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1. StaccaToe: A Single-Leg Robot that Mimics the Human Leg and Toe

Author

Perera, Nisal, Yu, Shangqun, Marew, Daniel, Tang, Mack, Suzuki, Ken, McCormack, Aidan, Zhu, Shifan, Kim, Yong-Jae, and Kim, Donghyun

Subjects
Computer Science - Robotics
Abstract

We introduce StaccaToe, a human-scale, electric motor-powered single-leg robot designed to rival the agility of human locomotion through two distinctive attributes: an actuated toe and a co-actuation configuration inspired by the human leg. Leveraging the foundational design of HyperLeg's lower leg mechanism, we develop a stand-alone robot by incorporating new link designs, custom-designed power electronics, and a refined control system. Unlike previous jumping robots that rely on either special mechanisms (e.g., springs and clutches) or hydraulic/pneumatic actuators, StaccaToe employs electric motors without energy storage mechanisms. This choice underscores our ultimate goal of developing a practical, high-performance humanoid robot capable of human-like, stable walking as well as explosive dynamic movements. In this paper, we aim to empirically evaluate the balance capability and the exertion of explosive ground reaction forces of our toe and co-actuation mechanisms. Throughout extensive hardware and controller development, StaccaToe showcases its control fidelity by demonstrating a balanced tip-toe stance and dynamic jump. This study is significant for three key reasons: 1) StaccaToe represents the first human-scale, electric motor-driven single-leg robot to execute dynamic maneuvers without relying on specialized mechanisms; 2) our research provides empirical evidence of the benefits of replicating critical human leg attributes in robotic design; and 3) we explain the design process for creating agile legged robots, the details that have been scantily covered in academic literature., Comment: Submitted to 2024 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2024)

Published
2024

2. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.

Author

Suzuki, Ken, Hatzikotoulas, Konstantinos, Southam, Lorraine, Taylor, Henry, Yin, Xianyong, Lorenz, Kim, Mandla, Ravi, Huerta-Chagoya, Alicia, Melloni, Giorgio, Kanoni, Stavroula, Rayner, Nigel, Bocher, Ozvan, Arruda, Ana, Sonehara, Kyuto, Namba, Shinichi, Lee, Simon, Preuss, Michael, Petty, Lauren, Schroeder, Philip, Vanderwerff, Brett, Kals, Mart, Bragg, Fiona, Lin, Kuang, Guo, Xiuqing, Zhang, Weihua, Yao, Jie, Kim, Young, Graff, Mariaelisa, Takeuchi, Fumihiko, Nano, Jana, Lamri, Amel, Nakatochi, Masahiro, Moon, Sanghoon, Scott, Robert, Cook, James, Lee, Jung-Jin, Pan, Ian, Taliun, Daniel, Parra, Esteban, Chai, Jin-Fang, Bielak, Lawrence, Tabara, Yasuharu, Hai, Yang, Thorleifsson, Gudmar, Grarup, Niels, Sofer, Tamar, Wuttke, Matthias, Sarnowski, Chloé, Gieger, Christian, Nousome, Darryl, Trompet, Stella, Kwak, Soo-Heon, Long, Jirong, Sun, Meng, Tong, Lin, Chen, Wei-Min, Nongmaithem, Suraj, Noordam, Raymond, Lim, Victor, Tam, Claudia, Joo, Yoonjung, Chen, Chien-Hsiun, Raffield, Laura, Prins, Bram, Nicolas, Aude, Yanek, Lisa, Chen, Guanjie, Brody, Jennifer, Kabagambe, Edmond, An, Ping, Xiang, Anny, Choi, Hyeok, Cade, Brian, Tan, Jingyi, Broadaway, K, Williamson, Alice, Kamali, Zoha, Cui, Jinrui, Thangam, Manonanthini, Adair, Linda, Adeyemo, Adebowale, Aguilar-Salinas, Carlos, Ahluwalia, Tarunveer, Anand, Sonia, Bertoni, Alain, Bork-Jensen, Jette, Brandslund, Ivan, Buchanan, Thomas, Burant, Charles, Butterworth, Adam, Canouil, Mickaël, Chan, Juliana, Chang, Li-Ching, Chee, Miao-Li, Chen, Ji, Chen, Shyh-Huei, Chen, Yuan-Tsong, Chen, Zhengming, Chuang, Lee-Ming, and Cushman, Mary

Subjects
Humans, Adipocytes, Chromatin, Coronary Artery Disease, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Disease Progression, Endothelial Cells, Enteroendocrine Cells, Epigenomics, Genetic Predisposition to Disease, Genome-Wide Association Study, Islets of Langerhans, Multifactorial Inheritance, Peripheral Arterial Disease, Single-Cell Analysis
Abstract

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P

Published
2024

4. Stress-Induced Acceleration of the Growth of δ-Phase Precipitates in Ni-Based Superalloy GH4169 (IN718) and Its Effect on the Acceleration of Intergranular Cracking Under Creep Loading at Elevated Temperature

Author

Nakayama, Ayumi, Wang, Run-Zi, Suzuki, Ken, Miura, Hideo, Cormier, Jonathan, editor, Edmonds, Ian, editor, Forsik, Stephane, editor, Kontis, Paraskevas, editor, O’Connell, Corey, editor, Smith, Timothy, editor, Suzuki, Akane, editor, Tin, Sammy, editor, and Zhang, Jian, editor

Published
2024
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6. System Configuration and Navigation of a Guide Dog Robot: Toward Animal Guide Dog-Level Guiding Work

Author

Hwang, Hochul, Xia, Tim, Keita, Ibrahima, Suzuki, Ken, Biswas, Joydeep, Lee, Sunghoon I., and Kim, Donghyun

Subjects
Computer Science - Robotics, Computer Science - Artificial Intelligence
Abstract

A robot guide dog has compelling advantages over animal guide dogs for its cost-effectiveness, potential for mass production, and low maintenance burden. However, despite the long history of guide dog robot research, previous studies were conducted with little or no consideration of how the guide dog handler and the guide dog work as a team for navigation. To develop a robotic guiding system that is genuinely beneficial to blind or visually impaired individuals, we performed qualitative research, including interviews with guide dog handlers and trainers and first-hand blindfold walking experiences with various guide dogs. Grounded on the facts learned from vivid experience and interviews, we build a collaborative indoor navigation scheme for a guide dog robot that includes preferred features such as speed and directional control. For collaborative navigation, we propose a semantic-aware local path planner that enables safe and efficient guiding work by utilizing semantic information about the environment and considering the handler's position and directional cues to determine the collision-free path. We evaluate our integrated robotic system by testing guide blindfold walking in indoor settings and demonstrate guide dog-like navigation behavior by avoiding obstacles at typical gait speed ($0.7 \mathrm{m/s}$)., Comment: First two authors contributed equally

