920 results on '"Sweat Gland Neoplasms diagnosis"'
Search Results
2. Milia-like appearance of vulvar syringoma.
- Author
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Yasunaga S, Oya K, Ishii Y, Anju K, Takano A, and Nomura T
- Subjects
- Humans, Female, Diagnosis, Differential, Adult, Keratosis, Syringoma pathology, Syringoma diagnosis, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Vulvar Neoplasms pathology, Vulvar Neoplasms diagnosis, Vulvar Neoplasms surgery
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- 2024
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3. Pedunculated eccrine poromas on non-acral sites.
- Author
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Kanagarajan A, Srinivasan H, and Rajeswaran PK
- Subjects
- Humans, Female, Middle Aged, Diagnosis, Differential, Breast Neoplasms pathology, Breast Neoplasms therapy, Granuloma, Pyogenic diagnosis, Granuloma, Pyogenic pathology, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms therapy, Sweat Gland Neoplasms diagnosis, Poroma pathology, Poroma diagnosis
- Abstract
A woman in her mid-50s, a patient with metastatic right breast carcinoma, postradical mastectomy and chemoradiation on hormonal therapy, presented with asymptomatic reddish lesions over the neck and trunk. Cutaneous examination revealed three discrete pedunculated, non-tender, firm erythematous growths with smooth surfaces over the neck, chest and abdomen. Histopathological examination was done with the differentials of pyogenic granuloma, haemangioma, giant acrochordon and vascular metastasis, revealing the diagnosis of eccrine poroma (EP). The remaining lesions were removed by electrocautery with no relapse till 1 year of follow-up. EP is a rare benign neoplasm arising from the acrosyringium that commonly presents as solitary, sessile or pedunculated asymptomatic papules or nodules over the palms and soles. Here we report the rare occurrence of multiple pedunculated EPs on a non-acral site in a patient who received chemoradiotherapy, which clinically mimicked pyogenic granuloma and vascular metastases. Thus, emphasising the importance of considering EP as a differential in lesions with vascular morphology., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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4. Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
- Author
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Nguyen AJ, Johnson E, Camilleri M, Wieland C, Lehman JS, Agrawal S, Comfere N, Fadra N, Knudson RA, Greipp P, Halling K, and Ray Guo R
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Adult, Aged, 80 and over, Reproducibility of Results, In Situ Hybridization, Fluorescence, Transcription Factors analysis, Predictive Value of Tests, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms genetics, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms classification, Immunohistochemistry, Biomarkers, Tumor analysis, Biomarkers, Tumor genetics
- Abstract
Sweat gland neoplasms represent a challenging area of dermatopathology, as they are relatively uncommon and often histopathologically complex. Recent studies have uncovered distinct immunohistochemical and molecular profiles in several sweat gland neoplasms, including digital papillary adenocarcinoma (DPA), papillary eccrine adenoma/tubular apocrine adenoma (PEA/TAA), poroid family tumors (PFT)/porocarcinoma, and clear cell hidradenoma (CCH)/clear cell hidradenocarcinoma (CCHCa). To further evaluate the diagnostic utility of ancillary studies in various sweat gland neoplasms, we performed an independent validation study in a cohort of patients with acral and non-acral tumors (9 DPA, 8 PEA/TAA, 13 PFT, 5 porocarcinoma, 23 CCH, 7 CCHCa, 6 sweat gland carcinoma not otherwise specified). p63 immunohistochemistry (IHC) demonstrated a myoepithelial pattern in 8/8 DPA and 4 of 4 tested PEA/TAA cases, and showed a ductal pattern in all tested PFT/porocarcinoma and CCH/CCHCa cases (42/42). All PEA/TAA (8/8) cases were positive for BRAF V600E IHC. 5 of 12 tested PFT and 5/5 porocarcinoma cases showed either positive staining with NUT IHC or harbored YAP1::NUTM1 fusion gene by RNA sequencing. MAML2 fluorescence in situ hybridization (FISH) was positive in all CCH and CCHCa cases (23/23 and 7/7, respectively). Our results further support the usefulness of appropriate ancillary studies in precise classification of sweat gland tumors, which may be routinely applied in diagnostic pathology practice when morphologic evaluation is in doubt., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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5. Eccrine poroma of the eyelid.
- Author
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McCoskey M, Neerukonda VK, Hatton MP, and Wolkow N
- Subjects
- Humans, Female, Male, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms diagnosis, Eyelid Neoplasms pathology, Eyelid Neoplasms surgery, Poroma pathology, Poroma diagnosis, Poroma surgery
- Abstract
Clinical and histopathologic case of an eyelid eccrine poroma, a benign adnexal neoplasm rarely found on the periorbital skin.
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- 2024
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6. Intradermal Syringocystadenoma Papilliferum on the Popliteal Fossa: A Rare Dermal Variant in an Atypical Location.
- Author
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Omer M, Na S, Joshipura D, and Robinson-Bostom L
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- Humans, Male, Middle Aged, Tubular Sweat Gland Adenomas pathology, Biopsy, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms diagnosis
- Abstract
Syringocystadenoma papilliferum (SCAP) is a benign adnexal tumor commonly found on the scalp and face, and often associated with nevus sebaceous, with about half of cases appearing in early childhood. SCAP exhibits cystic invaginations with papillary structures and a double-layered glandular epithelium linked to the epidermal surface and stromal plasma cells. We are reporting a rare instance of intradermal SCAP in a 55-year-old male. He sought evaluation for a long-standing asymptomatic dark-pink papule in his left popliteal fossa, measuring 0.7 x 0.5 x 0.4 cm. A shave biopsy revealed papillary dermal fibrosis, glandular epithelium with apocrine secretion, and papillary projections without an epidermal connection. Infundibulofollicular keratinization was observed, along with stromal plasma cells. The patient chose local excision as the treatment option. This case highlights the rarity of intradermal SCAP, especially in the left popliteal fossa, with only one other reported case in the literature.
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- 2024
7. Inverse Eruptive Syringoma in a Skin of Color Patient.
- Author
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Wang J, Yousefi N, Heilman E, and Jagdeo J
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- Humans, Female, Young Adult, Black or African American, Syringoma pathology, Syringoma diagnosis, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms pathology, Skin Pigmentation
- Abstract
Syringomas are benign neoplasms derived from eccrine sweat glands. Eruptive syringomas are a subtype of syringomas and are typically located on the chest, neck, and abdomen during puberty or childhood. Herein, we present a 20-year-old African American female with an atypical case of eruptive syringomas, characterized by an unusual distribution on her chest, abdomen, and anterior and posterior bilateral extremities. This case underscores the importance of recognizing diverse presentations of skin conditions in patients with skin of color and adds to the limited reports of eruptive syringoma in these populations. We present and emphasize this atypical manifestation of eruptive syringomas in an individual with darker skin to promote awareness and improve diagnosis and patient outcomes.J Drugs Dermatol. 2024;23(7):564-566. doi:10.36849/JDD.8103.
