Search

Your search keyword '"Swijnenburg, R"' showing total 232 results
Start Over Author "Swijnenburg, R"
232 results on '"Swijnenburg, R"'

5. Multisocietal European consensus on the terminology, diagnosis, and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE

Author

Siriwardena, A, Serrablo, A, Fretland, A, Wigmore, S, Ramia-Angel, J, Malik, H, Stattner, S, Soreide, K, Zmora, O, Meijerink, M, Kartalis, N, Lesurtel, M, Verhoef, K, Balakrishnan, A, Gruenberger, T, Jonas, E, Devar, J, Jamdar, S, Jones, R, Hilal, M, Andersson, B, Boudjema, K, Mullamitha, S, Stassen, L, Dasari, B, Frampton, A, Aldrighetti, L, Pellino, G, Buchwald, P, Gurses, B, Wasserberg, N, Gruenberger, B, Spiers, H, Jarnagin, W, Vauthey, J, Kokudo, N, Tejpar, S, Valdivieso, A, Adam, R, Lang, H, Smith, M, Deoliveira, M, Adair, A, Gilg, S, Swijnenburg, R, Jaekers, J, Jegatheeswaran, S, Buis, C, Parks, R, Bockhorn, M, Conroy, T, Petras, P, Primavesi, F, Chan, A, Cipriani, F, Rubbia-Brandt, L, Foster, L, Abdelaal, A, Yaqub, S, Rahbari, N, Fondevila, C, Abradelo, M, Kok, N, Tejedor, L, Martinez-Baena, D, Azoulay, D, Maglione, M, Serradilla-Martin, M, Azevedo, J, Romano, F, Line, P, Forcen, T, Panis, Y, Stylianides, N, Bale, R, Quaia, E, Yassin, N, Duque, V, Espin-Basany, E, Mellenhorst, J, Rees, A, Adeyeye, A, Tuynman, J, Simillis, C, Duff, S, Wilson, R, De Nardi, P, Palmer, G, Zakaria, A, Perra, T, Porcu, A, Tamini, N, Kelly, M, Metwally, I, Morarasu, S, Carbone, F, Estaire-Gomez, M, Perez, E, Seligmann, J, Gollins, S, Braun, M, Hessheimer, A, Alonso, V, Radhakrishna, G, Alam, N, Camposorias, C, Barriuoso, J, Ross, P, Ba-Ssalamah, A, Muthu, S, Filobbos, R, Nadarajah, V, Hattab, A, Newton, C, Barker, S, Sibbald, J, Hancock, J, de Liguori Carino, N, Deshpande, R, Lancellotti, F, Paterna, S, Gutierrez-Diez, M, Artigas, C, Siriwardena A. K., Serrablo A., Fretland A. A., Wigmore S. J., Ramia-Angel J. M., Malik H. Z., Stattner S., Soreide K., Zmora O., Meijerink M., Kartalis N., Lesurtel M., Verhoef K., Balakrishnan A., Gruenberger T., Jonas E., Devar J., Jamdar S., Jones R., Hilal M. A., Andersson B., Boudjema K., Mullamitha S., Stassen L., Dasari B. V. M., Frampton A. E., Aldrighetti L., Pellino G., Buchwald P., Gurses B., Wasserberg N., Gruenberger B., Spiers H. V. M., Jarnagin W., Vauthey J. -N., Kokudo N., Tejpar S., Valdivieso A., Adam R., Lang H., Smith M., deOliveira M. L., Adair A., Gilg S., Swijnenburg R. -J., Jaekers J., Jegatheeswaran S., Buis C., Parks R., Bockhorn M., Conroy T., Petras P., Primavesi F., Chan A. K. C., Cipriani F., Rubbia-Brandt L., Foster L., Abdelaal A., Yaqub S., Rahbari N., Fondevila C., Abradelo M., Kok N. F. M., Tejedor L., Martinez-Baena D., Azoulay D., Maglione M., Serradilla-Martin M., Azevedo J., Romano F., Line P. -D., Forcen T. A., Panis Y., Stylianides N., Bale R., Quaia E., Yassin N., Duque V., Espin-Basany E., Mellenhorst J., Rees A., Adeyeye A., Tuynman J. B., Simillis C., Duff S., Wilson R., De Nardi P., Palmer G. J., Zakaria A. D., Perra T., Porcu A., Tamini N., Kelly M. E., Metwally I., Morarasu S., Carbone F., Estaire-Gomez M., Perez E. M., Seligmann J., Gollins S., Braun M., Hessheimer A., Alonso V., Radhakrishna G., Alam N., Camposorias C., Barriuoso J., Ross P., Ba-Ssalamah A., Muthu S., Filobbos R., Nadarajah V., Hattab A., Newton C., Barker S., Sibbald J., Hancock J., de Liguori Carino N., Deshpande R., Lancellotti F., Paterna S., Gutierrez-Diez M., Artigas C., Siriwardena, A, Serrablo, A, Fretland, A, Wigmore, S, Ramia-Angel, J, Malik, H, Stattner, S, Soreide, K, Zmora, O, Meijerink, M, Kartalis, N, Lesurtel, M, Verhoef, K, Balakrishnan, A, Gruenberger, T, Jonas, E, Devar, J, Jamdar, S, Jones, R, Hilal, M, Andersson, B, Boudjema, K, Mullamitha, S, Stassen, L, Dasari, B, Frampton, A, Aldrighetti, L, Pellino, G, Buchwald, P, Gurses, B, Wasserberg, N, Gruenberger, B, Spiers, H, Jarnagin, W, Vauthey, J, Kokudo, N, Tejpar, S, Valdivieso, A, Adam, R, Lang, H, Smith, M, Deoliveira, M, Adair, A, Gilg, S, Swijnenburg, R, Jaekers, J, Jegatheeswaran, S, Buis, C, Parks, R, Bockhorn, M, Conroy, T, Petras, P, Primavesi, F, Chan, A, Cipriani, F, Rubbia-Brandt, L, Foster, L, Abdelaal, A, Yaqub, S, Rahbari, N, Fondevila, C, Abradelo, M, Kok, N, Tejedor, L, Martinez-Baena, D, Azoulay, D, Maglione, M, Serradilla-Martin, M, Azevedo, J, Romano, F, Line, P, Forcen, T, Panis, Y, Stylianides, N, Bale, R, Quaia, E, Yassin, N, Duque, V, Espin-Basany, E, Mellenhorst, J, Rees, A, Adeyeye, A, Tuynman, J, Simillis, C, Duff, S, Wilson, R, De Nardi, P, Palmer, G, Zakaria, A, Perra, T, Porcu, A, Tamini, N, Kelly, M, Metwally, I, Morarasu, S, Carbone, F, Estaire-Gomez, M, Perez, E, Seligmann, J, Gollins, S, Braun, M, Hessheimer, A, Alonso, V, Radhakrishna, G, Alam, N, Camposorias, C, Barriuoso, J, Ross, P, Ba-Ssalamah, A, Muthu, S, Filobbos, R, Nadarajah, V, Hattab, A, Newton, C, Barker, S, Sibbald, J, Hancock, J, de Liguori Carino, N, Deshpande, R, Lancellotti, F, Paterna, S, Gutierrez-Diez, M, Artigas, C, Siriwardena A. K., Serrablo A., Fretland A. A., Wigmore S. J., Ramia-Angel J. M., Malik H. Z., Stattner S., Soreide K., Zmora O., Meijerink M., Kartalis N., Lesurtel M., Verhoef K., Balakrishnan A., Gruenberger T., Jonas E., Devar J., Jamdar S., Jones R., Hilal M. A., Andersson B., Boudjema K., Mullamitha S., Stassen L., Dasari B. V. M., Frampton A. E., Aldrighetti L., Pellino G., Buchwald P., Gurses B., Wasserberg N., Gruenberger B., Spiers H. V. M., Jarnagin W., Vauthey J. -N., Kokudo N., Tejpar S., Valdivieso A., Adam R., Lang H., Smith M., deOliveira M. L., Adair A., Gilg S., Swijnenburg R. -J., Jaekers J., Jegatheeswaran S., Buis C., Parks R., Bockhorn M., Conroy T., Petras P., Primavesi F., Chan A. K. C., Cipriani F., Rubbia-Brandt L., Foster L., Abdelaal A., Yaqub S., Rahbari N., Fondevila C., Abradelo M., Kok N. F. M., Tejedor L., Martinez-Baena D., Azoulay D., Maglione M., Serradilla-Martin M., Azevedo J., Romano F., Line P. -D., Forcen T. A., Panis Y., Stylianides N., Bale R., Quaia E., Yassin N., Duque V., Espin-Basany E., Mellenhorst J., Rees A., Adeyeye A., Tuynman J. B., Simillis C., Duff S., Wilson R., De Nardi P., Palmer G. J., Zakaria A. D., Perra T., Porcu A., Tamini N., Kelly M. E., Metwally I., Morarasu S., Carbone F., Estaire-Gomez M., Perez E. M., Seligmann J., Gollins S., Braun M., Hessheimer A., Alonso V., Radhakrishna G., Alam N., Camposorias C., Barriuoso J., Ross P., Ba-Ssalamah A., Muthu S., Filobbos R., Nadarajah V., Hattab A., Newton C., Barker S., Sibbald J., Hancock J., de Liguori Carino N., Deshpande R., Lancellotti F., Paterna S., Gutierrez-Diez M., and Artigas C.

