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549 results on '"Suzuki, Shiho"'

7. Oral fidaxomicin versus vancomycin for the treatment of Clostridioides difficile infection: A systematic review and meta-analysis of randomized controlled trials

Author

Tashiro, Sho, Mihara, Takayuki, Sasaki, Moe, Shimamura, Chiaki, Shimamura, Rina, Suzuki, Shiho, Yoshikawa, Maiko, Hasegawa, Tatsuki, Enoki, Yuki, Taguchi, Kazuaki, Matsumoto, Kazuaki, Ohge, Hiroki, Suzuki, Hiromichi, Nakamura, Atsushi, Mori, Nobuaki, Morinaga, Yoshitomo, Yamagishi, Yuka, Yoshizawa, Sadako, Yanagihara, Katsunori, Mikamo, Hiroshige, and Kunishima, Hiroyuki

Published
2022
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8. The effect of calcitonin gene-related peptide monoclonal antibodies on restless legs syndrome in patients with migraine.

Author

Suzuki, Keisuke, Suzuki, Shiho, Fujita, Hiroaki, Kobayashi, Saro, Shioda, Mukuto, Hida, Ryotaro, and Hirata, Koichi

Abstract

Background: Calcitonin gene-related peptide monoclonal antibody (CGRP mAb) effects on restless legs syndrome (RLS) are unclear. Methods: Fifteen migraine patients (aged 49.1 ± 5.8 years; 14 women) with concomitant RLS who received CGRP mAbs (2 erenumab, 3 galcanezumab, and 10 fremanezumab) were retrospectively studied. Number of monthly migraine days (MMDs) was obtained from headache diaries. The primary outcome is changes in RLS severity as assessed by the International RLS Group Rating Scale (IRLS). Headache-related disability was assessed using the Migraine Disability Assessment (MIDAS). The severity of headache and RLS was rated using the Patient Global Impression of Change (PGIC) scale. Central sensitization was evaluated with the Central Sensitization Inventory (CSI). Results: At 1, 2, and 3 months, the percentages of patients with ≥ 50% improvement in number of MMDs were 53.3%, 66.6%, and 60.0%, respectively. From baseline to 3 months, there were significant reductions in the MIDAS (25.1 ± 23.2 vs. 19.7 ± 22.8, p = 0.005) and CSI scores (36.3 ± 12.9 vs. 29.1 ± 12.3, p = 0.001). IRLS scores decreased significantly from baseline to 1 month (-8.8 ± 2.1 points) and 3 months (-11.6 ± 2.3 points) after CGRP mAb treatment. On the PGIC scale, 86.7% and 73.3% of patients reported at least "minimal improvement" in migraine and RLS severity, respectively, with 46.7% and 26.7% reporting "very much improvement". Among those with a < 50% reduction in number of MMDs at 3 months, 66.6% reported at least "minimal improvement", with 33.3% reporting "very much improvement". Conclusion: Our study revealed that 3-month CGRP mAb treatment significantly alleviated RLS symptoms, central sensitization and headache-related disability in patients with comorbid migraine and RLS. [ABSTRACT FROM AUTHOR]

Published
2025
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9. N -(Trimethylsilyl)diethylamine-Promoted Intramolecular S N Ar Reaction of Electron-Rich Aryl Fluorides.

Author

Shigeta, Takashi, Ichikawa, Yurika, Suzuki, Shiho, Hamabe, Yui, Nakahara, Nanomi, Gonno, Yuka, Ozeki, Minoru, Kawasaki, Ikuo, and Egi, Masahiro

Subjects
CROWN ethers, LEWIS acids, DIETHYLAMINE, FLUORIDES, HETEROCYCLIC compounds
Abstract

