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14 results on '"Sweta Priyadarshini Pradhan"'

1. Antidepressant and Anticataleptic Effects of Eucalyptus tereticornis in Rats and Mice

Author

Sweta Priyadarshini Pradhan and Pratap Kumar Sahu

Subjects
catalepsy, depression, dopamine, haloperidol, monoamine oxidase, Medicine, Medicine (General), R5-920
Abstract

Background: Terpenoids possess antidepressant, memory enhancer, neuroprotective and other Central Nervous System (CNS) actions. Eucalyptus tereticornis is a rich source of terpenoids. Aim and Objectives: The aim of the present study is to evaluate anti-depressant and anti-cataleptic effect of Eucalyptus tereticornis. Molecular docking studies were also employed to study the mechanism of action. Material and Methods: Locomotor activity and muscle coordination was studied by using actophotometer and rotarod apparatus in rats. The evaluation of anti-depressant activity was studied by forced swimming and tail suspension test in mice. Haloperidol induced catalepsy model was used to evaluate anti-cataleptic effect. Different phytoconstituents present in Eucalyptus tereticornis like citronellal, geranyl acetate and terpine-4-ol were screened through computational assessment with the Lipinski's rule of 5, ADMET properties and molecular docking studies. Computational docking analysis was performed by AutoDock Vina 4.2.6 version. Results: Eucalyptus tereticornis significantly increases the locomotor activity and improves motor coordination. At 100 mg/kg hydroalcoholic extract of Eucalyptus tereticornis significantly shows anti-depressant and anti-cataleptic activity. Phytoconstituents like citronellal, geranyl acetate and terpinen-4-ol exhibit nonselective Monoamine Oxidase (MAO) inhibition activity. Conclusion: Hydroalcoholic extract of Eucalyptus tereticornis may possess anti-depressant and anti-cataleptic activity with efficient CNS stimulant action which may be attributed to non-selective MAOinhibition activity of its phytoconstituents like geranyl acetate, citronellal and terpinen-4-ol.

Published
2020

2. Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology

Author

Debashish Mohapatra, Srikant Kanungo, Sweta Priyadarshini Pradhan, Susmita Jena, Shakti Ketan Prusty, and Pratap Kumar Sahu

Subjects
Amyloid-β, Oxidative stress, ACE, Rennin angiotensin system, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Alzheimer's disease (AD) is a common neurodegenerative disorder. Aluminium chloride induces AD like pathology in rats. Renin angiotensin system plays a significant role in the pathogenesis and occurrence of Alzheimer's disease. In the present study we evaluated and compared the effect of Captopril and Perindopril against aluminium chloride induced amyloidogenesis and cognitive dysfunction in rats. Wistar rats of both sex were divided randomly into four groups i.e. Group I was served as normal control and treated with normal saline, Group II was administered with AlCl3 (100 mg/kg, p. o.) and Group III and IV received Captopril (30 mg/kg, p. o.) and Perindopril (5 mg/kg, p. o.) respectively 1hr prior to administration of AlCl3. All the doses were given once daily for 42 days. The evaluation of memory function was carried out in Y-maze (spontaneous alternation), radial arm maze (number of correct responses) and elevated plus maze (transfer latency). After behavioral studies, estimation of antioxidant status (brain and serum), amyloid-β content (brain) and histopathology of brain hippocampus region was done. Administration of AlCl3 for 42 days impaired cognitive dysfunction. Captopril and Perindopril prevented AlCl3 induced cognitive dysfunction by improving spontaneous alternation behavior, number of correct responses and reducing transfer latency. They also increase the antioxidant status, reduce the Aβ42 content in the brain and reverse the histopathological changes caused by AlCl3 in hippocampal region. Both Captopril and Perindopril protects against aluminium chloride induced amyloidogenesis and AD like pathology. Captopril is found to be more effective than Perindopril.

