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33 results on '"Sun, L. R."'

3. Cerebral Digital Subtraction Angiography in Acute Intracranial Hemorrhage: Considerations in Critically Ill Children.

Author

Harrar, D. B., Sun, L. R., Goss, M., and Pearl, M. S.

Subjects
*CRITICALLY ill children, *DIGITAL subtraction angiography, *INTRACRANIAL hemorrhage, *ARTERIOVENOUS malformation, *CEREBROVASCULAR disease, *CEREBRAL vasospasm, *CEREBRAL arteriovenous malformations
Abstract

Cerebrovascular disorders are an important cause of morbidity and mortality in children. Although minimally invasive, cerebral digital subtraction angiography (DSA) has been shown to be safe in children and is a valuable, and perhaps underutilized, technique for the diagnosis and management of pediatric cerebrovascular disorders in the critical care setting. Through a case-based approach, we explore the utility of DSA in critically ill children with acute intracranial hemorrhage (ICH). We discuss the use of DSA in the acute management of aneurysm and arteriovenous malformation rupture as well as cerebral vasospasm. Those caring for critically ill children with acute ICH should consider cerebral DSA as part of a comprehensive approach to the diagnosis and management of these conditions. [ABSTRACT FROM AUTHOR]

Published
2022
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6. Describing the quality of life of boys with haemophilia in China: Results of a multicentre study using the CHO-KLAT

Author

Tang, L., primary, Xu, W., additional, Li, C. G., additional, Hou, F., additional, Feng, X. Q., additional, Wang, H., additional, Li, X. J., additional, Li, W. L., additional, Liu, J. P., additional, Sun, L. R., additional, Wang, S. H., additional, Jin, J., additional, Fang, Q., additional, Luke, K. H., additional, Poon, M. C., additional, Blanchette, V. S., additional, Usuba, K., additional, Young, N. L., additional, and Wu, R., additional

Published
2017
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7. Performance of the RPCs for the ARGO detector operated at the YangBaJing laboratory (4300m a.s.l.)

Author

Bacci, C., Bao, K. Z., Barone, Fabrizio, Bartoli, B., Bastieri, D., Bernardini, P., Buonomo, R., Bussino, S., Calloni, E., Cao, B. Y., Cardarelli, R., Catalanotti, S., Cavaliere, A., Cesaroni, F., Creti, P., Danzengluobu, D'Ettorre Piazzoli, B., De Vincenzi, M., Di Girolamo, T., Di Sciascio, G., Feng, Z. Y., Fu, Y., Gao, X. Y., Geng, Q. X., Guo, H. W., H. H., He, He, M., Huang, Q., Iacovacci, M., Iucci, N., Jai, H. Y., Kong, F. M., Kuang, H. H., Labaciren, Li, B., J. Y., Li, Liu, Z. Q., Lu, H., X. H., Ma, Mancarella, G., Mari, S. M., Marsella, G., Martello, D., Mei, D. M., Meng, X. R., Milano, L., Morselli, A., Mu, J., Oliviero, M., Padovani, P., Panareo, M., Parisi, M., Pellizzoni, G., Peng, Z. R., Pistilli, P., Santonico, R., Sartori, G., Sbarra, C., Severino, G., Shen, P. R., Sparvoli, R., Stanescu, C., Su, J., Sun, L. R., Sun, S. C., Surdo, A., Tan, Y. H., Vernetto, S., Vietri, M., Wang, C. R., Wang, H., Wang, H. Y., Wei, Y. N., Yang, H. T., Yao, Q. K., G. C., Yu, Yue, X. D., Yuan, A. F., Zhang, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., Zhaxisangzhu, Zhaxiciren, Zhu, Q. Q., Bacci, C, Bao, Kz, Barone, F, Bartoli, B, Bernardini, P, Bussino, Severino Angelo Maria, Calloni, E, Cao, By, Cardarelli, R, Catalanotti, S, Cavaliere, S, Cesaroni, F, Creti, P, Danzengluobu, Piazzoli, Bd, De Vincenzi, M, Di Girolamo, T, Di Sciascio, G, Feng, Zy, Fu, Y, Gao, Xy, Geng, Qx, Guo, Hw, He, Hh, He, M, Huang, Q, Iacovacci, M, Iucci, N, Jai, Hy, Jing, Cl, Kong, Fm, Kuang, Hh, Labaciren, Li, B, Li, Jy, Liu, Zq, Lu, H, Ma, Xh, Mancarella, G, Mari, Stefano Maria, Marsella, G, Martello, D, Meng, Xr, Milano, L, Mu, J, Panareo, M, Peng, Zr, Pistilli, P, Saggese, L, Santonico, R, Shen, Pr, Stanescu, C, Sun, Lr, Sun, Sc, Surdo, A, Tan, Yh, Vernetto, S, Wang, Cr, Wang, H, Wang, Hy, Wei, Yn, Yang, Ht, Yao, Q, Yu, Gc, Yue, Xd, Yuan, Af, Zha, M, Zhang, Hm, Zhang, Jl, Zhang, Nj, Zhang, Xy, Zhaxisangzhu, Zhaxiciren, Zhu, Qq, C., Bacci, K. Z., Bao, F., Barone, Bartoli, Bruno, P., Bernardini, S., Bussino, Calloni, Enrico, B. Y., Cao, R., Cardarelli, Catalanotti, Sergio, S., Cavaliere, F., Cesaroni, P., Creti, D'ETTORRE PIAZZOLI, Benedetto, M. D., Vincenzi, DI GIROLAMO, Tristano, G. D., Sciascio, Z. Y., Feng, Y., Fu, X. Y., Gao, Q. X., Geng, H. W., Guo, H. H., He, M., He, Q., Huang, Iacovacci, Michele, N., Iucci, H. Y., Jai, C. L., Jing, F. M., Kong, H. H., Kuang, B., Li, J. Y., Li, Z. Q., Liu, H., Lu, X. H., Ma, G., Mancarella, S. M., Mari, G., Marsella, D., Martello, X. R., Meng, L., Milano, J., Mu, M., Panareo, Z. R., Peng, P., Pistilli, L., Saggese, R., Santonico, P. R., Shen, C., Stanescu, L. R., Sun, S. C., Sun, A., Surdo, Y. H., Tan, S., Vernetto, C. R., Wang, H., Wang, H. Y., Wang, Y. N., Wei, H. T., Yang, Q., Yao, G. C., Yu, X. D., Yue, A. F., Yuan, M., Zha, H. M., Zhang, J. L., Zhang, N. J., Zhang, X. Y., Zhang, Q. Q., Zhu, B., Bartoli, Bernardini, Paolo, E., Calloni, S., Catalanotti, B., D'ETTORRE PIAZZOLI, M., DE VINCENZI, T., DI GIROLAMO, G., DI SCIASCIO, M., Iacovacci, Mancarella, Giovanni, Marsella, Giovanni, Martello, Daniele, Panareo, Marco, and Q. K., Yao

Subjects
Physics, Nuclear and High Energy Physics, Gamma-ray Astronomy, Extensive air showers, RPCs, Gamma-ray astronomy, Detector, Astronomy, Extensive Air Shower, Time resolution, ARGO-YBJ experiment, chemistry.chemical_compound, chemistry, Operating temperature, Bakelite, Instrumentation, Argo, Counting rate, Remote sensing
Abstract

Bakelite RPCs, assembled according to the ARGO design, have been operated in the high altitude Laboratory of YBJ using dedicated electronics to pick-up the streamer signal. Here we report on the results concerning absorbed current, single counting rate, efficiency and time resolution. Environmental data concerning the operating temperature inside the ARGO experimental hall are also reported. (C) 2003 Elsevier Science B.V. All rights reserved.

Published
2003

10. Results of the ARGO-YBJ test experiment

Author

Bacci, C., Bao, K. Z., Barone, Fabrizio, Bartoli, B., Bastieri, D., Bernardini, P., Buonomo, R., Bussino, S., Calloni, E., Cao, B. Y., Cardarelli, R., Catalanotti, S., Cavaliere, A., Cesaroni, F., Creti, P., Danzengluobu, D'Ettorre Piazzoli, B., De Vincenzi, M., Di Girolamo, T., Di Sciascio, G., Feng, Z. Y., Fu, Y., Gao, X. Y., Geng, Q. X., Guo, H. W., H. H., He, He, M., Huang, Q., Iacovacci, M., Iucci, N., Jai, H. Y., Kong, F. M., Kuang, H. H., Labaciren, Li, B., J. Y., Li, Liu, Z. Q., Lu, H., X. H., Ma, Mancarella, G., Mari, S. M., Marsella, G., Martello, D., Mei, D. M., Meng, X. R., Milano, L., Morselli, A., Mu, J., Oliviero, M., Padovani, P., Panareo, M., Parisi, M., Pellizzoni, G., Peng, Z. R., Pistilli, P., Santonico, R., Sartori, G., Sbarra, C., Severino, G., Shen, P. R., Sparvoli, R., Stanescu, C., Su, J., Sun, L. R., Sun, S. C., Surdo, A., Tan, Y. H., Vernetto, S., Vietri, M., Wang, C. R., Wang, H., Wang, H. Y., Wei, Y. N., Yang, H. T., Yao, Q. K., G. C., Yu, Yue, X. D., Yuan, A. F., Zhang, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., Zhaxisangzhu, Zhaxiciren, Zhu, Q. Q., Bacci, C, Bao, Kz, Barone, F, Bartoli, B, Bernardini, Paolo, Bussino, S, Calloni, E, Cao, By, Cardarelli, R, Catalanotti, S, Cavaliere, S, Cesaroni, F, Creti, P, Danzengluobu, Piazzoli, Bd, DE VINCENZI, M, DI GIROLAMO, T, DI SCIASCIO, G, Feng, Zy, Fu, Y, Gao, Xy, Geng, Qx, Guo, Hw, He, Hh, He, M, Huang, Q, Iacovacci, M, Iucci, N, Jai, Hy, Jing, Cl, Kong, Fm, Kuang, Hh, Labaciren, Li, B, Li, Jy, Liu, Zq, Lu, H, Ma, Xh, Mancarella, Giovanni, Mari, Sm, Marsella, Giovanni, Martello, Daniele, Meng, Xr, Milano, L, Mu, J, Panareo, Marco, Peng, Zr, Pistilli, P, Santonico, R, Shen, Pr, Stanescu, C, Sun, Lr, Sun, Sc, Surdo, A, Tan, Yh, Vernetto, S, Wang, Cr, Wang, H, Wang, Hy, Wei, Yn, Yang, Ht, Yao, Qk, Yu, Gc, Yue, Xd, Yuan, Af, Zha, M, Zhang, Hm, Zhang, Jl, Zhang, Nj, Zhang, Xy, Zhaxisangzhu, Zhaxiciren, and Zhu, Qq