N -(Trimethylsilyl)diethylamine (TMSNEt 2) significantly promotes intramolecular nucleophilic aromatic substitution (S N Ar) reactions of electron-rich aryl fluorides with t -BuOK and crown ether. Although substrates bearing electron-donating groups are conventionally inert under S N Ar conditions, the activation of substrates by TMSNEt 2 enables the reactions to proceed even at room temperature. This method is applicable to the preparation of benzo-fused oxygen-containing heterocycles, such as 3,4-dihydro-2 H -1,4-benzoxazines, 3,4-dihydro-2 H -1,5-benzoxazepines, and 3,4-dihydro-2 H -1-benzopyran, in good to excellent yields (56–93%). [ABSTRACT FROM AUTHOR]

Published
2025
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22. Characterizing restless legs syndrome and leg motor restlessness in patients with Parkinson's disease: A multicenter case-controlled study

Author

Kadowaki, Taro, Yamamoto, Tatsuya, Hatano, Taku, Miyamoto, Tomoyuki, Suzuki, Shiho, Watanabe, Yuka, Shimura, Hideki, Urabe, Takao, Suzuki, Keisuke, Okuma, Yasuyuki, Uchiyama, Tomoyuki, Miyamoto, Masayuki, Sakakibara, Ryuji, Shimo, Yasushi, Hattori, Nobutaka, Kuwabara, Satoshi, Yamamoto, Toshimasa, Kaji, Yoshiaki, Hirano, Shigeki, Numao, Ayaka, and Hirata, Koichi

Published
2017
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28. Contributors

Author

Ahmar, Mohammed, primary, Bokor, Éva, additional, Borbás, Anikó, additional, Christensen, Bjørn E., additional, Comesse, Sébastien, additional, Dalheim, Marianne Øksnes, additional, Delbianco, Martina, additional, Dey, Supriya, additional, Fan, Weigang, additional, Fortuna, Andreia, additional, Gómez, Ana M., additional, Hettegger, Hubert, additional, Hotha, Srinivas, additional, Jayaraman, N., additional, Kelemen, Viktor, additional, Kitamura, Shinichi, additional, Lindner, Wolfgang, additional, López, J. Cristóbal, additional, Misra, Anup Kumar, additional, Popowycz, Florence, additional, Queneau, Yves, additional, Renou, Frédéric, additional, Rosenau, Thomas, additional, Samanta, Gopal Ch, additional, Si, Anshupriya, additional, Suzuki, Shiho, additional, Tan, Jia-Neng, additional, Verrier, Charlie, additional, Wang, Lianjie, additional, Xavier, Nuno M., additional, and Yu, Yang, additional

Published
2020
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47. Central Sensitization in Migraine: A Narrative Review

Author

Suzuki,Keisuke, Suzuki,Shiho, Shiina,Tomohiko, Kobayashi,Saro, and Hirata,Koichi

Subjects
Journal of Pain Research
Abstract

Keisuke Suzuki, Shiho Suzuki, Tomohiko Shiina, Saro Kobayashi, Koichi Hirata Department of Neurology, Dokkyo Medical University, Mibu, JapanCorrespondence: Keisuke Suzuki, Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Shimotsuga, Mibu, Tochigi, 321-0293, Japan, Tel +81-282-86-1111, Fax +81-282-86-5884, Email keisuke@dokkyomed.ac.jpAbstract: Central sensitization (CS) is an increase in the responsiveness of nociceptive neurons in the central nervous system to their normal afferent input. As a result, even minor irritation can induce severe pain, leading to the chronicity and severity of various diseases, such as neurological disorders. CS is associated with migraine, which is a major neurological disorder that inflicts a high disability in daily life. Specifically, CS is thought to be involved in the pathogenesis of cutaneous allodynia as well as chronification of migraine. In this article, we reviewed the association between CS and migraine, including pathophysiological aspects and evidence from clinical studies. We suggest that appropriate screening and management of CS in migraine could further improve the quality of life of migraine patients.Keywords: migraine, central sensitization, cutaneous allodynia, restless legs syndrome

Published
2022

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