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- 2024
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8. Adnexal neoplasms of the eye.
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Drozdowski R, Grant-Kels JM, Falcone M, and Stewart CL
- Subjects
- Humans, Neoplasms, Adnexal and Skin Appendage pathology, Neoplasms, Adnexal and Skin Appendage diagnosis, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Pilomatrixoma pathology, Pilomatrixoma diagnosis, Hidrocystoma pathology, Hidrocystoma diagnosis, Eyelid Neoplasms pathology, Eyelid Neoplasms diagnosis, Sebaceous Gland Neoplasms pathology, Sebaceous Gland Neoplasms diagnosis
- Abstract
Adnexal neoplasms of the eyelid encompass a wide variety of benign and malignant tumors of sebaceous, follicular, and sweat gland origin. Due to the specialized structures of the eyelid, these neoplasms present differently when compared with those of other locations. Although most dermatologists and ophthalmologists are familiar with the commonly reported adnexal tumors of the eyelid, such as hidrocystoma, pilomatrixoma, and sebaceous carcinoma, many other adnexal neoplasms have been reported at this unique anatomic site. Accurate and timely identification of these neoplasms is essential, as alterations of eyelid anatomy and function can have a negative impact on eye health, vision, and quality of life. We review the clinical and histopathologic features of common and rare eyelid adnexal neoplasms and discuss proposed treatment options., Competing Interests: Declaration of competing interest The authors declare no conflicts of interest., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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9. Hidrocystoma-like tumours with RET or ALK fusion: a study of four cases.
- Author
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Goto K, Kervarrec T, Tallet A, Macagno N, Pissaloux D, Fouchardière A, Battistella M, Kajiwara M, Nagao T, Fujita I, Kajimoto K, Goto H, Matsumura H, and Takai T
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Child, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms genetics, Sweat Gland Neoplasms diagnosis, Gene Rearrangement, Oncogene Proteins, Fusion genetics, Proto-Oncogene Proteins c-ret genetics, Anaplastic Lymphoma Kinase genetics, Anaplastic Lymphoma Kinase metabolism, Hidrocystoma pathology, Hidrocystoma genetics, Hidrocystoma diagnosis
- Abstract
Hidrocystoma is thought to be a benign retention cyst of sweat ductal units. The lesion is usually located in the periorbital skin; however, lesions with similar histopathological features are rarely observed in extra-facial sites. Herein, we present four cases of hidrocystoma-like tumours in extra-facial skin sites that harboured a RET or ALK rearrangement. This study features a 67-year-old female with a 10 mm-sized digital tumour (Case 1), a 62-year-old male with an 8 mm-sized clavicular tumour (Case 2), a 61-year-old male with a 19 mm-sized digital tumour (Case 3), and an 11-year-old female with a 10 mm-size lower leg tumour (Case 4) as well as five control cases (Cases 5-9) of classical periorbital hidrocystoma. In Cases 1-4, multicystic tumours comprising a two-cell layer of inner cuboidal ductoglandular (p63- and SOX10+/-) and outer flat myoepithelial (p63+ and SOX10+) cells were observed. The inner ductoglandular tumour cells exhibited micropapillary projections and Roman bridging structures. No apparent atypical cells were observed. NCOA4::RET in Cases 1 and 3, CCDC6::RET in Case 2, and SLC12A2::ALK in Case 4 were revealed by next-generation sequencing or Sanger sequencing. In contrast, control cases of classical hidrocystoma (Cases 5-9) did not show intracystic proliferation, abundant cytoplasm, ALK immunoreactivity, or NCOA4::RET detection in the tumour cells. RET/ALK-rearranged hidrocystoma-like tumours are tumour entities that can be distinguished from classical hidrocystoma. This RET/ALK-rearranged neoplasm is benign and is frequently observed in the digits. Future studies will establish the concept, detailed clinicopathological characteristics, and genetic variations of hidrocystoma-like tumours., (Copyright © 2024 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.)
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- 2024
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10. Spitz naevus with syringomatous eccrine ductal hyperplasia and ROS1 fusion.
- Author
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Wilsher MJ and Hepburn N
- Subjects
- Humans, Skin Neoplasms pathology, Skin Neoplasms diagnosis, Skin Neoplasms genetics, Hyperplasia pathology, Female, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Male, Adult, Protein-Tyrosine Kinases, Nevus, Epithelioid and Spindle Cell pathology, Nevus, Epithelioid and Spindle Cell genetics, Nevus, Epithelioid and Spindle Cell diagnosis, Eccrine Glands pathology, Proto-Oncogene Proteins genetics
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- 2024
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11. Syringocystadenocarcinoma papilliferum: a systematic review of clinical characteristics, reappraisal of associations, diagnostic pitfalls and management challenges.
- Author
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Wan L, Park A, and Khachemoune A
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- Humans, Male, Female, Aged, Mohs Surgery, Neoplasm Recurrence, Local epidemiology, Neoplasm Recurrence, Local diagnosis, Neoplasm Recurrence, Local pathology, Nevus, Sebaceous of Jadassohn diagnosis, Nevus, Sebaceous of Jadassohn pathology, Nevus, Sebaceous of Jadassohn surgery, Nevus, Sebaceous of Jadassohn therapy, Scalp pathology, Tubular Sweat Gland Adenomas diagnosis, Tubular Sweat Gland Adenomas pathology, Tubular Sweat Gland Adenomas surgery, Middle Aged, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms therapy
- Abstract
Syringocystadenocarcinoma papilliferum (SCACP) is a rare and aggressive malignant adnexal tumor originating from apocrine or pluripotent appendageal glands, often associated with a preceding syringocystadenoma papilliferum (SCAP) or nevus sebaceus (NS). This systematic review rigorously examines SCACP through an analysis of 78 cases documented between 1980 and 2024. The study aims to provide a comprehensive review of the clinical manifestations, diagnosis, treatment modalities, and outcomes associated with SCACP, while also reappraising its associations, particularly with NS. SCACP predominantly affects older adults, with an average age of 66.3 years and a slight male predominance, commonly presenting as ulcerated nodules or plaques on the scalp. This review highlights the aggressive nature of SCACP, evidenced by significant rates of metastasis and recurrence. Treatment is primarily surgical, with Mohs micrographic surgery offering potential benefits in terms of margin control and cosmetic outcomes. The association of SCACP with NS is critically evaluated, suggesting a complex etiopathogenesis and underscoring the importance of recognizing this association for timely diagnosis and management. Our review also briefly discusses potential pitfalls faced by clinicians in the diagnosis of SCACP. Our findings emphasize the need for standardized treatment protocols and further research into targeted therapies to improve patient outcomes in SCACP., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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12. Hidradenocarcinoma: A Case Series From the Scripps Clinic With a Systematic Review of the Literature.