Subjects
Astroparticle physics, Physics, Resistive touchscreen, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astronomy and Astrophysics, Cosmic ray, Gamma-ray astronomy, Gamma-ray Astronomy, Cosmic rays, Ground-based Astronomy, Nuclear physics, Angular distribution, High Energy Physics::Experiment, Argo, Time profile
Abstract

A resistive plate counters (RPCs) carpet of ∼50 m 2 has been put in operation in the Yangbajing Laboratory (Tibet, P.R. China) at 4300 m a.s.l., in order to study the RPCs performance at high altitude and the detector capability of imaging the EAS disc. This test has been performed in view of an enlarged use of RPCs for the ARGO-YBJ experiment. This experiment will be devoted to a wide range of fundamental issues in cosmic rays and astroparticle physics, including in particular γ-ray astronomy and γ-ray bursts physics at energies ⩾100 GeV. In this paper we present and discuss the procedures adopted to calibrate the detector and reconstruct the shower direction. Results concerning many shower features as the angular distribution, the density spectrum, the time profile of the shower front, are found well consistent with the expectation.

Published
2002

11. The Effect and Mechanisms of Proliferative Inhibition of Crocin on Human Leukaemia Jurkat Cells.

Author

Sun, Y., Wang, Z., Wang, L., Wang, L-Z., Zang, C., and Sun, L-R.

Abstract

Copyright of West Indian Medical Journal is the property of West Indian Medical Journal (WIMJ) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2015
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13. Crocin attenuates cisplatin-induced liver injury in the mice.

Author

Sun, Y, Yang, J, Wang, L-Z, Sun, L-R, and Dong, Q

Subjects
CROCIN, CISPLATIN, LABORATORY mice, GLUTATHIONE, LIVER
Abstract

Cisplatin (CDDP) is one of the most frequently used antitumor agents, but its application is significantly limited by its hepatotoxicity. In the present study, we investigated the effects of crocin against CDDP-induced oxidative stress and apoptosis in the liver of Kunming mice. Crocin was administered to the mice once daily for 7 consecutive days at the doses of 6.25 and 12.5 mg/kg body weight orally. On day 1, a single intraperitoneal injection of CDDP was given at the dose of 10 mg/kg body weight. Crocin treatment significantly improved CDDP-induced hepatic damage as indicated by serum aspartate aminotransferase and alanine aminotransferase levels. Crocin relieved CDDP-induced oxidative stress by reducing malondialdehyde level and recovering the levels of glutathione and antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. In addition, liver histopathology indicated that crocin alleviated CDDP-induced focal necrosis. Immunohistochemical staining and Western blot analysis showed that crocin significantly decreased the levels of phospho-p38 mitogen-activated protein kinase (MAPK), tumor protein 53 (p53), and cleaved caspase-3. Taken together, our data suggest that crocin provides protective effects against CDDP-induced hepatoxicity by attenuating oxidative stress and inhibiting the activation of p38 MAPK, p53, and caspase-3. [ABSTRACT FROM PUBLISHER]

Published
2014
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15. The ARGO-YBJ experiment in Tibet

Author

Aloisio, A., Bacci, C., Bao, K. Z., Barone, F., Bartoli, B., Bernardini, P., Bleve, C., Branchini, P., Bussino, S., Calloni, E., Camarri, P., Cao, B. Y., Cardarelli, R., Casolino, M., Catalanotti, S., Cavaliere, A., Cavaliere, S., Cesaroni, F., Cha, M., Creti, P., Cusumano, G., D Ali Staiti, G., Danzengluobu, D Elia, V., Mitri, I., D Ettorre-Piazzoli, B., Vincenzi, M., Di Girolamo, T., Di Sciascio, G., Feng, Z. Y., Fu, Y., Gao, X. Y., Geng, Q. X., Guo, H. W., He, H. H., Huang, Q., Iacovacci, M., Iucci, N., Jai, H. Y., Kong, F. M., Kuang, H. H., Labaciren, Li, B., Li, J. Y., Liberti, B., Liguori, G., Liu, Z. Q., Lu, H., Ma, X. H., Mancarella, G., Mari, S. M., Marsella, G., Martello, D., Meng, X. R., Milano, L., Mineo, T., Mu, J., Nicastro, L., Orlando, D., Panareo, M., Paolo Camarri, Peng, Z. R., Pistilli, P., Raso, G., Sacco, B., Saggese, L., Santonico, R., Scarsi, L., Shen, P. R., Stanescu, C., Storini, M., Sun, L. R., Sun, S. C., Surdo, A., Tan, Y. H., Vallania, P., Vernetto, S., Wang, C. R., Wang, H., Wang, H. Y., Wei, Y. N., Yao, Q. K., Yu, G. C., Yue, X. D., Yuan, A. F., Zhang, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., Zhaxisangzhu, Zhaxiciren, Zhu, Q. Q., Aloisio, A, Bacci, C, Bao, Kz, Barone, F, Bartoli, B, Bernardini, P, Bleve, C, Branchini, P, Bussino, Severino Angelo Maria, Calloni, E, Camarri, P, Cao, By, Cardarelli, R, Casolino, M, Catalanotti, S, Cavaliere, A, Cavaliere, S, Cesaroni, F, Cha, M, Creti, P, Cusimano, G, Staiti, Gd, Danzengluobu, D'Elia, V, De Mitri, I, D'Ettorre, B, Piazzoli, Bd, De Vincenzi, M, Di Girolamo, T, Di Sciascio, G, Feng, Zy, Fu, Y, Gao, Xy, Geng, Qx, Guo, Hw, He, Hh, Huang, Q, Iacovacci, M, Iucci, N, Jai, Hy, Kong, Fm, Kuang, Hh, Labaciren, Li, B, Li, Jy, Liberti, B, Liguori, G, Liu, Zq, Lu, H, Ma, Xh, Mancarella, G, Mari, Stefano Maria, Marsella, G, Martello, D, Meng, Xr, Milano, L, Mineo, T, Mu, J, Nicastro, L, Orlando, D, Panareo, M, Paoloni, A, Peng, Zr, Pistilli, P, Raso, G, Sacco, B, Saggese, L, Santonico, R, Scarsi, L, Shen, Pr, Stanescu, C, Storini, M, Sun, Lr, Sun, Sc, Surdo, A, Tan, Yh, Vallania, P, Vernetto, S, Wang, Cr, Wang, H, Wang, Hy, Wei, Yn, Yao, Qk, Yu, Gc, Yue, Xd, Yuan, Af, Zhang, Hm, Zhang, Jl, Zhang, Nj, Zhang, Tj, Zhang, Xy, Zhaxisangzhu, Zhaxiciren, Zhu, Qq, DE VINCENZI, Mario, Bussino, S, DE MITRI, Ivan, DE VINCENZI, M, DI GIROLAMO, T, DI SCIASCIO, G, Mari, Sm, Marsella, Giovanni, Martello, Daniele, Panareo, Marco, Aloisio, A., Bacci, C., Bao, K. Z., Barone, F., Bartoli, Bruno, Bernardini, P., Bleve, C., Branchini, P., Bussino, S., Calloni, Enrico, Camarri, P., Cao, B. Y., Cardarelli, R., Casolino, M., Catalanotti, Sergio, Cavaliere, A., Cavaliere, S., Cesaroni, F., Cha, M., Creti, P., Cusimano, G., Staiti, G. D., D'Elia, V., Mitri, I. D., D'Ettorre, B., D'ETTORRE PIAZZOLI, Benedetto, Vincenzi, M. D., DI GIROLAMO, Tristano, Sciascio, G. D., Feng, Z. Y., Fu, Y., Gao, X. Y., Geng, Q. X., Guo, H. W., H. H., He, Huang, Q., Iacovacci, Michele, Iucci, N., Jai, H. Y., Kong, F. M., Kuang, H. H., Li, B., J. Y., Li, Liberti, B., Liguori, G., Liu, Z. Q., Lu, H., X. H., Ma, Mancarella, G., Mari, S. M., Marsella, G., Martello, D., Meng, X. R., Milano, L., Mineo, T., Mu, J., Nicastro, L., Orlando, D., Panareo, M., Paoloni, A., Peng, Z. R., Pistilli, P., Raso, G., Sacco, B., Saggese, L., Santonico, R., Scarsi, L., Shen, P. R., Stanescu, C., Storini, M., Sun, L. R., Sun, S. C., Surdo, A., Tan, Y. H., Vallania, P., Vernetto, S., Wang, C. R., Wang, H., Wang, H. Y., Wei, Y. N., Yao, Q. K., G. C., Yu, Yue, X. D., Yuan, A. F., Zhang, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., Zhu, Q. Q., A., Aloisio, C., Bacci, K. Z., Bao, F., Barone, B., Bartoli, P., Bernardini, C., Bleve, P., Branchini, S., Bussino, E., Calloni, P., Camarri, B. Y., Cao, R., Cardarelli, M., Casolino, S., Catalanotti, A., Cavaliere, S., Cavaliere, F., Cesaroni, M., Cha, P., Creti, G., Cusimano, G. D., Staiti, V., D'Elia, B., D'Ettorre, B. D., Piazzoli, M. D., Vincenzi, T. D., Girolamo, G. D., Sciascio, Z. Y., Feng, Y., Fu, X. Y., Gao, Q. X., Geng, H. W., Guo, Q., Huang, M., Iacovacci, N., Iucci, H. Y., Jai, F. M., Kong, H. H., Kuang, B., Li, B., Liberti, G., Liguori, Z. Q., Liu, H., Lu, Mancarella, Giovanni, S. M., Mari, X. R., Meng, L., Milano, T., Mineo, J., Mu, L., Nicastro, D., Orlando, A., Paoloni, Z. R., Peng, P., Pistilli, G., Raso, B., Sacco, L., Saggese, R., Santonico, L., Scarsi, P. R., Shen, C., Stanescu, M., Storini, L. R., Sun, S. C., Sun, A., Surdo, Y. H., Tan, P., Vallania, S., Vernetto, C. R., Wang, H., Wang, H. Y., Wang, Y. N., Wei, Q. K., Yao, X. D., Yue, A. F., Yuan, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., Zhang, and Q. Q., Zhu

Subjects
Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics
Abstract

The ARCO-YBJ experiment, (Astrophysical Radiation Ground-based Observatory at YaugBaJing) is under construction in Tibet, 90 kill to the north of Lhasa. The full coverage approach and the high altitude location allow the study of many physics items in the field of low energy cosmic rays, namely gamma-ray astronomy, diffuse gamma-rays, gamma-ray bursts (GRBs), proton/antiproton ratio, primary proton spectrum and heliosphere physics, In this paper the expected sensitivities of ARGO-YBJ for gamma astronomy and GRB physics are presented and compared with the present experimental techniques and results. The performance of a test-module of similar to 50 m(2) operated on-site is, also discussed.