Published
2022
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6. Contributors

Author

Basheer Aaliya, C. Anandharamakrishnan, Laxmikant Shivnath Badwaik, Manish Bakshi, Rosy Bansal, Anindita Behera, Garima Bhardwaj, Abida Bhat, Rohini Bhat, Zahid Rafiq Bhat, Surekha Bhatia, Hanuman Bobade, Jinku Bora, Saba Bukhari, Ashish Chauhan, Hitesh Chopra, Monalisa Dash, Himjyoti Dutta, Omer Farooq, Apurba Gohain, Amir Gull, Antima Gupta, Prerna Gupta, Monika Hans, Ihsan-ul Haq, null Heena, Rhythm Kalsi, Mahaldeep Kaur, Sandeep Kaur, Jasmeet Kour, Srinivasan Krishnamoorthy, Amarjeet Kumar, Varun Kumar, Mushtaq Ahmad Lone, Charu Lata Mahanta, Nikhil Mahnot, Tanu Malik, Bharti Mittu, J.A. Moses, Gulzar Ahmad Nayik, Saniya Nissar, Mustafa Öz, Santwana Padhi, Santwana Palai, Jessica Pandohee, R. Paranthaman, Sweta Priyadarshini Pradhan, Md Ramim Tanver Rahman, Sangeeta Saikia, Aga Syed Sameer, Md Nazmus Saqib, Loveleen Sarao, Dharmesh Chandra Saxena, Ajay Sharma, Renu Sharma, Savita Sharma, Mohd Aaqib Sheikh, Ajay Singh, Harvinder Singh Sohal, Cherakkathodi Sudheesh, Kappat Valiyapeediyekkal Sunooj, Thoithoi Tongbram, İlknur Ucak, Altaf Ahmad Wani, Nusrath Yasmeen, Syeda Saniya Zahra, Rasiya Ul Zaman, Imtiyaz Ahmad Zargar, and Beenish Zehra

Published
2022
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7. Carotenoids

Author

Sweta Priyadarshini Pradhan, Santwana Padhi, Monalisa Dash, null Heena, Bharti Mittu, and Anindita Behera

Published
2022
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11. Contributors

Author

Kamel A. Abd-Elsalam, Farah K. Ahmed, Chongyang Ai, Hasnain Akmal, Melisew Tadele Alula, Jayshree Annamalai, Belete Asefa Aragaw, Kangkana Banerjee, Zdenka Bedlovičová, Anindita Behera, G. Bhagavanth Reddy, Pankaj Bhatt, Usharani Boopathy, Claudio Darío Borsarelli, Ana Belén Cisneros, Sergio Cuozzo, Paulami Dam, Awalagaway Dhulappa, María Cristina Diez, R. Divya Mohan, Asma Farheen, Said Fatouh Hamed, Mohamed Amine Gacem, Mauro Nicolás Gallucci, Bini George, Leonardo Gutierrez, Ayat F. Hashim, Husna Jalal, P.J. Jane Cypriyana, A. Jenifer Selvarani, Chunmei Jiang, Kashmala Karam, Mubarak Ali Khan, Muhammad Saleem Khan, Tariq Khan, Beom Soo Kim, Cecil K. King'ondu, K. Kishore Kumar, Stephen Majoni, Amit Kumar Mandal, Murugesan Manikandan, Muhammad Shahroz Maqsud, Arokia Vijaya Anand Mariadoss, Sabelo D. Mhlanga, Rittick Mondal, Harish Mudila, Karuvelan Murugan, Kasi Murugan, G. Narasimha, Manik Prabhu Narsing Rao, Lebea N. Nthunya, Andrei Yu. Olenin, Kanniah Paulkumar, Joana Claudio Pieretti, Paulraj Ponnaiah, Sweta Priyadarshini Pradhan, Parteek Prasher, Sajna Keeyari Purayil, Debraj Dhar Purkayastha, V. Ravishankar Rai, Valentina Rey, Heidi L. Richards, Olga Rubilar, Pathikrit Saha, S. Saigeetha, Heba H. Salama, Sreedha Sambhudevan, Antony V. Samrot, Kandasamy Saravanakumar, Anbazhagan Sathiyaseelan, Amedea Barozzi Seabra, Kondaiah Seku, Azeez Shajahan, Emad A. Shalaby, Jayashree Shanmugam, Mousmee Sharma, Mukti Sharma, Junling Shi, Aswathi Shyam, S. Smitha Chandran, Sudip Some, Man Mohan Srivastava, Shalini Srivastava, Gonzalo Tortella, Fiorella Tulli, María Beatriz Espeche Turbay, Ranjini Tyagi, Ali Umar, Alexander Yu. Vasil'kov, Amit Verma, Myeong-Hyeon Wang, Xiaoguang Xu, Lu Yan, and Xixi Zhao