Published
2022

7. Chiral symmetry restoration at high matter density observed in pionic atoms

Author

Nishi, Takahiro, Itahashi, Kenta, Ahn, DeukSoon, Berg, Georg P. A., Dozono, Masanori, Etoh, Daijiro, Fujioka, Hiroyuki, Fukuda, Naoki, Fukunishi, Nobuhisa, Geissel, Hans, Haettner, Emma, Hashimoto, Tadashi, Hayano, Ryugo S., Hirenzaki, Satoru, Horii, Hiroshi, Ikeno, Natsumi, Inabe, Naoto, Iwasaki, Masahiko, Kameda, Daisuke, Kisamori, Keichi, Kiyokawa, Yu, Kubo, Toshiyuki, Kusaka, Kensuke, Matsushita, Masafumi, Michimasa, Shin'ichiro, Mishima, Go, Miya, Hiroyuki, Murai, Daichi, Nagahiro, Hideko, Niikura, Megumi, Nose-Togawa, Naoko, Ota, Shinsuke, Sakamoto, Naruhiko, Sekiguchi, Kimiko, Shiokawa, Yuta, Suzuki, Hiroshi, Suzuki, Ken, Takaki, Motonobu, Takeda, Hiroyuki, Tanaka, Yoshiki K., Uesaka, Tomohiro, Wada, Yasumori, Watanabe, Atomu, Watanabe, Yuni N., Weick, Helmut, Yamakami, Hiroki, Yanagisawa, Yoshiyuki, and Yoshida, Koichi

Subjects
Nuclear Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

Modern theories of physics tell that the vacuum is not an empty space. Hidden in the vacuum is a structure of anti-quarks $\bar{q}$ and quarks $q$. The $\bar{q}$ and $q$ pair has the same quantum number as the vacuum and condensates in it since the strong interaction of the quantum chromodynamics (QCD) is too strong to leave it empty. The $\bar{q}q$ condensation breaks the chiral symmetry of the vacuum. The expectation value $<\bar{q}q>$ is an order parameter. For higher temperature or higher matter-density, $|<\bar{q}q>|$ decreases reflecting the restoration of the symmetry. In contrast to these clear-cut arguments, experimental evidence is so far limited. First of all, the $\bar{q}q$ is nothing but the vacuum itself. It is neither visible nor perceptible. In this article, we unravel this invisible existence by high precision measurement of pionic atoms, $\pi^-$-meson-nucleus bound systems. Using the $\pi^-$ as a probe, we demonstrate that $|<\bar{q}q>|$ is reduced in the nucleus at 58% of the normal nuclear density by a factor of 77 $\pm$ 2% compared with that in the vacuum. This reduction indicates that the chiral symmetry is partially restored due to the extremely high density of the nucleus. The present experimental result clearly exhibits the existence of the hidden structure, the chiral condensate, in the vacuum.

Published
2022
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10. Essays in Microeconomics

Author

Suzuki, Ken

Subjects
Economics
Abstract

This dissertation uses statistical causal inference methods to answer causal questions in the fields of health economics and economics of culture and institutions. The first chapter is an application of examiner designs in health economics. Despite efforts to reduce emergency department (ED) care and transition patients to alternative settings, there is limited evidence on its impact on patient outcomes. This chapter studies patients that call into a nurse advice line that are directed toward ED care in a rater instrumental variables design. Marginal patients are 5.3 percentage points more likely to be admitted as an inpatient within 3 days since triage and 3.7 percentage points more likely to have a second ED visit within 4 to 30 days. This chapter also shows increased outpatient utilization with no differences in short-term mortality, indicating efforts to divert patients to less acute settings are likely justified.The second chapter examines the origins of the cross-nurse difference in average ED visit rates of similar patients quasi-randomly assigned to telephone triage nurses. Medical practitioners often make substantially different choices for similar patients. This chapter examines how variation in telephone triage practice style across nurses affect downstream patient healthcare utilization. While a triage decision-support tool standardizes the telephone triage process across nurses, the triage nurses can still exercise discretion through two potential margins: (i) overriding triage recommendations and (ii) intensifying verbal communication to ensure patient compliance with triage disposition. I construct two nurse practice measures to quantify each nurse’s average ED recommendation and verbal communication tendencies, exploiting quasi-random assignment of calls to nurses within call centers. My reduced-form estimates suggest that reassigning a call to a nurse with a higher ED recommendation and a longer call duration tendency increases the patient’s probability of seeking in-person medical attention.The third chapter investigates the causal effects of superstitious beliefs that discriminate against women born in the years of Goat in the Chinese zodiac. Translating the Goat-year superstition into a simple framework of partner search under the zodiac discrimination, I consider two empirical strategies to test for the presence of marriage discrimination: a regression discontinuity (RD) design and a difference-in-differences (DID) method. The RD design identifies the superstition effects if women born just before and after the Goat-new year had, on average, the same unobserved characteristics. However, I find that marriage and other socioeconomic outcomes exhibit persistent seasonal patterns, suggesting that the Goat and adjacent birth cohorts are not comparable without controlling for the unobserved differences. Our DID method controls for the unobserved differences across cohorts around the RD threshold and identifies the causal effects of the Goat-year superstition. Applying the DID method to the 1979 Goat-year women in a 1% sample of the 2000 Chinese Population Census, I find no statistical evidence of the superstition effects on marriage and other outcomes.

Published
2024

11. Chiral symmetry restoration at high matter density observed in pionic atoms

Author

Nishi, Takahiro, Itahashi, Kenta, Ahn, DeukSoon, Berg, Georg P. A., Dozono, Masanori, Etoh, Daijiro, Fujioka, Hiroyuki, Fukuda, Naoki, Fukunishi, Nobuhisa, Geissel, Hans, Haettner, Emma, Hashimoto, Tadashi, Hayano, Ryugo S., Hirenzaki, Satoru, Horii, Hiroshi, Ikeno, Natsumi, Inabe, Naoto, Iwasaki, Masahiko, Kameda, Daisuke, Kisamori, Keichi, Kiyokawa, Yu, Kubo, Toshiyuki, Kusaka, Kensuke, Matsushita, Masafumi, Michimasa, Shin’ichiro, Mishima, Go, Miya, Hiroyuki, Murai, Daichi, Nagahiro, Hideko, Niikura, Megumi, Nose-Togawa, Naoko, Ota, Shinsuke, Sakamoto, Naruhiko, Sekiguchi, Kimiko, Shiokawa, Yuta, Suzuki, Hiroshi, Suzuki, Ken, Takaki, Motonobu, Takeda, Hiroyuki, Tanaka, Yoshiki K., Uesaka, Tomohiro, Wada, Yasumori, Watanabe, Atomu, Watanabe, Yuni N., Weick, Helmut, Yamakami, Hiroki, Yanagisawa, Yoshiyuki, and Yoshida, Koichi