16. First Measurements with the ARGO-YBJ Detector

Author

Surdo, A., Argo-Ybj, Collaboration, Bernardini, P., Bleve, C., Creti, P., Mitri, I., Devicenzi, M., Mancarella, G., Marsella, G., Martello, D., Panareo, M., Pino, C., Barone, F., Bartoli, B., Catalanotti, S., Cavaliere, S., D Ettorre Piazzoli, B., Di Girolamo, T., Di Sciascio, G., Iacovacci, M., Mastroianni, S., Milano, L., Rossi, E., Saggese, L., Cusomano, G., D Ali Staiti, G., Nicastro, L., Sacco, B., Liguori, G., Salvini, P., Aielli, G., Camarri, P., Cardelli, R., Cavaliere, A., Valerio D'Elia, Liberti, B., Santonico, R., Bacci, C., Bussino, S., Celio, P., Cesaroni, F., Marinis, E., Fratini, K., Mari, S. M., Pieri, L., Pistilli, P., Stanescu, C., Storini, M., Vallania, P., Vernetto, S., Gou, Q. B., He, H. H., Hu, H. B., Jing, C. L., Kuang, H. H., Lu, H., Shen, P. R., Sheng, X. D., Tan, Y. H., Wang, H., Wang, H. Y., Wu, C. Y., Zhang, H. M., Zhang, J. L., Zhang, Y., Zhu, Q. Q., Feng, C. F., He, M., Li, J. Y., Wang, Y. G., Xue, L., Zhang, N. J., Zhang, X. Y., Feng, Z. Y., Huang, Q., Jia, H. Y., Yu, G. C., Zhou, X. X., Danzengluobu, Ding, X. H., Guo, H. W., Hu, H., Labaciren, Meng, X. R., Ning, C. C., Yuan, A. F., Zhaxisangzhu, Gao, X. Y., Geng, Q. X., Liu, C. Q., Liu, J., Mu, J., Yangv, H. T., Yang, X. C., Zhang, L., Zhang, P., Bao, K. Z., Sun, L. R., Sun, S. C., Yue, X. D., Yao, Q. K., Ma, Y. M., Cheng, K. S., A., Surdo, P., Bernardini, C., Bleve, P., Creti, I., DE MITRI, DE VINCENZI, Mario, G., Mancarella, G., Marsella, D., Martello, M., Panareo, C., Pinto, F., Barone, B., Bartoli, S., Catalanotti, A., Cavaliere, B., D'ETTORRE PIAZZOLI, T., DI GIROLAMO, G., DI SCIASCIO, M., Iacovacci, S., Mastroianni, L., Milano, E., Rossi, L., Saggese, G., Cusumano, G., D'ALI STAITI, L., Nicastro, B., Sacco, G., Liguori, P., Salvini, G., Aielli, P., Camarri, R., Cardarelli, V., D'Elia, B., Liberti, R., Santonico, C., Bacci, Bussino, Severino Angelo Maria, P., Celio, F., Cesaroni, E., DE MARINIS, K., Fratini, Mari, Stefano Maria, L., Pieri, P., Pistilli, C., Stanescu, M., Storini, P., Vallania, S., Vernetto, Q. B., Gou, H. H., He, H. B., Hu, C. L., Jing, H. H., Kuang, H., Lu, P. R., Shen, X. D., Sheng, Y. H., Tan, H., Wang, H. Y., Wang, C. Y., Wu, H. M., Zhang, J. L., Zhang, Y., Zhang, Q. Q., Zhu, C. F., Feng, M., He, J. Y., Li, Y. G., Wang, L., Xue, N. J., Zhang, X. Y., Zhang, Z. Y., Feng, Q., Huang, H. Y., Jia, G. C., Yu, X. X., Zhou, Danzengluobu, X. H., Ding, H. W., Guo, H., Hu, Labaciren, X. R., Meng, C. C., Ning, A. F., Yuan, Zhaxisangzhu, X. Y., Gao, Q. X., Geng, C. Q., Liu, J., Liu, J., Mu, H. T., Yang, Q. Y., Yang, X. C., Yang, L., Zhang, P., Zhang, K. Z., Bao, L. R., Sun, S. C., Sun, X. D., Yue, Q. K., Yao, Y. M., Ma, and K. S., Cheng

17. Study on the performance of YBJ 50m(2) RPC carpet

Author

He, H. H., Bacci, C., Bao, K. Z., Barone, F., Bartoli, B., Bernardini, P., Bussino, S., Calloni, E., Cardarelli, R., Catalanotti, S., Cavaliere, S., Cesaroni, F., Cha, M., Creti, P., Danzengluobu, Piazzoli, B. D., Vincenzi, M., Di Girolamo, T., Di Sciascio, G., Feng, Z. Y., Fu, Y., Gao, X. Y., Geng, Q. X., Guo, H. W., He, M., Huang, Q., Iacovacci, M., Iucci, N., Jia, H. Y., Jing, C. L., Kong, F. M., Kuang, H. H., Labaciren, Li, J. Y., Liu, C. Q., Lu, H., Ma, X. H., Mancarella, G., Mari, S. M., Marsella, G., Daniele Martello, Meng, X. R., Milano, L., Mu, J., Peng, Z. R., Pistilli, P., Qu, R. F., Santonico, R., Sbarra, C., Shen, P. R., Stanescu, C., Sun, L. R., Sun, S. C., Surdo, A., Tan, Y. H., Vernetto, S., Wang, C. R., Wang, H., Wang, H. Y., Wei, Y. N., Yang, H. T., Yao, Q. K., Yu, G. C., Yue, X. D., Yuan, A. F., Zhang, H. M., Zhang, J. L., Zhang, N. J., Zhang, X. Y., Zhaxisangzhu, Zhaxiciren, Zhu, Q. Q., and Ybj-Argo Collaboration

18. Study on the performance of YBJ 50m2 RPC carpet

Author

He, H. -H, Bacci, C., Bao, K. -Z, Barone, F., Bartoli, B., Bernardini, P., Bussino, S., Calloni, E., Cardarelli, R., Catalanotti, S., Cavaliere, S., Cesaroni, F., Cha, M., Creti, P., Danzengluobu, D Ettorre Piazzoli, B., Vincenzi, M., Di Girolamo, T., Di Sciascio, G., Feng, Z. -Y, Fu, Y., Gao, X. -Y, Geng, Q. -X, Guo, H. -W, He, M., Huang, Q., Iacovacci, M., Iucci, N., Jia, H. -Y, Jing, C. -L, Kong, F. -M, Kuang, H. -H, Labaciren, Li, J. -Y, Liu, C. -Q, Lu, H., Ma, X. -H, Mancarella, G., Mari, S. M., Marsella, G., Daniele Martello, Meng, X. -R, Milano, L., Mu, J., Peng, Z. -R, Pistilli, P., Qu, R. -F, Santonico, R., Sbarra, C., Shen, P. -R, Stanescu, C., Sun, L. -R, Sun, S. -C, Surdo, A., Tan, Y. -H, Vernetto, S., Wang, C. -R, Wang, H., Wang, H. -Y, Wei, Y. -N, Yang, H. -T, Yao, Q. -K, Yu, G. -C, Yue, X. -D, Yuan, A. -F, Zhang, H. -M, Zhang, J. -L, Zhang, N. -J, Zhang, X. -Y, Zhaxisangzhu, Zhaxiciren, and Zhu, Q. -Q

19. Study on the performance of YBJ 50m2 RPC carpet

Author

He, H. -H, Bacci, C., Bao, K. -Z, Barone, F., Bartoli, B., Bernardini, P., Bussino, S., Calloni, E., Cardarelli, R., Catalanotti, S., Cavaliere, S., Cesaroni, F., Cha, M., Creti, P., Danzengluobu, D Ettorre Piazzoli, B., Vincenzi, M., Di Girolamo, T., Di Sciascio, G., Feng, Z. -Y, Fu, Y., Gao, X. -Y, Geng, Q. -X, Guo, H. -W, He, M., Huang, Q., Iacovacci, M., Iucci, N., Jia, H. -Y, Jing, C. -L, Kong, F. -M, Kuang, H. -H, Labaciren, Li, J. -Y, Liu, C. -Q, Lu, H., Ma, X. -H, Mancarella, G., Mari, S. M., Marsella, G., Martello, D., Meng, X. -R, Milano, L., Mu, J., Peng, Z. -R, Pistilli, P., Qu, R. -F, Santonico, R., Sbarra, C., Shen, P. -R, Stanescu, C., Sun, L. -R, Sun, S. -C, Antonio Surdo, Tan, Y. -H, Vernetto, S., Wang, C. -R, Wang, H., Wang, H. -Y, Wei, Y. -N, Yang, H. -T, Yao, Q. -K, Yu, G. -C, Yue, X. -D, Yuan, A. -F, Zhang, H. -M, Zhang, J. -L, Zhang, N. -J, Zhang, X. -Y, Zhaxisangzhu, Zhaxiciren, and Zhu, Q. -Q

