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2. Impact of the neutrophil-to-lymphocyte ratio on patients with locally advanced non-small cell lung cancer who suffer radiation pneumonitis during the course of induction chemoradiotherapy followed by surgery

Author

Kubo, Yujiro, Yamamoto, Hiromasa, Matsubara, Kei, Hashimoto, Kohei, Tanaka, Shin, Shien, Kazuhiko, Suzawa, Ken, Miyoshi, Kentaroh, Okazaki, Mikio, Sugimoto, Seiichiro, Katsui, Kuniaki, Hiraki, Takao, Kiura, Katsuyuki, and Toyooka, Shinichi

Published
2024
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5. Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer

Author

Takatsu, Fumiaki, Suzawa, Ken, Tomida, Shuta, Thu, Yin Min, Sakaguchi, Masakiyo, Toji, Tomohiro, Ohki, Masayoshi, Tsudaka, Shimpei, Date, Keiichi, Matsuda, Naoki, Iwata, Kazuma, Zhu, Yidan, Nakata, Kentaro, Shien, Kazuhiko, Yamamoto, Hiromasa, Nakayama, Akiko, Okazaki, Mikio, Sugimoto, Seiichiro, and Toyooka, Shinichi

Published
2023
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8. EGFR Mutation is a Prognostic Factor in Lung Cancer Patients with Pleural Dissemination Detected During or After Surgery

Author

Fujiwara, Toshiya, Shien, Kazuhiko, Matsuura, Motoki, Soh, Junichi, Yamamoto, Hiromasa, Takao, Soshi, Maki, Yuho, Ueno, Tsuyoshi, Sugimoto, Ryujiro, Suzawa, Ken, Okazaki, Mikio, Tao, Hiroyuki, Hayama, Makio, Kataoka, Masafumi, Sano, Yoshifumi, Inokawa, Hidetoshi, Yamashita, Motohiro, Kawamata, Osamu, Kataoka, Kazuhiko, and Toyooka, Shinichi

Published
2023
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11. Impact of central nervous system metastasis after complete resection of lung adenocarcinomas harboring common EGFR mutation – A real-world database study in Japan: The CReGYT-01 EGFR study

Author

Katsumata, Shinya, Shimokawa, Mototsugu, Hamada, Akira, Haratake, Naoki, Nomura, Kotaro, Fujino, Kosuke, Yoshikawa, Mao, Suzawa, Ken, Shien, Kazuhiko, Suda, Kenichi, Ohara, Shuta, Fukuda, Shota, Kinoshita, Fumihiko, Hayasaka, Kazuki, Notsuda, Hirotsugu, Takamori, Shinkichi, Muto, Satoshi, Takanashi, Yusuke, Mizuno, Kiyomichi, Kawase, Akikazu, Hayakawa, Takamitsu, Sekihara, Keigo, Toda, Michihito, Matsuo, Somei, Takegahara, Kyoshiro, Hashimoto, Masaki, Nakahashi, Kenta, Endo, Makoto, Ozawa, Hiroki, Fujikawa, Ryo, Tomioka, Yasuaki, Namba, Kei, Matsubara, Taichi, Suzuki, Jun, Watanabe, Hikaru, Takada, Kazuki, Hoshino, Hironobu, Kaiho, Taisuke, Toyoda, Takahide, Kouki, Yasunobu, Shiono, Satoshi, Soh, Junichi, and Ohde, Yasuhisa

Published
2024
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13. Clinical Features of Patients With Second Primary Lung Cancer After Head and Neck Cancer

Author

Takatsu, Fumiaki, Suzawa, Ken, Okazaki, Mikio, Shien, Kazuhiko, Yamamoto, Hiromasa, Watanabe, Mototsugu, Hayama, Makio, Ueno, Tsuyoshi, Sugimoto, Ryujiro, Maki, Yuho, Fujiwara, Toshiya, Okita, Riki, Inokawa, Hidetoshi, Tao, Hiroyuki, Hirami, Yuji, Matsuda, Eisuke, Kataoka, Kazuhiko, Yamashita, Motohiro, Sano, Yoshifumi, Matsuura, Motoki, Mizutani, Hisao, and Toyooka, Shinichi

Published
2024
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14. ASO Visual Abstract: Prognostic Impact of Tumor-Infiltrating Lymphocytes, Tertiary Lymphoid Structures, and Neutrophil-to-Lymphocyte Ratio in Pulmonary Metastases from Uterine Leiomyosarcoma