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Kent S, Jeha GM, Qiblawi S, Malinosky H, Greenway HT, and Kelley B
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- Female, Humans, Male, Middle Aged, Acrospiroma pathology, Acrospiroma diagnosis, Acrospiroma surgery, Mohs Surgery, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms therapy
- Abstract
Background: Hidradenocarcinoma (HAC) is a rare adnexal carcinoma. To the best of the authors' knowledge, there are no published systematic reviews on HAC., Objective: To incorporate a case series from the authors' institution and systematically integrate reported information to provide a reference tool for optimization of diagnosis and management., Methods: A comprehensive MEDLINE search was conducted from database inception to 2021 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. This yielded 225 studies with 165 cases of HAC. References of included articles were also searched. In addition, 9 patients with HAC were identified from the authors' institution over the past 10 years., Results: The mean age of HAC presentation is 60 years with a slight male predilection (60%). The head and neck is the most commonly affected region. Over 36% of cases either presented with metastatic disease or went on to metastasize. The most common treatment type was wide local excision, followed by Mohs micrographic surgery., Conclusion: Early detection with accurate histologic interpretation is prudent in all cases of HAC. Wide local excision is the current first-line treatment. However, Mohs micrographic surgery offers complete marginal analysis with evidence of reduced risk of metastasis and better outcomes compared with wide local excision. Currently, there are no National Comprehensive Cancer Network guidelines for the treatment of HAC, and consensus guidelines are limited to tumor and nodal metastasis staging provided by the American Joint Committee on Cancer, eighth edition. Thus, this case series and systematic review integrates important aspects of diagnosis, workup, and management of HAC., (Copyright © 2024 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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13. Botulinum toxin for periorbital hidrocystomas in a referral center in Mexico City.
- Author
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Schiappapietra-Gerez JM, Santiago-Rea N, Tovilla-Canales JL, Gonzalez-Mondragón E, and Nava-Castañeda A
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- Humans, Mexico epidemiology, Female, Male, Middle Aged, Adult, Referral and Consultation, Orbital Neoplasms drug therapy, Orbital Neoplasms diagnosis, Aged, Botulinum Toxins, Type A administration & dosage, Botulinum Toxins administration & dosage, Hidrocystoma pathology, Hidrocystoma drug therapy, Hidrocystoma diagnosis, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms diagnosis
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- 2024
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14. Porocarcinoma: Clinical and Histological Features, Immunohistochemistry and Outcomes: A Systematic Review.
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Bienstman T, Güvenç C, and Garmyn M
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- Humans, Immunohistochemistry, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms therapy, Sweat Gland Neoplasms metabolism, Sweat Gland Neoplasms diagnosis, Biomarkers, Tumor metabolism, YAP-Signaling Proteins, Eccrine Porocarcinoma pathology, Eccrine Porocarcinoma therapy, Eccrine Porocarcinoma metabolism, Eccrine Porocarcinoma diagnosis
- Abstract
Porocarcinoma (PC) is a rare adnexal tumor, mainly found in the elderly. The tumor arises from the acrosyringium of eccrine sweat glands. The risk of lymph node and distant metastasis is high. Differential diagnosis with squamous cell carcinoma is difficult, although NUT expression and YAP1 fusion products can be very useful for diagnosis. Currently, wide local excision is the main surgical treatment, although Mohs micrographic surgery is promising. To date, there is no consensus regarding the role of sentinel lymph node biopsy and consequential lymph node dissection. No guidelines exist for radiotherapy, which is mostly performed based on tumor characteristics and excision margins. Only a few studies report systemic treatment for advanced PC, although therapy with pembrolizumab and EGFR inhibitors show promise. In this review, we discuss epidemiology, clinical features, histopathological features, immunohistochemistry and fusion products, surgical management and survival outcomes according to stage, surgical management, radiotherapy and systemic therapy.
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- 2024
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15. Metastatic hidradenocarcinoma papilliferum in chronic hidradenitis: an emblematic case and a narrative review.
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Rosatti F, Orlando E, Alecci G, Ferraù F, and Cordova A
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- Humans, Male, Female, Middle Aged, Chronic Disease, Acrospiroma pathology, Acrospiroma diagnosis, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms diagnosis
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- 2024
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16. Syringomatous tumor of the nipple: a case report.
- Author
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Félix AVJ, Silva LV, da Costa REAR, Soares MJAP, Sobrinho RFO, Silva MCA, da Silva Júnior RG, and Vieira SC
- Subjects
- Humans, Female, Adult, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms surgery, Follow-Up Studies, Mammaplasty methods, Breast Neoplasms pathology, Breast Neoplasms diagnosis, Breast Neoplasms surgery, Nipples pathology, Syringoma pathology, Syringoma diagnosis, Syringoma surgery, Ultrasonography, Mammary
- Abstract
Syringomatous tumor of the nipple is a benign, locally infiltrative tumor. There are reports in the literature of tumor recurrence in cases of incomplete excision. Clinical and mammographic findings in syringomatous tumors are like those of breast carcinoma and the pathologist has a fundamental role in final tumor diagnosis. Therefore, the aim of this study was to report a case of syringoma located in the areolar region. A 33-year-old woman reported that she had noticed a nodule in her left areolar region 4 years previously (February 2019). A breast ultrasound was performed, detecting intraparenchymatous breast cysts. Surgical resection of the nodule was indicated although it was not performed. Two years later, in August 2021, the patient underwent a mastopexy with prosthesis inclusion. Histopathology study of the surgical specimen revealed a syringomatous tumor with positive margins. Thirteen (13) months after diagnosis (September 3, 2021 - October 16, 2022), the patient is doing well and receives clinical follow-up., Competing Interests: The authors declare no competing interests., (Copyright: Ana Vitória de Jesus Félix et al.)
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- 2024
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17. Five-year pattern of adnexal tumors of the skin in Ethiopia.
