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Objective: This research investigated the possible shielding properties of BB (Berberrubine) against the harmful auditory effects of cisplatin, preliminarily delving into the underlying mechanisms responsible for this protection. Methods: HEI-OC1 cell viability was determined using a Cell Counting Kit-8 (CCK-8). The impact of BB on cochlear hair cells was studied through in vitro cochlear explants culture. Apoptosis levels were measured through Annexin V-PI, Cleaved Caspase-3, and TUNEL staining. The level of ROS (reactive oxygen species) was measured through the application of DCFH-DA, MitoSOX, and JC-1 fluorescent dyes for staining. Immunofluorescence analysis of cochlear samples from mice was conducted to quantify the hair cell count, and concurrently, ABR (Auditory Brainstem Response) testing was utilized to evaluate auditory function. The mechanism of action of BB was explored using RNA-Seq and qRT-PCR analysis. Results: BB significantly improved cell survival rates under cisplatin treatment, reduced levels of apoptotic markers (TUNEL, Cleaved Caspase-3, Annexin V-PI), decreased ROS and MitoSOX levels, and improved JC-1 signals in both HEI-OC1 cells and cochlear hair cells in cochlear explants culture. Animal studies demonstrated that treatment with BB enhanced the survival of cochlear hair cells, reduced hearing impairment caused by cisplatin in mice. RNA-seq and qRT-PCR analysis revealed that BB influenced the expression levels of multiple genes (Ccnd2, Reln, Pgf, Mylk3, Ppplr12c, Thbsl), by promoting folate biosynthesis for hearing protection. Conclusion: Our findings suggest that BB protects against cisplatin-induced hearing damage by enhancing folate biosynthesis, decreasing intracellular ROS levels, and inhibiting apoptosis. [ABSTRACT FROM AUTHOR]

This article constructs the measurement index of core competence by text analysis method and empirically tests its impact on the cost of debt. We find that the stronger the core competence, the lower the cost of debt. The mechanism test shows that the impact of core competence on the cost of debt is mainly realized by reducing the default risk and alleviating the agency problem. In further research, after distinguishing the types of core competence, we find that core competence of resources, especially the tangible resources, is the key factor to effectively reduce the cost of debt; after distinguishing the nature of property rights, we find that the impact of core competence on the cost of debt mainly plays a role in non-state-owned enterprises with strong financing constraints. This article not only enriches the literature on the economic consequences of core competence and factors affecting the cost of debt, but also provides scientific support for the government and other relevant department to alleviate the problem of financing difficulties and financing expensive. [ABSTRACT FROM AUTHOR]

Objective: The aim of this meta-analysis is to compare the surgical results of endoscopic dacryocystorhinostomy (Endo-DCR) for chronic dacryocystitis (CD) with and without intraoperative hyaluronic acid (HA) application. Methods: An electronic literature search was performed using the PubMed, Embase, Cochrane Library, CNKI, and Wan Fang databases in April 1, 2022. Review Manager software version 5.4 was used for data synthesis and a forest plot was generated for each outcome measure. Results: Seven randomized control trials (RCTs), which involved 739 eyes, were included in this meta-analysis. Overall, compared with the control group, intraoperative HA application significantly enhance the success rate (odds ratio [OR] = 3.27, 95% confidence interval [CI]: 2.15–4.98, P <.00001), promote re-epithelization (OR = 2.93, 95% CI: 1.83–4.68, P <.00001), reduce granulation (OR = 0.41, 95% CI: 0.21–0.80, P =.008), and scar (OR = 0.39, 95% CI: 0.22–0.68, P =.001) formation after Endo-DCR. Conclusion: Intraoperative HA application seems to be a useful adjuvant that could enhance success rate by promoting re-epithelization and inhabiting granulation and scar formation around the ostium. [ABSTRACT FROM AUTHOR]