Author

Matsuda, Naoki, Yamamoto, Hiromasa, Habu, Tomohiro, Iwata, Kazuma, Matsubara, Kei, Tanaka, Shin, Hashimoto, Kohei, Shien, Kazuhiko, Suzawa, Ken, Miyoshi, Kentaroh, Toji, Tomohiro, Okazaki, Mikio, Sugimoto, Seiichiro, Takahashi, Katsuhito, and Toyooka, Shinichi

Published
2023
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15. Correction to: Periostin secreted by cancer‑associated fibroblasts promotes cancer progression and drug resistance in non‑small cell lung cancer

Author

Takatsu, Fumiaki, Suzawa, Ken, Tomida, Shuta, Thu, Yin Min, Sakaguchi, Masakiyo, Toji, Tomohiro, Ohki, Masayoshi, Tsudaka, Shimpei, Date, Keiichi, Matsuda, Naoki, Iwata, Kazuma, Zhu, Yidan, Nakata, Kentaro, Shien, Kazuhiko, Yamamoto, Hiromasa, Nakayama, Akiko, Okazaki, Mikio, Sugimoto, Seiichiro, and Toyooka, Shinichi

Published
2024
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16. ASO Visual Abstract: EGFR Mutation is a Prognostic Factor in Lung Cancer Patients with Pleural Dissemination Detected During or After Surgery

Author

Fujiwara, Toshiya, Shien, Kazuhiko, Matsuura, Motoki, Soh, Junichi, Yamamoto, Hiromasa, Takao, Soshi, Maki, Yuho, Ueno, Tsuyoshi, Sugimoto, Ryujiro, Suzawa, Ken, Okazaki, Mikio, Tao, Hiroyuki, Hayama, Makio, Kataoka, Masafumi, Sano, Yoshifumi, Inokawa, Hidetoshi, Yamashita, Motohiro, Kawamata, Osamu, Kataoka, Kazuhiko, and Toyooka, Shinichi

Published
2023
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20. One-step nucleic acid amplification for intraoperative diagnosis of lymph node metastasis in lung cancer patients: a single-center prospective study

Author

Namba, Kei, Suzawa, Ken, Shien, Kazuhiko, Miura, Akihiro, Takahashi, Yuta, Miyauchi, Shunsaku, Araki, Kota, Nakata, Kentaro, Tomida, Shuta, Tanaka, Shin, Miyoshi, Kentaroh, Otani, Shinji, Yamamoto, Hiromasa, Okazaki, Mikio, Sugimoto, Seiichiro, Soh, Junichi, Yamane, Masaomi, and Toyooka, Shinichi

Published
2022
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27. Adrenergic microenvironment driven by cancer‐associated Schwann cells contributes to chemoresistance in patients with lung cancer.

Author

Otani, Yusuke, Katayama, Haruyoshi, Zhu, Yidan, Huang, Rongsheng, Shigehira, Takafumi, Shien, Kazuhiko, Suzawa, Ken, Yamamoto, Hiromasa, Shien, Tadahiko, Toyooka, Shinichi, and Fujimura, Atsushi

Abstract

Doublecortin (DCX)‐positive neural progenitor‐like cells are purported components of the cancer microenvironment. The number of DCX‐positive cells in tissues reportedly correlates with cancer progression; however, little is known about the mechanism by which these cells affect cancer progression. Here we demonstrated that DCX‐positive cells, which are found in all major histological subtypes of lung cancer, are cancer‐associated Schwann cells (CAS) and contribute to the chemoresistance of lung cancer cells by establishing an adrenergic microenvironment. Mechanistically, the activation of the Hippo transducer YAP/TAZ was involved in the acquisition of new traits of CAS and DCX positivity. We further revealed that CAS express catecholamine‐synthesizing enzymes and synthesize adrenaline, which potentiates the chemoresistance of lung cancer cells through the activation of YAP/TAZ. Our findings shed light on CAS, which drive the formation of an adrenergic microenvironment by the reciprocal regulation of YAP/TAZ in lung cancer tissues. [ABSTRACT FROM AUTHOR]

Published
2024
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31. The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis

