intravitreal anti-VEGF drugs and PD or dementia, and related conditions. Methods: Using VigiBase, individual case safety reports (ICSRs) attributed to intravitreal ranibizumab, aflibercept, pegaptanib, and bevacizumab were identified from 2010 to 2016. Within Standardised Narrow Medical Dictionary for Regulatory Activities (MedDRA®) Queries (SMQs) for “Parkinson-like events” and “Dementia,” suspected events were identified using preferred terms (PTs). The Proportional Reporting Ratio (PRR) was estimated with the lower 95% confidence intervals (CIs) for all drug-event pairs with ≥3 suspected events. The vigiGrade completeness score was reported for the ICSRs. The analyses were repeated, including only persons aged 65 and over. Results: Out of 18.9 million ICSRs, 7,945 (0.004%) concerned intravitreal anti-VEGF drugs. Of these, 27 (0.34%) were identified concerning the SMQs “Dementia” (N = 17, 62.96%) and “Parkinson-like events” (N = 10, 37.94%) in persons of all ages. Among persons age 65 and over, 4,758 (59.88% of relevant ICSRs) ICSRs were identified for anti-VEGF drugs. When restricting disproportionality analysis to persons aged 65 and over, no disproportionality was seen for any of the drug-event pairs at the level of SMQ. However, on analysing disproportionality by PT, a potential signal emerged for intravitreal ranibizumab and Parkinson’s disease [N = 6 ICSRs; PRR: 3.05 (95% CI: 1.36-6.81)]. In general, the vigiGrade completeness score was low for all the ICSRs of interest, as no ICSR had a sco
- Published
- 2020
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38. Potential effects of vaccinations on the prevention of COVID-19: rationale, clinical evidence, risks and public health considerations
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Sultana, J, Mazzaglia, G, Luxi, N, Cancellieri, A, Capuano, A, Ferrajolo, C, de Waure, C, Ferlazzo, G, Trifirò, G, Sultana, J, Mazzaglia, G, Luxi, N, Cancellieri, A, Capuano, A, Ferrajolo, C, de Waure, C, Ferlazzo, G, and Trifirò, G
- Abstract
Introduction Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), has quickly spread around the world. Areas covered This review will discuss the available immunologic and clinical evidence to support the benefit of the influenza, pneumococcal, and tuberculosis vaccines in the context of COVID-19 as well as to provide an overview on the COVID-19-specific vaccines that are in the development pipeline. In addition, implications for vaccination strategies from a public health perspective will be discussed. Expert opinion Some vaccines are being considered for their potentially beneficial role in preventing or improving the prognosis of COVID-19: influenza, pneumococcal and tuberculosis vaccines. These vaccines may have either direct effect on COVID-19 via different types of immune responses or indirect effects by reducing the burden of viral and bacterial respiratory diseases on individual patients and national healthcare system and by facilitating differential diagnoses with other viral/bacterial respiratory disease. On the other hand, a large number of candidate vaccines against SARS-CoV-2 are currently in the pipeline and undergoing phase I, II, and III clinical studies. As SARS-CoV-2 vaccines are expected to be marketed through accelerated regulatory pathways, vaccinovigilance as well as planning of a successful vaccination campaign will play a major role in protecting public health.
- Published
- 2020
39. Intravitreal Anti-VEGF Drugs and Signals of Dementia and Parkinson-Like Events: Analysis of the VigiBase Database of Spontaneous Reports
- Author
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Sultana, J, Scondotto, G, Cutroneo, PM, Morgante, F, Trifiro, Gianluca, Sultana, J, Scondotto, G, Cutroneo, PM, Morgante, F, and Trifiro, Gianluca
- Published
- 2020
40. Adoption of Climate Resilient Cropping Patterns in Southern Coastal Region of Bangladesh: Farmer’s’ Perception
- Author
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Sultana, J, primary, Ahmed, MB, primary, and Ali, MY, primary
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- 2021
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41. A High Efficiency Si-Ge Based Novel Multijunction Solar Cell
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Sultana, J., primary, Habib, M. A., additional, Sakib, S.N., additional, and Mina, M. S., additional
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- 2021
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42. Luminosity Correlations for Gamma-Ray Bursts and Implications for Their Prompt and Afterglow Emission Mechanisms
- Author
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Sultana, J, Kazanas, D, and Fukumura, K
- Subjects
Astrophysics - Abstract
We present the relation between the (z- and k-corrected) spectral lags, tau, for the standard Swift energy bands 50 - 100 keV and 100 - 200 keV and the peak isotropic luminosity, L(sub iso) (a relation reported first by Norris et al.), for a subset of 12 long Swift GRBs taken from a recent study of this relation by Ukwatta et al. The chosen GRBs are also a subset of the Dainotti et al. sample, a set of Swift GRBs of known redshift, employed in establishing a relation between the (GRB frame) luminosity, L(sub x), of the shallow (or constant) flux portion of the typical XRT GRB-afterglow light curve and the (GRB frame) time of transition to the normal decay rate, T(sub brk). We also present the L(sub x) - T(sub brk) relation using only the bursts common in the two samples. The two relations exhibit a significant degree of correlation (rho = -0.65 for the L(sub iso) - tao and rho = -0.88 for the L(sub x) -T(sub brk) relation) and have surprisingly similar best-fit power law indices (-1.19 +/- 0.17 for L(sub iso) - tau and -1.10 +/- 0.03 for L(sub x) - T(sub brk)). Even more surprisingly, we noted that although tau and T(sub brk) represent different GRB time variables, it appears that the first relation (L(sub iso) - tao) extrapolates into the second one for timescales tau similar to T(sub brk) This fact suggests that these two relations have a common origin, which we conjecture to be kinematic. This relation adds to the recently discovered relations between properties of the prompt and afterglow GRB phases, indicating a much more intimate relation between these two phases than hitherto considered.
