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249 results on '"Svenningsen, S."'

2. Magnetic Resonance Imaging Ventilation Phenotypes of Severe Asthma

Author

Thakar, A., primary, Ragunayakam, N., additional, Friedlander, Y., additional, Venegas Garrido, C., additional, Kjarsgaard, M., additional, Huang, C., additional, Radford, K., additional, Zhang, K., additional, Konyer, N., additional, Haider, E., additional, Mukherjee, M., additional, Dvorkin-Gheva, A., additional, Nair, P., additional, and Svenningsen, S., additional

Published
2024
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3. St. George's Respiratory Questionnaire (SGRQ) Based Cluster Analysis of Post-acute COVID-19 Sequelae

Author

Chiu, M.N., primary, Zhang, K., additional, Chowdhury, A., additional, Mukherjee, M., additional, Thakar, A., additional, Somalwar, S., additional, Sidhom, K., additional, Jegatheeswaran, M., additional, Thanavala, N., additional, Sedhom, N., additional, Venegas Garrido, C., additional, Radadia, N., additional, Son, K., additional, Jamil, R., additional, Patel, Z., additional, Gershon, A.S., additional, Nair, P., additional, Duong, M.L., additional, Ho, T., additional, Balakrishnan, N., additional, Tselios, K., additional, Satia, I., additional, and Svenningsen, S., additional

Published
2024
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5. Ventilation Defect Burden Quantified by Technegas SPECT and 129Xe MRI Predicts Lung Cancer Resection Outcomes

Author

Radadia, N., primary, Priel, E., additional, Friedlander, Y., additional, Konyer, N., additional, Huang, C., additional, Jamal, M., additional, Farncombe, T., additional, Marriott, C., additional, Finley, C., additional, Agzarian, J., additional, Noseworthy, M., additional, Nair, P., additional, Shargall, Y., additional, and Svenningsen, S., additional

Published
2024
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9. Respiratory Post Acute COVID-19 Sequelae (PACS)-A Phenotype of Long COVID

Author

Zhang, K., primary, Thakar, A., additional, Somalwar, S., additional, Sidhom, K., additional, Thanavala, N., additional, Sedhom, N., additional, Venegas Garrido, C., additional, Radadia, N., additional, Son, K., additional, Lavigne, N., additional, Jamil, R., additional, Patel, Z., additional, Gershon, A.S., additional, Nair, P., additional, Duong, M.L., additional, Ho, T., additional, Tselios, K., additional, Satia, I., additional, Svenningsen, S., additional, and Mukherjee, M., additional

Published
2023
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11. Dupilumab Reduces Sputum Eosinophils, Mucus Plugging and Improves Ventilation in Patients With Moderate-to-Severe Asthma

Author

Svenningsen, S., primary, Kjarsgaard, M., additional, Haider, E., additional, Serajeddini, H., additional, Venegas Garrido, C., additional, Konyer, N., additional, Radford, K., additional, Huang, C., additional, Lavigne, N., additional, Friedlander, Y., additional, Thakar, A., additional, Radadia, N., additional, Nasir, N., additional, Mukherjee, M., additional, Boylan, C., additional, Kirby, M., additional, and Nair, P., additional

Published
2023
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14. Elevated CD27-IgD- B cells in Post-Acute COVID-19 Sequalae Patients with Rheumatological Symptoms

Author

Tan, N S, primary, Zhang, K, additional, Koenig, J F, additional, Somalwar, S, additional, Sedhom, N, additional, Chiu, M N, additional, Jamil, R, additional, Patel, Z, additional, Larché, M, additional, Ho, T, additional, Svenningsen, S, additional, Bowdish, D M, additional, Jordana, M, additional, Tselios, K, additional, and Mukherjee, M, additional

Published
2023
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20. Prevalence and Clinical Relevance of Ventilation Heterogeneity and Luminal Cellular Inflammation in Lung Cancer Patients Prior to Lung Resection: An Interim Analysis

Author

Radadia, N., primary, Jamal, M., additional, Begum, H., additional, Huang, C., additional, Radford, K., additional, Lavigne, N., additional, Farncombe, T., additional, Konyer, N.B., additional, Marriott, C., additional, Noseworthy, M., additional, Priel, E., additional, Nair, P., additional, Shargall, Y., additional, and Svenningsen, S., additional

Published
2022
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21. Circulating Autoantibodies in Post-Acute Sequelae of COVID-19

Author

Jamil, R., primary, Son, K., additional, Venegas, C.P., additional, Miyasaki, K., additional, Ho, T.N., additional, Kennedy, A., additional, Patel, Z., additional, Swindall, T., additional, Banerjee, S., additional, Cowbrough, B., additional, Huang, C., additional, Kjarsgaard, M., additional, Radford, K., additional, Smith, J., additional, Dvorkin-Gheva, A., additional, Li, Q.-Z., additional, Nair, P.K., additional, Nazy, I., additional, Bowdish, D., additional, Carlsten, C., additional, Svenningsen, S., additional, and Mukherjee, M., additional