To date, no specific biomarkers for idiopathic sudden sensorineural hearing loss (ISSHL) have been used. The aim of this study is to investigate whether prestin, the motor protein of cochlear outer hair cells, could be used as a biomarker candidate for the diagnosis and prognosis judgement of ISSHL. Blood samples of 14 ISSHL patients and 28 control patients without history of hearing loss were collected. Plasma prestin concentration was measured using Human Prestin (SLC26A5) ELISA Kit. The results showed that prestin was detectable in the plasma of all patients and the concentration of prestin was significantly higher in ISSHL patients with about half being above the average range of control patients. Moreover, in treatment responsive group, 6 of 10 patients had decreased prestin levels after treatment compared to those of before treatment, while the prestin levels of all the 4 patients in treatment unresponsive group increased in varying degrees. Our promising preliminary results suggest that prestin has the potential to serve as a biomarker to assist diagnosis and judge response to pharmacological treatments. [ABSTRACT FROM AUTHOR]

Objective The purposes of this study were to verify the effectiveness of the narrow band imaging (NBI) system in diagnosing nasopharyngeal cancer (NPC) as compared with white light endoscopy. Data Sources PubMed, Cochrane Library, EMBASE, CNKI, and Wan Fang databases. Review Methods Data analyses were performed with Meta-Disc. The updated Quality Assessment of Diagnostic Accuracy Studies-2 tool was used to assess study quality and potential bias. Publication bias was assessed with a Deeks asymmetry test. The registry number of the protocol published on PROSPERO is CRD42015026244. Results This meta-analysis included 10 studies of 1337 lesions. For NBI diagnosis of NPC, the pooled values were as follows: sensitivity, 0.83 (95% CI, 0.80-0.86); specificity, 0.91 (95% CI, 0.89-0.93); positive likelihood ratio, 8.82 (95% CI, 5.12-15.21); negative likelihood ratio, 0.18 (95% CI, 0.12-0.27); and diagnostic odds ratio, 65.73 (95% CI, 36.74-117.60). The area under the curve was 0.9549. For white light endoscopy in diagnosing NPC, the pooled values were as follows: sensitivity, 0.79 (95% CI, 0.75-0.83); specificity, 0.87 (95% CI, 0.84-0.90); positive likelihood ratio, 5.02 (95% CI, 1.99-12.65); negative likelihood ratio, 0.34 (95% CI, 0.24-0.49); and diagnostic odds ratio, 16.89 (95% CI, 5.98-47.66). The area under the curve was 0.8627. The evaluation of heterogeneity, calculated per the diagnostic odds ratio, gave an I2 of 0.326. No marked publication bias ( P = .68) existed in this meta-analysis. Conclusion The sensitivity and specificity of NBI for the diagnosis of NPC are similar to those of white light endoscopy, and the potential value of NBI for the diagnosis of NPC needs to be validated further. [ABSTRACT FROM AUTHOR]

For Certain applications, in this paper, studied a constant temperature control system of microwave oven on the base of analyzing the principle and method of microwave power regulation, desiyned the overall schematic diagram and the hardware structure diagram of the system. [ABSTRACT FROM AUTHOR]

This thesis mainly study the application of the fuzzy neural network based on the genetic algorithm to the position control system of some type of surface mounting machine. The structure of the fuzzy neural network, the optimization process of the network structure and the membership function by the genetic algorithm are detailed to introduce by a instance. By the simulation results it is explicitly shown the excellent performance of the fuzzy neural network and the powerful advantage of the genetic algorithm in the multi-objective optimization. [ABSTRACT FROM AUTHOR]

Propese a real-time workflow time modeling and verification method based on timed automata. First, trans-form timed workflow digrams to timed automata model, and then verify the time constrains via using the mechanism of timed automata. [ABSTRACT FROM AUTHOR]

this paper introduced a project design of TPMS,The main content is about the system's makeup, working principles ,the hardware Structure diagram, and the program flow chart. [ABSTRACT FROM AUTHOR]