20. The ARGO-YBJ detector and high energy GRBs

Author

Bacci, C., Bao, K. Z., Barone, F., Bartoli, B., Bastieri, D., Bernardini, P., Buonomo, R., Bussino, S., Calloni, E., Cao, B. Y., Cardarelli, R., Catalanotti, S., Cavaliere, A., Cesaroni, F., Creti, P., Danzengluobu, D'Ettorre Piazzoli, B., De Vincenzi, M., Di Girolamo, T., Di Sciascio, G., Feng, Z. Y., Fu, Y., Gao, X. Y., Geng, Q. X., Guo, H. W., He, H. H., He, M., Huang, Q., Iacovacci, M., Iucci, N., Jai, H. Y., Kong, F. M., Kuang, H. H., Labaciren, Li, B., Li, J. Y., Liu, Z. Q., Lu, H., Ma, X. H., Mancarella, G., Mari, S. M., Marsella, G., Martello, D., Mei, D. M., Meng, X. R., Milano, L., Morselli, A., Mu, J., Oliviero, M., Padovani, P., Panareo, M., Parisi, M., Pellizzoni, G., Peng, Z. R., Pistilli, P., Santonico, R., Sartori, G., Sbarra, C., Severino, G., Shen, P. R., Sparvoli, R., Stanescu, C., Su, J., Sun, L. R., Sun, S. C., Surdo, A., Tan, Y. H., Vernetto, S., Vietri, M., Wang, C. R., Wang, H., Wang, H. Y., Wei, Y. N., Yang, H. T., Yao, Q. K., Yu, G. C., Yue, X. D., Yuan, A. F., Zhang, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., Zhaxisangzhu, Zhaxiciren, Zhu, Q. Q., Bacci, C., Bao, K. Z., Barone, F., Bartoli, B., Bastieri, D., Bernardini, P., Buonomo, R., Bussino, S., Calloni, E., Cao, B. Y., Cardarelli, R., Catalanotti, S., Cavaliere, A., Cesaroni, F., Creti, P., Danzengluobu, D'Ettorre Piazzoli, B., De Vincenzi, M., Di Girolamo, T., Di Sciascio, G., Feng, Z. Y., Fu, Y., Gao, X. Y., Geng, Q. X., Guo, H. W., He, H. H., He, M., Huang, Q., Iacovacci, M., Iucci, N., Jai, H. Y., Kong, F. M., Kuang, H. H., Labaciren, Li, B., Li, J. Y., Liu, Z. Q., Lu, H., Ma, X. H., Mancarella, G., Mari, S. M., Marsella, G., Martello, D., Mei, D. M., Meng, X. R., Milano, L., Morselli, A., Mu, J., Oliviero, M., Padovani, P., Panareo, M., Parisi, M., Pellizzoni, G., Peng, Z. R., Pistilli, P., Santonico, R., Sartori, G., Sbarra, C., Severino, G., Shen, P. R., Sparvoli, R., Stanescu, C., Su, J., Sun, L. R., Sun, S. C., Surdo, A., Tan, Y. H., Vernetto, S., Vietri, M., Wang, C. R., Wang, H., Wang, H. Y., Wei, Y. N., Yang, H. T., Yao, Q. K., Yu, G. C., Yue, X. D., Yuan, A. F., Zhang, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., Zhaxisangzhu, Zhaxiciren, and Zhu, Q. Q.

Abstract

ARGO-YBJ (Astrophysical Radiation with Ground-based Observatory at YangBaJing) is a detector optimized to study small size air showers. It consists of a layer of Resistive Plate Counters (RPCs) covering an area of ~ 6500 m2and will be located in the Yangbajing Laboratory (Tibet, China) at 4300 m a.s.l. ARGO-YBJ will be devoted to a wide range of fundamental issues in cosmic rays and astroparticle physics, including in particular gamma-ray astronomy and gamma-ray bursts physics in the range $10~{\rm GeV} \div 500~{\rm TeV}$. The sensitivity of ARGO-YBJ to detect high energy GRBs is presented.

Published
1999
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22. Analysis of meat flavor compounds in pedigree and two-strain Yangzhou geese.

Author

Cui, L. L., Wang, J. F., Xie, K. Z., Li, A. H., Geng, T. Y., Sun, L. R., Liu, J. Y., Zhao, M., Zhang, G. X., Dai, G. J., and Wang, J. Y.

Subjects
*GEESE, *ANIMAL pedigrees, *MEAT flavor & odor, *INOSINE, *UNSATURATED fatty acids, *AMINO acids in the body, *MUSCLE analysis, *PHYSIOLOGY
Abstract

In this study, we evaluated the meat flavor compounds of Yangzhou geese, including one group of pedigree strain (AA group) and 4 groups of 2-strain crossbreds (KA, KB, CA, and SA). Each group consisted of 100 geese comprised of 5 replicates of 10 males and 10 females each. Inosine 5-monophosphate (IMP), amino acid (AA), and fatty acid (FA) levels in breast and thigh muscle were determined. Results showed that AA group had the highest levels of total amino acid (TAA) and dissolved free amino acids (DFAA) in breast muscle and of polyunsaturated fatty acids (PUFA) in thigh muscle (P<0.05). In SA group, the levels of C17:1, C22:0, C22:1, C20:4, and C24:1 in breast muscle were significantly higher in SA than in other groups (P<0.05). KB group had the lowest glycine levels in breast muscle (P<0.05) while MUFA levels were significantly higher in KB than in other groups (P<0.05). In KA, the levels of C18:3 in breast muscle in were higher than in CA and KB (P<0.05). CA had relevant higher IMPc levels in breast muscle than SA (P<0.05) and other groups (P>0.05); however, no significant differences were obtained in thigh muscle (P>0.05). In conclusion, Yangzhou AA goose has high levels of meat flavor compounds than its crossbreeds. Future efforts should focus on assessing meat flavor through measurement of sensory characteristics of Yangzhou geese. [ABSTRACT FROM AUTHOR]

Published
2015
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23. The ARGO-YBJ experiment in Tibet

Author

A. ALOISIO, C. BACCI, K. Z. BAO, F. BARONE, B. BARTOLI, P. BERNARDINI, C. BLEVE, P. BRANCHINI, S. BUSSINO, E. CALLONI, P. CAMARRI, B. Y. CAO, R. CARDARELLI, M. CASOLINO, S. CATALANOTTI, A. CAVALIERE, S. CAVALIERE, F. CESARONI, M. CHA, P. CRETI, G. CUSIMANO, G. D'ALI STAITI, DANZENGLUOBU, V. D'ELIA, B. D'ETTORRE PIAZZOLI, M. DE VINCENZI, T. DI GIROLAMO, G. DI SCIASCIO, Z. Y. FENG, Y. FU, X. Y. GAO, Q. X. GENG, H. W. GUO, H. H. HE, Q. HUANG, M. IACOVACCI, N. IUCCI, H. Y. JAI, F. M. KONG, H. H. KUANG, LABACIREN, B. LI, J. Y. LI, B. LIBERTI, G. LIGUORI, Z. Q. LIU, H. LU, X. H. MA, G. MANCARELLA, S. M. MARI, MARSELLA, GIOVANNI, MARTELLO, Daniele, X. R. MENG, L. MILANO, T. MINEO, J. MU, L. NICASTRO, D. ORLANDO, A. PAOLONI, Z. R. PENG, P. PISTILLI, G. RASO, B. SACCO, L. SAGGESE, R. SANTONICO, L. SCARSI, P. R. SHEN, C. STANESCU, M. STORINI, L. R. SUN, S. C. SUN, A. SURDO, Y. H. TAN, P. VALLANIA, S. VERNETTO, C. R. WANG, H. WANG, H. Y. WANG, Y. N. WEI, Q. K. YAO, G. C. YU, X. D. YUE, A. F. YUAN, H. M. ZHANG, J. L. ZHANG, N. J. ZHANG, T. J. ZHANG, X. Y. ZHANG, ZHAXISANGZHU, ZHAXICIREN, Q. Q. ZHU, DE MITRI, Ivan, PANAREO, Marco, Aloisio, A., Bacci, C., Bao, K. Z., Barone, F., Bartoli, B., Bernardini, P., Bleve, C., Branchini, P., Bussino, S., Calloni, E., Camarri, P., Cao, B. Y., Cardarelli, R., Casolino, M., Catalanotti, S., Cavaliere, A., Cavaliere, S., Cesaroni, F., Cha, M., Creti, P., Cusimano, G., D'ALI STAITI, G., Danzengluobu, D'Elia, V., DE MITRI, Ivan, D'ETTORRE PIAZZOLI, B., DE VINCENZI, M., DI GIROLAMO, T., DI SCIASCIO, G., Feng, Z. Y., Fu, Y., Gao, X. Y., Geng, Q. X., Guo, H. W., H. H., He, Huang, Q., Iacovacci, M., Iucci, N., Jai, H. Y., Kong, F. M., Kuang, H. H., Labaciren, Li, B., J. Y., Li, Liberti, B., Liguori, G., Liu, Z. Q., Lu, H., X. H., Ma, Mancarella, G., Mari, S. M., Marsella, Giovanni, Martello, Daniele, Meng, X. R., Milano, L., Mineo, T., Mu, J., Nicastro, L., Orlando, D., Panareo, Marco, Paoloni, A., Peng, Z. R., Pistilli, P., Raso, G., Sacco, B., Saggese, L., Santonico, R., Scarsi, L., Shen, P. R., Stanescu, C., Storini, M., Sun, L. R., Sun, S. C., Surdo, A., Tan, Y. H., Vallania, P., Vernetto, S., Wang, C. R., Wang, H., Wang, H. Y., Wei, Y. N., Yao, Q. K., G. C., Yu, Yue, X. D., Yuan, A. F., Zhang, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., Zhaxisangzhu, Zhaxiciren, and Zhu, Q. Q.