Abstract

Background: Contemporary management of patients with synchronous colorectal cancer and liver metastases is complex. The aim of this project was to provide a practical framework for care of patients with synchronous colorectal cancer and liver metastases, with a focus on terminology, diagnosis, and management. Methods: This project was a multiorganizational, multidisciplinary consensus. The consensus group produced statements which focused on terminology, diagnosis, and management. Statements were refined during an online Delphi process, and those with 70 per cent agreement or above were reviewed at a final meeting. Iterations of the report were shared by electronic mail to arrive at a final agreed document comprising 12 key statements. Results: Synchronous liver metastases are those detected at the time of presentation of the primary tumour. The term 'early metachronous metastases' applies to those absent at presentation but detected within 12 months of diagnosis of the primary tumour, the term 'late metachronous metastases' applies to those detected after 12 months. 'Disappearing metastases' applies to lesions that are no longer detectable on MRI after systemic chemotherapy. Guidance was provided on the recommended composition of tumour boards, and clinical assessment in emergency and elective settings. The consensus focused on treatment pathways, including systemic chemotherapy, synchronous surgery, and the staged approach with either colorectal or liver-directed surgery as first step. Management of pulmonary metastases and the role of minimally invasive surgery was discussed. Conclusion: The recommendations of this contemporary consensus provide information of practical value to clinicians managing patients with synchronous colorectal cancer and liver metastases.

Published
2023

6. The multi-societal European consensus on the terminology, diagnosis and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE

Author

Siriwardena, A, Serrablo, A, Fretland, A, Wigmore, S, Ramia-Angel, J, Malik, H, Stattner, S, Soreide, K, Zmora, O, Meijerink, M, Kartalis, N, Lesurtel, M, Verhoef, C, Balakrishnan, A, Gruenberger, T, Jonas, E, Devar, J, Jamdar, S, Jones, R, Hilal, M, Andersson, B, Boudjema, K, Mullamitha, S, Stassen, L, Dasari, B, Frampton, A, Aldrighetti, L, Pellino, G, Buchwald, P, Gurses, B, Wasserberg, N, Gruenberger, B, Spiers, H, Jarnagin, W, Vauthey, J, Kokudo, N, Tejpar, S, Valdivieso, A, Adam, R, Hauke, L, Smith, M, Deoliveira, M, Adair, A, Gilg, S, Swijnenburg, R, Jaekers, J, Jegatheeswaran, S, Buis, C, Parks, R, Bockhorn, M, Conroy, T, Petras, P, Primavesi, F, Chan, A, Cipriani, F, Rubbia-Brandt, L, Foster, L, Abdelaal, A, Yaqub, S, Rahbari, N, Fondevila, C, Abradelo, M, Kok, N, Tejedor, L, Martinez-Baena, D, Azoulay, D, Maglione, M, Serradilla-Martin, M, Azevedo, J, Romano, F, Line, P, Forcen, T, Panis, Y, Stylianides, N, Bale, R, Quaia, E, Yassin, N, Duque, V, Espin-Basany, E, Mellenhorst, J, Rees, A, Adeyeye, A, Tuynman, J, Simillis, C, Duff, S, Wilson, R, De Nardi, P, Palmer, G, Zakaria, A, Perra, T, Porcu, A, Tamini, N, Kelly, M, Metwally, I, Morarasu, S, Carbone, F, Estaire-Gomez, M, Perez, E, Seligmann, J, Gollins, S, Braun, M, Hessheimer, A, Alonso, V, Radhakrishna, G, Alam, N, Camposorias, C, Barriuoso, J, Ross, P, Ba-Ssalamah, A, Muthu, S, Filobbos, R, Nadarajah, V, Hattab, A, Newton, C, Barker, S, Sibbald, J, Hancock, J, de Liguori Carino, N, Deshpande, R, Lancellotti, F, Paterna, S, Gutierrez-Diez, M, Artigas, C, Siriwardena A. K., Serrablo A., Fretland A. A., Wigmore S. J., Ramia-Angel J. M., Malik H. Z., Stattner S., Soreide K., Zmora O., Meijerink M., Kartalis N., Lesurtel M., Verhoef C., Balakrishnan A., Gruenberger T., Jonas E., Devar J., Jamdar S., Jones R., Hilal M. A., Andersson B., Boudjema K., Mullamitha S., Stassen L., Dasari B. V. M., Frampton A. E., Aldrighetti L., Pellino G., Buchwald P., Gurses B., Wasserberg N., Gruenberger B., Spiers H. V. M., Jarnagin W., Vauthey J. -N., Kokudo N., Tejpar S., Valdivieso A., Adam R., Hauke Lang, Smith M., deOliveira M. L., Adair A., Gilg S., Swijnenburg R. -J., Jaekers J., Jegatheeswaran S., Buis C., Parks R., Bockhorn M., Conroy T., Petras P., Primavesi F., Chan A. K. C., Cipriani F., Rubbia-Brandt L., Foster L., Abdelaal A., Yaqub S., Rahbari N., Fondevila C., Abradelo M., Kok N. F., Tejedor L., Martinez-Baena D., Azoulay D., Maglione M., Serradilla-Martin M., Azevedo J., Romano F., Line P. -D., Forcen T. A., Panis Y., Stylianides N., Bale R., Quaia E., Yassin N., Duque V., Espin-Basany E., Mellenhorst J., Rees A., Adeyeye A., Tuynman J. B., Simillis C., Duff S., Wilson R., De Nardi P., Palmer G. J., Zakaria A. D., Perra T., Porcu A., Tamini N., Kelly M. E., Metwally I., Morarasu S., Carbone F., Estaire-Gomez M., Perez E. M., Seligmann J., Gollins S., Braun M., Hessheimer A., Alonso V., Radhakrishna G., Alam N., Camposorias C., Barriuoso J., Ross P., Ba-Ssalamah A., Muthu S., Filobbos R., Nadarajah V., Hattab A., Newton C., Barker S., Sibbald J., Hancock J., de Liguori Carino N., Deshpande R., Lancellotti F., Paterna S., Gutierrez-Diez M., Artigas C., Siriwardena, A, Serrablo, A, Fretland, A, Wigmore, S, Ramia-Angel, J, Malik, H, Stattner, S, Soreide, K, Zmora, O, Meijerink, M, Kartalis, N, Lesurtel, M, Verhoef, C, Balakrishnan, A, Gruenberger, T, Jonas, E, Devar, J, Jamdar, S, Jones, R, Hilal, M, Andersson, B, Boudjema, K, Mullamitha, S, Stassen, L, Dasari, B, Frampton, A, Aldrighetti, L, Pellino, G, Buchwald, P, Gurses, B, Wasserberg, N, Gruenberger, B, Spiers, H, Jarnagin, W, Vauthey, J, Kokudo, N, Tejpar, S, Valdivieso, A, Adam, R, Hauke, L, Smith, M, Deoliveira, M, Adair, A, Gilg, S, Swijnenburg, R, Jaekers, J, Jegatheeswaran, S, Buis, C, Parks, R, Bockhorn, M, Conroy, T, Petras, P, Primavesi, F, Chan, A, Cipriani, F, Rubbia-Brandt, L, Foster, L, Abdelaal, A, Yaqub, S, Rahbari, N, Fondevila, C, Abradelo, M, Kok, N, Tejedor, L, Martinez-Baena, D, Azoulay, D, Maglione, M, Serradilla-Martin, M, Azevedo, J, Romano, F, Line, P, Forcen, T, Panis, Y, Stylianides, N, Bale, R, Quaia, E, Yassin, N, Duque, V, Espin-Basany, E, Mellenhorst, J, Rees, A, Adeyeye, A, Tuynman, J, Simillis, C, Duff, S, Wilson, R, De Nardi, P, Palmer, G, Zakaria, A, Perra, T, Porcu, A, Tamini, N, Kelly, M, Metwally, I, Morarasu, S, Carbone, F, Estaire-Gomez, M, Perez, E, Seligmann, J, Gollins, S, Braun, M, Hessheimer, A, Alonso, V, Radhakrishna, G, Alam, N, Camposorias, C, Barriuoso, J, Ross, P, Ba-Ssalamah, A, Muthu, S, Filobbos, R, Nadarajah, V, Hattab, A, Newton, C, Barker, S, Sibbald, J, Hancock, J, de Liguori Carino, N, Deshpande, R, Lancellotti, F, Paterna, S, Gutierrez-Diez, M, Artigas, C, Siriwardena A. K., Serrablo A., Fretland A. A., Wigmore S. J., Ramia-Angel J. M., Malik H. Z., Stattner S., Soreide K., Zmora O., Meijerink M., Kartalis N., Lesurtel M., Verhoef C., Balakrishnan A., Gruenberger T., Jonas E., Devar J., Jamdar S., Jones R., Hilal M. A., Andersson B., Boudjema K., Mullamitha S., Stassen L., Dasari B. V. M., Frampton A. E., Aldrighetti L., Pellino G., Buchwald P., Gurses B., Wasserberg N., Gruenberger B., Spiers H. V. M., Jarnagin W., Vauthey J. -N., Kokudo N., Tejpar S., Valdivieso A., Adam R., Hauke Lang, Smith M., deOliveira M. L., Adair A., Gilg S., Swijnenburg R. -J., Jaekers J., Jegatheeswaran S., Buis C., Parks R., Bockhorn M., Conroy T., Petras P., Primavesi F., Chan A. K. C., Cipriani F., Rubbia-Brandt L., Foster L., Abdelaal A., Yaqub S., Rahbari N., Fondevila C., Abradelo M., Kok N. F., Tejedor L., Martinez-Baena D., Azoulay D., Maglione M., Serradilla-Martin M., Azevedo J., Romano F., Line P. -D., Forcen T. A., Panis Y., Stylianides N., Bale R., Quaia E., Yassin N., Duque V., Espin-Basany E., Mellenhorst J., Rees A., Adeyeye A., Tuynman J. B., Simillis C., Duff S., Wilson R., De Nardi P., Palmer G. J., Zakaria A. D., Perra T., Porcu A., Tamini N., Kelly M. E., Metwally I., Morarasu S., Carbone F., Estaire-Gomez M., Perez E. M., Seligmann J., Gollins S., Braun M., Hessheimer A., Alonso V., Radhakrishna G., Alam N., Camposorias C., Barriuoso J., Ross P., Ba-Ssalamah A., Muthu S., Filobbos R., Nadarajah V., Hattab A., Newton C., Barker S., Sibbald J., Hancock J., de Liguori Carino N., Deshpande R., Lancellotti F., Paterna S., Gutierrez-Diez M., and Artigas C.