Published
2023
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12. Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study

Author

Dofuku, Shogo, Sonehara, Kyuto, Miyawaki, Satoru, Sakaue, Saori, Imai, Hideaki, Shimizu, Masahiro, Hongo, Hiroki, Shinya, Yuki, Ohara, Kenta, Teranishi, Yu, Okano, Atsushi, Ono, Hideaki, Nakatomi, Hirofumi, Teraoka, Akira, Yamamoto, Kenichi, Maeda, Yuichi, Nii, Takuro, Kishikawa, Toshihiro, Suzuki, Ken, Hirata, Jun, Takahashi, Meiko, Matsuda, Koichi, Kumanogoh, Atsushi, Matsuda, Fumihiko, Okada, Yukinori, and Saito, Nobuhito

Published
2023
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17. Measurement of KN scattering below the KN mass threshold

Author

Noumi Hiroyuki, Inoue Kentaro, Kawasaki Shingo, Aikawa Shuu, Ajimura Shuhei, Akaishi Takaya, Asano Hidemitsu, Beer George, Berucci Carolina, Bragadireau Mario, Buehler Paul Alois, Busso Luigi, Cargnelli Michael, Choi Seonho, Curceanu Catalina, Enomoto Shun, Fujioka Hiroyuki, Fujiwara Yuya, Fukuda Tomokazu, Guaraldo Carlo, Hashimoto Tadashi, Hayano Ryugo S., Hiraiwa Toshihiko, Iio Masami, Iliescu Mihai, Ishiguro Yusuke, Ishimoto Shigeru, Ishikawa Takashi, Ithashi Kenta, Iwai Massaki, Iwasaki Masahiko, Kanno Koki, Kato Kazuma, kato Yuko, Kienle Paul, Komatsu Yusuke, Kou Hiroshi, Ma Yue, Marton Johann, Matsuda Yasuyuki, MIzoi Yutaka, Morra Ombretta, Murayama Rie, Nagae To-mofumi, Ohnishi Hiroaki, Okada Shinji, Omar Zhadyra, Outa Haruhiko, Piscicchia Kristian, Sada Yuta, Sakaguchi Atsushi, Sakuma Fuminori, Sato Masaharu, Scordo Alessadro, Sekimoto Michiko, Shi Hexi, Shirotori Kotaro, Sirghi Diana, Sirghi Florin, Suzuki Ken, Suzuki Shoji, Suzuki Takatoshi, Tanida Kiyoshi, Tatsuno Hideyuki, Tokiyasu Atsushi O., Tokuda Makoto, Tomono Dai, Toyoda Akihisa, Tsukada Kyo, Vazquez-Doce Oton, Widmann Eberhard, Yamaga Takumi, Yamazaki Toshimitsu, Yim Heejoong, Zhang Qi, and Zmeskal Johannes

Subjects
Physics, QC1-999
Abstract

Abstract. We measured πE invariant mass spectra below and above the K¯N mass threshold in the K−d → NπE reaction in order to study the K¯N interaction and the Λ(1405) resonance. This reaction can be described by the two-step process: (i) K¯N1 → K¯N followed by (ii) K¯N2 → πΣ, where N1 and N2 are nucleons bound in the deuteron. We deduced the S -wave scattering amplitude of K¯N →K¯N in the framework of the K¯N πΣ coupled channel so as to reproduce the observed πΣ spectra in the I = 0 channel. We found a resonance pole at 1417.7-7.4+6.0 (fitting error)-1.0+1.1 (systematic error) - i[26.9-7.9+6.0 (fitting error)-2.0+1.7 (systematic error)]MeV/c2.

Published
2024
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18. Identification of type 2 diabetes loci in 433,540 East Asian individuals

Author

Spracklen, Cassandra N, Horikoshi, Momoko, Kim, Young Jin, Lin, Kuang, Bragg, Fiona, Moon, Sanghoon, Suzuki, Ken, Tam, Claudia HT, Tabara, Yasuharu, Kwak, Soo-Heon, Takeuchi, Fumihiko, Long, Jirong, Lim, Victor JY, Chai, Jin-Fang, Chen, Chien-Hsiun, Nakatochi, Masahiro, Yao, Jie, Choi, Hyeok Sun, Iyengar, Apoorva K, Perrin, Hannah J, Brotman, Sarah M, van de Bunt, Martijn, Gloyn, Anna L, Below, Jennifer E, Boehnke, Michael, Bowden, Donald W, Chambers, John C, Mahajan, Anubha, McCarthy, Mark I, Ng, Maggie CY, Petty, Lauren E, Zhang, Weihua, Morris, Andrew P, Adair, Linda S, Akiyama, Masato, Bian, Zheng, Chan, Juliana CN, Chang, Li-Ching, Chee, Miao-Li, Chen, Yii-Der Ida, Chen, Yuan-Tsong, Chen, Zhengming, Chuang, Lee-Ming, Du, Shufa, Gordon-Larsen, Penny, Gross, Myron, Guo, Xiuqing, Guo, Yu, Han, Sohee, Howard, Annie-Green, Huang, Wei, Hung, Yi-Jen, Hwang, Mi Yeong, Hwu, Chii-Min, Ichihara, Sahoko, Isono, Masato, Jang, Hye-Mi, Jiang, Guozhi, Jonas, Jost B, Kamatani, Yoichiro, Katsuya, Tomohiro, Kawaguchi, Takahisa, Khor, Chiea-Chuen, Kohara, Katsuhiko, Lee, Myung-Shik, Lee, Nanette R, Li, Liming, Liu, Jianjun, Luk, Andrea O, Lv, Jun, Okada, Yukinori, Pereira, Mark A, Sabanayagam, Charumathi, Shi, Jinxiu, Shin, Dong Mun, So, Wing Yee, Takahashi, Atsushi, Tomlinson, Brian, Tsai, Fuu-Jen, van Dam, Rob M, Xiang, Yong-Bing, Yamamoto, Ken, Yamauchi, Toshimasa, Yoon, Kyungheon, Yu, Canqing, Yuan, Jian-Min, Zhang, Liang, Zheng, Wei, Igase, Michiya, Cho, Yoon Shin, Rotter, Jerome I, Wang, Ya-Xing, Sheu, Wayne HH, Yokota, Mitsuhiro, Wu, Jer-Yuarn, Cheng, Ching-Yu, Wong, Tien-Yin, Shu, Xiao-Ou, Kato, Norihiro, and Park, Kyong-Soo

Subjects
Human Genome, Diabetes, Biotechnology, Genetics, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Aldehyde Dehydrogenase, Mitochondrial, Alleles, Ankyrins, Asian People, Body Mass Index, Case-Control Studies, Diabetes Mellitus, Type 2, Europe, Eye Proteins, Asia, Eastern, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Homeodomain Proteins, Humans, Male, Nerve Tissue Proteins, RNA, Messenger, Transcription Factors, Transcription, Genetic, General Science & Technology
Abstract

Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D)1,2; however, most of these loci have been identified in analyses of individuals with European ancestry. Here, to examine T2D risk in East Asian individuals, we carried out a meta-analysis of GWAS data from 77,418 individuals with T2D and 356,122 healthy control individuals. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci that are newly implicated in predisposition to T2D. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. Previously undescribed associations include signals in or near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect the differentiation of muscle and adipose cells3. At another locus, expression quantitative trait loci at two overlapping T2D signals affect two genes-NKX6-3 and ANK1-in different tissues4-6. Association studies in diverse populations identify additional loci and elucidate disease-associated genes, biology, and pathways.