Published
2022
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12. Photocatalysis of environmental organic pollutants and antioxidant activity of flavonoid conjugated gold nanoparticles

Author

Sweta Priyadarshini Pradhan, Sunsita Swain, Nishigandha Sa, Satya Narayan Pilla, Anindita Behera, Pratap Kumar Sahu, and Sudam Chandra Si

Subjects
Flavonoids, Hesperidin, Metal Nanoparticles, Bromcresol Green, Antioxidants, Catalysis, Atomic and Molecular Physics, and Optics, Analytical Chemistry, Methylene Blue, Environmental Pollutants, Gold, Coloring Agents, Instrumentation, Spectroscopy
Abstract

The unique properties of nanomaterials have the potential application in different fields of biomedical application along with the management of environmental pollutants. This research work involved the isolation of hesperidin from the orange peel and the preparation of hesperidin gold nanoparticles by the chemical reduction method. The high substrate specificity and lower band gap enable the excitation of gold nanoparticles in visible light. Hence gold nanoparticles are chosen nowadays for the management and removal of organic pollutants. The efficacy of hesperidin gold nanoparticles was evaluated by the photocatalytic activity on organic dyes and pollutants like methyl orange, methylene blue, bromocresol green, and 4 - nitro phenol with sodium borohydride as reducing agent and the antioxidant study by scavenging of free radicals of DPPH, ABTS, and hydroxyl free radicals of hydrogen peroxide. The kinetics of photocatalytic degradation of organic dyes and 4 - nitro phenol was found to follow the first order with rate constants of 10 × 10

Published
2022
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13. Captopril Is More Effective than Perindopril Against Aluminium Chloride Induced Amyloidogenesis and Cognitive Dysfunction

Author

Susmita Jena, Shakti Ketan Prusty, Debashis Mohapatra, Srikant Kanungo, Sweta Priyadarshini Pradhan, and Pratap Kumar Sahu

Subjects
History, Elevated plus maze, Radial arm maze, Polymers and Plastics, business.industry, medicine.medical_treatment, Captopril, Spontaneous alternation, Pharmacology, medicine.disease_cause, Industrial and Manufacturing Engineering, medicine, Perindopril, Hippocampus (mythology), Business and International Management, business, Saline, Oxidative stress, circulatory and respiratory physiology, medicine.drug
Abstract

Alzheimer’s disease (AD) is a common neurodegenerative disorder. Aluminium chloride induces AD like pathology in rats. Renin angiotensin system plays a significant role in the pathogenesis and occurrence of Alzheimer’s disease. In the present study we evaluated and compared the effect of Captopril and Perindopril against aluminium chloride induced amyloidogenesis and cognitive dysfunction in rats. Wistar rats of both sex were divided randomly into four groups i.e. Group I was served as normal control and treated with normal saline, Group II was administered with AlCl3 (100 mg/kg) and Group III and IV received Captopril (30 mg/kg) and Perindopril (5 mg/kg) respectively 1hr prior to administration of AlCl3. All the doses were given once daily for 42 days. The evaluation of memory function was carried out in Y-maze (spontaneous alternation), radial arm maze (number of correct responses) and elevated plus maze (transfer latency). After behavioural studies, estimation of antioxidant status (brain and serum), amyloid-β content (brain) and histopathology of brain hippocampus region was done. Administration of AlCl3 for 42 days impaired cognitive dysfunction. Captopril and Perindopril prevented AlCl3 induced cognitive dysfunction by improving spontaneous alternation behaviour, number of correct responses and reducing transfer latency. They also increase the antioxidant status, reduce the Aβ42 content in the brain and reverse the histopathological changes caused by AlCl3 in hippocampal region. Both Captopril and Perindopril protects against aluminium chloride induced amyloidogenesis and cognitive dysfunction. Captopril is found to be more effective than Perindopril. Funding Information: The authors are thankful to Siksha O Anusandhan University for providing the funding for this research work. Declaration of Interests: None to declare. Ethics Approval Statement: All the protocols used in the experiment were approved by Institutional Animal Ethical Committee of School of Pharmaceutical Sciences and ethical guidelines were strictly followed during the experiments.

Published
2021
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