- Author
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Abdullahi SM, Hailu SG, Kidane TY, Gebremariam AM, Debele YL, and Degfe FZ
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- Humans, Retrospective Studies, Female, Male, Adult, Ethiopia epidemiology, Middle Aged, Young Adult, Adolescent, Child, Aged, Neoplasms, Adnexal and Skin Appendage pathology, Neoplasms, Adnexal and Skin Appendage epidemiology, Neoplasms, Adnexal and Skin Appendage diagnosis, Child, Preschool, Biopsy, Aged, 80 and over, Head and Neck Neoplasms pathology, Head and Neck Neoplasms epidemiology, Head and Neck Neoplasms diagnosis, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms epidemiology, Sweat Gland Neoplasms diagnosis, Skin Neoplasms pathology, Skin Neoplasms epidemiology, Skin Neoplasms diagnosis
- Abstract
Background: Adnexal tumors of the skin are rare neoplasms that encompass a wide range of dermatologic entities. Here, we investigated the pattern of adnexal tumors of the skin in the All African Leprosy and Tuberculosis Rehabilitation and Training Center (ALERT) hospital retrospectively., Methods: A hospital-based retrospective study was conducted at ALERT from histopathology records in the Armauer Hansen Research Institute (AHRI) pathology laboratory of patients diagnosed with any of the skin adnexal tumors during the time period January 2017 to December 2021. A structured data extraction sheet was used. Data entry was done using EpiData 4.6.0.6. Data were analyzed using SPSS version 25., Result: A total of 146 skin adnexal tumors were identified making the magnitude 2.8% of total biopsies. The 3rd decade of life was found to be the most common age group. Male-to-female ratio was 1 : 1.05. Majority of the tumors were benign (82.2%) and had sweat gland differentiation at 48.6%. Poroma (10.9%) was the most frequent tumor, whereas porocarcinoma (6.8%) made up the most frequent malignant tumor. The most common site was the head and neck region (48.6%). Only 21.2% of the tumors were correctly identified clinically., Conclusion: The magnitude of skin adnexal tumors is found to be slightly higher than other similar studies which could be because it was carried out in the largest dermatologic center in the country. The most common skin adnexal tumors identified, their localizations, and lines of differentiation are all in line with other studies. Histopathologic examination is mandatory for the accurate diagnosis of these tumors., (© 2024 the International Society of Dermatology.)
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- 2024
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18. Dermoscopic features of dermal duct tumors.
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Barei F, Belotti A, Bortoluzzi P, Mattioli MA, Passoni E, Marzano AV, and Nazzaro G
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- Aged, Humans, Male, Skin Neoplasms pathology, Skin Neoplasms diagnosis, Skin Neoplasms diagnostic imaging, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Dermoscopy
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- 2024
- Full Text
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19. Generalized Eruptive Syringoma.
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Wang Q and Liu J
- Subjects
- Humans, Female, Male, Adult, Syringoma pathology, Syringoma diagnosis, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms diagnosis
- Published
- 2024
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20. Orbital apocrine hidrocystoma. Report of two cases.
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Di Marino M, Quaranta Leoni F, Ranazzi G, and Quaranta Leoni FM
- Subjects
- Humans, Male, Middle Aged, Aged, Tomography, X-Ray Computed, Ophthalmologic Surgical Procedures, Apocrine Glands pathology, Apocrine Glands surgery, Magnetic Resonance Imaging, Diagnosis, Differential, Hidrocystoma surgery, Hidrocystoma diagnosis, Hidrocystoma pathology, Orbital Neoplasms surgery, Orbital Neoplasms diagnosis, Orbital Neoplasms pathology, Orbital Neoplasms diagnostic imaging, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms pathology
- Abstract
Introduction: We report the clinical features and the management of two cases of orbital hidrocystoma in the setting of an enlarging orbital mass., Cases Description: A 48-year-old man presented with a mass in the right upper medial orbital quadrant, firmly attached to the supraorbital incisure. A 70-year-old man had a well demarcated lesion in the upper lateral orbital quadrant adherent to the lacrimal gland. There was no history of previous orbital trauma. In both cases histopathology confirmed a diagnosis of apocrine hidrocystoma. Following surgery, the first patient complained of mild hypoesthesia in the territory of the supraorbital nerve that resolved spontaneously within 3 weeks. Surgery was uneventful in the other patient. No recurrence was seen during the follow up., Conclusions: Apocrine hidrocystomas have been rarely described in the orbit, but should be considered in the differential diagnosis of orbital cystic masses. Recurrence is rare following complete surgical excision., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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21. Case of eccrine chondroid syringoma of the upper lip.
- Author
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Chon J, Laub P, Alhalaseh Y, and Ogrodnik J
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- Humans, Male, Adult, Diagnosis, Differential, Lip pathology, Lip surgery, Eccrine Glands pathology, Adenoma, Pleomorphic pathology, Adenoma, Pleomorphic surgery, Adenoma, Pleomorphic diagnosis, Adenoma, Pleomorphic diagnostic imaging, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms diagnosis, Lip Neoplasms pathology, Lip Neoplasms diagnosis, Lip Neoplasms surgery
- Abstract
Chondroid syringoma (CS) is a benign, slow-growing mixed tumour that arises from the sweat glands and usually presents in the head and neck area. Histopathological examination is important for proper diagnosis, as CS is often confused with epidermal cysts due to its rare presentation. This article presents a man in his 40s with a right upper lip mass that emerged 6 months prior to presentation. An intraoral surgical excision was performed and the histopathological analysis revealed solid epithelial cells that formed multiple, non-branching ducts lined by cuboidal epithelium. Cystic spaces were filled by heterogeneous eosinophilic material embedded in chondromyxoid stroma. Histopathology identified the lesion as an eccrine-variant CS. The patient recovered well., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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22. Nodular hidradenoma: clinical, dermoscopic, and histopathological features.
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Correia C, De Vasconcelos P, and Soares-de-Almeida L
- Subjects
- Humans, Female, Middle Aged, Diagnosis, Differential, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Dermoscopy, Acrospiroma pathology, Acrospiroma diagnosis
- Abstract
Nodular hidradenoma is an infrequent benign tumor originating from the proximal portion of the sweat glands, most commonly associated with the apocrine glands. Owing to its variable clinical presentation, correctly diagnosing nodular hidradenoma can be challenging, with several potential conditions in the differential diagnosis to consider. This article presents a healthy 52-year-old woman with an atypical location of nodular hidradenoma, highlighting the critical role of integrating clinical, dermoscopic, and histopathological characteristics for an accurate diagnosis. We discuss the clinical features, dermoscopic findings, histological examination, differential diagnosis, and treatment options for nodular hidradenoma, emphasizing the importance of surgical intervention in preventing potential malignant transformation.
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- 2024
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23. A Rare Case of Axillary Extramammary Paget's Disease with an Underlying Adenocarcinoma.