Published
2020

21. DOCK2 is involved in the host genetics and biology of severe COVID-19

Author

Namkoong, Ho, Edahiro, Ryuya, Takano, Tomomi, Nishihara, Hiroshi, Shirai, Yuya, Sonehara, Kyuto, Tanaka, Hiromu, Azekawa, Shuhei, Mikami, Yohei, Lee, Ho, Hasegawa, Takanori, Okudela, Koji, Okuzaki, Daisuke, Motooka, Daisuke, Kanai, Masahiro, Naito, Tatsuhiko, Yamamoto, Kenichi, Wang, Qingbo S., Saiki, Ryunosuke, Ishihara, Rino, Matsubara, Yuta, Hamamoto, Junko, Hayashi, Hiroyuki, Yoshimura, Yukihiro, Tachikawa, Natsuo, Yanagita, Emmy, Hyugaji, Takayoshi, Shimizu, Eigo, Katayama, Kotoe, Kato, Yasuhiro, Morita, Takayoshi, Takahashi, Kazuhisa, Harada, Norihiro, Naito, Toshio, Hiki, Makoto, Matsushita, Yasushi, Takagi, Haruhi, Aoki, Ryousuke, Nakamura, Ai, Harada, Sonoko, Sasano, Hitoshi, Kabata, Hiroki, Masaki, Katsunori, Kamata, Hirofumi, Ikemura, Shinnosuke, Chubachi, Shotaro, Okamori, Satoshi, Terai, Hideki, Morita, Atsuho, Asakura, Takanori, Sasaki, Junichi, Morisaki, Hiroshi, Uwamino, Yoshifumi, Nanki, Kosaku, Uchida, Sho, Uno, Shunsuke, Nishimura, Tomoyasu, Ishiguro, Takashi, Isono, Taisuke, Shibata, Shun, Matsui, Yuma, Hosoda, Chiaki, Takano, Kenji, Nishida, Takashi, Kobayashi, Yoichi, Takaku, Yotaro, Takayanagi, Noboru, Ueda, Soichiro, Tada, Ai, Miyawaki, Masayoshi, Yamamoto, Masaomi, Yoshida, Eriko, Hayashi, Reina, Nagasaka, Tomoki, Arai, Sawako, Kaneko, Yutaro, Sasaki, Kana, Tagaya, Etsuko, Kawana, Masatoshi, Arimura, Ken, Takahashi, Kunihiko, Anzai, Tatsuhiko, Ito, Satoshi, Endo, Akifumi, Uchimura, Yuji, Miyazaki, Yasunari, Honda, Takayuki, Tateishi, Tomoya, Tohda, Shuji, Ichimura, Naoya, Sonobe, Kazunari, Sassa, Chihiro Tani, Nakajima, Jun, Nakano, Yasushi, Nakajima, Yukiko, Anan, Ryusuke, Arai, Ryosuke, Kurihara, Yuko, Harada, Yuko, Nishio, Kazumi, Ueda, Tetsuya, Azuma, Masanori, Saito, Ryuichi, Sado, Toshikatsu, Miyazaki, Yoshimune, Sato, Ryuichi, Haruta, Yuki, Nagasaki, Tadao, Yasui, Yoshinori, Hasegawa, Yoshinori, Mutoh, Yoshikazu, Kimura, Tomoki, Sato, Tomonori, Takei, Reoto, Hagimoto, Satoshi, Noguchi, Yoichiro, Yamano, Yasuhiko, Sasano, Hajime, Ota, Sho, Nakamori, Yasushi, Yoshiya, Kazuhisa, Saito, Fukuki, Yoshihara, Tomoyuki, Wada, Daiki, Iwamura, Hiromu, Kanayama, Syuji, Maruyama, Shuhei, Yoshiyama, Takashi, Ohta, Ken, Kokuto, Hiroyuki, Ogata, Hideo, Tanaka, Yoshiaki, Arakawa, Kenichi, Shimoda, Masafumi, Osawa, Takeshi, Tateno, Hiroki, Hase, Isano, Yoshida, Shuichi, Suzuki, Shoji, Kawada, Miki, Horinouchi, Hirohisa, Saito, Fumitake, Mitamura, Keiko, Hagihara, Masao, Ochi, Junichi, Uchida, Tomoyuki, Baba, Rie, Arai, Daisuke, Ogura, Takayuki, Takahashi, Hidenori, Hagiwara, Shigehiro, Nagao, Genta, Konishi, Shunichiro, Nakachi, Ichiro, Murakami, Koji, Yamada, Mitsuhiro, Sugiura, Hisatoshi, Sano, Hirohito, Matsumoto, Shuichiro, Kimura, Nozomu, Ono, Yoshinao, Baba, Hiroaki, Suzuki, Yusuke, Nakayama, Sohei, Masuzawa, Keita, Namba, Shinichi, Suzuki, Ken, Naito, Yoko, Liu, Yu-Chen, Takuwa, Ayako, Sugihara, Fuminori, Wing, James B., Sakakibara, Shuhei, Hizawa, Nobuyuki, Shiroyama, Takayuki, Miyawaki, Satoru, Kawamura, Yusuke, Nakayama, Akiyoshi, Matsuo, Hirotaka, Maeda, Yuichi, Nii, Takuro, Noda, Yoshimi, Niitsu, Takayuki, Adachi, Yuichi, Enomoto, Takatoshi, Amiya, Saori, Hara, Reina, Yamaguchi, Yuta, Murakami, Teruaki, Kuge, Tomoki, Matsumoto, Kinnosuke, Yamamoto, Yuji, Yamamoto, Makoto, Yoneda, Midori, Kishikawa, Toshihiro, Yamada, Shuhei, Kawabata, Shuhei, Kijima, Noriyuki, Takagaki, Masatoshi, Sasa, Noah, Ueno, Yuya, Suzuki, Motoyuki, Takemoto, Norihiko, Eguchi, Hirotaka, Fukusumi, Takahito, Imai, Takao, Fukushima, Munehisa, Kishima, Haruhiko, Inohara, Hidenori, Tomono, Kazunori, Kato, Kazuto, Takahashi, Meiko, Matsuda, Fumihiko, Hirata, Haruhiko, Takeda, Yoshito, Koh, Hidefumi, Manabe, Tadashi, Funatsu, Yohei, Ito, Fumimaro, Fukui, Takahiro, Shinozuka, Keisuke, Kohashi, Sumiko, Miyazaki, Masatoshi, Shoko, Tomohisa, Kojima, Mitsuaki, Adachi, Tomohiro, Ishikawa, Motonao, Takahashi, Kenichiro, Inoue, Takashi, Hirano, Toshiyuki, Kobayashi, Keigo, Takaoka, Hatsuyo, Watanabe, Kazuyoshi, Miyazawa, Naoki, Kimura, Yasuhiro, Sado, Reiko, Sugimoto, Hideyasu, Kamiya, Akane, Kuwahara, Naota, Fujiwara, Akiko, Matsunaga, Tomohiro, Sato, Yoko, Okada, Takenori, Hirai, Yoshihiro, Kawashima, Hidetoshi, Narita, Atsuya, Niwa, Kazuki, Sekikawa, Yoshiyuki, Nishi, Koichi, Nishitsuji, Masaru, Tani, Mayuko, Suzuki, Junya, Nakatsumi, Hiroki, Ogura, Takashi, Kitamura, Hideya, Hagiwara, Eri, Murohashi, Kota, Okabayashi, Hiroko, Mochimaru, Takao, Nukaga, Shigenari, Satomi, Ryosuke, Oyamada, Yoshitaka, Mori, Nobuaki, Baba, Tomoya, Fukui, Yasutaka, Odate, Mitsuru, Mashimo, Shuko, Makino, Yasushi, Yagi, Kazuma, Hashiguchi, Mizuha, Kagyo, Junko, Shiomi, Tetsuya, Fuke, Satoshi, Saito, Hiroshi, Tsuchida, Tomoya, Fujitani, Shigeki, Takita, Mumon, Morikawa, Daiki, Yoshida, Toru, Izumo, Takehiro, Inomata, Minoru, Kuse, Naoyuki, Awano, Nobuyasu, Tone, Mari, Ito, Akihiro, Nakamura, Yoshihiko, Hoshino, Kota, Maruyama, Junichi, Ishikura, Hiroyasu, Takata, Tohru, Odani, Toshio, Amishima, Masaru, Hattori, Takeshi, Shichinohe, Yasuo, Kagaya, Takashi, Kita, Toshiyuki, Ohta, Kazuhide, Sakagami, Satoru, Koshida, Kiyoshi, Hayashi, Kentaro, Shimizu, Tetsuo, Kozu, Yutaka, Hiranuma, Hisato, Gon, Yasuhiro, Izumi, Namiki, Nagata, Kaoru, Ueda, Ken, Taki, Reiko, Hanada, Satoko, Kawamura, Kodai, Ichikado, Kazuya, Nishiyama, Kenta, Muranaka, Hiroyuki, Nakamura, Kazunori, Hashimoto, Naozumi, Wakahara, Keiko, Sakamoto, Koji, Omote, Norihito, Ando, Akira, Kodama, Nobuhiro, Kaneyama, Yasunari, Maeda, Shunsuke, Kuraki, Takashige, Matsumoto, Takemasa, Yokote, Koutaro, Nakada, Taka-Aki, Abe, Ryuzo, Oshima, Taku, Shimada, Tadanaga, Harada, Masahiro, Takahashi, Takeshi, Ono, Hiroshi, Sakurai, Toshihiro, Shibusawa, Takayuki, Kimizuka, Yoshifumi, Kawana, Akihiko, Sano, Tomoya, Watanabe, Chie, Suematsu, Ryohei, Sageshima, Hisako, Yoshifuji, Ayumi, Ito, Kazuto, Takahashi, Saeko, Ishioka, Kota, Nakamura, Morio, Masuda, Makoto, Wakabayashi, Aya, Watanabe, Hiroki, Ueda, Suguru, Nishikawa, Masanori, Chihara, Yusuke, Takeuchi, Mayumi, Onoi, Keisuke, Shinozuka, Jun, Sueyoshi, Atsushi, Nagasaki, Yoji, Okamoto, Masaki, Ishihara, Sayoko, Shimo, Masatoshi, Tokunaga, Yoshihisa, Kusaka, Yu, Ohba, Takehiko, Isogai, Susumu, Ogawa, Aki, Inoue, Takuya, Fukuyama, Satoru, Eriguchi, Yoshihiro, Yonekawa, Akiko, Kan-o, Keiko, Matsumoto, Koichiro, Kanaoka, Kensuke, Ihara, Shoichi, Komuta, Kiyoshi, Inoue, Yoshiaki, Chiba, Shigeru, Yamagata, Kunihiro, Hiramatsu, Yuji, Kai, Hirayasu, Asano, Koichiro, Oguma, Tsuyoshi, Ito, Yoko, Hashimoto, Satoru, Yamasaki, Masaki, Kasamatsu, Yu, Komase, Yuko, Hida, Naoya, Tsuburai, Takahiro, Oyama, Baku, Takada, Minoru, Kanda, Hidenori, Kitagawa, Yuichiro, Fukuta, Tetsuya, Miyake, Takahito, Yoshida, Shozo, Ogura, Shinji, Abe, Shinji, Kono, Yuta, Togashi, Yuki, Takoi, Hiroyuki, Kikuchi, Ryota, Ogawa, Shinichi, Ogata, Tomouki, Ishihara, Shoichiro, Kanehiro, Arihiko, Ozaki, Shinji, Fuchimoto, Yasuko, Wada, Sae, Fujimoto, Nobukazu, Nishiyama, Kei, Terashima, Mariko, Beppu, Satoru, Yoshida, Kosuke, Narumoto, Osamu, Nagai, Hideaki, Ooshima, Nobuharu, Motegi, Mitsuru, Umeda, Akira, Miyagawa, Kazuya, Shimada, Hisato, Endo, Mayu, Ohira, Yoshiyuki, Watanabe, Masafumi, Inoue, Sumito, Igarashi, Akira, Sato, Masamichi, Sagara, Hironori, Tanaka, Akihiko, Ohta, Shin, Kimura, Tomoyuki, Shibata, Yoko, Tanino, Yoshinori, Nikaido, Takefumi, Minemura, Hiroyuki, Sato, Yuki, Yamada, Yuichiro, Hashino, Takuya, Shinoki, Masato, Iwagoe, Hajime, Takahashi, Hiroshi, Fujii, Kazuhiko, Kishi, Hiroto, Kanai, Masayuki, Imamura, Tomonori, Yamashita, Tatsuya, Yatomi, Masakiyo, Maeno, Toshitaka, Hayashi, Shinichi, Takahashi, Mai, Kuramochi, Mizuki, Kamimaki, Isamu, Tominaga, Yoshiteru, Ishii, Tomoo, Utsugi, Mitsuyoshi, Ono, Akihiro, Tanaka, Toru, Kashiwada, Takeru, Fujita, Kazue, Saito, Yoshinobu, Seike, Masahiro, Watanabe, Hiroko, Matsuse, Hiroto, Kodaka, Norio, Nakano, Chihiro, Oshio, Takeshi, Hirouchi, Takatomo, Makino, Shohei, Egi, Moritoki, Omae, Yosuke, Nannya, Yasuhito, Ueno, Takafumi, Katayama, Kazuhiko, Ai, Masumi, Fukui, Yoshinori, Kumanogoh, Atsushi, Sato, Toshiro, Hasegawa, Naoki, Tokunaga, Katsushi, Ishii, Makoto, Koike, Ryuji, Kitagawa, Yuko, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, Fukunaga, Koichi, and Okada, Yukinori