Abstract

Background: Contemporary management of patients with synchronous colorectal cancer and liver metastases is complex. The aim of this project was to provide a practical framework for care of patients with synchronous colorectal cancer and liver metastases with a focus on terminology, diagnosis and management. Methods: This project was a multi-organisational, multidisciplinary consensus. The consensus group produced statements which focused on terminology, diagnosis and management. Statements were refined during an online Delphi process and those with 70% agreement or above were reviewed at a final meeting. Iterations of the report were shared by electronic mail to arrive at a final agreed document comprising twelve key statements. Results: Synchronous liver metastases are those detected at the time of presentation of the primary tumour. The term “early metachronous metastases” applies to those absent at presentation but detected within 12 months of diagnosis of the primary tumour with “late metachronous metastases” applied to those detected after 12 months. Disappearing metastases applies to lesions which are no longer detectable on MR scan after systemic chemotherapy. Guidance was provided on the recommended composition of tumour boards and clinical assessment in emergency and elective settings. The consensus focused on treatment pathways including systemic chemotherapy, synchronous surgery and the staged approach with either colorectal or liver-directed surgery as first step. Management of pulmonary metastases and the role of minimally invasive surgery was discussed. Conclusions: The recommendations of this contemporary consensus provide information of practical value to clinicians managing patients with synchronous colorectal cancer and liver metastases.

Published
2023

8. Impact of shifting from laparoscopic to robotic surgery during 600 minimally invasive pancreatic and liver resections

Author

Emmen, Anouk M.L.H., Görgec, B., Zwart, M. J.W., Daams, F., Erdmann, J., Festen, S., Gouma, D. J., van Gulik, T. M., van Hilst, J., Kazemier, G., Lof, S., Sussenbach, S. I., Tanis, P. J., Zonderhuis, B. M., Busch, O. R., Swijnenburg, R. J., Besselink, M. G., Emmen, Anouk M.L.H., Görgec, B., Zwart, M. J.W., Daams, F., Erdmann, J., Festen, S., Gouma, D. J., van Gulik, T. M., van Hilst, J., Kazemier, G., Lof, S., Sussenbach, S. I., Tanis, P. J., Zonderhuis, B. M., Busch, O. R., Swijnenburg, R. J., and Besselink, M. G.

Abstract

Background: Many centers worldwide are shifting from laparoscopic to robotic minimally invasive hepato-pancreato-biliary resections (MIS-HPB) but large single center series assessing this process are lacking. We hypothesized that the introduction of robot-assisted surgery was safe and feasible in a high-volume center. Methods: Single center, post-hoc assessment of prospectively collected data including all consecutive MIS-HPB resections (January 2010–February 2022). As of December 2018, all MIS pancreatoduodenectomy and liver resections were robot-assisted. All surgeons had participated in dedicated training programs for laparoscopic and robotic MIS-HPB. Primary outcomes were in-hospital/30-day mortality and Clavien-Dindo ≥ 3 complications. Results: Among 1875 pancreatic and liver resections, 600 (32%) were MIS-HPB resections. The overall rate of conversion was 4.3%, Clavien-Dindo ≥ 3 complications 25.7%, and in-hospital/30-day mortality 1.8% (n = 11). When comparing the period before and after the introduction of robotic MIS-HPB (Dec 2018), the overall use of MIS-HPB increased from 25.3 to 43.8% (P < 0.001) and blood loss decreased from 250 ml [IQR 100–500] to 150 ml [IQR 50–300] (P < 0.001). The 291 MIS pancreatic resections included 163 MIS pancreatoduodenectomies (52 laparoscopic, 111 robotic) with 4.3% conversion rate. The implementation of robotic pancreatoduodenectomy was associated with reduced operation time (450 vs 361 min; P < 0.001), reduced blood loss (350 vs 200 ml; P < 0.001), and a decreased rate of delayed gastric emptying (28.8% vs 9.9%; P = 0.009). The 309 MIS liver resections included 198 laparoscopic and 111 robotic procedures with a 3.6% conversion rate. The implementation of robotic liver resection was associated with less overall complications (24.7% vs 10.8%; P = 0.003) and shorter hospital stay (4 vs 3 days; P < 0.001). Conclusion: The introduction of robotic surgery was associated with greater implementation of MIS-HPB in

Published
2023

9. Adjuvant hepatic arterial infusion pump chemotherapy and resection versus resection alone in patients with low-risk resectable colorectal liver metastases – the multicenter randomized controlled PUMP trial

Author

Buisman, F. E., Homs, M. Y. V., Grünhagen, D. J., Filipe, W. F., Bennink, R. J., Besselink, M. G. H., Borel Rinkes, I. H. M., Bruijnen, R. C. G., Cercek, A., D’Angelica, M. I., van Delden, O. M., Donswijk, M. L., van Doorn, L., Doornebosch, P. G., Emmering, J., Erdmann, J. I., IJzerman, N. S., Grootscholten, C., Hagendoorn, J., Kemeny, N. E., Kingham, T. P., Klompenhouwer, E. G., Kok, N. F. M., Koolen, S., Kuhlmann, K. F. D., Kuiper, M. C., Lam, M. G. E., Mathijssen, R. H. J., Moelker, A., Oomen-de Hoop, E., Punt, C. J. A., te Riele, W. W., Roodhart, J. M. L., Swijnenburg, R. J., Prevoo, W., Tanis, P. J., Vermaas, M., Versleijen, M. W. J., Veuger, F. P., Weterman, M. J., Verhoef, C., and Groot Koerkamp, B.