- Published
- 2013
43. Beyond the budget silo approach: estimating health system sustainability for future dementia drugs
- Author
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Gozzo, L., primary, Benfatto, G., additional, Giorgianni, F., additional, Sultana, J., additional, Rossi, E., additional, Longo, L., additional, Mansueto, S., additional, Vitale, D.C., additional, Savoca, C., additional, Caraci, F., additional, De Rosa, M., additional, Trifiro, G., additional, and Drago, F., additional
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- 2020
- Full Text
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44. What can real world evidence contribute to regulatory science in pre and post marketing setting?
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Martini, N., primary, Sultana, J., additional, Addis, ., additional, Braga, M., additional, Corrao, G., additional, Campomori, A., additional, Capuano, A., additional, Gini, R., additional, Mazzaglia, G., additional, Patarnello, F., additional, Petrini, C., additional, Pierini, A., additional, Pippo, L., additional, Popoli, P., additional, Russo, P., additional, Scondotto, G., additional, and Trifirò, G., additional
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- 2020
- Full Text
- View/download PDF
45. Unsuspected Paraganglioma—Infratemporal Fossa
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Sultana J, Nikhat, additional, Gurrala, Shekhar R., additional, Kommula, Lakshman K., additional, and Boola, Gnana R., additional
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- 2020
- Full Text
- View/download PDF
46. Climate Change Impact on Agriculture and Related Sustainable Land Management Practices in Bangladesh – A Review
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Hossain, M. A., primary, Amin, M. N., primary, Sultana, J., primary, and Siddique, M. N. A., primary
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- 2020
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- View/download PDF
47. Adherence of Elderly Patients with Cardiovascular Disease to Statins and the Risk of Exacerbation of Chronic Obstructive Pulmonary Disease: Evidence from an Italian Real-World Investigation
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Rea, F, Calusi, G, Franchi, M, Vetrano, Dl, Roberto, G, Bonassi, S, Kirchmayer, U, Chinellato, A, Bettiol, A, Sultana, J, Mugelli, A, Corrao, G, Agabiti, N, Bartolini, C, Bernabei, Rita, Caputi, Ap, Cascini, S, Cipriani, F, Davoli, M, Fini, M, Gini, R, Giorgianni, F, Lapi, F, Lombardi, N, Lucenteforte, E, Onder, G, Sorge, C, Tari, M, Trifirò, G, Vannacci, A, Vitale, C., Rea, F, Calusi, G, Franchi, M, Vetrano, D, Borloni, R, Bonassi, S, Kirchmayer, U, Chinellato, A, Bettiol, A, Sultana, J, Mugelli, A, Corrao, G, Agabiti, N, Bartolini, C, Bernabei, R, Caputi, A, Cascini, S, Cipriani, F, Davoli, M, Fini, M, Gini, R, Giorgianni, F, Lapi, F, Lombardi, N, Lucenteforte, E, Onder, G, Sorge, C, Tari, M, Trifirò, G, Vannacci, A, and Vitale, C
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Male ,medicine.medical_specialty ,Exacerbation ,Disease ,Lower risk ,Medication Adherence ,Geriatrics and Gerontology ,Pharmacology (medical) ,Cohort Studies ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Internal medicine ,Medicine ,Humans ,030212 general & internal medicine ,Aged ,Aged, 80 and over ,Cardiovascular Diseases ,Female ,Hospitalization ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Italy ,Proportional Hazards Models ,business.industry ,Proportional hazards model ,Hazard ratio ,Confidence interval ,030228 respiratory system ,Cohort ,business ,Cohort study - Abstract
Objective: The objective of this study was to investigate the relationship between adherence to statin therapy and the risk of exacerbation among elderly individuals affected by chronic obstructive pulmonary disease and cardiovascular disease. Methods: Using the healthcare utilisation databases of five Italian territorial units accounting for nearly 35% of the Italian population, we recruited a cohort of 6263 elderly persons (i.e. aged 65 years or older) with co-existing chronic obstructive pulmonary disease and cardiovascular disease who initiated statin therapy. Exposure was adherence to statins measured by the proportion of days of follow-up covered. Outcome was the first hospital admission for chronic obstructive pulmonary disease occurring in the period of observation. A