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Cigarette smoking causes multiple cancers by directly influencing mutation burden of driver mutations. However, the mechanism between somatic mutation caused by cigarette smoking and bladder tumorigenesis remains elusive. Smoking‐related mutation profile of bladder cancer was characterized by The Cancer Genome Atlas cohort. Integraticve OncoGenomics database was utilized to detect the smoking‐related driver genes, and its biological mechanism predictions were interpreted based on bulk transcriptome and single‐cell transcriptome, as well as cell experiments. Cigarette smoking was associated with an increased tumor mutational burden under 65 years old (p = 0.031), and generated specific mutational signatures in smokers. RB1 was identified as a differentially mutated driver gene between smokers and nonsmokers, and the mutation rate of RB1 increased twofold after smoking (p = 0.008). RB1 mutations and the 4‐aminobiphenyl interference could significantly decrease the RB1 expression level and thus promote the proliferation, invasion, and migration ability of bladder cancer cells. Enrichment analysis and real‐time quantitative PCR (RT‐qPCR) data showed that RB1 mutations inhibited cytochrome P450 pathway by reducing expression levels of UGT1A6 and AKR1C2. In addition, we also observed that the component of immunological cells was regulated by RB1 mutations through the stronger cell‐to‐cell interactions between epithelial scissor+ cells and immune cells in smokers. This study highlighted that RB1 mutations could drive smoking‐related bladder tumorigenesis through inhibiting cytochrome P450 pathway and regulating tumor immune microenvironment. [ABSTRACT FROM AUTHOR]

Different human-machine collaboration modes and driving simulation tests with the orthogonal method considered are designed for a series of typical intelligent highway landscapes. The feedback of drivers under different interaction modes is evaluated through NASA-LTX questionnaire, driving simulator, eye tracker, and electroencephalograph (EEG). This optimal interaction mode (including voice form, broadcasting timing, and frequency) of each driving assistance scene in CVI (Cooperative Vehicle Infrastructure) environment under the conditions of high and low traffic is determined from subjective and objective perspectives. In accordance with feedback of these subjects on each set scene, the voice information structure of each assistance mode plays the most important role on drivers followed by the broadcasting timing and frequency. These broadcasts which provide good effects include scenarios such as various assistance scenes at curves and an early warning timing at a long-distance trip as well as a high early warning frequency; in addition, as for an exit-tip assistance scenario, a voice mode assistance is preferred; and for various speed assistance scenes, the beep mode is better. Furthermore, it is found that, at a higher traffic level but a short-distance trip, an early warning timing is favored generally for various scenes while under a low traffic level, a long-distance early warning timing is better., Author(s): Yicheng Zhou [1]; Tuo Sun [2]; Shunzhi Wen [1]; Hao Zhong (corresponding author) [2]; Youkai Cui [1]; Jiemin Xie [3]; Wei Wu [1]; Wanjing Ma [2] 1. Introduction and [...]

Travel time is one of the most critical parameters in proactive traffic management and the deployment of advanced traveler information systems. This paper proposes a hybrid model named LSTM-CNN for predicting the travel time of highways by integrating the long short-term memory (LSTM) and the convolutional neural networks (CNNs) with the attention mechanism and the residual network. The highway is divided into multiple segments by considering the traffic diversion and the relative location of automatic number plate recognition (ANPR). There are four steps in this hybrid approach. First, the average travel time of each segment in each interval is calculated from ANPR and fed into LSTM in the form of a multidimensional array. Second, the attention mechanism is adopted to combine the hidden layer of LSTM with dynamic temporal weights. Third, the residual network is introduced to increase the network depth and overcome the vanishing gradient problem, which consists of three pairs of one-dimensional convolutional layers (Conv1D) and batch normalization (BatchNorm) with the rectified linear unit (ReLU) as the activation function. Finally, a series of Conv1D layers is connected to extract features further and reduce dimensionality. The proposed LSTM-CNN approach is tested on the three-month ANPR data of a real-world 39.25km highway with four pairs of ANPR detectors of the uplink and downlink, Zhejiang, China. The experimental results indicate that LSTM-CNN learns spatial, temporal, and depth information better than the state-of-the-art traffic forecasting models, so LSTM-CNN can predict more accurate travel time. Moreover, LSTM-CNN outperforms the state-of-the-art methods in nonrecurrent prediction, multistep-ahead prediction, and long-term prediction. LSTM-CNN is a promising model with scalability and portability for highway traffic prediction and can be further extended to improve the performance of the advanced traffic management system (ATMS) and advanced traffic information system (ATIS)., Author(s): Wenjun Du [1]; Bo Sun [2]; Jiating Kuai [1]; Jiemin Xie [3]; Jie Yu [1]; Tuo Sun (corresponding author) [4] 1. Introduction With the increase of the cooperative vehicle [...]