- Author
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Felts C, Durkin V, and Kerkvliet A
- Subjects
- Humans, Aged, Male, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Skin Neoplasms pathology, Skin Neoplasms diagnosis, Paget Disease, Extramammary diagnosis, Paget Disease, Extramammary pathology, Adenocarcinoma pathology, Adenocarcinoma diagnosis, Axilla
- Abstract
Extramammary Paget's disease (EMPD) is an uncommon cutaneous neoplasm almost exclusively located in the vulvar, perianal, and male genitalia regions. Evaluation and management are complicated given the average delay in diagnosis is two years and approximately 30% of cases are associated with underlying malignancies. The axilla is a unique location for EMPD. We report a rare case of a 78-year-old male with axillary EMPD associated with an underlying adenocarcinoma. A 1-cm tender and pruritic erythematous plaque with surrounding erythema appeared in the patient's axilla. An irritated seborrheic keratosis secondarily impetiginized along with irritant contact dermatitis was suspected. Treatment of cefdinir and topical hydrocortisone failed and a biopsy was taken. Microscopic and immunohistochemical examination showed ulceration with an underlying proliferation of atypical glands (Figure 2A) and a nested intraepidermal proliferation with pagetoid spread (Figure 2B). The atypical cells were positive for gross cystic disease fluid protein 15 (Figure 2C), epithelial membrane antigen (Figure 2D), cytokeratin 5/6, and cytokeratin 7. These findings were supportive of an apocrine adenocarcinoma arising in association with EMPD. Wide location excision was performed. Screening for associated malignancies or lymphatic spread is the primary goal during evaluation. Outcomes are favorable when the primary neoplasm is of limited distribution. The accepted treatment for primary lesions is wide local excision, although anatomic tissue constraints necessitate further research into other treatment modalities. To our knowledge, this is the 14th reported case of axillary EMPD with an underlying adenocarcinoma which may help with identification and management of future cases., (Copyright© South Dakota State Medical Association.)
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- 2024
24. Clinical, dermoscopic, and histological findings of a solitary de novo syringocystadenoma papilliferum: a case report.
- Author
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Romagnuolo M, Boggio F, Benzecry Mancin V, Marzano AV, and Moltrasio C
- Subjects
- Humans, Tubular Sweat Gland Adenomas pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms pathology, Head and Neck Neoplasms
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- 2024
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25. Endocrine mucin-producing sweat gland carcinoma of the eyelid - A diagnostic challenge.
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Bhanvadia VM, Kathiara R, Shah A, and Asari W
- Subjects
- Humans, Male, Aged, Eyelids pathology, Diagnosis, Differential, Carcinoma diagnosis, Carcinoma pathology, Immunohistochemistry, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms pathology, Eyelid Neoplasms diagnosis, Eyelid Neoplasms pathology, Mucins
- Abstract
Abstract: Skin adnexal or sweat gland neoplasms are rare adnexal tumors that pose a diagnostic challenge for both ophthalmologists and pathologists. Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is an uncommon low grade carcinoma of eccrine ducts with a predilection to occur in the periocular region in the elderly female. We present a rare case of 65-year-old healthy male who presented with a lobulated mass in the left eye lower lid, clinically suspected as sebaceous gland carcinoma, diagnosed as endocrine mucin-producing sweat gland carcinoma histopathologically., (Copyright © 2023 Copyright: © 2023 Indian Journal of Pathology and Microbiology.)
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- 2024
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26. Syringoid eccrine carcinoma of the nipple in a male patient with lymph node metastasis: A case report.
- Author
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Sable M, Sahoo N, Panigrahi C, Mishra P, and Kumar P
- Subjects
- Humans, Male, Middle Aged, Lymph Nodes pathology, Immunohistochemistry, Eccrine Glands pathology, Biomarkers, Tumor analysis, Axilla, Carcinoma pathology, Carcinoma diagnosis, Carcinoma secondary, Nipples pathology, Lymphatic Metastasis, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Breast Neoplasms, Male pathology, Breast Neoplasms, Male diagnosis
- Abstract
Abstract: Syringoid eccrine carcinoma of nipple is an extremely rare neoplasm of adnexal origin with variable clinical appearance and diverse histologic findings. Syringoid eccrine carcinoma (SEC) is often a diagnostic dilemma due to its morphology and presentation. Usually, these malignancies arise as non-ulcerated nodules or plaques in the head & neck region including the trunk. They are locally aggressive and have an infiltrative growth pattern with a propensity for metastasis. SEC is characterized by syringoma-like tadpole morphology with ductular differentiation and predominant desmoplasia. Immunostaining in SEC is variable and this variability is believed to arise from the tumor's ability to differentiate along multiple routes including sweat secretory and or ductal differentiation. Here we present a rare case of SEC/ syringomatous carcinoma of nipple in a 51-year-old male breast with associated axillary lymph node metastasis. As per English literature, this is the second case of SEC in nipple of male patient., (Copyright © 2024 Copyright: © 2024 Indian Journal of Pathology and Microbiology.)
- Published
- 2024
- Full Text
- View/download PDF
27. Challenging diagnosis of male intraductal papilloma masquerading as eccrine hidradenoma in the breast: Case report.
- Author
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Liu X, Du J, and Zhao L
- Subjects
- Male, Humans, Aged, Middle Aged, Nipples pathology, Acrospiroma pathology, Papilloma, Intraductal diagnosis, Papilloma, Intraductal surgery, Papilloma, Intraductal pathology, Breast Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms pathology, Papilloma pathology
- Abstract
Rationale: This article presents a challenging case involving an elderly male patient with a misdiagnosed intraductal mammary papilloma initially identified as a sweat adenoma through ultrasound imaging. The study aims to explore the histopathology, clinical presentations, and sonographic features of both conditions, emphasizing the contributing factors to the diagnostic misstep., Patient Concerns: A 61-year-old male reported a persistent left breast mass, along with pain and swelling, spanning a 6-month duration., Diagnoses: Ultrasound examination indicated a deep, square, mixed-echo mass in the left nipple, initially suggestive of a sweat adenoma. However, subsequent pathological analysis following resection under general anesthesia confirmed an intraductal papilloma., Intervention: The patient underwent surgical resection of the left breast mass under general anesthesia., Outcome: Post-surgery, the patient exhibited satisfactory recovery; however, regrettably, he was lost to follow-up., Lessons: This study underscores the challenge in differentiating between clear cell sweat adenoma and male intraductal mammary papilloma solely based on ultrasonic characteristics. It emphasizes the susceptibility of ultrasound-based diagnoses to misinterpretation, highlighting the critical need for a comprehensive pathological examination to establish a definitive diagnosis., Competing Interests: The authors have no funding and conflicts of interest to disclose., (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2024
- Full Text
- View/download PDF
28. Cutaneous eccrine spiradenoma: Insights into cytomorphological features via fine needle aspiration biopsy and a comprehensive literature review.