Published
2019
Full Text
View/download PDF

11. Clinical Added Value of Gadoxetic Acid Enhanced Liver MRI in Patients Scheduled for Local Therapy of Colorectal Liver Metastases Based on CT Imaging (CAMINO)

Author

Görgec, B., primary, Hansen, I., additional, Hartgrink, H.H., additional, Grünhagen, D., additional, Kok, N., additional, Kuhlmann, K., additional, Swijnenburg, R.-J., additional, Fretland, A.A., additional, Verhoef, K., additional, Besselink, M.G., additional, and Stoker, J., additional

Published
2023
Full Text
View/download PDF

14. First-line Systemic Treatment Strategies in Patients with Initially Unresectable Colorectal Liver Metastases: Phase III CAIRO5 Study of the Dutch Colorectal Cancer Group

Author

Bond, M.J., primary, Bolhuis, K., additional, Kazemier, G., additional, Klaase, J.M., additional, Liem, M.S., additional, Rijken, A.M., additional, Verhoef, C., additional, de Wilt, J.H., additional, Lopez-Yurda, M., additional, Punt, C.J., additional, and Swijnenburg, R.-J., additional

Published
2023
Full Text
View/download PDF

15. Impact of merging two university hospitals on surgical outcome after esophagogastric and hepato-pancreato-biliary surgery: Results from a retrospective study

Author

Ingwersen, E. W., Stam, W. T., van Kesteren, L. J., Wissink, I. J. A., van Berge Henegouwen, M. I., Besselink, M. G., Busch, O. R., Erdmann, J. I., Eshuis, W. J., Gisbertz, S. S., Kazemier, G., van der Peet, D. L., Swijnenburg, R. J., Zonderhuis, B., Daams, F., Surgery, CCA - Cancer Treatment and quality of life, CCA - Cancer biology and immunology, AII - Cancer immunology, Amsterdam Gastroenterology Endocrinology Metabolism, AGEM - Re-generation and cancer of the digestive system, APH - Quality of Care, ACS - Microcirculation, Graduate School, Intensive Care Medicine, CCA - Cancer Treatment and Quality of Life, CCA - Imaging and biomarkers, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, and Cancer Center Amsterdam

Subjects
Hepato-biliary-pancreatic, Complications, Merge, Upper gastrointestinal, Quality of care, Surgery, University centers
Abstract

Background: Due to centralization and super-specialization in medicine, hospital mergers are increasingly common. Their effect on postoperative outcomes in highly specialized surgical departments is unclear. As quality metrics often worsen after major organizational changes, preservation of quality of care during an hospital merge is of the utmost importance. Objective: To evaluate the effect of a merger of two Dutch university hospitals on quality of surgical care, volume, and timeliness of care. Methods: The upper gastro-intestinal and hepato-biliary-pancreatic sections merged on the 27th of January 2020 and the 31th of May 2021 respectively. Outcomes of all adult surgical patients were compared six months before and six months after the merger. Short-term quality metrics, volume, and timeliness of care were assessed. Results: Overall, a cohort of 631 patients were included of whom 195 were upper gastro-intestinal (97 prior to the merger, 98 after the merger) and 436 (223 prior to the merger, 213 after) hepato-biliary-pancreatic patients. There were no differences in mortality, readmission, number and severity of complications, volume, and timeliness of care six months post-merger as compared to before merger. Conclusion: This study shows that a hospital merger of two university hospitals can be performed without jeopardizing patient safety and while benefitting from centralization of highly specialized care and enhancement of medical research. Key message: This study investigated the impact of a merger of two Dutch university hospitals on quality of care, timeliness of care, and volume. It showed no deterioration in the evaluated short-term quality metrics, volume or timeliness for upper GI and HPB surgery, suggesting that a hospital merger of two university hospitals can be performed safely, while benefitting from centralization of highly specialized care and enhancement of medical research.

Published
2023
Full Text
View/download PDF

17. LBA21 FOLFOX/FOLFIRI plus either bevacizumab or panitumumab in patients with initially unresectable colorectal liver metastases (CRLM) and left-sided and RAS/BRAFV600E wild-type tumour: Phase III CAIRO5 study of the Dutch Colorectal Cancer Group

Author

Bond, M.J.G., primary, Bolhuis, K., additional, Loosveld, O.J.L., additional, Droogendijk, H.J., additional, de Groot, J.W.B., additional, Hendriks, M.P., additional, De Valk, B., additional, Liem, M.S.L., additional, Rijken, A.M., additional, Verhoef, K., additional, de Wilt, J.H.W., additional, de Jong, K.P., additional, Kazemier, G., additional, van Amerongen, M.J., additional, Engelbrecht, M.R.W., additional, Klaase, J.M., additional, Komurcu, A., additional, Lopez-Yurda, M.I., additional, Swijnenburg, R-J., additional, and Punt, C.J.A., additional

Published
2022
Full Text
View/download PDF

18. Value of routine intraoperative frozen sections of proximal bile duct margins in perihilar cholangiocarcinoma, a retrospective multicenter and matched case-control study

Author

Nooijen, L. E., Franken, L. C., de Boer, M. T., Buttner, S., van Dieren, S., Koerkamp, B. Groot, Hoogwater, F. J.H., Kazemier, G., Klümpen, H. J., Kuipers, H., Olthof, P. B., Swijnenburg, R. J., Verheij, J., Zonderhuis, B. M., van Gulik, T. M., Erdmann, J. I., Nooijen, L. E., Franken, L. C., de Boer, M. T., Buttner, S., van Dieren, S., Koerkamp, B. Groot, Hoogwater, F. J.H., Kazemier, G., Klümpen, H. J., Kuipers, H., Olthof, P. B., Swijnenburg, R. J., Verheij, J., Zonderhuis, B. M., van Gulik, T. M., and Erdmann, J. I.

Abstract

Background: Currently, the potential benefits of additional resection after positive proximal intraoperative frozen sections (IFS) in perihilar cholangiocarcinoma (pCCA) on residual disease and oncological outcome remain uncertain. Therefore, the aim of this study is to investigate the number of R0 resections after additional resection of a positive proximal IFS and the influence of additional resections on overall survival (OS) in patients with pCCA. Materials and methods: A retrospective, multicenter, matched case-control study was performed, including patients undergoing resection for pCCA between 2000 and 2019 at three tertiary centers. Primary outcome was the number of achieved ‘additional’ R0 resections. Secondary outcomes were OS, recurrence, severe morbidity and mortality. Results: Forty-four out of 328 patients undergoing resection for pCCA had a positive proximal IFS. An additional resection was performed in 35 out of 44 (79.5%) patients, which was negative in 24 (68.6%) patients. Nevertheless, seven out of these 24 patients were eventually classified as R1 resection due to other positive resection margins. Therefore, 17 (48.6%) patients could be classified as “true” R0 resection after additional resection. Ninety-day mortality after R1 resections was high (25%) and strongly influenced OS. After correction for 90-day mortality, median OS after negative additional resection was 33 months (95%CI:29.5–36.5) compared to 30 months (95%CI:24.4–35.6) after initial R1 (P = 0.875) and 46 months (95%CI:32.7–59.3) after initial R0 (P = 0.348). Conclusion: There were only 17 patients (out of a total of 328 patients) that potentially benefitted from routine IFS. Additional resection for a positive IFS leading to R0 resection was not associated with improved long-term survival.

