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Electrochemical research often requires stringent combinations of experimental parameters that are demanding to manually locate. Recent advances in automated instrumentation and machine-learning algorithms unlock the possibility for accelerated studies of electrochemical fundamentals via high-throughput, online decision-making. Here we report an autonomous electrochemical platform that implements an adaptive, closed-loop workflow for mechanistic investigation of molecular electrochemistry. As a proof-of-concept, this platform autonomously identifies and investigates an EC mechanism, an interfacial electron transfer (E step) followed by a solution reaction (C step), for cobalt tetraphenylporphyrin exposed to a library of organohalide electrophiles. The generally applicable workflow accurately discerns the EC mechanisms presence amid negative controls and outliers, adaptively designs desired experimental conditions, and quantitatively extracts kinetic information of the C step spanning over 7 orders of magnitude, from which mechanistic insights into oxidative addition pathways are gained. This work opens opportunities for autonomous mechanistic discoveries in self-driving electrochemistry laboratories without manual intervention.

Integrating light-harvesting materials with microbial biochemistry is a viable approach to produce chemicals with high efficiency from the air, water, and sunlight. Yet it remains unclear whether all absorbed photons in the materials can be transferred through the material-biology interface for solar-to-chemical production and whether the presence of materials beneficially affect the microbial metabolism. Here we report a microbe-semiconductor hybrid by interfacing CO2/N2-fixing bacterium Xanthobacter autotrophicus with CdTe quantum dots for light-driven CO2 and N2 fixation with internal quantum efficiencies of 47.2 ± 7.3% and 7.1 ± 1.1%, respectively, reaching the biochemical limits of 46.1% and 6.9% imposed by the stoichiometry in biochemical pathways. Photophysical studies suggest fast charge-transfer kinetics at the microbe-semiconductor interfaces, while proteomics and metabolomics indicate a material-induced regulation of microbial metabolism favoring higher quantum efficiencies compared to the biological counterparts alone.

AIM: To investigate the effect of adalimumab combined with dexamethasone intravitreal implant in the treatment of refractory non-infectious uveitis macular edema(UME).METHODS: A total of 92 cases(131 eyes)of refractory non-infectious UME patients admitted to our hospital from January 2020 to January 2022 were selected and randomly divided into control group, with 46 cases(63 eyes)treated with dexamethasone intravitreal implant and observation group, with 46 cases(68 eyes)treated with adalimumab subcutaneous injection combined with dexamethasone intravitreal implant. The best corrected visual acuity(BCVA), central retinal thickness(CRT), vitreous opacity and Th17/Treg cytokines were measured before and after treatment, and the occurrence of adverse reactions was recorded.RESULTS: Totally 3 cases(4 eyes)were lost to follow-up. After treatment for 1, 3, 6 and 12 mo, BCVA was improved in both groups compared with that before treatment, and CRT, vitreous opacity score, serum interleukin(IL)-17 and IL-22 levels were decreased compared with those before treatment, and serum transforming growth factor-β(TGF-β)and IL-10 levels were increased compared with those before treatment. BCVA in the observation group was better than that in the control group, and CRT, vitreous opacity score, serum IL-17 and IL-22 levels were lower than those in the control group, and serum TGF-β and IL-10 levels were higher than those in the control group(all P

As the core of Traditional Chinese Medicine (TCM) nursing, TCM nursing technology is a unique set of techniques and methods different from modern nursing. On the basis of long-term clinical practice, nursing methods by TCM syndrome differentiation and the appropriate technology with TCM characteristics has been summed up from theory to practice, especially the pivotal role of appropriate TCM technology in diagnosis, treatment and nursing. The training of TCM nursing talents is the foundation, the level of specialization is the key, and the management mechanism is the guarantee to the standardization of TCM nursing technology. This article summarizes the effective means to improve the TCM nursing technology, in order to provide reference for the standardization and promotion of TCM nursing technology. (中医护理操作技术是中医护理的核心, 是一套不同于现代护理操作的独特技术与方法。中医临床护理通过长期实践, 总结出了从理论到实践的辨证施护方法和中医特色适宜技术, 尤其是中医特色适宜技术在诊疗护理方面起着举足轻重的作用。中医护理人才培养是基础, 专业化水平是关键, 管理机制是保障。本文通过总结提升中医护理技术的有效手段, 以便为中医护理技术的规范与推广提供参考。)

旨在为炸制鱼饼中晚期糖基化终末产物（AGEs）含量的控制提供理论依据和参考，以冷冻鲢鱼糜为原料制作鱼饼，通过分析连续炸制过程中（每3 h炸制1次）鱼饼中AGEs的生成与其理化指标和油脂氧化程度之间的相关性，探讨炸制过程中油脂氧化对鱼饼中AGEs生成的影响。结果表明：鱼饼外层AGEs含量显著高于内层，炸制9~18 h，鱼饼AGEs含量显著高于其他阶段（p

Supramolecular chemistry during the synthesis of carbon-nitrogen-based materials has recently experienced a renaissance in the arena of photocatalysis and electrocatalysis. In this review, we start with the discussion of supramolecular assemblies-derived carbon-nitrogen-based materials’ regulation from the aspect of morphology, chemical composition, and micro/nanostructural control. Afterwards the recent advances of these materials in energy and environment related applications, including degradation of pollutants, water splitting, oxygen reduction reactions, CO2 reduction reactions along with organic synthesis are summarized. The correlations between the structural features and physicochemical properties of the carbon-nitrogen-based materials and the specific catalytic activity are discussed in depth. By highlighting the opportunities and challenges of supramolecular assembly strategies, we attempt an outlook on possible future developments for highly efficient carbon-based photo/electrocatalysts.