Subjects
Ground based detectors, Gamma-ray sources, Gamma-ray bursts, Cosmic rays
Published
2001

24. High Altitude test of RPCs for the ARGO-YBJ experiment

Author

THE ARGO YBJ COLLABORATION, G. AIELLI, R. ASSIRO, C. BACCI, B. BARTOLI, P. BERNARDINI, X. J. BI, B. BIONDO, C. BLEVE, S. BRICOLA, F. BUDANO, BUSSINO, Severino Angelo Maria, A. K. CALABRESE MELCARNE, P. CAMARRI, D. CAMPANA, Z. CAO, R. CARDARELLI, S. CATALANOTTI, S. CAVALIERE, P. CELIO, N. CHENG, P. CRETI, G. CUSUMANO, B. Z. DAI, G. DALI STAITI, DANZENGLUOBU, B. DAQUINO, E. DE MARINIS, I. DE MITRI, B. DETTORRE PIAZZOLI, M. DE VINCENZI, T. DI GIROLAMO, X. H. DING, G. DI SCIASCIO, C. F. FENG, ZHAOYANG FENG, ZHENYONG FENG, K. FRATINI, X. F. GAO, Q. B. GOU, H. H. HE, M. HE, HAIBING HU, HONGBO HU, Q. HUANG, M. IACOVACCI, I. JAMES, H. Y. JIA, LABACIREN, H. J. LI, J. Y. LI, B. LIBERTI, G. LIGUORI, C. Q. LIU, J. LIU, H. LU, G. MANCARELLA, A. MANGANO, G. MARSELLA, D. MARTELLO, S. MASTROIANNI, X. R. MENG, J. MU, L. NICASTRO, C. C. NING, M. PANAREO, L. PERRONE, C. PINO, C. PINTO, P. PISTILLI, E. ROSSI, L. SAGGESE, P. SALVINI, R. SANTONICO, P. R. SHEN, X. D. SHENG, F. SHI, C. STANESCU, A. SURDO, Y. H. TAN, P. VALLANIA, S. VERNETTO, H. WANG, YONGGANG WANG, YUNGANG WANG, C. Y. WU, H. R. WU, L. XUE, H. T. YANG, Q. Y. YANG, X. C. YANG, G. C. YU, A. F. YUAN, M. ZHA, H. M. ZHANG, J. L. ZHANG, L. ZHANG, N. J. ZHANG, P. ZHANG, X. Y. ZHANG, Y. ZHANG, ZHAXISANGZHU, X. X. ZHOL, F. R. ZHU, Q. Q. ZHU, MARI, Stefano Maria, Bacci, C., Bao, K. Z., Barone, F., Bartoli, B., Bernardini, Paolo, Buonomo, R., Bussino, S., Calloni, E., Cao, B. Y., Cardarelli, R., Catalanotti, S., Cavaliere, A., Cesaroni, F., Creti, P., Danzengluobu, D'ETTORRE PIAZZOLI, B., DE VINCENZI, M., DI GIROLAMO, T., DI SCIASCIO, G., Feng, Z. Y., Fu, Y., Gao, X. Y., Geng, Q. X., Guo, H. W., H. H., He, He, M., Huang, Q., Iacovacci, M., Iucci, N., Jai, H. Y., Kong, F. M., Kuang, H. H., Labaciren, Li, B., J. Y., Li, Liu, Z. Q., Lu, H., X. H., Ma, Mancarella, G., Mari, S. M., Marsella, Giovanni, Martello, Daniele, Mei, D. M., Meng, X. R., Milano, L., Morselli, A., Mu, J., Panareo, Marco, Parisi, M., Pellizzoni, G., Peng, Z. R., Pinto, C., Pistilli, P., Reali, E., Santonico, R., Severino, G., Shen, P. R., Stanescu, C., Su, J., Sun, L. R., Sun, S. C., Surdo, A., Tan, Y. H., Vernetto, S., Wang, C. R., Wang, H., Wang, H. Y., Wei, Y. N., Yang, H. T., Yao, Q. K., G. C., Yu, Yue, X. D., Yuan, A. F., Zhang, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., Zhaxisangzhu, Zhaxiciren, Zhu, Q. Q., Bernardini, P., Calloni, Enrico, Cesaroni, CARLO FRANCESCO, Danzengluobu, M., D'Ettorre, Piazzoli, Benedetto, De Vincenzi, M., Girolamo, Di, DI GIROLAMO, Tristano, Di Sciascio, G., He, Chaojie, Huang, Weiping, Iacovacci, Michele, Marsella, G., Martello, D., Panareo, M., Zhaxisangzhu, Zhaxiciren, Q. Q. Zhu, THE ARGO YBJ, Collaboration, G., Aielli, R., Assiro, C., Bacci, B., Bartoli, P., Bernardini, X. J., Bi, B., Biondo, C., Bleve, S., Bricola, F., Budano, Bussino, Severino Angelo Maria, A. K., CALABRESE MELCARNE, P., Camarri, D., Campana, Z., Cao, R., Cardarelli, S., Catalanotti, S., Cavaliere, P., Celio, N., Cheng, P., Creti, G., Cusumano, B. Z., Dai, G., DALI STAITI, B., Daquino, E., DE MARINIS, I., DE MITRI, B., DETTORRE PIAZZOLI, M., DE VINCENZI, T., DI GIROLAMO, X. H., Ding, G., DI SCIASCIO, C. F., Feng, Zhaoyang, Feng, Zhenyong, Feng, K., Fratini, X. F., Gao, Q. B., Gou, M., He, Haibing, Hu, Hongbo, Hu, Q., Huang, M., Iacovacci, I., Jame, H. Y., Jia, H. J., Li, B., Liberti, G., Liguori, C. Q., Liu, J., Liu, H., Lu, G., Mancarella, A., Mangano, Mari, Stefano Maria, G., Marsella, D., Martello, S., Mastroianni, X. R., Meng, J., Mu, L., Nicastro, C. C., Ning, M., Panareo, L., Perrone, C., Pino, C., Pinto, P., Pistilli, E., Rossi, L., Saggese, P., Salvini, R., Santonico, P. R., Shen, X. D., Sheng, F., Shi, C., Stanescu, A., Surdo, Y. H., Tan, P., Vallania, S., Vernetto, H., Wang, Yonggang, Wang, Yungang, Wang, C. Y., Wu, H. R., Wu, L., Xue, H. T., Yang, Q. Y., Yang, X. C., Yang, A. F., Yuan, M., Zha, H. M., Zhang, J. L., Zhang, L., Zhang, N. J., Zhang, P., Zhang, X. Y., Zhang, Y., Zhang, X. X., Zhol, F. R., Zhu, and Q. Q., Zhu

Subjects
Physics, Nuclear and High Energy Physics, ARGO-YBJ, Astronomy, Cosmic ray, Gamma-ray astronomy, Astrophysics, Extensive air-shower, Effects of high altitude on humans, Electrode impedance, gamma-ray astronomy, RPCs, High mountain, High Energy Physics - Experiment, Ionization chamber, Instrumentation, Argo
Abstract

A 50 m**2 RPC carpet was operated at the YangBaJing Cosmic Ray Laboratory (Tibet) located 4300 m a.s.l. The performance of RPCs in detecting Extensive Air Showers was studied. Efficiency and time resolution measurements at the pressure and temperature conditions typical of high mountain laboratories, are reported., Comment: 16 pages, 10 figures, submitted to Nucl. Instr. Meth