proportional hazards model was used to estimate the hazard ratio and 95% confidence intervals for the exposure–outcome association, after adjusting for several covariates. A set of sensitivity analyses was performed to account for sources of systematic uncertainty. Results: During an average follow-up of about 4 years, 1307 cohort members experienced the outcome. Compared with patients with low adherence (proportion of days of follow-up covered ≤ 40%), those with intermediate (proportion of days of follow-up covered 41–80%) and high (proportion of days of follow-up covered > 80%) adherence exhibited a lower risk of exacerbation of 16% (95% confidence interval 3–27) and 23% (95% confidence interval 10–34). Conclusions: In a real-world setting, we observed evidence that adherence to statin therapy markedly reduced the risk of chronic obstructive pulmonary disease exacerbations in elderly patients with co-existing chronic obstructive pulmonary disease and cardiovascular disease. Given the limited and controversial evidence from trials, more randomised controlled trials are urgently needed to better examine the potential benefits of statins as adjunct therapy in chronic obstructive pulmonary disease.
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- 2018
48. Adherence to Antidepressants and Mortality in Elderly Patients with Cardiovascular Disease
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Biffi, A, Scotti, L, Rea, F, Lucenteforte, E, Chinellato, A, Vetrano, Dl, Vitale, C, Agabiti, N, Sultana, J, Roberto, G, Mugelli, A, G Agabiti N, Corrao, Bartolini, C, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, Ap, Cascini, S, Cipriani, F, Corrao, G, Davoli, M, Fini, M, Gini, R, Giorgianni, F, Kirchmayer, U, Lapi, F, Lombardi, N, Onder, G, Sorge, C, Tari, M, Trifirò, G, Vannacci, A, Vitale, C., Biffi, A, Scotti, L, Rea, F, Lucenteforte, E, Chinellato, A, Vetrano, D, Vitale, C, Agabiti, N, Sultana, J, Roberto, G, Mugelli, A, and Corrao, G
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Male ,medicine.medical_specialty ,Databases, Factual ,MEDLINE ,Antidepressant ,Disease ,030204 cardiovascular system & hematology ,Medication Adherence ,Cohort Studies ,03 medical and health sciences ,Databases ,0302 clinical medicine ,Pharmacotherapy ,Internal medicine ,80 and over ,Medicine ,Humans ,Pharmacology (medical) ,030212 general & internal medicine ,Medical prescription ,Mortality ,Factual ,Antihypertensive Agents ,Aged ,Aged, 80 and over ,Antidepressive Agents ,Cardiovascular Diseases ,Female ,Follow-Up Studies ,Italy ,business.industry ,Proportional hazards model ,General Medicine ,Cardiovascular disease ,Adherence ,Cohort ,business ,Cohort study - Abstract
Background and Objective: Conflicting findings from studies evaluating the association between use of antidepressant drugs and mortality have been reported. We tested the hypothesis that better adherence to antidepressant therapy may reduce mortality. Methods: The cohort included 29,845 individuals aged ≥ 65 years from several Italian health units who were newly treated with antidepressant drugs after hospital discharge with a diagnosis for cardiovascular disease during 2008–2010. These individuals were observed from the first prescription until the end of data availability (i.e. 2012–2014, depending on the local database). During this period, information on (1) prescription of antidepressants and other medications and (2) death from any cause (outcome) was recorded. Proportional hazards models were fitted to estimate the association between better adherence to antidepressants (defined as proportion of days covered ≥ 75%) and outcome, by adjusting and stratifying for several covariates. Results: Patients with better adherence to antidepressants had a reduced mortality of 9% (95% CI 3–14). Patients who did not use other medicaments during follow-up had reduced mortality associated with better adherence to antidepressants of 21% (− 1–38), 14% (7–20), 20% (13–26) and 13% (7–19) for no users of antihypertensive agents, lipid-lowering agents, other cardiovascular drugs and antidiabetics, respectively. Conclusions: Better adherence to antidepressants is associated with reduced all-cause mortality, mainly in patients who did not use other pharmacological treatments. Behavioural changes to enhance adherence among the elderly with cardiovascular disease might offer important benefits in reducing their mortality.
