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30 results on '"Suzuki, Kaho"'

10. The Study which Reconsiders the Contents which Practiced Nurture in a University Accessory Kindergarten:Based on a Nurture Practice Example as 'Asobimaturi '

Author

Oda, Shinichi, Kobayashi, Isao, yamamoto, Rimiko, Yanagawa, Chihiro, Otomo, Natsuko, Sanada, Sawako, Shimoyama, Masumi, Kikuchi, Hanae, Nakamura, Ayana, Wajima, Mari, Suzuki, Kaho, Tominaga, Ryoko, and Nagaoka, Manami

Subjects
制限の少ない遊び環境, 保育者の認め合い, 保育の見直し
Abstract

幼稚園の保育を捉えなおす試みについての研究．子どもたちの遊びが途中で途切れることがな いような保育を計画し実践した．幼稚園の園舎，園庭のどこででも遊ぶことができる日を設定し，「あ そびまつり」と名付けた．子どもたちは，その環境の下で自己発揮するとともに，保育者にとっても多 様な学びがあった．子ども理解や関りのあり方がより深く捉えられるようになった．保育者の専門性の 自覚が深まったなどである．積極的な保育の見直しにより，カリキュラムマネージメントがなされた． キーワード：保育の見直し，制限の少ない遊び環境，保育者の認め合い

Published
2020

16. A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery

Author

Nagamata, Satoshi, Nakasuji, Yukiko, Yamanaka, Keitaro, Azumi, Maho, Washio, Keiichi, Shimizu, Maho, Takahashi, Ryosuke, Matsumoto, Kazuyo, Murata, Yuka, Suzuki, Kaho, Deguchi, Masashi, Yamada, Hideto, and Terai, Yoshito

Subjects
Article Subject
Abstract

Primary peritoneal carcinosarcomas which arise from extragenital locations are extremely rare. Carinosarcomas contain both carcinomatous and sarcomatous elements and can be mainly detected in the female genital tract. We herein report a case of primary peritoneal carcinosarcoma diagnosed by laparoscopic surgery and treated with olaparib. A 62-year-old woman referred to our hospital due to abdominal distension. From imaging findings, we suspected advanced primary peritoneal carcinoma, and laparoscopic surgery was thereafter performed. The pathological diagnosis was carcinosarcoma, and the patient received chemotherapy with docetaxel and carboplatin. After three cycles of chemotherapy, the interval debulking surgery was attempted but resulted in suboptimal results. Because the bilateral ovaries were observed with a normal size and normal findings, we considered that the most likely diagnosis was primary peritoneal carcinosarcoma. After the additional chemotherapy and a 6-month observation period, the tumor relapsed. The patient received chemotherapy again, and the peritoneal carcinosarcoma was judged to be a platinum-sensitive tumor. Oral administration of olaparib was thus initiated. Although a dose reduction was needed due to anemia, olaparib was effective, and the patient could continue the drug for another 7 months. This is the first report of primary peritoneal carcinosarcoma treated with olaparib and shows that it could be a treatment option for platinum-sensitive tumors.

Published
2020
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17. Genetic Variation in Y-Chromosome Genes of Sika Deer (Cervus nippon) in Japan

Author

Tanaka, Kazuaki, primary, Hoshi, Asuka, additional, Nojima, Rai, additional, Suzuki, Kaho, additional, Takiguchi, Harutaka, additional, Takatsuki, Seiki, additional, Takizawa, Tatsuya, additional, Hosoi, Eiji, additional, Tamate, Hidetoshi B., additional, Hayashida, Maki, additional, Anezaki, Tomoko, additional, Fukue, Yuko, additional, and Minami, Masato, additional

Published
2020
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29. A Fluorescence Anisotropy-Based Comprehensive Method for the In Vitro Screening of COI1-JAZs Agonists and Antagonists.

Author

Takaoka Y, Hayashi K, Suzuki K, Azizah IN, and Ueda M

Subjects
Drug Evaluation, Preclinical, Ligands, Peptide Fragments chemical synthesis, Peptide Fragments chemistry, Plant Proteins chemistry, Plant Proteins isolation & purification, Protein Binding, Protein Interaction Mapping methods, Workflow, Drug Discovery methods, Fluorescence Polarization methods, Plant Proteins agonists, Plant Proteins antagonists & inhibitors, Recombinant Fusion Proteins, Repressor Proteins chemistry, Transcription Factors
Abstract

The phytohormone (+)-7-iso-jasmonoyl-L-isoleucine (JA-Ile) causes protein-protein interactions (PPI) between F-box Protein CORONATINE INSENSITIVE 1 (COI1) and JASMONATE ZIM DOMAIN (JAZ) transcriptional repressor. A total of 13 JAZ subtypes are encoded in the genome of Arabidopsis thaliana; however, their genetic redundancy obfuscates the individual function of each JAZ. One approach to decipher this redundant signaling network is chemical genetics, using small molecules specific to individual JAZ subtype, for which a reliable and high-throughput screening system of the ligands for all combinations of COI1-JAZs would be indispensable. In this chapter, we describe a fluorescence anisotropy-based quantitative screening system for the ligands of COI1-JAZ co-receptors. Our method is applicable to agonists and antagonists of the COI1-JAZs.

Published
2020
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30. Near-Infrared-Emitting Nitrogen-Doped Nanographenes.

Author

Yamato K, Sekiya R, Suzuki K, and Haino T

Abstract

The quantum-size effect, which enables nanographenes to emit photoluminescence (PL) in the UV to visible region, has inspired intense research. However, the control of the PL properties of nanographenes through manipulation of their π-system by post-modifications is not well developed. By utilizing a ring-closure reaction between an aromatic 1,2-dicarboxylic acid and a 1,8-naphthalenediamine derivative, which produces a perimidine framework, nitrogen-doped nanographenes were realized. Two nanographenes produced by a one-pot reaction of edge-oxidized nanographene (GQD-2) with 1,8-naphthalenediamine derivatives (GQD-1 a and GQD-1 b) displayed an absorption band extending to >1000 nm; furthermore, the PL wavelength of GQD-1 a was significantly red-shifted into the near-infrared (NIR) region in which it can be used for bioimaging. Time-dependent DFT calculations of model nanographenes showed that the functional groups narrow the HOMO-LUMO gap, realizing the NIR-emitting nanographenes., (© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2019
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