Author

Araki, Kota, Kinoshita, Rie, Tomonobu, Nahoko, Gohara, Yuma, Tomida, Shuta, Takahashi, Yuta, Senoo, Satoru, Taniguchi, Akihiko, Itano, Junko, Yamamoto, Ken-ichi, Murata, Hitoshi, Suzawa, Ken, Shien, Kazuhiko, Yamamoto, Hiromasa, Okazaki, Mikio, Sugimoto, Seiichiro, Ichimura, Kouichi, Nishibori, Masahiro, Miyahara, Nobuaki, Toyooka, Shinichi, and Sakaguchi, Masakiyo

Published
2021
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32. Correction to: Periostin secreted by cancer‑associated fibroblasts promotes cancer progression and drug resistance in non‑small cell lung cancer

Author

Takatsu, Fumiaki, primary, Suzawa, Ken, additional, Tomida, Shuta, additional, Thu, Yin Min, additional, Sakaguchi, Masakiyo, additional, Toji, Tomohiro, additional, Ohki, Masayoshi, additional, Tsudaka, Shimpei, additional, Date, Keiichi, additional, Matsuda, Naoki, additional, Iwata, Kazuma, additional, Zhu, Yidan, additional, Nakata, Kentaro, additional, Shien, Kazuhiko, additional, Yamamoto, Hiromasa, additional, Nakayama, Akiko, additional, Okazaki, Mikio, additional, Sugimoto, Seiichiro, additional, and Toyooka, Shinichi, additional

Published
2023
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37. PAI-1 mediates acquired resistance to MET-targeted therapy in non-small cell lung cancer.

Author

Thu, Yin Min, Suzawa, Ken, Tomida, Shuta, Ochi, Kosuke, Tsudaka, Shimpei, Takatsu, Fumiaki, Date, Keiichi, Matsuda, Naoki, Iwata, Kazuma, Nakata, Kentaro, Shien, Kazuhiko, Yamamoto, Hiromasa, Okazaki, Mikio, Sugimoto, Seiichiro, and Toyooka, Shinichi

Subjects
*NON-small-cell lung carcinoma, *MITOGEN-activated protein kinases, *PLASMINOGEN, *PLASMINOGEN activators, *PROTEIN-tyrosine kinase inhibitors, *CELLULAR therapy
Abstract

Mechanisms underlying primary and acquired resistance to MET tyrosine kinase inhibitors (TKIs) in managing non-small cell lung cancer remain unclear. In this study, we investigated the possible mechanisms acquired for crizotinib in MET-amplified lung carcinoma cell lines. Two MET-amplified lung cancer cell lines, EBC-1 and H1993, were established for acquired resistance to MET-TKI crizotinib and were functionally elucidated. Genomic and transcriptomic data were used to assess the factors contributing to the resistance mechanism, and the alterations hypothesized to confer resistance were validated. Multiple mechanisms underlie acquired resistance to crizotinib in MET-amplified lung cancer cell lines. In EBC-1-derived resistant cells, the overexpression of SERPINE1, the gene encoding plasminogen activator inhibitor-1 (PAI-1), mediated the drug resistance mechanism. Crizotinib resistance was addressed by combination therapy with a PAI-1 inhibitor and PAI-1 knockdown. Another mechanism of resistance in different subline cells of EBC-1 was evaluated as epithelial-to-mesenchymal transition with the upregulation of antiapoptotic proteins. In H1993-derived resistant cells, MEK inhibitors could be a potential therapeutic strategy for overcoming resistance with downstream mitogen-activated protein kinase pathway activation. In this study, we revealed the different mechanisms of acquired resistance to the MET inhibitor crizotinib with potential therapeutic application in patients with MET-amplified lung carcinoma. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Restrictive allograft dysfunction rather than bronchiolitis obliterans syndrome had a major impact on the overall survival after living-donor lobar lung transplantation

Author

Matsubara, Kei, primary, Otani, Shinji, additional, Yamamoto, Haruchika, additional, Hashimoto, Kohei, additional, Tanaka, Shin, additional, Shien, Kazuhiko, additional, Suzawa, Ken, additional, Miyoshi, Kentaroh, additional, Yamamoto, Hiromasa, additional, Okazaki, Mikio, additional, Sugimoto, Seiichiro, additional, and Toyooka, Shinichi, additional

Published
2023
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40. Percentage of low attenuation area on computed tomography detects chronic lung allograft dysfunction, especially bronchiolitis obliterans syndrome, after bilateral lung transplantation

Author

Kubo, Yujiro, primary, Sugimoto, Seiichiro, additional, Shiotani, Toshio, additional, Matsubara, Kei, additional, Hashimoto, Kohei, additional, Tanaka, Shin, additional, Shien, Kazuhiko, additional, Suzawa, Ken, additional, Miyoshi, Kentaroh, additional, Yamamoto, Hiromasa, additional, Okazaki, Mikio, additional, and Toyooka, Shinichi, additional

