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Your search keyword '"Sun, Heung-Suk"' showing total 8 results
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8 results on '"Sun, Heung-Suk"'

7. Possible Pathophysiological Role of Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Metastatic Brain Tumor-associated Intracerebral Hemorrhage

Author

Jung, Shin, primary, Moon, Kyung-Sub, additional, Jung, Tae-Young, additional, Kim, In-Young, additional, Lee, Young-Hwa, additional, Rhu, Hyang-Hwa, additional, Sun, Heung-Suk, additional, Jeong, Young-Il, additional, Kim, Kyung-Keun, additional, and Kang, Sam-Suk, additional

Published
2005
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8. Expression of Nm23 in gliomas and its effect on migration and invasion in vitro.

Author

Jung S, Paek YW, Moon KS, Wee SC, Ryu HH, Jeong YI, Sun HS, Jin YH, Kim KK, and Ahn KY

Subjects
Astrocytoma metabolism, Brain Neoplasms metabolism, Cell Growth Processes physiology, Cell Line, Tumor, Gene Expression, Green Fluorescent Proteins biosynthesis, Green Fluorescent Proteins genetics, Green Fluorescent Proteins isolation & purification, Humans, NM23 Nucleoside Diphosphate Kinases, Neoplasm Invasiveness, Nucleoside-Diphosphate Kinase biosynthesis, Transfection, Astrocytoma genetics, Astrocytoma pathology, Brain Neoplasms genetics, Brain Neoplasms pathology, Cell Movement genetics, Nucleoside-Diphosphate Kinase genetics
Abstract

Background: Despite the well-documented importance of Nm23 in the control of metastasis, there is currently a paucity of data regarding the role of this gene family in the control of glioma invasion., Materials and Methods: Nm23-H1 expression in gliomas was assessed via immunohistochemistry, Western blot, RT-PCR and Northern blot analyses. The migration and invasion ability were also investigated in primary glioma culture cells, human glioma cell lines and nm23-H1 transfectant, using an in vitro brain slice invasion model and a simple scratch technique., Results: Although no significant correlations were detected between nm23-H1 expression and pathological grade, the endogenous nm23-H1 expression in gliomas was found to be inversely correlated with their migratory abilities. Additionally, the nm23-H1 transfectant resulted in a reduction of approximately 45% of the migratory ability and suppressed the invasiveness of the parental cell line., Conclusion: Our overall findings suggest that nm23-H1 may play an important role in the suppression of glioma invasion and migration.

Published
2006

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