Published
2000

25. Results from the analysis of data collected with a 50m(2) RPC carpet at YangBaJing

Author

THE ARGO YBJ COLLABORATION, G. AIELLI, R. ASSIRO, C. BACCI, B. BARTOLI, P. BERNARDINI, X. J. BI, B. BIONDO, C. BLEVE, S. BRICOLA, F. BUDANO, BUSSINO, Severino Angelo Maria, A. K. CALABRESE MELCARNE, P. CAMARRI, D. CAMPANA, Z. CAO, R. CARDARELLI, S. CATALANOTTI, S. CAVALIERE, P. CELIO, N. CHENG, P. CRETI, G. CUSUMANO, B. Z. DAI, G. DALI STAITI, DANZENGLUOBU, B. DAQUINO, E. DE MARINIS, I. DE MITRI, B. DETTORRE PIAZZOLI, M. DE VINCENZI, T. DI GIROLAMO, X. H. DING, G. DI SCIASCIO, C. F. FENG, ZHAOYANG FENG, ZHENYONG FENG, K. FRATINI, X. F. GAO, Q. B. GOU, H. H. HE, M. HE, HAIBING HU, HONGBO HU, Q. HUANG, M. IACOVACCI, I. JAMES, H. Y. JIA, LABACIREN, H. J. LI, J. Y. LI, B. LIBERTI, G. LIGUORI, C. Q. LIU, J. LIU, H. LU, G. MANCARELLA, A. MANGANO, G. MARSELLA, D. MARTELLO, S. MASTROIANNI, X. R. MENG, J. MU, L. NICASTRO, C. C. NING, M. PANAREO, L. PERRONE, C. PINO, C. PINTO, P. PISTILLI, E. ROSSI, L. SAGGESE, P. SALVINI, R. SANTONICO, P. R. SHEN, X. D. SHENG, F. SHI, C. STANESCU, A. SURDO, Y. H. TAN, P. VALLANIA, S. VERNETTO, H. WANG, YONGGANG WANG, YUNGANG WANG, C. Y. WU, H. R. WU, L. XUE, H. T. YANG, Q. Y. YANG, X. C. YANG, G. C. YU, A. F. YUAN, M. ZHA, H. M. ZHANG, J. L. ZHANG, L. ZHANG, N. J. ZHANG, P. ZHANG, X. Y. ZHANG, Y. ZHANG, ZHAXISANGZHU, X. X. ZHOL, F. R. ZHU, Q. Q. ZHU, MARI, Stefano Maria, Bacci, C., Bao, K. Z., Barone, F., Bartoli, B., Bernardini, P., Bussino, S., Calloni, E., Cao, B. Y., Cardarelli, R., Catalanotti, S., Cavaliere, A., Cavaliere, S., Cesaroni, F., Creti, P., Danzengluobu, D'ETTORRE PIAZZOLI, B., DE VINCENZI, M., DI GIROLAMO, T., DI SCIASCIO, G., Feng, Z. Y., Fu, Y., Gao, X. Y., Geng, Q. X., Guo, H. W., H. H., He, He, M., Huang, Q., Iacovacci, M., Iucci, N., Jai, H. Y., Kong, F. M., Kuang, H. H., Labaciren, Li, B., J. Y., Li, Liu, Z. Q., Lu, H., X. H., Ma, Mancarella, G., Mari, S. M., Marsella, Giovanni, Martello, Daniele, Mei, D. M., Meng, X. R., Milano, L., Mu, J., Panareo, Marco, Pellizzoni, G., Peng, Z. R., Pinto, C., Pistilli, P., Reali, E., Santonico, R., Sbarra, C., Shen, P. R., Stanescu, C., Su, J., Sun, L. R., Sun, S. C., Surdo, A., Tan, Y. H., Vernetto, S., Wang, C. R., Wang, H., Wang, H. Y., Wei, Y. N., Yang, H. T., Yao, Q. K., G. C., Yu, Yue, X. D., Yuan, A. F., Zhang, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., Zhaxisangzhu, Zhaxiciren, Zhu, Q. Q., C., Bacci, K. Z., Bao, F., Barone, Bartoli, Bruno, P., Bernardini, S., Bussino, Calloni, Enrico, B. Y., Cao, R., Cardarelli, Catalanotti, Sergio, A., Cavaliere, S., Cavaliere, F., Cesaroni, P., Creti, D'ETTORRE PIAZZOLI, Benedetto, M. D., Vincenzi, DI GIROLAMO, Tristano, G. D., Sciascio, Z. Y., Feng, Y., Fu, X. Y., Gao, Q. X., Geng, H. W., Guo, M., He, Q., Huang, Iacovacci, Michele, N., Iucci, H. Y., Jai, F. M., Kong, H. H., Kuang, B., Li, Z. Q., Liu, H., Lu, G., Mancarella, S. M., Mari, G., Marsella, D., Martello, D. M., Mei, X. R., Meng, L., Milano, J., Mu, M., Panareo, C., Pellizzoni, Z. R., Peng, C., Pinto, P., Pistilli, E., Reali, R., Santonico, C., Sbarra, P. R., Shen, C., Stanescu, J., Su, L. R., Sun, S. C., Sun, A., Surdo, Y. H., Tan, S., Vernetto, C. R., Wang, H., Wang, H. Y., Wang, Y. N., Wei, H. T., Yang, Q. K., Yao, X. D., Yue, A. F., Yuan, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., Zhang, Q. Q., Zhu, Piazzoli, B. D., Vincenzi, M. D., Girolamo, T. D., Sciascio, G. D., Mancarella, Giovanni, Pellizzoni, C., THE ARGO YBJ, Collaboration, G., Aielli, R., Assiro, B., Bartoli, X. J., Bi, B., Biondo, C., Bleve, S., Bricola, F., Budano, Bussino, Severino Angelo Maria, A. K., CALABRESE MELCARNE, P., Camarri, D., Campana, Z., Cao, S., Catalanotti, P., Celio, N., Cheng, G., Cusumano, B. Z., Dai, G., DALI STAITI, B., Daquino, E., DE MARINIS, I., DE MITRI, B., DETTORRE PIAZZOLI, M., DE VINCENZI, T., DI GIROLAMO, X. H., Ding, G., DI SCIASCIO, C. F., Feng, Zhaoyang, Feng, Zhenyong, Feng, K., Fratini, X. F., Gao, Q. B., Gou, Haibing, Hu, Hongbo, Hu, M., Iacovacci, I., Jame, H. Y., Jia, H. J., Li, B., Liberti, G., Liguori, C. Q., Liu, J., Liu, A., Mangano, Mari, Stefano Maria, S., Mastroianni, L., Nicastro, C. C., Ning, L., Perrone, C., Pino, E., Rossi, L., Saggese, P., Salvini, X. D., Sheng, F., Shi, P., Vallania, Yonggang, Wang, Yungang, Wang, C. Y., Wu, H. R., Wu, L., Xue, Q. Y., Yang, X. C., Yang, M., Zha, L., Zhang, P., Zhang, Y., Zhang, Zhaxisangzhu, X. X., Zhol, F. R., Zhu, Bacci, C, Bao, Kz, Barone, F, Bartoli, B, Bernardini, P, Calloni, E, Cao, By, Cardarelli, R, Catalanotti, S, Cavaliere, A, Cavaliere, S, Cesaroni, F, Creti, P, Piazzoli, Bd, De Vincenzi, M, Di Girolamo, T, Di Sciascio, G, Feng, Zy, Fu, Y, Gao, Xy, Geng, Qx, Guo, Hw, He, Hh, He, M, Huang, Q, Iacovacci, M, Iucci, N, Jai, Hy, Kong, Fm, Kuang, Hh, Li, B, Li, Jy, Liu, Zq, Lu, H, Ma, Xh, Mancarella, G, Marsella, G, Martello, D, Mei, Dm, Meng, Xr, Milano, L, Mu, J, Panareo, M, Pellizzoni, C, Peng, Zr, Pinto, C, Pistilli, P, Reali, E, Santonico, R, Sbarra, C, Shen, Pr, Stanescu, C, Su, J, Sun, Lr, Sun, Sc, Surdo, A, Tan, Yh, Vernetto, S, Wang, Cr, Wang, H, Wang, Hy, Wei, Yn, Yang, Ht, Yao, Qk, Yu, Gc, Yue, Xd, Yuan, Af, Zhang, Hm, Zhang, Jl, Zhang, Nj, Zhang, Tj, Zhang, Xy, and Zhu, Qq

Subjects
Physics, gamma ray detector, Nuclear and High Energy Physics, Shower, Air shower, Altitude, Meteorology, Data analysis, Gamma Ray Bursts, Effects of high altitude on humans, Instrumentation
Abstract

An RPC carpet covering similar to 10(4) m(2) (ARGO-YBJ experiment) will be installed in the YangBaJing Laboratory (Tibet, People's Republic of China) at an altitude of 4300 m a.s.l. A test-module of similar to 50 m(2) has been put in operation in this laboratory and about 10(6) air shower events have been collected. The RPC performance at high altitude and the carpet capability of reconstructing the shower features are presented. (C) 2000 Elsevier Science B.V. All rights reserved.

Published
2000

26. The ARGO-YBJ detector and high energy GRBs

Author

J. Mu, H.H. He, A. Cavaliere, R. Santonico, J. Su, Q. X. Geng, M. Vietri, A. Surdo, H.H. Kuang, S. M. Mari, N. Iucci, Jy Li, K.Z. Bao, M. Parisi, F Cesaroni, T. Di Girolamo, Paolo Padovani, G. Marsella, Cristian Stanescu, H.T. Yang, D. Martello, B. Bartoli, Z.Q. Liu, L.R. Sun, S.C. Sun, G.C. Yu, H.Y. Jai, Y.N. Wei, Paolo Bernardini, B.Y. Cao, S. Vernetto, L. Milano, P. Pistilli, H. M. Zhang, M. Oliviero, X.D. Yue, Denis Bastieri, M. Iacovacci, Roberta Sparvoli, Labaciren, N.J. Zhang, Hong-peng Lu, G. Mancarella, Enrico Calloni, M. Panareo, Zhaxiciren, Severino Angelo Maria Bussino, M. He, Q. Huang, P. Creti, A Morselli, C Sbarra, T.J. Zhang, P. R. Shen, C.R. Wang, X. Y. Gao, Q. Q. Zhu, X. R. Meng, G. Pellizzoni, Q.K. Yao, F.M. Kong, Dongming Mei, Danzengluobu, G. Sartori, Z.Y. Feng, BD Piazzoli, Roberto Cardarelli, Huaguang Wang, Fabrizio Barone, Y. H. Tan, J.L. Zhang, X. Y. Zhang, G. Severino, A. F. Yuan, Zhaxisangzhu, Z.R. Peng, H.Y. Wang, B. Li, Xh Ma, C. Bacci, Y Fu, G. Di Sciascio, M. De Vincenzi, S. Catalanotti, Hw Guo, R. Buonomo, C., Bacci, K. Z., Bao, F., Barone, Bartoli, Bruno, D., Bastieri, P., Bernardini, R., Buonomo, S., Bussino, Calloni, Enrico, B. Y., Cao, R., Cardarelli, Catalanotti, Sergio, A., Cavaliere, F., Cesaroni, P., Creti, Danzengluobu, D'ETTORRE PIAZZOLI, Benedetto, M., De Vincenzi, DI GIROLAMO, Tristano, G., Di Sciascio, Z. Y., Feng, Y., Fu, X. Y., Gao, Q. X., Geng, H. W., Guo, H. H., He, M., He, Q., Huang, Iacovacci, Michele, N., Iucci, H. Y., Jai, F. M., Kong, H. H., Kuang, Labaciren, B., Li, J. Y., Li, Z. Q., Liu, H., Lu, X. H., Ma, G., Mancarella, S. M., Mari, G., Marsella, D., Martello, D. M., Mei, X. R., Meng, Milano, Leopoldo, A., Morselli, J., Mu, M., Oliviero, P., Padovani, M., Panareo, M., Parisi, G., Pellizzoni, Z. R., Peng, P., Pistilli, R., Santonico, G., Sartori, C., Sbarra, G., Severino, P. R., Shen, R., Sparvoli, C., Stanescu, J., Su, L. R., Sun, S. C., Sun, A., Surdo, Y. H., Tan, S., Vernetto, M., Vietri, C. R., Wang, H., Wang, H. Y., Wang, Y. N., Wei, H. T., Yang, Q. K., Yao, G. C., Yu, X. D., Yue, A. F., Yuan, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., Zhang, Zhaxisangzhu, Zhaxiciren, Q. Q., Zhu, B., Bartoli, E., Calloni, S., Catalanotti, B. D., Piazzoli, M. D., Vincenzi, T. D., Girolamo, G. D., Sciascio, M., Iacovacci, Mancarella, Giovanni, Marsella, Giovanni, Martello, Daniele, L., Milano, Panareo, Marco, Bacci, C., Bao, K. Z., Barone, F., Bartoli, B., Bastieri, D., Bernardini, P., Buonomo, R., Bussino, S., Calloni, E., Cao, B. Y., Cardarelli, R., Catalanotti, S., Cavaliere, A., Cesaroni, F., Creti, P., D'ETTORRE PIAZZOLI, B., DE VINCENZI, M., DI GIROLAMO, T., DI SCIASCIO, G., Feng, Z. Y., Fu, Y., Gao, X. Y., Geng, Q. X., Guo, H. W., He, M., Huang, Q., Iacovacci, M., Iucci, N., Jai, H. Y., Kong, F. M., Kuang, H. H., Li, B., Liu, Z. Q., Lu, H., Mancarella, G., Mari, S. M., Mei, D. M., Meng, X. R., Milano, L., Morselli, A., Mu, J., Oliviero, M., Padovani, P., Parisi, M., Pellizzoni, G., Peng, Z. R., Pistilli, P., Santonico, R., Sartori, G., Sbarra, C., Severino, G., Shen, P. R., Sparvoli, R., Stanescu, C., Su, J., Sun, L. R., Sun, S. C., Surdo, A., Tan, Y. H., Vernetto, S., Vietri, M., Wang, C. R., Wang, H., Wang, H. Y., Wei, Y. N., Yang, H. T., Yao, Q. K., Yue, X. D., Yuan, A. F., Zhang, H. M., Zhang, J. L., Zhang, N. J., Zhang, T. J., Zhang, X. Y., and Zhu, Q. Q.