Published
2022
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23. Corrigendum to “Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure” [Biomaterials 154 (2018) 12–23]

Author

Ichihara, Yuki, primary, Kaneko, Masahiro, additional, Yamahara, Kenichi, additional, Koulouroudias, Marinos, additional, Sato, Nobuhiko, additional, Uppal, Rakesh, additional, Yamazaki, Kenji, additional, Saito, Satoshi, additional, and Suzuki, Ken, additional

Published
2024
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24. Corrigendum to “On-site fabrication of bi-layered adhesive mesenchymal stromal cell dressings for the treatment of heart failure” [Biomaterials 209 (2019) 41–53]

Author

Kobayashi, Kazuya, primary, Ichihara, Yuki, additional, Sato, Nobuhiko, additional, Umeda, Nobuyoshi, additional, Fields, Laura, additional, Fukumitsu, Masafumi, additional, Tago, Yoshiyuki, additional, Ito, Tomoya, additional, Kainuma, Satoshi, additional, Podaru, Mihai, additional, Lewis-McDougall, Fiona, additional, Yamahara, Kenichi, additional, Uppal, Rakesh, additional, and Suzuki, Ken, additional

Published
2024
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25. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Author

Mahajan, Anubha, Spracklen, Cassandra N., Zhang, Weihua, Ng, Maggie C. Y., Petty, Lauren E., Kitajima, Hidetoshi, Yu, Grace Z., Rüeger, Sina, Speidel, Leo, Kim, Young Jin, Horikoshi, Momoko, Mercader, Josep M., Taliun, Daniel, Moon, Sanghoon, Kwak, Soo-Heon, Robertson, Neil R., Rayner, Nigel W., Loh, Marie, Kim, Bong-Jo, Chiou, Joshua, Miguel-Escalada, Irene, della Briotta Parolo, Pietro, Lin, Kuang, Bragg, Fiona, Preuss, Michael H., Takeuchi, Fumihiko, Nano, Jana, Guo, Xiuqing, Lamri, Amel, Nakatochi, Masahiro, Scott, Robert A., Lee, Jung-Jin, Huerta-Chagoya, Alicia, Graff, Mariaelisa, Chai, Jin-Fang, Parra, Esteban J., Yao, Jie, Bielak, Lawrence F., Tabara, Yasuharu, Hai, Yang, Steinthorsdottir, Valgerdur, Cook, James P., Kals, Mart, Grarup, Niels, Schmidt, Ellen M., Pan, Ian, Sofer, Tamar, Wuttke, Matthias, Sarnowski, Chloe, Gieger, Christian, Nousome, Darryl, Trompet, Stella, Long, Jirong, Sun, Meng, Tong, Lin, Chen, Wei-Min, Ahmad, Meraj, Noordam, Raymond, Lim, Victor J. Y., Tam, Claudia H. T., Joo, Yoonjung Yoonie, Chen, Chien-Hsiun, Raffield, Laura M., Lecoeur, Cécile, Prins, Bram Peter, Nicolas, Aude, Yanek, Lisa R., Chen, Guanjie, Jensen, Richard A., Tajuddin, Salman, Kabagambe, Edmond K., An, Ping, Xiang, Anny H., Choi, Hyeok Sun, Cade, Brian E., Tan, Jingyi, Flanagan, Jack, Abaitua, Fernando, Adair, Linda S., Adeyemo, Adebowale, Aguilar-Salinas, Carlos A., Akiyama, Masato, Anand, Sonia S., Bertoni, Alain, Bian, Zheng, Bork-Jensen, Jette, Brandslund, Ivan, Brody, Jennifer A., Brummett, Chad M., Buchanan, Thomas A., Canouil, Mickaël, Chan, Juliana C. N., Chang, Li-Ching, Chee, Miao-Li, Chen, Ji, Chen, Shyh-Huei, Chen, Yuan-Tsong, Chen, Zhengming, Chuang, Lee-Ming, Cushman, Mary, Das, Swapan K., de Silva, H. Janaka, Dedoussis, George, Dimitrov, Latchezar, Doumatey, Ayo P., Du, Shufa, Duan, Qing, Eckardt, Kai-Uwe, Emery, Leslie S., Evans, Daniel S., Evans, Michele K., Fischer, Krista, Floyd, James S., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Frayling, Timothy M., Freedman, Barry I., Fuchsberger, Christian, Genter, Pauline, Gerstein, Hertzel C., Giedraitis, Vilmantas, González-Villalpando, Clicerio, González-Villalpando, Maria Elena, Goodarzi, Mark O., Gordon-Larsen, Penny, Gorkin, David, Gross, Myron, Guo, Yu, Hackinger, Sophie, Han, Sohee, Hattersley, Andrew T., Herder, Christian, Howard, Annie-Green, Hsueh, Willa, Huang, Mengna, Huang, Wei, Hung, Yi-Jen, Hwang, Mi Yeong, Hwu, Chii-Min, Ichihara, Sahoko, Ikram, Mohammad Arfan, Ingelsson, Martin, Islam, Md Tariqul, Isono, Masato, Jang, Hye-Mi, Jasmine, Farzana, Jiang, Guozhi, Jonas, Jost B., Jørgensen, Marit E., Jørgensen, Torben, Kamatani, Yoichiro, Kandeel, Fouad R., Kasturiratne, Anuradhani, Katsuya, Tomohiro, Kaur, Varinderpal, Kawaguchi, Takahisa, Keaton, Jacob M., Kho, Abel N., Khor, Chiea-Chuen, Kibriya, Muhammad G., Kim, Duk-Hwan, Kohara, Katsuhiko, Kriebel, Jennifer, Kronenberg, Florian, Kuusisto, Johanna, Läll, Kristi, Lange, Leslie A., Lee, Myung-Shik, Lee, Nanette R., Leong, Aaron, Li, Liming, Li, Yun, Li-Gao, Ruifang, Ligthart, Symen, Lindgren, Cecilia M., Linneberg, Allan, Liu, Ching-Ti, Liu, Jianjun, Locke, Adam