Published
2022

19. Impact of shifting from laparoscopic to robotic surgery during 600 minimally invasive pancreatic and liver resections

Author

Emmen, Anouk. M. L. H., Görgec, B., Zwart, M. J. W., Daams, F., Erdmann, J., Festen, S., Gouma, D. J., van Gulik, T. M., van Hilst, J., Kazemier, G., Lof, S., Sussenbach, S. I., Tanis, P. J., Zonderhuis, B. M., Busch, O. R., Swijnenburg, R. J., Besselink, M. G., Graduate School, Radiology and Nuclear Medicine, Surgery, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer biology and immunology, and CCA - Imaging and biomarkers

Subjects
Pancreatoduodenectomy, Distal pancreatectomy, Minimally invasive, Liver surgery
Abstract

Background: Many centers worldwide are shifting from laparoscopic to robotic minimally invasive hepato-pancreato-biliary resections (MIS-HPB) but large single center series assessing this process are lacking. We hypothesized that the introduction of robot-assisted surgery was safe and feasible in a high-volume center. Methods: Single center, post-hoc assessment of prospectively collected data including all consecutive MIS-HPB resections (January 2010–February 2022). As of December 2018, all MIS pancreatoduodenectomy and liver resections were robot-assisted. All surgeons had participated in dedicated training programs for laparoscopic and robotic MIS-HPB. Primary outcomes were in-hospital/30-day mortality and Clavien-Dindo ≥ 3 complications. Results: Among 1875 pancreatic and liver resections, 600 (32%) were MIS-HPB resections. The overall rate of conversion was 4.3%, Clavien-Dindo ≥ 3 complications 25.7%, and in-hospital/30-day mortality 1.8% (n = 11). When comparing the period before and after the introduction of robotic MIS-HPB (Dec 2018), the overall use of MIS-HPB increased from 25.3 to 43.8% (P < 0.001) and blood loss decreased from 250 ml [IQR 100–500] to 150 ml [IQR 50–300] (P < 0.001). The 291 MIS pancreatic resections included 163 MIS pancreatoduodenectomies (52 laparoscopic, 111 robotic) with 4.3% conversion rate. The implementation of robotic pancreatoduodenectomy was associated with reduced operation time (450 vs 361 min; P < 0.001), reduced blood loss (350 vs 200 ml; P < 0.001), and a decreased rate of delayed gastric emptying (28.8% vs 9.9%; P = 0.009). The 309 MIS liver resections included 198 laparoscopic and 111 robotic procedures with a 3.6% conversion rate. The implementation of robotic liver resection was associated with less overall complications (24.7% vs 10.8%; P = 0.003) and shorter hospital stay (4 vs 3 days; P < 0.001). Conclusion: The introduction of robotic surgery was associated with greater implementation of MIS-HPB in up to nearly half of all pancreatic and liver resections. Although mortality and major morbidity were not affected, robotic surgery was associated with improvements in some selected outcomes. Ultimately, randomized studies and high-quality registries should determine its added value. Graphical Abstract: [Figure not available: see fulltext.]

Published
2022

21. Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Resected Perihilar Cholangiocarcinoma, the ENS-CCA Registry

Author

Nooijen, L.E., primary, Bañales, J., additional, de Boer, M.T., additional, Braconi, C., additional, Folseraas, T., additional, Forner, A., additional, Holowko, W., additional, Hoogwater, F.J.H., additional, Klümpen, H.-J., additional, Groot-Koerkamp, B., additional, Lamarca, A., additional, Landa-Magdalena, A., additional, López-López, F., additional, Sánchez, L. Izquierdo, additional, Scheiter, A., additional, Utpatel, K., additional, Swijnenburg, R.-J., additional, and Erdmann, J.I., additional

Published
2022
Full Text
View/download PDF

23. Interobserver Variability in Morphologic Tumor Response Assessment Following Systemic Therapy in Patients with Initially Unresectable Colorectal Liver Metastases

Author

Wesdorp, N.J., primary, Kemna, R., additional, Waesberghe, J.-H.T. van, additional, Nota, I.M., additional, Struik, F., additional, Abdennabi, I. Oulad, additional, Phoa, S.S., additional, van Dieren, S., additional, Swijnenburg, R.-J., additional, Punt, C.J., additional, Huiskens, J., additional, Stoker, J., additional, and Kazemier, G., additional

Published
2022
Full Text
View/download PDF

25. Development and Validation of Auto-segmentation Deep Learning Models for Automatic Total Tumor Volume Assessment in Patients with Initially Unresectable Colorectal Liver Metastases

Author

Wesdorp, N.J., primary, Zeeuw, J.M., additional, Postma, S.C., additional, Roor, J., additional, Vadakkumpadan, F., additional, Ambrozic, C., additional, Waesberghe, J.-H.T. van, additional, Swijnenburg, R.-J., additional, Punt, C.J., additional, Huiskens, J., additional, and Kazemier, G., additional

Published
2022
Full Text
View/download PDF

27. Clinical added value of MRI to CT in patients scheduled for local therapy of colorectal liver metastases (CAMINO)

Author

Görgec, B., Hansen, I., Kemmerich, G., Syversveen, T., Abu Hilal, M., Belt, E. J. T., Bisschops, R. H. C., Bollen, T. L., Bosscha, K., Burgmans, M. C., Cappendijk, V., de Boer, M. T., D’Hondt, M., Edwin, B., Gielkens, H., Grünhagen, D. J., Gillardin, P., Gobardhan, P. D., Hartgrink, H. H., Horsthuis, K., Kok, N. F. M., Kint, P. A. M., Kruimer, J. W. H., Leclercq, W. K. G., Lips, D. J., Lutin, B., Maas, M., Marsman, H. A., Morone, M., Pennings, J. P., Peringa, J., te Riele, W. W., Vermaas, M., Wicherts, D., Willemssen, F. E. J. A., Zonderhuis, B. M., Bossuyt, P. M. M., Swijnenburg, R. J., Fretland, A., Verhoef, C., Besselink, M. G., Stoker, J., Bnà, C., de Meyere, C., Draaisma, W. A., Gerhards, M. F., Imani, F., Kuhlmann, K. F. D., Liem, M. S. L., Meyer, Y., Surgery, Radiology & Nuclear Medicine, Graduate School, Radiology and Nuclear Medicine, AMS - Rehabilitation & Development, AMS - Sports, Amsterdam Gastroenterology Endocrinology Metabolism, Epidemiology and Data Science, APH - Methodology, APH - Personalized Medicine, CCA - Imaging and biomarkers, CCA - Cancer Treatment and Quality of Life, Radiology and nuclear medicine, Pathology, Obstetrics and gynaecology, CCA - Cancer Treatment and quality of life, AGEM - Re-generation and cancer of the digestive system, and VU University medical center

Subjects
Gadolinium DTPA, Cancer Research, Colorectal cancer, Gadoxetic acid, Contrast Media, Diagnostic accuracy, Multimodal Imaging, Liver MRI, Study Protocol, Liver metastases, Prospective Studies, FDG-PET, RC254-282, OUTCOMES, medicine.diagnostic_test, Minimal clinically important difference, Liver Neoplasms, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Magnetic Resonance Imaging, Oncology, SURVIVAL, Radiology, Colorectal Neoplasms, Life Sciences & Biomedicine, medicine.drug, Adult, medicine.medical_specialty, STRATEGIES, HEPATIC RESECTION, SDG 3 - Good Health and Well-being, Genetics, medicine, Humans, In patient, CANCER PATIENTS, RADIOFREQUENCY ABLATION, Liver surgery, RECURRENCE, Protocol (science), Science & Technology, business.industry, Abdominal CT scan, Magnetic resonance imaging, Diffusion weighted imaging, PERFORMANCE, medicine.disease, Thermal ablation, Colorectal liver metastases, CONTRAST-ENHANCED CT, Tomography, X-Ray Computed, business, Diffusion MRI
Abstract