Published
2023
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43. Abstract 5845: Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer

Author

Yoshikawa, Mao, primary, Takatsu, Fumiaki, additional, Suzawa, Ken, additional, Habu, Tomohiro, additional, Masayoshi, Ohki, additional, Iwata, Kazuma, additional, Matsuda, Naoki, additional, Thu, Yin Min, additional, Shien, Kazuhiko, additional, Yamamoto, Hiromasa, additional, and Toyooka, Shinichi, additional

Published
2023
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44. Figure S4 from Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14–mutant Non–small Cell Lung Cancer

Author

Suzawa, Ken, primary, Offin, Michael, primary, Lu, Daniel, primary, Kurzatkowski, Christopher, primary, Vojnic, Morana, primary, Smith, Roger S., primary, Sabari, Joshua K., primary, Tai, Huichun, primary, Mattar, Marissa, primary, Khodos, Inna, primary, de Stanchina, Elisa, primary, Rudin, Charles M., primary, Kris, Mark G., primary, Arcila, Maria E., primary, Lockwood, William W., primary, Drilon, Alexander, primary, Ladanyi, Marc, primary, and Somwar, Romel, primary

Published
2023
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45. supplemental tables and figures from Concurrent Alterations in EGFR-Mutant Lung Cancers Associated with Resistance to EGFR Kinase Inhibitors and Characterization of MTOR as a Mediator of Resistance

Author

Yu, Helena A., primary, Suzawa, Ken, primary, Jordan, Emmet, primary, Zehir, Ahmet, primary, Ni, Ai, primary, Kim, Ryan, primary, Kris, Mark G., primary, Hellmann, Matthew D., primary, Li, Bob T., primary, Somwar, Romel, primary, Solit, David B., primary, Berger, Michael F., primary, Arcila, Maria, primary, Riely, Gregory J., primary, and Ladanyi, Marc, primary

Published
2023
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46. Supplementary Methods from Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14–mutant Non–small Cell Lung Cancer

Author

Suzawa, Ken, primary, Offin, Michael, primary, Lu, Daniel, primary, Kurzatkowski, Christopher, primary, Vojnic, Morana, primary, Smith, Roger S., primary, Sabari, Joshua K., primary, Tai, Huichun, primary, Mattar, Marissa, primary, Khodos, Inna, primary, de Stanchina, Elisa, primary, Rudin, Charles M., primary, Kris, Mark G., primary, Arcila, Maria E., primary, Lockwood, William W., primary, Drilon, Alexander, primary, Ladanyi, Marc, primary, and Somwar, Romel, primary

Published
2023
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47. Percentage of low attenuation area on computed tomography detects chronic lung allograft dysfunction, especially bronchiolitis obliterans syndrome, after bilateral lung transplantation

Author

Kubo, Yujiro, Sugimoto, Seiichiro, Shiotani, Toshio, Matsubara, Kei, Hashimoto, Kohei, Tanaka, Shin, Shien, Kazuhiko, Suzawa, Ken, Miyoshi, Kentaroh, Yamamoto, Hiromasa, Okazaki, Mikio, Toyooka, Shinichi, Kubo, Yujiro, Sugimoto, Seiichiro, Shiotani, Toshio, Matsubara, Kei, Hashimoto, Kohei, Tanaka, Shin, Shien, Kazuhiko, Suzawa, Ken, Miyoshi, Kentaroh, Yamamoto, Hiromasa, Okazaki, Mikio, and Toyooka, Shinichi

Abstract

Introduction: The percentage of low attenuation area (%LAA) on computed tomography (CT) is useful for evaluating lung emphysema, and higher %LAA was observed in patients with chronic lung allograft dysfunction (CLAD). This study investigated the relationship between the %LAA and the development of CLAD after bilateral lung transplantation (LT). Methods: We conducted a single-center retrospective study of 75 recipients who underwent bilateral LT; the recipients were divided into a CLAD group (n = 30) and a non-CLAD group (n = 45). The %LAA was calculated using CT and compared between the two groups from 4 years before to 4 years after the diagnosis of CLAD. The relationships between the %LAA and the percent baseline values of the pulmonary function test parameters were also calculated. Results: The %LAA was significantly higher in the CLAD group than in the non-CLAD group from 2 years before to 2 years after the diagnosis of CLAD (P < .05). In particular, patients with bronchiolitis obliterans syndrome (BOS) exhibited significant differences even from 4 years before to 4 years after diagnosis (P < .05). Significant negative correlations between the %LAA and the percent baseline values of the forced expiratory volume in 1 s (r = −.36, P = .0031), the forced vital capacity (r = −.27, P = .027), and the total lung capacity (r = −.40, P < .001) were seen at the time of CLAD diagnosis. Conclusion: The %LAA on CT was associated with the development of CLAD and appears to have the potential to predict CLAD, especially BOS, after bilateral LT.