- Author
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Shaker N, Vohra P, Li Z, Sangueza OP, and Abid A
- Subjects
- Humans, Biopsy, Fine-Needle, Skin pathology, Acrospiroma pathology, Skin Neoplasms diagnosis, Skin Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms pathology
- Published
- 2024
- Full Text
- View/download PDF
29. How could we help to diagnose an atypical eccrine porocarcinoma?
- Author
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Yang L, Lai MY, You FR, and Guo HW
- Subjects
- Humans, Eccrine Porocarcinoma diagnosis, Eccrine Porocarcinoma surgery, Eccrine Porocarcinoma pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms pathology
- Abstract
Competing Interests: Declaration of competing interest The authors report no conflict of interest related to this manuscript.
- Published
- 2024
- Full Text
- View/download PDF
30. NUT Expression Is of Diagnostic Utility in the Distinction of Digital Papillary Carcinoma From Poroid Hidradenoma.
- Author
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Iacobelli J, Harvey NT, Ardakani NM, Ng L, Preston H, and Wood BA
- Subjects
- Male, Humans, Carcinoma, Papillary, Acrospiroma pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms genetics, Sweat Gland Neoplasms metabolism, Adenocarcinoma, Papillary, Poroma
- Abstract
Abstract: The distinction between digital papillary adenocarcinoma (DPAC) and benign cutaneous adnexal tumors is clinically important and can be challenging. Poroid hidradenoma frequently occurs at acral sites and can show a number of histological features, which overlap with digital papillary adenocarcinoma. Recent work has shown that YAP1-NUTM1 fusions are frequent in poroid hidradenoma and are associated with nuclear protein in testis (NUT) expression by immunohistochemistry. We evaluated the expression of NUT-1 by immunohistochemistry in 4 cases of DPAC and 4 cases of poroid hidradenoma. Three of 4 cases of poroid hidradenoma showed strong NUT-1 expression, with no staining in any of the cases of DPAC. These results suggest that NUT-1 immunohistochemistry may be a useful additional tool in evaluating this differential diagnosis., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
31. TRPS1 Expression in Endocrine Mucin-Producing Sweat Gland Carcinoma: Diagnostic Utility and Pitfalls.
- Author
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Liu YA and Cho WC
- Subjects
- Humans, Mucins, Sweat Glands metabolism, Repressor Proteins, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms metabolism, Neoplasms, Cystic, Mucinous, and Serous, Carcinoma
- Abstract
Competing Interests: All authors declare no conflicts of interest.
- Published
- 2024
- Full Text
- View/download PDF
32. Gene fusions in poroma, porocarcinoma and related adnexal skin tumours: An update.
- Author
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Kervarrec T, Pissaloux D, Tirode F, de la Fouchardière A, Sohier P, Frouin E, Hamard A, Houben R, Schrama D, Barlier A, Cribier B, Battistella M, and Macagno N
- Subjects
- Humans, Skin pathology, Transcription Factors genetics, Poroma genetics, Poroma metabolism, Poroma pathology, Eccrine Porocarcinoma genetics, Eccrine Porocarcinoma pathology, Skin Neoplasms genetics, Skin Neoplasms pathology, Sweat Gland Neoplasms diagnosis
- Abstract
Poroma is a benign sweat gland tumour showing morphological features recapitulating the superficial portion of the eccrine sweat coil. A subset of poromas may transform into porocarcinoma, its malignant counterpart. Poroma and porocarcinoma are characterised by recurrent gene fusions involving YAP1, a transcriptional co-activator, which is controlled by the Hippo signalling pathway. The fusion genes frequently involve MAML2 and NUTM1, which are also rearranged in other cutaneous and extracutaneous neoplasms. We aimed to review the clinical, morphological and molecular features of this category of adnexal neoplasms with a special focus upon emerging differential diagnoses, and discuss how their systematic molecular characterisation may contribute to a standardisation of diagnosis, more accurate classification and, ultimately, refinement of their prognosis and therapeutic modalities., (© 2023 The Authors. Histopathology published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
33. Pigmented Poroma of the Lower Eyelid: A Case Report and Literature Review.
- Author
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Bogomolets O, Rojczyk E, Hryshchenko R, Bogomolets C, and Berezkin O
- Subjects
- Adult, Female, Humans, Diagnosis, Differential, Eyelids, Pigmentation Disorders, Poroma diagnosis, Poroma pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms pathology
- Abstract
BACKGROUND Eyelid tumors belong to a diverse group of neoplasms ranging from benign lesions to malignant tumors. Poromas are common, benign, mostly unpigmented tumors of the epidermal sweat duct unit, that usually grow slowly and occur in elderly people on the palms and soles. In most poroma cases some gene fusions were detected, which were caused by chromosomal aberrations. CASE REPORT We report the atypical case of a 30-year-old female patient suffering for more than 15 years from a solitary, polypoid, pigmented formation with a focal tuberous surface on the left lower eyelid. The lesion was not growing during the first years, but in the last 6 months before diagnosis its size more than doubled, finally reaching 12×14 mm. It was removed and histopathological analysis confirmed the diagnosis of a rare tumor - a poroma. There were no complications during healing and no recurrence was reported. CONCLUSIONS There have so far been only 9 reports of eyelid poromas, and the presented case significantly differed from the previous ones, as it appeared at an early age and showed rapid growth during a short time due to the war-related acute psychological stress. Moreover, it had unusual pigmentation and unpleasant smell. Reporting such untypical cases is clinically important because it is crucial to be aware of the diversity of eccrine poroma manifestation to distinguish it from malignant lesions.