Background Abdominal computed tomography (CT) is the standard imaging method for patients with suspected colorectal liver metastases (CRLM) in the diagnostic workup for surgery or thermal ablation. Diffusion-weighted and gadoxetic-acid-enhanced magnetic resonance imaging (MRI) of the liver is increasingly used to improve the detection rate and characterization of liver lesions. MRI is superior in detection and characterization of CRLM as compared to CT. However, it is unknown how MRI actually impacts patient management. The primary aim of the CAMINO study is to evaluate whether MRI has sufficient clinical added value to be routinely added to CT in the staging of CRLM. The secondary objective is to identify subgroups who benefit the most from additional MRI. Methods In this international multicentre prospective incremental diagnostic accuracy study, 298 patients with primary or recurrent CRLM scheduled for curative liver resection or thermal ablation based on CT staging will be enrolled from 17 centres across the Netherlands, Belgium, Norway, and Italy. All study participants will undergo CT and diffusion-weighted and gadoxetic-acid enhanced MRI prior to local therapy. The local multidisciplinary team will provide two local therapy plans: first, based on CT-staging and second, based on both CT and MRI. The primary outcome measure is the proportion of clinically significant CRLM (CS-CRLM) detected by MRI not visible on CT. CS-CRLM are defined as liver lesions leading to a change in local therapeutical management. If MRI detects new CRLM in segments which would have been resected in the original operative plan, these are not considered CS-CRLM. It is hypothesized that MRI will lead to the detection of CS-CRLM in ≥10% of patients which is considered the minimal clinically important difference. Furthermore, a prediction model will be developed using multivariable logistic regression modelling to evaluate the predictive value of patient, tumor and procedural variables on finding CS-CRLM on MRI. Discussion The CAMINO study will clarify the clinical added value of MRI to CT in patients with CRLM scheduled for local therapy. This study will provide the evidence required for the implementation of additional MRI in the routine work-up of patients with primary and recurrent CRLM for local therapy. Trial registration The CAMINO study was registered in the Netherlands National Trial Register under number NL8039 on September 20th 2019.

Published
2021
Full Text
View/download PDF

28. Comparing practice and outcome of laparoscopic liver resection between high-volume expert centres and nationwide low-to-medium volume centres

Author

Görgec, B, primary, Fichtinger, R S, additional, Ratti, F, additional, Aghayan, D, additional, Van der Poel, M J, additional, Al-Jarrah, R, additional, Armstrong, T, additional, Cipriani, F, additional, Fretland, Å A, additional, Suhool, A, additional, Bemelmans, M, additional, Bosscha, K, additional, Braat, A E, additional, De Boer, M T, additional, Dejong, C H C, additional, Doornebosch, P G, additional, Draaisma, W A, additional, Gerhards, M F, additional, Gobardhan, P D, additional, Hagendoorn, J, additional, Kazemier, G, additional, Klaase, J, additional, Leclercq, W K G, additional, Liem, M S, additional, Lips, D J, additional, Marsman, H A, additional, Mieog, J S D, additional, Molenaar, Q I, additional, Nieuwenhuijs, V B, additional, Nota, C L, additional, Patijn, G A, additional, Rijken, A M, additional, Slooter, G D, additional, Stommel, M W J, additional, Swijnenburg, R J, additional, Tanis, P J, additional, Te Riele, W W, additional, Terkivatan, T, additional, Van den Tol, P M P, additional, Van den Boezem, P B, additional, Van der Hoeven, J A, additional, Vermaas, M, additional, Edwin, B, additional, Aldrighetti, L A, additional, Van Dam, R M, additional, Abu Hilal, M, additional, and Besselink, M G, additional

Published
2021
Full Text
View/download PDF

30. Additional file 1 of Clinical added value of MRI to CT in patients scheduled for local therapy of colorectal liver metastases (CAMINO): study protocol for an international multicentre prospective diagnostic accuracy study

Author

Görgec, B., Hansen, I., Kemmerich, G., Syversveen, T., Abu Hilal, M., Belt, E. J. T., Bisschops, R. H. C., Bollen, T. L., Bosscha, K., Burgmans, M. C., Cappendijk, V., De Boer, M. T., D’Hondt, M., Edwin, B., Gielkens, H., Grünhagen, D. J., Gillardin, P., Gobardhan, P. D., Hartgrink, H. H., Horsthuis, K., Kok, N. F. M., Kint, P. A. M., Kruimer, J. W. H., Leclercq, W. K. G., Lips, D. J., Lutin, B., Maas, M., Marsman, H. A., Morone, M., Pennings, J. P., Peringa, J., Te Riele, W. W., Vermaas, M., Wicherts, D., Willemssen, F. E. J. A., Zonderhuis, B. M., Bossuyt, P. M. M., Swijnenburg, R. J., Fretland, Å. A., Verhoef, C., Besselink, M. G., and Stoker, J.

Abstract

Additional file 1. SPIRIT checklist

Published
2021
Full Text
View/download PDF

31. Additional file 2 of Clinical added value of MRI to CT in patients scheduled for local therapy of colorectal liver metastases (CAMINO): study protocol for an international multicentre prospective diagnostic accuracy study

Author

Görgec, B., Hansen, I., Kemmerich, G., Syversveen, T., Abu Hilal, M., Belt, E. J. T., Bisschops, R. H. C., Bollen, T. L., Bosscha, K., Burgmans, M. C., Cappendijk, V., De Boer, M. T., D’Hondt, M., Edwin, B., Gielkens, H., Grünhagen, D. J., Gillardin, P., Gobardhan, P. D., Hartgrink, H. H., Horsthuis, K., Kok, N. F. M., Kint, P. A. M., Kruimer, J. W. H., Leclercq, W. K. G., Lips, D. J., Lutin, B., Maas, M., Marsman, H. A., Morone, M., Pennings, J. P., Peringa, J., Te Riele, W. W., Vermaas, M., Wicherts, D., Willemssen, F. E. J. A., Zonderhuis, B. M., Bossuyt, P. M. M., Swijnenburg, R. J., Fretland, Å. A., Verhoef, C., Besselink, M. G., and Stoker, J.

Abstract

Additional file 2. Imaging Protocols of The Radiological Society of the Netherlands

Published
2021
Full Text
View/download PDF

32. Clinical added value of MRI to CT in patients scheduled for local therapy of colorectal liver metastases (CAMINO):study protocol for an international multicentre prospective diagnostic accuracy study

Author

Görgec, B, Hansen, I, Kemmerich, G, Syversveen, T, Abu Hilal, M, Belt, E J T, Bisschops, R H C, Bollen, T L, Bosscha, K, Burgmans, M C, Cappendijk, V, De Boer, M T, D'Hondt, M, Edwin, B, Gielkens, H, Grünhagen, D J, Gillardin, P, Gobardhan, P D, Hartgrink, H H, Horsthuis, K, Kok, N F M, Kint, P A M, Kruimer, J W H, Leclercq, W K G, Lips, D J, Lutin, B, Maas, M, Marsman, H A, Morone, M, Pennings, J P, Peringa, J, Te Riele, W W, Vermaas, M, Wicherts, D, Willemssen, F E J A, Zonderhuis, B M, Bossuyt, P M M, Swijnenburg, R J, Fretland, Å A, Verhoef, C, Besselink, M G, Stoker, J, Görgec, B, Hansen, I, Kemmerich, G, Syversveen, T, Abu Hilal, M, Belt, E J T, Bisschops, R H C, Bollen, T L, Bosscha, K, Burgmans, M C, Cappendijk, V, De Boer, M T, D'Hondt, M, Edwin, B, Gielkens, H, Grünhagen, D J, Gillardin, P, Gobardhan, P D, Hartgrink, H H, Horsthuis, K, Kok, N F M, Kint, P A M, Kruimer, J W H, Leclercq, W K G, Lips, D J, Lutin, B, Maas, M, Marsman, H A, Morone, M, Pennings, J P, Peringa, J, Te Riele, W W, Vermaas, M, Wicherts, D, Willemssen, F E J A, Zonderhuis, B M, Bossuyt, P M M, Swijnenburg, R J, Fretland, Å A, Verhoef, C, Besselink, M G, and Stoker, J