Published
2022
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26. Protocols for multi-site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129Xe MRI clinical trials consortium

Author

Niedbalski, P.J., Hall, C.S., Castro, M., Eddy, R.L., Rayment, J.H., Svenningsen, S., Parraga, G., Zanette, B., Santyr, G.E., Thomen, R.P., Stewart, N.J., Collier, G.J., Chan, H., Wild, J.M., Fain, S.B., Miller, G.W., Mata, J.F., Mugler, J.P., Driehuys, B., Willmering, M.M., Cleveland, Z.I., and Woods, J.C.

Abstract

Hyperpolarized (HP) 129Xe MRI uniquely images pulmonary ventilation, gas exchange, and terminal airway morphology rapidly and safely, providing novel information not possible using conventional imaging modalities or pulmonary function tests. As such, there is mounting interest in expanding the use of biomarkers derived from HP 129Xe MRI as outcome measures in multi-site clinical trials across a range of pulmonary disorders. Until recently, HP 129Xe MRI techniques have been developed largely independently at a limited number of academic centers, without harmonizing acquisition strategies. To promote uniformity and adoption of HP 129Xe MRI more widely in translational research, multi-site trials, and ultimately clinical practice, this position paper from the 129Xe MRI Clinical Trials Consortium (https://cpir.cchmc.org/XeMRICTC) recommends standard protocols to harmonize methods for image acquisition in HP 129Xe MRI. Recommendations are described for the most common HP gas MRI techniques—calibration, ventilation, alveolar-airspace size, and gas exchange—across MRI scanner manufacturers most used for this application. Moreover, recommendations are described for 129Xe dose volumes and breath-hold standardization to further foster consistency of imaging studies. The intention is that sites with HP 129Xe MRI capabilities can readily implement these methods to obtain consistent high-quality images that provide regional insight into lung structure and function. While this document represents consensus at a snapshot in time, a roadmap for technical developments is provided that will further increase image quality and efficiency. These standardized dosing and imaging protocols will facilitate the wider adoption of HP 129Xe MRI for multi-site pulmonary research.

Published
2021

31. Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections

Author

Kennedy, AE, Cook, L, Breznik, JA, Cowbrough, B, Wallace, JG, Huynh, A, Smith, JW, Son, K, Stacey, H, Ang, J, McGeer, A, Coleman, BL, Larche, M, Hambly, N, Nair, P, Ask, K, Miller, MS, Bramson, J, Levings, MK, Nazy, I, Svenningsen, S, Mukherjee, M, Bowdish, DME, Kennedy, AE, Cook, L, Breznik, JA, Cowbrough, B, Wallace, JG, Huynh, A, Smith, JW, Son, K, Stacey, H, Ang, J, McGeer, A, Coleman, BL, Larche, M, Hambly, N, Nair, P, Ask, K, Miller, MS, Bramson, J, Levings, MK, Nazy, I, Svenningsen, S, Mukherjee, M, and Bowdish, DME

Abstract

Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular immune phenotype and function in individuals who had recovered from mild SARS-CoV-2 infections (n = 22), compared to those that had recovered from other mild respiratory infections (n = 11). Individuals who had experienced mild SARS-CoV-2 infections had elevated levels of C-reactive protein 1-3 months after symptom onset, and changes in phenotype and function of circulating T-cells that were not apparent in individuals 6-9 months post-symptom onset. Markers of monocyte activation, and expression of adherence and chemokine receptors indicative of altered migratory capacity, were also higher at 1-3 months post-infection in individuals who had mild SARS-CoV-2, but these were no longer elevated by 6-9 months post-infection. Perhaps most surprisingly, significantly more T-cells could be activated by polyclonal stimulation in individuals who had recently experienced a mild SARS-CoV-2, infection compared to individuals with other recent respiratory infections. These data are indicative of prolonged immune activation and systemic inflammation that persists for at least three months after mild or asymptomatic SARS-CoV-2 infections.