- Published
- 2023
- Full Text
- View/download PDF
34. Dermpath: Eruptive syringoma mimicking cutaneous mastocytosis.
- Author
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Rosell-Díaz ÁM, Ortiz-Berciano V, Nájera-Botello L, and Roustan-Gullón G
- Subjects
- Humans, Syringoma diagnosis, Sweat Gland Neoplasms diagnosis, Mastocytosis, Cutaneous diagnosis
- Published
- 2023
- Full Text
- View/download PDF
35. Nipple apocrine hidrocystoma in a male adolescent: A rare lesion site.
- Author
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Tsai IJ, Chou CM, Huang SY, and Chen HC
- Subjects
- Male, Humans, Adolescent, Nipples, Hidrocystoma surgery, Hidrocystoma pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms pathology
- Published
- 2023
- Full Text
- View/download PDF
36. Apocrine Hidrocystoma of the Parotid Gland.
- Author
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Kharrat I, Achour I, Thabet W, Chaabouni MA, Trigui M, Triki M, Hammami B, and Charfeddine I
- Subjects
- Male, Humans, Young Adult, Adult, Parotid Gland surgery, Parotid Gland pathology, Eyelids, Diagnosis, Differential, Hidrocystoma diagnosis, Hidrocystoma surgery, Hidrocystoma pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms pathology
- Abstract
Apocrine hidrocystoma is a cystic tumor originating from apocrine sweat glands. It is predominantly located in the eyelid margins. Here, we report a case of apocrine hidrocystoma of the parotid gland in a 19-year-old man who was referred to our outpatient clinic with a 5-year history of a gradual swelling in the left parotid region. The patient underwent left superficial parotidectomy. Histological examination confirmed the diagnosis of apocrine hidrocystoma. The case is original by the tumor's location: to the best of our knowledge, this could be the first case in English and French literature reporting an apocrine hidrocystoma affecting the parotid gland. The purpose of this article is to report our case and discuss its clinical and anatomopathological features as well as its differential diagnoses., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2023
- Full Text
- View/download PDF
37. Eccrine Ductal Carcinoma of the Eyelid.
- Author
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Casale JJ, Uddin SB, and Proia AD
- Subjects
- Humans, Female, Neoplasm Recurrence, Local pathology, Meibomian Glands pathology, Eccrine Glands pathology, Keratosis, Actinic pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms pathology, Carcinoma, Squamous Cell pathology, Carcinoma, Ductal pathology
- Abstract
The authors present the third example of an eccrine ductal carcinoma of the eyelid. A woman in her early 70s presented with a lesion of the central right lower eyelid margin in the vicinity where an actinic keratosis was diagnosed by biopsy 2.75 years previously. Her dermatologist and ophthalmologist monitored the area of actinic keratosis, and it was stable for 2.5 years until the area became ulcerated and thickened with the loss of eyelashes. A wedge resection disclosed a squamous cell carcinoma in situ and a separate eccrine ductal carcinoma. The eccrine ductal carcinoma had in situ tumor thickening, an eccrine duct component, and an invasive tumor infiltrating the tarsal plate and replacing the normal meibomian glands. The invasive eccrine ductal carcinoma only mildly thickened the tarsal plate and was most likely an incidental finding in a biopsy prompted by the squamous cell carcinoma in situ. The 5-year relative survival rate for malignant apocrine-eccrine tumors is approximately 97%, and our patient is alive and without evidence of local or distant tumor recurrence 5.5 years following the excision of her eyelid tumor., Competing Interests: The authors have no financial or conflicts of interest to disclose., (Copyright © 2023 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.)
- Published
- 2023
- Full Text
- View/download PDF
38. Eruptive milium-like syringoma: A case report.
- Author
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Takahashi T, Fujimura T, and Asano Y
- Subjects
- Humans, Syringoma diagnosis, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms surgery, Epidermal Cyst, Exanthema
- Published
- 2023
- Full Text
- View/download PDF
39. Pericanalicular eccrine hidrocystoma of the upper eyelid in a child.
- Author
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Natarajan K, Pratima GC, Kasturi N, and Nachiappa Ganesh R
- Subjects
- Humans, Child, Eyelids surgery, Hidrocystoma diagnosis, Hidrocystoma surgery, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms surgery, Eyelid Neoplasms diagnosis, Eyelid Neoplasms surgery, Lacrimal Apparatus
- Abstract
A rare case of pericanalicular eccrine hidrocystoma of the upper eyelid is reported in a child who underwent surgical excision and canalicular repair with a successful outcome., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
- Full Text
- View/download PDF
40. Syringocystadenoma papilliferum presenting as an isolated scalp nodule.
- Author
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Mittal S, Kanagarajan A, Ravichandran J, and Shanmugasundaram S
- Subjects
- Humans, Scalp, Tubular Sweat Gland Adenomas, Skin Neoplasms, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms surgery, Adenoma, Sweat Gland
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2023
- Full Text
- View/download PDF
41. Plaquelike Syringoma Mimicking Microcystic Adnexal Carcinoma: A Potential Histologic Pitfall.
- Author
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Michaelis TC, Wieland CN, and Brewer JD
- Subjects
- Humans, Syringoma diagnosis, Syringoma pathology, Skin Neoplasms diagnosis, Skin Neoplasms pathology, Neoplasms, Adnexal and Skin Appendage, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms pathology
- Published
- 2023
- Full Text
- View/download PDF
42. Intraepidermal Poroma (Hidroacanthoma Simplex) Versus Clonal Seborrheic Keratosis: Will GATA3 Immunohistochemistry Help in the Differential Diagnosis?
- Author
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Schukow C, McCalmont TH, Surprenant D, and Yang HH
- Subjects
- Humans, Immunohistochemistry, Diagnosis, Differential, GATA3 Transcription Factor, Keratosis, Seborrheic diagnosis, Poroma diagnosis, Skin Neoplasms diagnosis, Eccrine Porocarcinoma diagnosis, Carcinoma in Situ diagnosis, Sweat Gland Neoplasms diagnosis
- Published
- 2023
- Full Text
- View/download PDF
43. 'Poroma-like' branched vessels with rounded endings in dermoscopy of basal cell carcinoma: a new unusual structure.
- Author
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Cavallo F, Mazzoletti V, Zelin E, Avallone G, Roccuzzo G, Bottomicca F, Quaglino P, Zalaudek I, and Ribero S
- Subjects
- Humans, Dermoscopy, Diagnosis, Differential, Poroma, Carcinoma, Basal Cell diagnostic imaging, Skin Neoplasms diagnosis, Sweat Gland Neoplasms diagnosis
- Abstract
Competing Interests: Conflicts of interest the authors declare no conflicts of interest.
- Published
- 2023
- Full Text
- View/download PDF
44. Endocrine Mucin-Producing Sweat Gland Carcinoma and Primary Cutaneous Mucinous Carcinoma: A Case Series.
- Author
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Grushchak S, Barlow T, Palla B, Mannor GE, Greenway HT, and Kelley BF
- Subjects
- Humans, Sweat Glands pathology, Mucins, Adenocarcinoma, Mucinous diagnosis, Adenocarcinoma, Mucinous surgery, Adenocarcinoma, Mucinous pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms pathology, Carcinoma, Skin Appendage, Skin Neoplasms diagnosis, Skin Neoplasms surgery, Skin Neoplasms pathology
- Abstract
Endocrine mucin-producing sweat gland carcinoma (EMPSGC) and primary cutaneous mucinous carcinoma (PCMC) are rare low-grade neoplasms thought to arise from apocrine glands that share many histological features and are proposed to be on a single histopathologic continuum, with EMPSGC as the in situ form that may progress to the invasive PCMC. Management involves a metastatic workup and either wide local excision (WLE) with greater than 5 mm margins or Mohs micrographic surgery (MMS) in anatomically sensitive areas. We present 2 cases of EMPSGC and 3 cases of PCMC and review their clinical and histopathologic features, differential diagnoses, and treatment.