E., Louie, Tin, Luan, Jian’an, Luk, Andrea O., Luo, Xi, Lv, Jun, Lyssenko, Valeriya, Mamakou, Vasiliki, Mani, K. Radha, Meitinger, Thomas, Metspalu, Andres, Morris, Andrew D., Nadkarni, Girish N., Nadler, Jerry L., Nalls, Michael A., Nayak, Uma, Nongmaithem, Suraj S., Ntalla, Ioanna, Okada, Yukinori, Orozco, Lorena, Patel, Sanjay R., Pereira, Mark A., Peters, Annette, Pirie, Fraser J., Porneala, Bianca, Prasad, Gauri, Preissl, Sebastian, Rasmussen-Torvik, Laura J., Reiner, Alexander P., Roden, Michael, Rohde, Rebecca, Roll, Kathryn, Sabanayagam, Charumathi, Sander, Maike, Sandow, Kevin, Sattar, Naveed, Schönherr, Sebastian, Schurmann, Claudia, Shahriar, Mohammad, Shi, Jinxiu, Shin, Dong Mun, Shriner, Daniel, Smith, Jennifer A., So, Wing Yee, Stančáková, Alena, Stilp, Adrienne M., Strauch, Konstantin, Suzuki, Ken, Takahashi, Atsushi, Taylor, Kent D., Thorand, Barbara, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tomlinson, Brian, Torres, Jason M., Tsai, Fuu-Jen, Tuomilehto, Jaakko, Tusie-Luna, Teresa, Udler, Miriam S., Valladares-Salgado, Adan, van Dam, Rob M., van Klinken, Jan B., Varma, Rohit, Vujkovic, Marijana, Wacher-Rodarte, Niels, Wheeler, Eleanor, Whitsel, Eric A., Wickremasinghe, Ananda R., van Dijk, Ko Willems, Witte, Daniel R., Yajnik, Chittaranjan S., Yamamoto, Ken, Yamauchi, Toshimasa, Yengo, Loïc, Yoon, Kyungheon, Yu, Canqing, Yuan, Jian-Min, Yusuf, Salim, Zhang, Liang, Zheng, Wei, Raffel, Leslie J., Igase, Michiya, Ipp, Eli, Redline, Susan, Cho, Yoon Shin, Lind, Lars, Province, Michael A., Hanis, Craig L., Peyser, Patricia A., Ingelsson, Erik, Zonderman, Alan B., Psaty, Bruce M., Wang, Ya-Xing, Rotimi, Charles N., Becker, Diane M., Matsuda, Fumihiko, Liu, Yongmei, Zeggini, Eleftheria, Yokota, Mitsuhiro, Rich, Stephen S., Kooperberg, Charles, Pankow, James S., Engert, James C., Chen, Yii-Der Ida, Froguel, Philippe, Wilson, James G., Sheu, Wayne H. H., Kardia, Sharon L. R., Wu, Jer-Yuarn, Hayes, M. Geoffrey, Ma, Ronald C. W., Wong, Tien-Yin, Groop, Leif, Mook-Kanamori, Dennis O., Chandak, Giriraj R., Collins, Francis S., Bharadwaj, Dwaipayan, Paré, Guillaume, Sale, Michèle M., Ahsan, Habibul, Motala, Ayesha A., Shu, Xiao-Ou, Park, Kyong-Soo, Jukema, J. Wouter, Cruz, Miguel, McKean-Cowdin, Roberta, Grallert, Harald, Cheng, Ching-Yu, Bottinger, Erwin P., Dehghan, Abbas, Tai, E-Shyong, Dupuis, Josée, Kato, Norihiro, Laakso, Markku, Köttgen, Anna, Koh, Woon-Puay, Palmer, Colin N. A., Liu, Simin, Abecasis, Goncalo, Kooner, Jaspal S., Loos, Ruth J. F., North, Kari E., Haiman, Christopher A., Florez, Jose C., Saleheen, Danish, Hansen, Torben, Pedersen, Oluf, Mägi, Reedik, Langenberg, Claudia, Wareham, Nicholas J., Maeda, Shiro, Kadowaki, Takashi, Lee, Juyoung, Millwood, Iona Y., Walters, Robin G., Stefansson, Kari, Myers, Simon R., Ferrer, Jorge, Gaulton, Kyle J., Meigs, James B., Mohlke, Karen L., Gloyn, Anna L., Bowden, Donald W., Below, Jennifer E., Chambers, John C., Sim, Xueling, Boehnke, Michael, Rotter, Jerome I., McCarthy, Mark I., and Morris, Andrew P.

Published
2022
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26. Foreign Portfolio Investment and Economy: The Network Perspective

Author

Hakeem, Muhammad Mohsin and Suzuki, Ken-ichi

Subjects
Quantitative Finance - General Finance
Abstract

The European Union and Eurozone present an inquisitive case of strongly interconnected network with high degree of dependence among nodes. This research focused on investment network of European Union and its major trading partners for specific time period 2001 to 2014. The changing investment patterns within Eurozone suggest strong financial and trade links with central and large economies. This study is about the association between portfolio investment and economic indicators with respect to financial networks. The analysis used the strongly connected investment network of Eurozone and its large trading partners. A strong correlation between, increasing or decreasing investment patterns with economic indicators of particular economy was found. Interestingly correlation patterns for network members other than Eurozone states were not as strong and depicted mild behavior. This as well, explains the significance of interconnectedness level among nodes of one network with varying centrality measures. Investment network visualization techniques helped to validate the results based on network`s statistical measures.