The combination of electric vehicle (EV) and carsharing is expected to provide social and environmental benefits, like encouraging sustainable travel behaviors (reducing car ownership and vehicle kilometres of travel) and improving the accessibility and flexibility of urban transport. Thus, electric carsharing is encouraged to be adopted for daily trips, and the operators propose the friend-invitation promotion scheme for the membership expansion. This study explores the effectiveness of this scheme and the characteristics of the scheme participants and their invited friends (e.g., age, friend-invitation pattern, and EV rental pattern). The analysis found that 28.4% of these invited friends would make at least one EV rental after registration, whereas 30.4% of the other members who registered in the same period would do so, indicating that these invited friends were less active. Therefore, suggestions are given based on the EV rental pattern of these invited friends (preferring a longer journey using a smaller but cheaper EV) to enhance the effectiveness of the friend-invitation promotion scheme., Author(s): Jiemin Xie [1]; Tuo Sun (corresponding author) [2]; Shuangjian Yang [3] 1. Introduction The ownership of private car keeps increasing [1], and China has been estimated to have 530-623 [...]

Traffic prediction is highly significant for intelligent traffic systems and traffic management. eXtreme Gradient Boosting (XGBoost), a scalable tree lifting algorithm, is proposed and improved to predict more high-resolution traffic state by utilizing origin-destination (OD) relationship of segment flow data between upstream and downstream on the highway. In order to achieve fine prediction, a generalized extended-segment data acquirement mode is added by incorporating information of Automatic Number Plate Recognition System (ANPRS) from exits and entrances of toll stations and acquired by mathematical OD calculation indirectly without cameras. Abnormal data preprocessing and spatio-temporal relationship matching are conducted to ensure the effectiveness of prediction. Pearson analysis of spatial correlation is performed to find the relevance between adjacent roads, and the relative importance of input modes can be verified by spatial lag input and ordinary input. Two improved models, independent XGBoost (XGBoost-I) with individual adjustment parameters of different sections and static XGBoost (XGBoost-S) with overall adjustment of parameters, are conducted and combined with temporal relevant intervals and spatial staggered sectional lag. The early_stopping_rounds adjustment mechanism (EAM) is introduced to improve the effect of the XGBoost model. The prediction accuracy of XGBoost-I-lag is generally higher than XGBoost-I, XGBoost-S-lag, XGBoost-S, and other baseline methods for short-term and long-term multistep ahead. Additionally, the accuracy of the XGBoost-I-lag is evaluated well in nonrecurrent conditions and missing cases with considerable running time. The experiment results indicate that the proposed framework is convincing, satisfactory, and computationally reasonable., Author(s): Bo Sun [1,2]; Tuo Sun [1,3]; Pengpeng Jiao (corresponding author) [1] 1. Introduction As a key technological component of intelligent transportation systems (ITS), traffic flow prediction has become an [...]

About 90% of traffic crashes are caused by human factors, within which traffic violations are one of the most typical and common causes. In order to investigate the relationship between traffic violations and traffic crashes, this research targets signalized intersections in two Chinese cities: Yinchuan and Suqian. Thirty-one intersections are selected as the research sites, and additionally, the traffic volume, traffic violation, and traffic crash data of each intersection are collected for one year. A White's test is conducted to test the homoscedasticity of the data and a multiple linear regression model is employed to investigate the relationship between traffic crashes and violations. The results show the following: (1) although the research sites are located in two different cities, the data is homoscedastic, which suggests that the above result may be statistically stable between different cities. (2) There is a significant multiple linear regression relationship (R[sup.2]=0.782, adjusted R[sup.2]=0.716) between the total number of traffic crashes and traffic violations. Among the chosen 7 independent variables, four are significantly related to the dependent variable, namely, driving commercial vehicle during internship, wrong-way entry, speeding, and traffic-light violation. (3) With the increase of annual average daily traffic (AADT), the number of total crashes goes up; however, the injury-or-fatality rate decreases, which means that intersections with smaller traffic volumes tend to have higher traffic crash severity. Based on the above conclusions, it is possible to conduct more targeted enforcement to improve the safety of intersections., Author(s): Ze-Hao Jiang [1]; Xiao-Guang Yang [2]; Tuo Sun [2]; Tao Wang [3]; Zheng Yang (corresponding author) [3] 1. Introduction The traffic safety situation around the world is still not [...]