Published
2023

48. S100A8/A9 as a prognostic biomarker in lung transplantation.

Author

Nakata, Kentaro, Okazaki, Mikio, Kawana, Shinichi, Kubo, Yujiro, Shimizu, Dai, Tanaka, Shin, Hashimoto, Kohei, Suzawa, Ken, Shien, Kazuhiko, Miyoshi, Kentaroh, Yamamoto, Hiromasa, Sugimoto, Seiichiro, and Toyooka, Shinichi

Subjects
LUNG transplantation, BIOMARKERS, REGRESSION analysis, OVERALL survival, SURVIVAL analysis (Biometry)
Abstract

Objectives: S100A8/A9 is a damage‐associated molecule that augments systemic inflammation. However, its role in the acute phase after lung transplantation (LTx) remains elusive. This study aimed to determine S100A8/A9 levels after lung transplantation (LTx) and evaluate their impact on overall survival (OS) and chronic lung allograft dysfunction (CLAD)‐free survival. Methods: Sixty patients were enrolled in this study, and their plasma S100A8/A9 levels were measured on days 0, 1, 2, and 3 after LTx. The association of S100A8/A9 levels with OS and CLAD‐free survival was assessed using univariate and multivariate Cox regression analyses. Results: S100A8/A9 levels were elevated in a time‐dependent manner until 3 days after LTx. Ischemic time was significantly longer in the high S100A8/9 group than in the low S100A8/A9 group (p =.017). Patients with high S100A8/A9 levels (> 2844 ng/mL) had worse prognosis (p =.031) and shorter CLAD‐free survival (p =.045) in the Kaplan–Meier survival analysis than those with low levels. Furthermore, multivariate Cox regression analysis showed that high S100A8/A9 levels were a determinant of poor OS (hazard ratio [HR]: 3.7; 95% confidence interval [CI]: 1.2–12; p =.028) and poor CLAD‐free survival (HR: 4.1; 95% CI: 1.1–15; p =.03). In patients with a low primary graft dysfunction grade (0–2), a high level of S100A8/A9 was also a poor prognostic factor. Conclusions: Our study provided novel insights into the role of S100A8/A9 as a prognostic biomarker and a potential therapeutic target for LTx. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Donor's long‐term quality of life following living‐donor lobar lung transplantation

Author

Fujii, Kento, primary, Tanaka, Shin, additional, Ishihara, Megumi, additional, Matsubara, Kei, additional, Hashimoto, Kohei, additional, Okahara, Shuji, additional, Shien, Kazuhiko, additional, Suzawa, Ken, additional, Miyoshi, Kentaroh, additional, Otani, Shinji, additional, Yamamoto, Hiromasa, additional, Okazaki, Mikio, additional, Sugimoto, Seiichiro, additional, Yamane, Masaomi, additional, and Toyooka, Shinichi, additional

Published
2023
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50. Surgical outcome of ipsilateral anatomical resection for lung cancer after pulmonary lobectomy

Author

Okazaki, Mikio, primary, Suzawa, Ken, additional, Shien, Kazuhiko, additional, Yamamoto, Hiromasa, additional, Araki, Kota, additional, Watanabe, Mototsugu, additional, Okada, Masanori, additional, Maki, Yuho, additional, Ueno, Tsuyoshi, additional, Otani, Shinji, additional, Sugimoto, Ryujiro, additional, Nishikawa, Hitoshi, additional, Okita, Riki, additional, Hayama, Makio, additional, Tao, Hiroyuki, additional, Fujiwara, Toshiya, additional, Inokawa, Hidetoshi, additional, Hirami, Yuji, additional, Sano, Yoshifumi, additional, Yamashita, Motohiro, additional, Kawamata, Osamu, additional, Matsuura, Motoki, additional, and Toyooka, Shinichi, additional

Published
2023
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