- Published
- 2023
- Full Text
- View/download PDF
45. Apocrine Cystadenoma of the Eyelid, a Rare Neoplasm: Expanded Immunohistologic Profile.
- Author
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Charles NC, McGee RP, and Kim ET
- Subjects
- Female, Humans, Aged, 80 and over, Biomarkers, Tumor, Eyelids pathology, Mucins, Apocrine Glands pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms pathology, Hidrocystoma pathology, Cystadenoma pathology
- Abstract
An 83-year-old woman experienced the slow enlargement of a right lower eyelid mass. Histopathologic examination of the excised tissue showed a mucin-filled cystic tumor emanating from an apocrine bilayer that displayed bleb-like apocrine decapitation secretion. The outer flattened myoepithelial layer of the bilayer reacted with immunohistochemical stains for smooth muscle actin and calponin. In foci, the tumor exhibited a cribriform architecture with small pockets of mucin. Tumor cells were reactive for cytokeratin 7, Gross Cystic Disease Fluid Protein 15 (BRST-2), estrogen and progesterone receptors, androgen receptors, mammaglobin, epithelial membrane antigen, and GATA3. Ki67 showed a very low proliferation fraction. The lesion exemplifies the fourth instance of an eyelid apocrine cystadenoma in the literature., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2023 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.)
- Published
- 2023
- Full Text
- View/download PDF
46. Syringomatous dermatitis: a myth or an existing entity?
- Author
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Hassab-El-Naby HMM and Nouh AH
- Subjects
- Humans, Retrospective Studies, Skin pathology, Inflammation, Syringoma diagnosis, Syringoma pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms pathology, Dermatitis
- Abstract
Syringoma is rare disease that in classical variant occurs mainly on lower eyelids. In previously published researches, there is increasing evidence that eruptive syringomas must be discussed as an inflammatory dermal reaction pattern. And there was a proposal to change a name from eruptive syringoma to reactive syringomatous proliferation in appropriate cases. We conduct retrospective study on histopathological archived material to study the histopathological findings in cases of eruptive syringomas and correlate it with hypothesis that eruptive syringomas is not true adnexal neoplasms "de novo" but a hyperplastic response of the acrosyringium to an inflammatory process.According to obtained data and literature correlation, we can conclude that there is apparent diversity in eruptive syringomas. Part of cases can be calculated as neoplastic lesions arising "de novo," and another part as reactive syringomatous proliferation due to preceding cutaneous inflammatory process. Thus, term "eruptive syringoma" may be changed in appropriate cases to a "reactive syringomatous proliferation."Clinical variants of eruptive syringoma with evidence of underlying inflammatory process may be more responsive on types of treatments used for inflammatory disorders. Thus, more global clinicopathological correlative researches should be conducted and classification with terminology should be appropriately changed., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
47. Wide Local Excision for Eccrine Porocarcinoma of the Forearm.
- Author
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Dale P and Richard Olusanya O
- Subjects
- Male, Humans, Aged, Forearm surgery, Biopsy, Eccrine Porocarcinoma surgery, Eccrine Porocarcinoma diagnosis, Eccrine Porocarcinoma pathology, Sweat Gland Neoplasms surgery, Sweat Gland Neoplasms diagnosis, Neoplasms, Second Primary
- Abstract
Eccrine porocarcinoma is a rare and aggressive cutaneous malignancy that develops in the seventh and eight decades of life. We present a 76-year-old male with eccrine porocarcinoma developing from a long standing previously benign lesion who underwent successful treatment with wide local excision. It can also develop de novo, presenting most commonly as a mass or nodule. Tissue biopsy with histopathology is required to confirm the diagnosis. Wide local excision is recommended for local disease. Radiation and chemotherapy can be used as adjuncts in advanced and metastatic disease. Given its rarity, there are no guidelines to direct therapy for locally advance or metastatic disease and for follow-up. Further studies are needed to better understand and guide management of this entity.
- Published
- 2023
- Full Text
- View/download PDF
48. Primary Cylindroma of the Breast with Brisk Mitosis: A Case Report and Review of Literature.
- Author
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Liu H, Wei C, Ding H, and Zhang H
- Subjects
- Female, Humans, Breast surgery, Breast pathology, Diagnosis, Differential, Biopsy, Carcinoma, Adenoid Cystic diagnosis, Carcinoma, Adenoid Cystic surgery, Carcinoma, Adenoid Cystic pathology, Sweat Gland Neoplasms diagnosis
- Abstract
Primary cylindroma of the breast is extremely rare. To the best of our knowledge, there have been only 18 tumors reported. All of them were benign and had no mitosis. However, the rarity of this entity made the correct diagnosis preoperatively very difficult. Here we present a unique cylindroma with focal brisk mitosis and largest diameter of 5cm in an 80-year woman, she was misdiagnosed as adenoid cystic carcinoma in biopsy and then underwent a radical breast resection. We reviewed the related literature and emphasized differential diagnosis.
- Published
- 2023
- Full Text
- View/download PDF
49. Combined tumour of aberrant cytokeratin expressing acral lentiginous melanoma and poroma: Diagnostic challenge.
- Author
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Sevim S, Akay BN, Kozan EN, Heper AO, and Kirmizi A
- Subjects
- Humans, Melanoma, Cutaneous Malignant, Poroma diagnosis, Skin Neoplasms pathology, Melanoma pathology, Sweat Gland Neoplasms diagnosis
- Abstract
Combined tumours are uncommon and therefore these tumours may pose a diagnostic challenge. In the current case report, it is aimed to present the clinicopathological features of a combined tumour including melanoma with aberrant cytokeratin expression and poroma., (© 2023 Australasian College of Dermatologists.)
- Published
- 2023
- Full Text
- View/download PDF
50. A novel presentation of multiple milium-like syringomas on the lower legs of an elderly male.
- Author
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Kuritza VC and Pei S
- Subjects
- Humans, Male, Aged, Leg, Lower Extremity, Syringoma diagnosis, Sweat Gland Neoplasms diagnosis, Epidermal Cyst
- Published
- 2023
- Full Text
- View/download PDF
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