Subjects
Astroparticle physics, Physics, Range (particle radiation), Physics::Instrumentation and Detectors, Large detector systems for particle and astroparticle physics, Astrophysics::High Energy Astrophysical Phenomena, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, General Physics and Astronomy, Astronomy, Cosmic ray, Astrophysics, Radiation, gamma-ray: bursts, gamma-ray detector, Gamma Ray Burst, Observatory, Gamma-ray burst, Argo
Abstract

ARGO-YBJ (Astrophysical Radiation with Ground-based Observatory at YangBaJing) is a detector optimized to study small size air showers. It consists of a layer of Resistive Plate Counters (RPCs) covering an area of similar to 6500 m(2) and will be located in the Yangbajing Laboratory (Tibet, China) at 4300 m a.s.l. ARGO-YBJ will be devoted to a wide range of fundamental issues in cosmic rays and astroparticle physics, including in particular gamma-ray astronomy and gamma-ray bursts physics in the range 10 GeV divided by 500 TeV. The sensitivity of ARGO-YBJ to detect high energy GRBs is presented.

Published
1999

27. [A multicenter study on effect of delayed chemotherapy on prognosis of Burkitt lymphoma in children].

Author

Song L, Jin L, Zhang YH, Yang XM, Duan YL, Zheng MC, Zhai XW, Liu Y, Liu W, Liu AS, Yuan XJ, Dai YP, Zhang LP, Wang J, Sun LR, Liu R, Zhang BX, Jiang L, Wei HX, Chen KL, Jin RM, Wang XG, Zhou HX, Wang HM, Zhuang SS, Zhou CJ, Gao ZF, Mu X, Zhang KH, and Li F

Subjects
Humans, Retrospective Studies, Child, Female, Male, Prognosis, Child, Preschool, Adolescent, Time-to-Treatment, China, Tumor Lysis Syndrome etiology, Survival Rate, Infant, Burkitt Lymphoma drug therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use
Abstract

Objective: To analyze the factors affecting delayed chemotherapy in children with Burkitt lymphoma (BL) and their influence on prognosis. Methods: Retrospective cohort study. Clinical data of 591 children aged ≤18 years with BL from May 2017 to December 2022 in China Net Childhood Lymphoma (CNCL) was collected. The patients were treated according to the protocol CNCL-BL-2017. According to the clinical characteristics, therapeutic regimen was divided into group A, group B and group C .Based on whether the total chemotherapy time was delayed, patients were divided into two groups: the delayed chemotherapy group and the non-delayed chemotherapy group. Based on the total delayed time of chemotherapy, patients in group C were divided into non-delayed chemotherapy group, 1-7 days delayed group and more than 7 days delayed group. Relationships between delayed chemotherapy and gender, age, tumor lysis syndrome before chemotherapy, bone marrow involvement, disease group (B/C group), serum lactate dehydrogenase (LDH) > 4 times than normal, grade Ⅲ-Ⅳ myelosuppression after chemotherapy, minimal residual disease in the interim assessment, and severe infection (including severe pneumonia, sepsis, meningitis, chickenpox, etc.) were analyzed. Logistic analysis was used to identify the relevant factors. Kaplan-Meier method was used to analyze the patients' survival information. Log-Rank was used for comparison between groups. Results: Among 591 patients, 504 were males and 87 were females, the follow-up time was 34.8 (18.6,50.1) months. The 3-year overall survival (OS) rate was (92.5±1.1)%,and the 3-year event-free survival (EFS) rate was (90.5±1.2)%. Seventy-three (12.4%) patients were in delayed chemotherapy group and 518 (87.6%) patients were in non-delayed chemotherapy group. The reasons for chemotherapy delay included 72 cases (98.6%) of severe infection, 65 cases (89.0%) of bone marrow suppression, 35 cases (47.9%) of organ dysfunction, 22 cases (30.1%) of tumor lysis syndrome,etc. There were 7 cases of chemotherapy delay in group B, which were seen in COPADM (vincristine+cyclophosphamide+prednisone+daunorubicin+methotrexate+intrathecal injection,4 cases) and CYM (methotrexate+cytarabine+intrathecal injection,3 cases) stages. There were 66 cases of chemotherapy delay in group C, which were common in COPADM (28 cases) and CYVE 1 (low dose cytarabine+high dose cytarabine+etoposide+methotrexate, 12 cases) stages. Multinomial Logistic regression analysis showed that the age over 10 years old ( OR =0.54,95% CI 0.30-0.93), tumor lysis syndrome before chemotherapy ( OR =0.48,95% CI 0.27-0.84) and grade Ⅲ-Ⅳ myelosuppression after chemotherapy ( OR =0.55,95% CI 0.33-0.91)were independent risk factors for chemotherapy delay.The 3-year OS rate and the 3-year EFS rate of children with Burkitt lymphoma in the delayed chemotherapy group were lower than those in the non-delayed chemotherapy group ((79.4±4.9)% vs. (94.2±1.1)%, (80.2±4.8)% vs. (92.0±1.2)%,both P <0.05). The 3-year OS rate of the group C with chemotherapy delay >7 days (42 cases) was lower than that of the group with chemotherapy delay of 1-7 days (22 cases) and the non-delay group (399 cases) ((76.7±6.9)% vs. (81.8±8.2)% vs. (92.7±1.3)%, P =0.002).The 3-year OS rate of the chemotherapy delay group (9 cases) in the COP (vincristine+cyclophosphamide+prednisone) phase was lower than that of the non-chemotherapy delay group (454 cases) ((66.7±15.7)% vs. (91.3±1.4)%, P =0.005). Similarly, the 3-year OS rate of the chemotherapy delay group (11 cases) in the COPADM1 phase was lower than that of the non-chemotherapy delay group (452 cases) ((63.6±14.5)% vs. (91.5±1.3)%, P =0.001). Conclusions: The delayed chemotherapy was related to the age over 10 years old, tumor lysis syndrome before chemotherapy and grade Ⅲ-Ⅳ myelosuppression after chemotherapy in pediatric BL. There is a significant relationship between delayed chemotherapy and prognosis of BL in children.

Published
2024
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28. [Interim efficacy of a multicenter cohort study for China Net Childhood Lymphoma mature B-cell lymphoma 2017 regimen in the treatment of pediatric High-grade-B cell lymphoma].

Author

Zhao Y, Huang S, Jia YP, Zhang LP, Duan YL, Jin L, Zhai XW, Wang HS, Hu B, Liu Y, Liu AS, Liu W, Zheng MC, Li F, Sun LR, Yuan XJ, Dai YP, Zhang BX, Jiang L, Wang XG, Wang HM, Zhou CJ, Gao ZF, and Zhang YH

Subjects
Humans, Retrospective Studies, Child, China, Adolescent, Female, Male, Proto-Oncogene Proteins c-bcl-6 genetics, Cohort Studies, Proto-Oncogene Proteins c-bcl-2 genetics, Child, Preschool, In Situ Hybridization, Fluorescence, Treatment Outcome, Proto-Oncogene Proteins c-myc genetics, Lymphoma, B-Cell drug therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use
Abstract

Objective: To analyze the mid-term efficacy of the China Net Childhood Lymphoma mature B-cell lymphoma 2017 (CNCL-B-NHL-2017) regimen in treating children with high-grade B-cell lymphoma (HGBL). Methods: Clinical and pathological data of HGBL children aged≤18 years admitted to 16 hospitals of the Chinese Children's Lymphoma Collaborative Group (CNCL) from May 2017 to April 2021 were collected retrospectively. They were divided in to high-grade B-cell lymphoma with double hit/triple hit (HGBL-DH/TH) group and high-grade B-cell lymphoma non-specified (HGBL-NOS) group, according to the 2016 version of the World Health Organization (WHO) Hematopoietic and Lymphoid Tissues Cancer Classification. Both groups of patients were treated with stratified chemotherapy by risk according to the CNCL-B-NHL-2017 scheme. The deadline for follow-up was December 31, 2023. All the patients were examined by chromosome fluorescence in situ hybridization (FISH), and the rearrangement of genes MYC, BCL-2 and BCL-6 was confirmed. The clinical and pathological characteristics of patients at disease onset were analyzed, and the therapeutic effects of patients in different clinical stages and risk groups were compared. Survival analysis was drawn by Kaplan Meier method, the log-rank test was used to compare the differences in the cumulative survival rate between different groups, and multivariate Cox regression model was used to identify the prognostic factors. Results: A total of 62 patients were included, with an onset age [ M ( Q 1 , Q 3 )] of 7 (4, 11) years, including 48 males and 14 females. There were 11 (17.7%) patients in stageⅡ, 33(53.2%)patients in stage Ⅲ and 18(29.1%)patients in stage Ⅳ. FISH testing showed that 4 cases (6.5%) were HGBL-DH and 3 (4.8%) were HGBL-TH. The remaining 55 cases (88.7%) were HGBL-NOS, with 18 cases accompanied by MYC rearrangement. There were 7 cases in the HGBL-DH/TH group and 55 cases in the HGBL-NOS group. Thirteen cases (20.9%) were treated with the B1 regimen, 3 cases (4.8%) with B2 regimen, 37 cases (59.6%) with C1 regimen, and 9 cases (14.7%) with the C2 regimen. Forty-eight cases (77.4%) received rituximab therapy at the same time. Five cases (8.0%) progressed during treatment. The follow-up time [ M ( Q 1 , Q 3 )] was 43.5 (36.1, 53.7) months. The complete remission rate was 91.9% (57/62). The 3 year overall survival rate was 93.5% and event-free survival (EFS) rate was 91.9%. The 3-year overall survival rate in the HGBL-NOS group was higher than that in the HGBL-DH/TH group (96.3% vs 71.4%, P =0.011). The 3-year EFS rate of the HGBL-NOS group was higher than that of the HGBL-DH/TH group (94.5% vs 71.4%, P =0.037). In the HGBL-NOS subgroup, the overall survival rate of children with MYC rearrangement was lower (100% vs 88.9%, P =0.039). Multivariate Cox regression analysis showed that central invasion ( HR =6.05, 95% CI : 1.96-38.13, P =0.046) was a risk factor for overall survival. Conclusion: CNCL-B-NHL-2017 regimen shows significant effects in the treatment of pediatric HGBL, with a good prognosis.