Published
2017

28. A common deletion at BAK1 reduces enhancer activity and confers risk of intracranial germ cell tumors

Author

Sonehara, Kyuto, Kimura, Yui, Nakano, Yoshiko, Ozawa, Tatsuya, Takahashi, Meiko, Suzuki, Ken, Fujii, Takashi, Matsushita, Yuko, Tomiyama, Arata, Kishikawa, Toshihiro, Yamamoto, Kenichi, Naito, Tatsuhiko, Suzuki, Tomonari, Yamaguchi, Shigeru, Miwa, Tomoru, Sasaki, Hikaru, Kitagawa, Masashi, Ohe, Naoyuki, Fukai, Junya, Ogiwara, Hideki, Kawamura, Atsufumi, Miyawaki, Satoru, Matsuda, Fumihiko, Kiyokawa, Nobutaka, Ichimura, Koichi, Nishikawa, Ryo, Okada, Yukinori, and Terashima, Keita

Published
2022
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36. Effective or Self-Selective: Random Assignment Demonstrates Short-Term Study Abroad Effectively Encourages Further Study Abroad

Author

Kato, Maki and Suzuki, Ken

Abstract

Much attention has been paid to the effects of study abroad, especially because of recent increases in participation in such programs. One problem, however, is the selection bias of participants inherent in study abroad programs. The present study examines whether participation in a short-term study abroad program leads to participation in further long-term study abroad programs. Data were obtained from 705 applicants in the 2013-2015 academic year at a Japanese university, 300 of whom were assigned randomly to participate in a short-term study abroad program. The study results showed a significantly higher participation rate among previous participants than among nonparticipants. The results of a questionnaire completed by the former participants of the short-term program showed that they were more likely to translate plans for participating in the long-term study abroad program into action based on their prior overseas experiences.

Published
2019
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38. Clinical usefulness of multigene screening with phenotype-driven bioinformatics analysis for the diagnosis of patients with monogenic diabetes or severe insulin resistance

Author

Hosoe, Jun, Miya, Fuyuki, Kadowaki, Hiroko, Fujiwara, Toyofumi, Suzuki, Ken, Kato, Takashi, Waki, Hironori, Sasako, Takayoshi, Aizu, Katsuya, Yamamura, Natsumi, Sasaki, Fusako, Kurano, Makoto, Hara, Kazuo, Tanaka, Masaki, Ishiura, Hiroyuki, Tsuji, Shoji, Honda, Kenjiro, Yoshimura, Jun, Morishita, Shinichi, Matsuzawa, Fumiko, Aikawa, Sei-Ichi, Boroevich, Keith A., Nangaku, Masaomi, Okada, Yukinori, Tsunoda, Tatsuhiko, Shojima, Nobuhiro, Yamauchi, Toshimasa, and Kadowaki, Takashi

Published
2020
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39. Corticosteroid‐triggered acute skeletal muscle loss in lipodystrophy: A case report.

Author

Sasako, Takayoshi, Suzuki, Ken, Odawara, Sara, Suwanai, Hirotsugu, Akuta, Naoko, Kubota, Naoto, Ueki, Kohjiro, Kadowaki, Takashi, and Yamauchi, Toshimasa

Subjects
*WEIGHT loss, *LIPODYSTROPHY, *SKELETAL muscle, *LEAN body mass, *INSULIN resistance, *SKELETAL muscle injuries, *HYPERGLYCEMIA
Abstract

The potential liability to hypercatabolism in lipodystrophy remains to be fully elucidated. Here we report a 28‐year‐old Japanese woman with acquired generalized lipodystrophy, who presented with recurrence of panniculitis and anemia. After corticosteroid treatment was started, she showed rapid reductions in body weight and lean mass by 15% at maximum, accompanied by an elevated urea nitrogen/creatinine ratio, which recovered almost fully as the corticosteroid treatment was tapered and discontinued. She had multiple risk factors for hypercatabolism: lack of metabolic reserves, insulin resistance, and hyperglycemia due to lipodystrophy, lowered daily activity due to anemia, persistent inflammation, and wasting associated with panniculitis, and relatively insufficient energy and protein intake during hospitalization. More attention should be paid to the potential liability to hypercatabolism in patients with lipodystrophy, and to skeletal muscle loss as an adverse effect of corticosteroid treatment in patients at high risk, such as those with diabetes or decreased metabolic reserves. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Degradation of the Strength of a Grain Boundary in Ni-Base Superalloy Under Creep-Fatigue Loading

Author

Suzuki, Wataru, Sawase, Akari, Suzuki, Ken, Miura, Hideo, Correia, José A.F.O., Series Editor, De Jesus, Abílio M.P., Series Editor, Ayatollahi, Majid Reza, Advisory Editor, Berto, Filippo, Advisory Editor, Fernández-Canteli, Alfonso, Advisory Editor, Hebdon, Matthew, Advisory Editor, Kotousov, Andrei, Advisory Editor, Lesiuk, Grzegorz, Advisory Editor, Murakami, Yukitaka, Advisory Editor, Carvalho, Hermes, Advisory Editor, Zhu, Shun-Peng, Advisory Editor, and Gdoutos, Emmanuel E., editor

Published
2019
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43. GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway

Author

Ishida, Hidekazu, primary, Saba, Rie, additional, Kokkinopoulos, Ioannis, additional, Hashimoto, Masakazu, additional, Yamaguchi, Osamu, additional, Nowotschin, Sonja, additional, Shiraishi, Manabu, additional, Ruchaya, Prashant, additional, Miller, Duncan, additional, Harmer, Stephen, additional, Poliandri, Ariel, additional, Kogaki, Shigetoyo, additional, Sakata, Yasushi, additional, Dunkel, Leo, additional, Tinker, Andrew, additional, Hadjantonakis, Anna-Katerina, additional, Sawa, Yoshiki, additional, Sasaki, Hiroshi, additional, Ozono, Keiichi, additional, Suzuki, Ken, additional, and Yashiro, Kenta, additional

Published
2023
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50. Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis

Author

Sakaue, Saori, Yamaguchi, Etsuro, Inoue, Yoshikazu, Takahashi, Meiko, Hirata, Jun, Suzuki, Ken, Ito, Satoru, Arai, Toru, Hirose, Masaki, Tanino, Yoshinori, Nikaido, Takefumi, Ichiwata, Toshio, Ohkouchi, Shinya, Hirano, Taizou, Takada, Toshinori, Miyawaki, Satoru, Dofuku, Shogo, Maeda, Yuichi, Nii, Takuro, Kishikawa, Toshihiro, Ogawa, Kotaro, Masuda, Tatsuo, Yamamoto, Kenichi, Sonehara, Kyuto, Tazawa, Ryushi, Morimoto, Konosuke, Takaki, Masahiro, Konno, Satoshi, Suzuki, Masaru, Tomii, Keisuke, Nakagawa, Atsushi, Handa, Tomohiro, Tanizawa, Kiminobu, Ishii, Haruyuki, Ishida, Manabu, Kato, Toshiyuki, Takeda, Naoya, Yokomura, Koshi, Matsui, Takashi, Watanabe, Masaki, Inoue, Hiromasa, Imaizumi, Kazuyoshi, Goto, Yasuhiro, Kida, Hiroshi, Fujisawa, Tomoyuki, Suda, Takafumi, Yamada, Takashi, Satake, Yasuomi, Ibata, Hidenori, Hizawa, Nobuyuki, Mochizuki, Hideki, Kumanogoh, Atsushi, Matsuda, Fumihiko, Nakata, Koh, Hirota, Tomomitsu, Tamari, Mayumi, and Okada, Yukinori

Published
2021
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