226 results on '"Sutton, Vivien R."'
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2. Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1
3. Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus
4. Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells.
5. Cytotoxic T Lymphocyte-Induced Killing in the Absence of Granzymes A and B Is Unique and Distinct from Both Apoptosis and Perforin-Dependent Lysis
6. A Clathrin/Dynamin- and Mannose-6-Phosphate Receptor-Independent Pathway for Granzyme B-Induced Cell Death
7. The Histone Deacetylase Inhibitor and Chemotherapeutic Agent Suberoylanilide Hydroxamic Acid (SAHA) Induces a Cell-Death Pathway Characterized by Cleavage of Bid and Production of Reactive Oxygen Species
8. The Drug Efflux Protein, P-Glycoprotein, Additionally Protects Drug-Resistant Tumor Cells from Multiple Forms of Caspase-Dependent Apoptosis
9. Data from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome
10. Supplementary Figure S1 from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome
11. Supplementary Table S1 from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome
12. Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity
13. Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack
14. Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction
15. Residual Active Granzyme B in Cathepsin C-Null Lymphocytes Is Sufficient for Perforin-Dependent Target Cell Apoptosis
16. Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors
17. Cathepsin H Is an Additional Convertase of Pro-granzyme B
18. Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity
19. Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules
20. Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function
21. Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function
22. ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome
23. Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L
24. Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining
25. Lymphocyte granule-mediated cell death
26. A Central Role for Bid in Granzyme B-induced Apoptosis
27. Antigen‐specific <scp>CD</scp> 4 + <scp>CD</scp> 25 + T cells induced by locally expressed <scp>ICOS</scp> ‐Ig: the role of Foxp3, Perforin, Granzyme B and <scp>IL</scp> ‐10 ‐ an experimental study
28. In vitro and in vivo antitumour activity of a chimeric anti-CD19 antibody
29. Granzyme B–Mediated Death of Pancreatic β-Cells Requires the Proapoptotic BH3-Only Molecule Bid
30. Caspase Activation by Granzyme B Is Indirect, and Caspase Autoprocessing Requires the Release of Proapoptotic Mitochondrial Factors
31. An aberrantDRB4 null gene transcript is found that could encode a novel HLA-DR chain
32. Granzyme B: pro-apoptotic, antiviral and antitumor functions
33. Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis
34. Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B-mediated Caspase Activation
35. Antigen‐specific CD 4 + CD 25 + T cells induced by locally expressed ICOS ‐Ig: the role of Foxp3, Perforin, Granzyme B and IL ‐10 ‐ an experimental study
36. Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction
37. Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo
38. BCL-2 Blocks Perforin-induced Nuclear Translocation of Granzymes Concomitant with Protection against the Nuclear Events of Apoptosis
39. Antigen‐specific CD4+CD25+ T cells induced by locally expressed ICOS‐Ig: the role of Foxp3, Perforin, Granzyme B and IL‐10 ‐ an experimental study.
40. An Abnormal DRB4 (DRw53) mRNA Is Produced by DR7 Individuals Who Fail to Express the Gene Product
41. The Ly-25.1 specificity: Definition with a monoclonal antibody
42. An altered splice site is found in the DRB4 gene that is not expressed in HLA-DR7, Dw11 individuals
43. Definition of new alloantigens encoded by genes in the Ly-6 complex
44. Identification of two forms of the Ly-6.2 antigen showing differential expression
45. Granzyme H Is a Novel Protease Expressed by Human Mast Cells
46. A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection
47. KILLER CELLS—DELIVERERS OF EXOGENOUS DEATH PROTEASES
48. Cytotoxic Granules House Potent Proapoptotic Toxins Critical for Antiviral Responses and Immune Homeostasis
49. A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection
50. A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
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