Published
2024
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30. [Mid-term efficacy of China Net Childhood Lymphoma-mature B-cell lymphoma 2017 regimen in the treatment of pediatric Burkitt lymphoma].

Author

Zhang M, Wu P, Duan YL, Jin L, Yang J, Huang S, Liu Y, Hu B, Zhai XW, Wang HS, Fu Y, Li F, Yang XM, Liu AS, Qin S, Yuan XJ, Dong YS, Liu W, Zhou JW, Zhang LP, Jia YP, Wang J, Qu LJ, Dai YP, Guan GT, Sun LR, Jiang J, Liu R, Jin RM, Wang ZJ, Wang XG, Zhang BX, Chen KL, Zhuang SQ, Zhang J, Zhou CJ, Gao ZF, Zheng MC, and Zhang Y

Subjects
Adolescent, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Child, Disease-Free Survival, Female, Humans, Lactate Dehydrogenases, Male, Prognosis, Retrospective Studies, Rituximab therapeutic use, Treatment Outcome, Burkitt Lymphoma drug therapy, Lymphoma, B-Cell drug therapy
Abstract

Objective: To analyze the clinical characteristics of children with Burkitt lymphoma (BL) and to summarize the mid-term efficacy of China Net Childhood Lymphoma-mature B-cell lymphoma 2017 (CNCL-B-NHL-2017) regimen. Methods: Clinical features of 436 BL patients who were ≤18 years old and treated with the CNCL-B-NHL-2017 regimen from May 2017 to April 2021 were analyzed retrospectively. Clinical characteristics of patients at disease onset were analyzed and the therapeutic effects of patients with different clinical stages and risk groups were compared. Survival analysis was performed by Kaplan-Meier method, and Cox regression was used to identify the prognostic factors. Results: Among 436 patients, there were 368 (84.4%) males and 68 (15.6%) females, the age of disease onset was 6.0 (4.0, 9.0) years old. According to the St. Jude staging system, there were 4 patients (0.9%) with stage Ⅰ, 30 patients (6.9%) with stage Ⅱ, 217 patients (49.8%) with stage Ⅲ, and 185 patients (42.4%) with stage Ⅳ. All patients were stratified into following risk groups: group A ( n =1, 0.2%), group B1 ( n =46, 10.6%), group B2 ( n =19, 4.4%), group C1 ( n =285, 65.4%), group C2 ( n =85, 19.5%). Sixty-three patients (14.4%) were treated with chemotherapy only and 373 patients (85.6%) were treated with chemotherapy combined with rituximab. Twenty-one patients (4.8%) suffered from progressive disease, 3 patients (0.7%) relapsed, and 13 patients (3.0%) died of treatment-related complications. The follow-up time of all patients was 24.0 (13.0, 35.0) months, the 2-year event free survival (EFS) rate of all patients was (90.9±1.4) %. The 2-year EFS rates of group A, B1, B2, C1 and C2 were 100.0%, 100.0%, (94.7±5.1) %, (90.7±1.7) % and (85.9±4.0) %, respectively. The 2-year EFS rates was higher in group A, B1, and B2 than those in group C1 (χ 2 =4.16, P =0.041) and group C2 (χ 2 =7.21, P =0.007). The 2-year EFS rates of the patients treated with chemotherapy alone and those treated with chemotherapy combined with rituximab were (79.3±5.1)% and (92.9±1.4)% (χ 2 =14.23, P <0.001) respectively. Multivariate analysis showed that stage Ⅳ (including leukemia stage), serum lactate dehydrogenase (LDH)>4-fold normal value, and with residual tumor in the mid-term evaluation were risk factors for poor prognosis ( HR =1.38,1.23,8.52,95% CI 1.05-1.82,1.05-1.43,3.96-18.30). Conclusions: The CNCL-B-NHL-2017 regimen show significant effect in the treatment of pediatric BL. The combination of rituximab improve the efficacy further.

Published
2022
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31. [Multicenter clinical study on the diagnosis and treatment of childhood renal tumor].

Author

Zhang AA, Tang JY, Xu M, Fang YJ, Yan J, Gao J, Yuan XJ, Li F, Ju XL, Liu W, Wu XJ, Sun LR, Jiang L, Zhang WL, Chu JH, and Lu XY

Subjects
Antineoplastic Combined Chemotherapy Protocols therapeutic use, Child, Humans, Infant, Multicenter Studies as Topic, Neoplasm Staging, Prognosis, Prospective Studies, Kidney Neoplasms drug therapy, Kidney Neoplasms therapy, Wilms Tumor drug therapy, Wilms Tumor therapy
Abstract

Objective: To summarize the effect of Chinese Children's Cancer Group (CCCG) Wilms tumor (WT)-2015 protocol. Methods: This was a prospective study. CCCG-WT-2015 protocol was revised on the basis of the CCCG-WT-2009 protocol. Clinical data of 288 children diagnosed with newly diagnosed kidney neoplasms in fourteen pediatric centers between September 2015 to December 2018 were summarized. The age of onset, distribution of pathological subtypes, staging, curative effect and prognostic factors of these children were analyzed. Kaplan-Meier method was used for survival curve and Log-Rank method was used for univariate analysis. Results: Among 288 cases with kidney neoplasms, there were 261 cases of WT, including 254 cases (97.3%) with favorable histology (FH) WT and 7 cases (2.7%) with unfavorable histology WT (UFHWT). The 3 year events free survival (EFS) rate for FHWT and UFHWT were (88.9±2.1)% and (80.0±17.9)%, which were better than that in WT-2009 (81.2% and 71.7%). In the 96 cases of stage Ⅲ/Ⅳ FHWT with indications for radiotherapy, 76 cases received radiation, another 20 cases received M protocol chemotherapy (cyclophosphamide, etoposide, gentamycin, vincristine and adriamycin) instead of radiation. The 3 year EFS rate for these two groups were (84.7±4.3)% and (84.7±8.1)%(χ 2 =0.015, P =0.902). There were 22 renal clear cell sarcoma and 5 malignant rhabdoid tumor, 3 year EFS rate of them was (94.4±5.4)% and (20.0±17.9)%. Univariate analysis was performed for age, gender, pathological type, stage, whether rupture occurred during operation, whether complete remission (CR) occurred at the end of treatment and radiotherapy. Pathological types (χ 2 =44.329, P <0.01) and failure to achieve CR at the end of the treatment (χ 2 =49.459, P <0.01) were independent factor for predicting survival. Conclusion: Compared with CCCG-WT-2009, treatment of renal tumors in CCCG-WT-2015 study yielded good survival outcome, which can be further applied.

Published
2021
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32. [Long-term results of multicenter study based on childhood acute lymphoblastic leukemia 2005 protocol].

Author

Cai JY, Wang NL, Jiang H, Shen SH, Xue HL, Chen J, Pan C, Gao YJ, Sun LR, Yuan XJ, Gu LJ, and Tang JY

Subjects
Child, China, Disease-Free Survival, Humans, Neoplasm, Residual, Prognosis, Remission Induction, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hematopoietic Stem Cell Transplantation, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Abstract

Objective: To evaluate the long-term efficacy and prognostic factors of childhood acute lymphoblastic leukemia (ALL) enrolled in Shanghai Children's Medical Center-Acute Lymphoblastic Leukemia-2005(SCMC-ALL-2005) multicenter study. Methods: Between May 2005 and December 2014, 1 497 newly diagnosed ALL patients were enrolled and treated in 5 hospitals of SCMC-ALL-2005 study group, using risk-stratified SCMC-ALL-2005 protocol. Risk group classification and treatment intensity were based on clinical features, genetic abnormalities, early response to treatment and levels of minimal residual disease (MRD). Kaplan-Meier method was used to generate overall survival (OS) and event-free survival(EFS) curves. Cox proportional hazards models were used for multivariate analyses. Results: The patients were followed up to December 31, 2016, the median follow-up time was 69 months (24-141 months). The 5-year and 10-year OS rates were (80.0±1.0)% and (76.0±2.0)%. The 5-year and 10-year EFS rates were (69.0±1.0)% and (66.0±2.0)%. The 5-year and 10-year relapse rates were (23.0±1.0)% and (25.0±2.0)%. The 5-year OS and EFS for low risk (LR), intermediate risk (IR) and high risk (HR) were (91.1±1.4)% and (83.3±1.8)%, (79.2±1.5)% and (68.9±1.7)%, (52.9±4.4)% and (30.0±3.8)%, respectively. MRD negative status (<0.01%) on day 55 was seen in 792 patients (82.8%) and positive MRD on day 55 was associated with poor prognosis ( OR= 1.9, 95% CI: 1.3-2.7, P= 0.001). Twenty-four HR patients received allogeneic hematopoietic stem cell transplantation and 17(70.8%) of them were alive and in remission. A total of 164 severe adverse events occurred, 46 of them died, treatment-related mortality was 3.1%. Conclusions: In this large sample research, the overall outcome for multi-center SCMC-ALL-2005 study was favorable. This helps to promote the standardized treatment of childhood ALL to the whole country. MRD results on day 55 of induction therapy have important prognostic and therapeutic implications.

Published
2018
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