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- 2018
49. Unsuspected Paraganglioma—Infratemporal Fossa
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Lakshman K. Kommula, Shekhar R. Gurrala, Gnana R. Boola, and Nikhat Sultana J
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Tachycardia ,medicine.medical_specialty ,Carotid arteries ,Anesthetic management ,infratemporal fossa ,Critical Care and Intensive Care Medicine ,Paraganglioma ,Anesthesiology ,Medicine ,RD78.3-87.3 ,biology ,business.industry ,Infratemporal fossa ,Syncope (genus) ,medicine.disease ,biology.organism_classification ,undiagnosed catecholamine secreting tumor ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Histopathology ,Neurology (clinical) ,Radiology ,medicine.symptom ,business ,paraganglionoma ,Hemodynamic instability - Abstract
Paraganglioma of the infratemporal fossa is exceedingly rare, with no more than a handful of documented cases. Undiagnosed paraganglioma poses a great challenge. We present a 39-year-old hypertensive female, who presented with giddiness and headache for 3 months and four episodes of syncope over 3 months. CT and MRI revealed an enhancing infratemporal region space-occupying mass close proximity to petrous carotid artery. Intraoperatively, the patient had hemodynamic instability (tachycardia and hypertension) when the mass was surgically manipulated. Diagnosis of paraganglioma was suspected, based on hemodynamic instability, which was later confirmed by histopathology. Undiagnosed paraganglioma pose a great challenge to the anesthetic management. Low-threshold of suspicion has to be there to avoid significant morbidity and mortality.
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- 2020
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50. Global epidemiology of Duchenne muscular dystrophy: an updated systematic review and meta-analysis
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Crisafulli, S., Sultana, J., Fontana, A., Salvo, F., Messina, S., Trifiro, G., Universita degli Studi di Messina, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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0301 basic medicine ,Male ,Duchenne muscular dystrophy ,medicine.medical_specialty ,Funnel plot ,Epidemiology ,Population ,lcsh:Medicine ,Review ,Strengthening the reporting of observational studies in epidemiology ,03 medical and health sciences ,0302 clinical medicine ,Rare Diseases ,Prevalence ,Medicine ,Humans ,Pharmacology (medical) ,education ,Genetics (clinical) ,Birth prevalence ,PharmacoEpi-Drugs ,education.field_of_study ,030102 biochemistry & molecular biology ,business.industry ,Incidence (epidemiology) ,Incidence ,lcsh:R ,General Medicine ,Publication bias ,Metaanalysis ,3. Good health ,Muscular Dystrophy, Duchenne ,Meta-analysis ,Systematic review ,Observational study ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,030217 neurology & neurosurgery ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Demography - Abstract
Background Duchenne Muscular Dystrophy (DMD) is a rare disorder caused by mutations in the dystrophin gene. A recent systematic review and meta-analysis of global DMD epidemiology is not available. This study aimed to estimate the global overall and birth prevalence of DMD through an updated systematic review of the literature. Methods MEDLINE and EMBASE databases were searched for original research articles on the epidemiology of DMD from inception until 1st October 2019. Studies were included if they were original observational research articles written in English, reporting DMD prevalence and/or incidence along with the number of individuals of the underlying population. The quality of the studies was assessed using a STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) checklist adapted for observational studies on rare diseases. To derive the pooled epidemiological prevalence estimates, a meta-analysis was performed using random-effects logistic models for overall and birth prevalence and within two different underlying populations (i.e. all individuals and in males only), separately. Heterogeneity was assessed using Cochran’s Q-test along with its derived measure of inconsistency I2. Results A total of 44 studies reporting the global epidemiology of DMD were included in the systematic review and only 40 were included in the meta-analysis. The pooled global DMD prevalence was 7.1 cases (95% CI: 5.0–10.1) per 100,000 males and 2.8 cases (95% CI: 1.6–4.6) per 100,000 in the general population, while the pooled global DMD birth prevalence was 19.8 (95% CI:16.6–23.6) per 100,000 live male births. A very high between-study heterogeneity was found for each epidemiological outcome and for all underlying populations (I2 > 90%). The test for funnel plot asymmetry suggested the absence of publication bias. Of the 44 studies included in this systematic review, 36 (81.8%) were assessed as being of medium and 8 (18.2%) of low quality, while no study was assessed as being of high quality. Conclusions Generating epidemiological evidence on DMD is fundamental to support public health decision-making. The high heterogeneity and the lack of high quality studies highlights the need to conduct better quality studies on rare diseases.
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- 2019
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