Abstract

BACKGROUND: Abdominal computed tomography (CT) is the standard imaging method for patients with suspected colorectal liver metastases (CRLM) in the diagnostic workup for surgery or thermal ablation. Diffusion-weighted and gadoxetic-acid-enhanced magnetic resonance imaging (MRI) of the liver is increasingly used to improve the detection rate and characterization of liver lesions. MRI is superior in detection and characterization of CRLM as compared to CT. However, it is unknown how MRI actually impacts patient management. The primary aim of the CAMINO study is to evaluate whether MRI has sufficient clinical added value to be routinely added to CT in the staging of CRLM. The secondary objective is to identify subgroups who benefit the most from additional MRI.METHODS: In this international multicentre prospective incremental diagnostic accuracy study, 298 patients with primary or recurrent CRLM scheduled for curative liver resection or thermal ablation based on CT staging will be enrolled from 17 centres across the Netherlands, Belgium, Norway, and Italy. All study participants will undergo CT and diffusion-weighted and gadoxetic-acid enhanced MRI prior to local therapy. The local multidisciplinary team will provide two local therapy plans: first, based on CT-staging and second, based on both CT and MRI. The primary outcome measure is the proportion of clinically significant CRLM (CS-CRLM) detected by MRI not visible on CT. CS-CRLM are defined as liver lesions leading to a change in local therapeutical management. If MRI detects new CRLM in segments which would have been resected in the original operative plan, these are not considered CS-CRLM. It is hypothesized that MRI will lead to the detection of CS-CRLM in ≥10% of patients which is considered the minimal clinically important difference. Furthermore, a prediction model will be developed using multivariable logistic regression modelling to evaluate the predictive value of patient, tumor and procedural va

Published
2021

33. Comparing practice and outcome of laparoscopic liver resection between high-volume expert centres and nationwide low-to-medium volume centres

Author

Zorgeenheid Vaatchirurgie Zorg, MS CGO, Cancer, Görgec, B., Fichtinger, R. S., Ratti, F., Aghayan, D., Van der Poel, M. J., Al-Jarrah, R., Armstrong, T., Cipriani, F., Fretland, ÅA, Suhool, A., Bemelmans, M., Bosscha, K., Braat, A. E., De Boer, M. T., Dejong, C. H.C., Doornebosch, P. G., Draaisma, W. A., Gerhards, M. F., Gobardhan, P. D., Hagendoorn, J., Kazemier, G., Klaase, J., Leclercq, W. K.G., Liem, M. S., Lips, D. J., Marsman, H. A., Mieog, J. S.D., Molenaar, Q. I., Nieuwenhuijs, V. B., Nota, C. L., Patijn, G. A., Rijken, A. M., Slooter, G. D., Stommel, M. W.J., Swijnenburg, R. J., Tanis, P. J., Te Riele, W. W., Terkivatan, T., Van den Tol, P. M.P., Van den Boezem, P. B., Van der Hoeven, J. A., Vermaas, M., Edwin, B., Aldrighetti, L. A., Van Dam, R. M., Abu Hilal, M., Besselink, M. G., Zorgeenheid Vaatchirurgie Zorg, MS CGO, Cancer, Görgec, B., Fichtinger, R. S., Ratti, F., Aghayan, D., Van der Poel, M. J., Al-Jarrah, R., Armstrong, T., Cipriani, F., Fretland, ÅA, Suhool, A., Bemelmans, M., Bosscha, K., Braat, A. E., De Boer, M. T., Dejong, C. H.C., Doornebosch, P. G., Draaisma, W. A., Gerhards, M. F., Gobardhan, P. D., Hagendoorn, J., Kazemier, G., Klaase, J., Leclercq, W. K.G., Liem, M. S., Lips, D. J., Marsman, H. A., Mieog, J. S.D., Molenaar, Q. I., Nieuwenhuijs, V. B., Nota, C. L., Patijn, G. A., Rijken, A. M., Slooter, G. D., Stommel, M. W.J., Swijnenburg, R. J., Tanis, P. J., Te Riele, W. W., Terkivatan, T., Van den Tol, P. M.P., Van den Boezem, P. B., Van der Hoeven, J. A., Vermaas, M., Edwin, B., Aldrighetti, L. A., Van Dam, R. M., Abu Hilal, M., and Besselink, M. G.

Published
2021

34. LBA27 First-line systemic treatment in patients with initially unresectable colorectal cancer liver metastases (CRLM): Overall survival of the phase III CAIRO5 study of the Dutch Colorectal Cancer Group

Author

Punt, C.J.A., Bond, M.J.G., Bolhuis, K., Loosveld, O.J.L., de Groot, J.W., Droogendijk, H., Helgason, H.H., Hendriks, M.P., Klaase, J.M., Kazemier, G., Liem, M.S.L., Rijken, A.M., Verhoef, C., de Wilt, J.H.W., de Jong, K.P., van Amerongen, M.J., De Valk, B., Kerver, E.D., Komurcu, A., and Swijnenburg, R-J.

Published
2023
Full Text
View/download PDF

36. Intraoperative Imaging Techniques to Visualize Hepatic (Micro)Perfusion: An Overview

Author

Uz, Z. (Zühre), Shen, L. (Lucinda), Milstein, D.M.J. (Dan), Van Lienden, K.P. (Krijn P.), Swijnenburg, R.-J. (Rutger-Jan), Ince, C. (Can), Gulik, T.M. (Thomas) van, Uz, Z. (Zühre), Shen, L. (Lucinda), Milstein, D.M.J. (Dan), Van Lienden, K.P. (Krijn P.), Swijnenburg, R.-J. (Rutger-Jan), Ince, C. (Can), and Gulik, T.M. (Thomas) van

Abstract

The microcirculation plays a crucial role in the distribution of perfusion to organs. Studies have shown that microcirculatory dysfunction is an independent predictor of morbidity and mortality. Hence, asse

Published
2020
Full Text
View/download PDF

37. Volume–outcome relationship of liver surgery: a nationwide analysis

Author

Olthof, P.B. (P. B.), Elfrink, A.K.E. (A. K.E.), Marra, E. (E.), Belt, E.J.T. (Eric), Boezem, P.B. van den, Bosscha, K. (Koop), Consten, E.C. (Esther), den Dulk, M. (M.), Gobardhan, P.D. (Paul), Hagendoorn, J. (Jeroen), van Heek, T.N.T. (T. N.T.), IJzermans, J.N.M. (Jan), Klaase, J.M. (Joost), Kuhlmann, K.F.D. (K. F.D.), Leclercq, W.K.G. (W. K.G.), Liem, M. (Marieke), Manusama, E.R. (Eric), Marsman, H.A. (H. A.), Mieog, J.S.D. (Sven), Oosterling, S.J. (S.), Patijn, G.A. (Gijs A.), te Riele, W. (W.), Swijnenburg, R.-J. (R. J.), Torrenga, H. (H.), Duijvendijk, P. (Peter) van, Vermaas, M. (Maarten), Kok, N.F.M. (Niels), Grunhagen, D.J. (Dirk Jan), Besselink, M.G. (Marc), Boer, M.T. (Marieke) de, Buis, C.I. (Carlijn I.), Gulik, T.M. (Thomas) van, Hoogwater, F.J.H. (F. J.H.), Molenaar, I.Q. (I. Quintus), Dejong, C.H. (Cees), Verhoef, C. (Kees), Olthof, P.B. (P. B.), Elfrink, A.K.E. (A. K.E.), Marra, E. (E.), Belt, E.J.T. (Eric), Boezem, P.B. van den, Bosscha, K. (Koop), Consten, E.C. (Esther), den Dulk, M. (M.), Gobardhan, P.D. (Paul), Hagendoorn, J. (Jeroen), van Heek, T.N.T. (T. N.T.), IJzermans, J.N.M. (Jan), Klaase, J.M. (Joost), Kuhlmann, K.F.D. (K. F.D.), Leclercq, W.K.G. (W. K.G.), Liem, M. (Marieke), Manusama, E.R. (Eric), Marsman, H.A. (H. A.), Mieog, J.S.D. (Sven), Oosterling, S.J. (S.), Patijn, G.A. (Gijs A.), te Riele, W. (W.), Swijnenburg, R.-J. (R. J.), Torrenga, H. (H.), Duijvendijk, P. (Peter) van, Vermaas, M. (Maarten), Kok, N.F.M. (Niels), Grunhagen, D.J. (Dirk Jan), Besselink, M.G. (Marc), Boer, M.T. (Marieke) de, Buis, C.I. (Carlijn I.), Gulik, T.M. (Thomas) van, Hoogwater, F.J.H. (F. J.H.), Molenaar, I.Q. (I. Quintus), Dejong, C.H. (Cees), and Verhoef, C. (Kees)