Published
2021

40. Anatomical pulmonary magnetic resonance imaging segmentation for regional structure-function measurements of asthma

Author

Guo, F, Svenningsen, S, Eddy, R L, Capaldi, D P I, Sheikh, K, Fenster, A, and Parraga, G

Subjects
convex optimization, volume proportion prior, multiregion segmentation, Medical Biophysics, 1H MRI
Abstract

PURPOSE: Pulmonary magnetic-resonance-imaging (MRI) and x-ray computed-tomography have provided strong evidence of spatially and temporally persistent lung structure-function abnormalities in asthmatics. This has generated a shift in their understanding of lung disease and supports the use of imaging biomarkers as intermediate endpoints of asthma severity and control. In particular, pulmonary (1)H MRI can be used to provide quantitative lung structure-function measurements longitudinally and in response to treatment. However, to translate such biomarkers of asthma, robust methods are required to segment the lung from pulmonary (1)H MRI. Therefore, their objective was to develop a pulmonary (1)H MRI segmentation algorithm to provide regional measurements with the precision and speed required to support clinical studies. METHODS: The authors developed a method to segment the left and right lung from (1)H MRI acquired in 20 asthmatics including five well-controlled and 15 severe poorly controlled participants who provided written informed consent to a study protocol approved by Health Canada. Same-day spirometry and plethysmography measurements of lung function and volume were acquired as well as (1)H MRI using a whole-body radiofrequency coil and fast spoiled gradient-recalled echo sequence at a fixed lung volume (functional residual capacity + 1 l). We incorporated the left-to-right lung volume proportion prior based on the Potts model and derived a volume-proportion preserved Potts model, which was approximated through convex relaxation and further represented by a dual volume-proportion preserved max-flow model. The max-flow model led to a linear problem with convex and linear equality constraints that implicitly encoded the proportion prior. To implement the algorithm, (1)H MRI was resampled into ∼3 × 3 × 3 mm(3) isotropic voxel space. Two observers placed seeds on each lung and on the background of 20 pulmonary (1)H MR images in a randomized dataset, on five occasions, five consecutive days in a row. Segmentation accuracy was evaluated using the Dice-similarity-coefficient (DSC) of the segmented thoracic cavity with comparison to five-rounds of manual segmentation by an expert observer. The authors also evaluated the root-mean-squared-error (RMSE) of the Euclidean distance between lung surfaces, the absolute, and percent volume error. Reproducibility was measured using the coefficient of variation (CoV) and intraclass correlation coefficient (ICC) for two observers who repeated segmentation measurements five-times. RESULTS: For five well-controlled asthmatics, forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) was 83% ± 7% and FEV1 was 86 ± 9%pred. For 15 severe, poorly controlled asthmatics, FEV1/FV C = 66% ± 17% and FEV1 = 72 ± 27%pred. The DSC for algorithm and manual segmentation was 91% ± 3%, 92% ± 2% and 91% ± 2% for the left, right, and whole lung, respectively. RMSE was 4.0 ± 1.0 mm for each of the left, right, and whole lung. The absolute (percent) volume errors were 0.1 l (∼6%) for each of right and left lung and ∼0.2 l (∼6%) for whole lung. Intra- and inter-CoV (ICC) were0.91%) for DSC and0.93%) for RMSE. While segmentation required 10 s including ∼6 s for user interaction, the smallest detectable difference was 0.24 l for algorithm measurements which was similar to manual measurements. CONCLUSIONS: This lung segmentation approach provided the necessary and sufficient precision and accuracy required for research and clinical studies.

Published
2016

47. This is what asthma looks like: Review of new and emerging functional imaging methods and results

Author

Eddy, R. L., Svenningsen, S., Kassay, A., McCormack, D. G., Nair, P., and Parraga, G.

Abstract

ABSTRACTIn asthma, diffuse and homogeneously distributed airway abnormalities have been thought responsible for symptoms and disease worsening, despite evidence over six-decades ago of ventilation heterogeneity using multiple-breath gas-washout studies. Such ventilation heterogeneity could stem from heterogeneously distributed airway abnormalities and, recently, pulmonary imaging including nuclear medicine methods, x-ray computed tomography (CT) and magnetic resonance imaging (MRI), has revealed focal ventilation defects and abnormal, heterogeneous ventilation patterns in asthmatics. In this review, we summarize pulmonary functional MRI findings that provide supportive evidence that in asthmatics, some ventilation abnormalities are temporally and spatially persistent while others come and go intermittently, but in the same, predictable spatial locations. Importantly, MRI ventilation defects also worsen in response to methacholine and exercise in the same spatial locations, despite differing underlying asthma response mechanisms, and in most patients, ventilation defects improve post-bronchodilator. In asthmatics, focal ventilation defects have been shown to be quantitatively and spatially related to airways with abnormal wall and lumen morphology, possibly stemming from remodelling, smooth muscle dysfunction and/or inflammation that may occur concurrently or independently. Finally, because MRI ventilation defects were also shown to be related to eosinophilic airway inflammation, asthma symptoms and disease control, we think MRI may be considered clinically to guide asthma therapy decisions in patients, to develop novel therapies and better understand mechanisms of asthma progression and therapy response in individual patients.

Published
2018
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