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4. Evaluation of efficacy and safety after replacement of methyl hydrogen with Deuterium at 7-position methyl formate of Clopidogrel

Author

Xu, zhiping, primary, Miao, Yujia, additional, Wu, Tianlong, additional, Chen, Liang, additional, Gao, Mingyue, additional, Sun, Yantong, additional, Liu, Yingze, additional, Niu, Jinjin, additional, Cai, Deqi, additional, Li, Xiaohua, additional, Chen, Chen, additional, Liu, Shengyang, additional, Gu, Jingkai, additional, and Cao, Xia, additional

Published
2024
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15. Evaluation of efficacy and safety after replacement of methyl hydrogen with deuterium at methyl formate of Clopidogrel

Author

Xu, Zhiping, primary, Miao, Yujia, additional, Wu, Tianlong, additional, Chen, Liang, additional, Gao, Mingyue, additional, Sun, Yantong, additional, Liu, Yingze, additional, Niu, Jinjin, additional, Cai, Deqi, additional, Li, Xiaohua, additional, Chen, Chen, additional, Liu, Shengyang, additional, Gu, Jingkai, additional, and Cao, Xia, additional

Published
2022
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26. Evaluation of Efficacy and Safety After Replacement of Methyl Hydrogen With Deuterium at 7-position Methyl Formate of Clopidogrel

Author

Xu, Zhiping, primary, Miao, Yujia, additional, Wu, Tianlong, additional, Chen, Liang, additional, Gao, Mingyue, additional, Sun, Yantong, additional, Liu, Yingze, additional, Niu, Jinjin, additional, Cai, Deqi, additional, Li, Xiaohua, additional, Chen, Chen, additional, Liu, Shengyang, additional, Gu, Jingkai, additional, and Cao, Xia, additional

Published
2021
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31. Development and Application of an MSALL-Based Approach for the Quantitative Analysis of Linear Polyethylene Glycols in Rat Plasma by Liquid Chromatography Triple-Quadrupole/Time-of-Flight Mass Spectrometry

Author

Zhou, Xiaotong, primary, Meng, Xiangjun, additional, Cheng, Longmei, additional, Su, Chong, additional, Sun, Yantong, additional, Sun, Lingxia, additional, Tang, Zhaohui, additional, Fawcett, John Paul, additional, Yang, Yan, additional, and Gu, Jingkai, additional

Published
2017
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48. Method Development and Validation of Olprinone in Human Plasma by HPLC Coupled with ESI-MS-MS: Application to a Pharmacokinetic Study.

Author

Wang, Hongbo, Zhang, Baochang, Sun, Xilin, Sun, Yantong, and Shi, Meiyun

Subjects
HIGH performance liquid chromatography, LIQUID chromatography-mass spectrometry, PHARMACOKINETICS, LIQUID-liquid extraction, ETHYL acetate, AMMONIUM acetate
Abstract

A simple, specific and highly sensitive assay using liquid chromatography–tandem mass spectrometry with electrospray ionization was developed for the determination of olprinone in human plasma. Following the addition of codeine as an internal standard and simple liquid–liquid extraction with ethyl acetate–isopropanol (95:5, v/v), the analytes were separated on a Zorbax SB-C18 column (4.6 × 150 mm i.d., 5 µm) and eluted with a mobile phase consisting of methanol–10 mmol/L ammonium acetate containing 1% formic acid (50:50, v/v) at a flow rate of 1.0 mL/min. Detection was achieved with electrospray positive ionization mass spectrometry using multiple reaction monitoring mode. Linear calibration curves were obtained in the concentration range of 0.1–100 ng/mL (r = 0.9995), with a lower limit of quantification of 0.1 ng/mL. The intra-day and inter-day precision values, as relative deviation, were below 6.06% and the accuracy, as relative error, was below 9.92% at all quality control concentrations. The method was applicable to clinical pharmacokinetic study of an olprinone hydrochloride hydrate injection in healthy Chinese volunteers. [ABSTRACT FROM AUTHOR]

Published
2014
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49. Trantinterol, a Novel β2-Adrenoceptor Agonist, Noncompetitively Inhibits P-Glycoprotein Function in Vitroand in Vivo

Author

Wang, Tingting, Sun, Yantong, Ma, Wenxiao, Yang, Zhichao, Yang, Junfeng, Liu, Jingrui, Fan, Hongbo, Yang, Yan, Gu, Jingkai, Fawcett, John Paul, and Guo, Yingjie

Abstract

P-glycoprotein (P-gp)-mediated drug–drug interactions are important factors causing adverse effects of drugs in clinical use. The aim of this study was to determine whether trantinterol (also known as SPFF), a novel β2-adrenoceptor agonist, was a P-gp inhibitor or substrate. The results showed that trantinterol was not a substrate of P-gp but increased rhodamine 123 (Rho 123) uptake by MDCK-MDR1 cells and decreased the efflux transport of both Rho 123 and cyclosporine A (CsA) in bidirectional transport studies across MDCK-MDR1 cell monolayers. This suggested that trantinterol was a P-gp inhibitor but not a P-gp substrate. The mechanism of inhibition was investigated in the P-gp-Glo assay system, where it was found that trantinterol inhibited P-gp ATPase activity in a dose-dependent manner. A subsequent study using the antibody binding assay with the conformation-sensitive P-gp-specific antibody UIC2 confirmed that trantinterol decreased UIC2 binding at 10 μM in contrast to the competitive inhibitor, verapamil. This suggested that trantinterol was a noncompetitive inhibitor of P-gp. Finally, a pharmacokinetic study in rat showed that trantinterol significantly increased the area under the plasma concentration–time curve (AUC) and maximum plasma concentration (Cmax) of digoxin and paclitaxel (PAC), and the Cmaxof cyclosporine A (CsA). In summary, trantinterol is a potent noncompetitive P-gp inhibitor which may increase the bioavailability of other P-gp substrate drugs coadministered with it.

Published
2015
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50. Determination of Prostaglandin E1 in dog plasma using liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study.

Author

Zhang, Yunhui, Sun, Yantong, Li, Guoqing, Yin, Lei, Wang, Tingting, Yang, Yan, and Gu, Jingkai

Subjects
*PROSTAGLANDIN E1, *BLOOD plasma, *LIQUID chromatography-mass spectrometry, *PHARMACOKINETICS, *LABORATORY dogs, *EXTRACTION (Chemistry), *DRUG dosage
Abstract

Highlights: [•] An LC–MS/MS was developed and validated for the determination of PGE1 in beagle dog plasma. [•] An LLOQ of 10pg/mL was achieved. [•] Indomethacin was added to plasma to avoid significant endogenous interfere. [•] A simple one-step sample extraction was used followed by a short cycle time of 3min. [•] The method was applied to a pharmacokinetic study in dogs at a clinical relevant dose. [ABSTRACT FROM AUTHOR]

Published
2013
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