Abstract

Background: Evidence for an association between hospital volume and outcomes for liver surgery is abundant. The current Dutch guideline requires a minimum volume of 20 annual procedures per centre. The aim of this study was to investigate the association between hospital volume and postoperative outcomes using data from the nationwide Dutch Hepato Biliary Audit. Methods: This was a nationwide study in the Netherlands. All liver resections reported in the Dutch Hepato Biliary Audit between 2014 and 2017 were included. Annual centre volume was calculated and classified in categories of 20 procedures per year. Main outcomes were major morbidity (Clavien–Dindo grade IIIA or higher) and 30-day or in-hospital mortality. Results: A total of 5590 liver resections were done across 34 centres with a median annual centre volume of 35 (i.q.r. 20–69) procedures. Overall major morbidity and mortality rates were 11·2 and 2·0 per cent respectively. The mortality rate was 1·9 per cent after resection for colorectal liver metastases (CRLMs), 1·2 per cent for non-CRLMs, 0·4 per cent for benign tumours, 4·9 per cent for hepatocellular carcinoma and 10·3 per cent for biliary tumours. Higher-volume centres performed more major liver resections, and more resections for hepatocellular carcinoma and biliary cancer. There was no association between hospital volume and either major morbidity or mortality in multivariable analysis, after adjustment for known risk factors for adverse events. Conclusion: Hospital volume and postoperative outcomes were not associated.

Published
2020
Full Text
View/download PDF

38. Volume-outcome relationship of liver surgery:a nationwide analysis

Author

Olthof, P B, Elfrink, A K E, Marra, E, Belt, E J T, van den Boezem, P B, Bosscha, K, Consten, E C J, den Dulk, M, Gobardhan, P D, Hagendoorn, J, van Heek, T N T, IJzermans, J N M, Klaase, J M, Kuhlmann, K F D, Leclercq, W K G, Liem, M S L, Manusama, E R, Marsman, H A, Mieog, J S D, Oosterling, S J, Patijn, G A, Te Riele, W, Swijnenburg, R-J, Torrenga, H, van Duijvendijk, P, Vermaas, M, Kok, N F M, Grünhagen, D J, Olthof, P B, Elfrink, A K E, Marra, E, Belt, E J T, van den Boezem, P B, Bosscha, K, Consten, E C J, den Dulk, M, Gobardhan, P D, Hagendoorn, J, van Heek, T N T, IJzermans, J N M, Klaase, J M, Kuhlmann, K F D, Leclercq, W K G, Liem, M S L, Manusama, E R, Marsman, H A, Mieog, J S D, Oosterling, S J, Patijn, G A, Te Riele, W, Swijnenburg, R-J, Torrenga, H, van Duijvendijk, P, Vermaas, M, Kok, N F M, and Grünhagen, D J

Abstract

BACKGROUND: Evidence for an association between hospital volume and outcomes for liver surgery is abundant. The current Dutch guideline requires a minimum volume of 20 annual procedures per centre. The aim of this study was to investigate the association between hospital volume and postoperative outcomes using data from the nationwide Dutch Hepato Biliary Audit.METHODS: This was a nationwide study in the Netherlands. All liver resections reported in the Dutch Hepato Biliary Audit between 2014 and 2017 were included. Annual centre volume was calculated and classified in categories of 20 procedures per year. Main outcomes were major morbidity (Clavien-Dindo grade IIIA or higher) and 30-day or in-hospital mortality.RESULTS: A total of 5590 liver resections were done across 34 centres with a median annual centre volume of 35 (i.q.r. 20-69) procedures. Overall major morbidity and mortality rates were 11·2 and 2·0 per cent respectively. The mortality rate was 1·9 per cent after resection for colorectal liver metastases (CRLMs), 1·2 per cent for non-CRLMs, 0·4 per cent for benign tumours, 4·9 per cent for hepatocellular carcinoma and 10·3 per cent for biliary tumours. Higher-volume centres performed more major liver resections, and more resections for hepatocellular carcinoma and biliary cancer. There was no association between hospital volume and either major morbidity or mortality in multivariable analysis, after adjustment for known risk factors for adverse events.CONCLUSION: Hospital volume and postoperative outcomes were not associated.

Published
2020

39. One-year Impact of Surgery for Perihilar Cholangiocarcinoma

Author

van Keulen, A.-M., primary, Büttner, S., additional, Besselink, M.G., additional, Busch, O.R., additional, van Gulik, T.M., additional, IJzermans, J.N., additional, de Jonge, J., additional, Polak, W.G., additional, Swijnenburg, R.-J., additional, Groot Koerkamp, B., additional, Erdmann, J.I., additional, and Olthof, P.B., additional

Published
2021
Full Text
View/download PDF

42. Comparing Practice and Outcome of Laparoscopic Liver Resection Between High-volume Expert Centres and Nationwide Low-medium Volume Centres

Author

Görgec, B., primary, Fichtinger, R., additional, Ratti, F., additional, Aghayan, D., additional, van der Poel, M., additional, Al-Jarrah, R., additional, Armstrong, T., additional, Cipriani, F., additional, Fretland, Å., additional, Suhool, A., additional, Bemelmans, M., additional, Bosscha, K., additional, Braat, A., additional, de Boer, M., additional, Dejong, C., additional, Doornebosch, P., additional, Draaisma, W., additional, Gerhards, M., additional, Gobardhan, P., additional, Hagendoorn, J., additional, Kazemier, G., additional, Klaase, J., additional, Leclerq, W., additional, Liem, M., additional, Lips, D., additional, Marsman, H., additional, Mieog, J., additional, Molenaar, Q., additional, Nieuwenhuijs, V., additional, Nota, C., additional, Patijn, G., additional, Rijken, A., additional, Slooter, G., additional, Stommel, M., additional, Swijnenburg, R., additional, Tanis, P., additional, Riele, W. Te, additional, Terkivatan, T., additional, van den Tol, P., additional, van den Boezem, P., additional, van der Hoeven, J., additional, Vermaas, M., additional, Edwin, B., additional, Aldrighetti, L., additional, van Dam, R., additional, Hilal, M. Abu, additional, and Besselink, M., additional

Published
2021
Full Text
View/download PDF

47. Volume–outcome relationship of liver surgery: a nationwide analysis

Author

Olthof, P B, primary, Elfrink, A K E, additional, Marra, E, additional, Belt, E J T, additional, van den Boezem, P B, additional, Bosscha, K, additional, Consten, E C J, additional, den Dulk, M, additional, Gobardhan, P D, additional, Hagendoorn, J, additional, van Heek, T N T, additional, IJzermans, J N M, additional, Klaase, J M, additional, Kuhlmann, K F D, additional, Leclercq, W K G, additional, Liem, M S L, additional, Manusama, E R, additional, Marsman, H A, additional, Mieog, J S D, additional, Oosterling, S J, additional, Patijn, G A, additional, te Riele, W, additional, Swijnenburg, R-J, additional, Torrenga, H, additional, van Duijvendijk, P, additional, Vermaas, M, additional, Kok, N F M, additional, Grünhagen, D J, additional, Besselink, M G H, additional, de Boer, M T, additional, Buis, C I, additional, van Gulik, T M, additional, Hoogwater, F J H, additional, Molenaar, I Q, additional, Dejong, C H C, additional, and Verhoef, C, additional

Published
2020
Full Text
View/download PDF

50. A nationwide training program for robotic pancreatoduodenectomy (LAELAPS-3): analysis of the first trained surgeons and first 87 patients

Author

Zwart, M., primary, De Rooij, T., additional, Van hilst, J., additional, Stommel, M., additional, Van den Boezem, P., additional, Wijsman, J., additional, Van der Schelling, G., additional, Schreinemakers, J., additional, Daams, F., additional, Zonderhuis, B., additional, Kazemier, G., additional, Mieog, S., additional, Vahrmeijer, A., additional, Swijnenburg, R., additional, Bonsing, B., additional, Besselink, M., additional, Koerkamp, B Groot, additional, and DPCG, For the, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results