Search

Your search keyword '"Swijnenburg, R.J."' showing total 121 results
Start Over Author "Swijnenburg, R.J."
121 results on '"Swijnenburg, R.J."'

1. Surgeon personality diversity across generations and subspecialties

Author

Beetz, I., Bessems, M.A., Boerma, D., Castenmiller, P.H., De Bruin, J.L., De Jonge, C., Den Hoed, P.T., Derksen, R.J., Doornebosch, P.G., Duijff, J.W., Engelen, M.P.J., Evers, D.J., Furnée, E.J.B., Gardenbroek, T.J., Geelkerken, R.H., Heemskerk, J., Hellingman, A.A., Hissink, R.J., Hoek, P.E.N., Hoogstins, C.E.S., Houwert, R.M., Iordens, G.I.T., Johannesma, P., Kelder, W., Kleinveld, S., Kruijff, Schelto, Kuipers, M.M., Lardenoije, J.H.P., Levert-Brand, L., Lijkwan, M.A., Logeman, F., Meesters, B., Molegraaf, M.J., Molenkamp, B.G., Möllers, M., Naves, C.C.L.M., Nijhof, H.W., Pierie, J.P.E.N., Schok, T., Sier, M.F., Sintenie, J.B., Swijnenburg, R.J., Teijink, J.A.W., Ten Bosch, J.A., Tiernan, J., Van ‘t Sant, H.P., Van Beek, F.J., Van de Luijtgaarden, K.M., Van den Brand, J.G.H., Van Duijvendijk, P., Van Eijck, G.J., Van Essen, J.A., Van Tongeren, R.B.M., Van Weel, V., Van Workum, F., Veldman, P., Veltkamp, S.C., Verhoeven, B.H., Wiersema, A.M., Woltz, S., Zeestraten, E.C.M., Sier, Vincent Q., Schmitz, Roderick F., Wertenbroek, Reinier W.A.M., Schepers, Abbey, and van der Vorst, Joost R.

Published
2025
Full Text
View/download PDF

4. The role of tumour biological factors in technical anatomical resectability assessment of colorectal liver metastases following induction systemic treatment: An analysis of the Dutch CAIRO5 trial.

Author

Bolhuis, K., Bond, M.J.G., Amerongen, M.J. van, Komurcu, A., Chapelle, T., Dejong, C.H.C., Engelbrecht, M.R., Gerhards, M.F., Grünhagen, D.J., Gulik, T.M. van, Hermans, J.J., Jong, K.P. de, Kazemier, G., Klaase, J.M., Kok, N.F.M., Leclercq, W.K., Liem, M.S., Lienden, K.P. van, Molenaar, I.Q., Neumann, U.P., Patijn, G.A., Rijken, A.M., Ruers, T.M., Verhoef, C., Wilt, J.H.W. de, May, A.M., Punt, C.J.A., Swijnenburg, R.J., Bolhuis, K., Bond, M.J.G., Amerongen, M.J. van, Komurcu, A., Chapelle, T., Dejong, C.H.C., Engelbrecht, M.R., Gerhards, M.F., Grünhagen, D.J., Gulik, T.M. van, Hermans, J.J., Jong, K.P. de, Kazemier, G., Klaase, J.M., Kok, N.F.M., Leclercq, W.K., Liem, M.S., Lienden, K.P. van, Molenaar, I.Q., Neumann, U.P., Patijn, G.A., Rijken, A.M., Ruers, T.M., Verhoef, C., Wilt, J.H.W. de, May, A.M., Punt, C.J.A., and Swijnenburg, R.J.

Abstract

01 april 2023, Item does not contain fulltext, BACKGROUND: Large inter-surgeon variability exists in technical anatomical resectability assessment of colorectal cancer liver-only metastases (CRLM) following induction systemic therapy. We evaluated the role of tumour biological factors in predicting resectability and (early) recurrence after surgery for initially unresectable CRLM. METHODS: 482 patients with initially unresectable CRLM from the phase 3 CAIRO5 trial were selected, with two-monthly resectability assessments by a liver expert panel. If no consensus existed among panel surgeons (i.e. same vote for (un)resectability of CRLM), conclusion was based on majority. The association of tumour biological (sidedness, synchronous CRLM, carcinoembryonic antigen and RAS/BRAF(V600E) mutation status) and technical anatomical factors with consensus among panel surgeons, secondary resectability and early recurrence (<6 months) without curative-intent repeat local treatment was analysed by uni- and pre-specified multivariable logistic regression. RESULTS: After systemic treatment, 240 (50%) patients received complete local treatment of CRLM of which 75 (31%) patients experienced early recurrence without repeat local treatment. Higher number of CRLM (odds ratio 1.09 [95% confidence interval 1.03-1.15]) and age (odds ratio 1.03 [95% confidence interval 1.00-1.07]) were independently associated with early recurrence without repeat local treatment. In 138 (52%) patients, no consensus among panel surgeons was present prior to local treatment. Postoperative outcomes in patients with and without consensus were comparable. CONCLUSIONS: Almost a third of patients selected by an expert panel for secondary CRLM surgery following induction systemic treatment experience an early recurrence only amenable to palliative treatment. Number of CRLM and age, but no tumour biological factors are predictive, suggesting that until there are better biomarkers; resectability assessment remains primarily a technical anatomical decision.

Published
2023

5. Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases: Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group.

Author

Bond, M.J.G., Kuiper, B.I., Bolhuis, K., Komurcu, A., Amerongen, M.J. van, Chapelle, T., Dejong, C.H.C., Engelbrecht, M.R.W., Gerhards, M.F., Grünhagen, D.J., Gulik, T. van, Hermans, J.J., Jong, K.P. de, Klaase, J.M., Kok, N.F.M., Leclercq, W.K.G., Liem, M.S.L., Lienden, K.P. van, Molenaar, I.Q., Neumann, U.P., Patijn, G.A., Rijken, A.M., Ruers, T.M., Verhoef, C., Wilt, J.H.W. de, Kazemier, G., May, A.M., Punt, C.J.A., Swijnenburg, R.J., Bond, M.J.G., Kuiper, B.I., Bolhuis, K., Komurcu, A., Amerongen, M.J. van, Chapelle, T., Dejong, C.H.C., Engelbrecht, M.R.W., Gerhards, M.F., Grünhagen, D.J., Gulik, T. van, Hermans, J.J., Jong, K.P. de, Klaase, J.M., Kok, N.F.M., Leclercq, W.K.G., Liem, M.S.L., Lienden, K.P. van, Molenaar, I.Q., Neumann, U.P., Patijn, G.A., Rijken, A.M., Ruers, T.M., Verhoef, C., Wilt, J.H.W. de, Kazemier, G., May, A.M., Punt, C.J.A., and Swijnenburg, R.J.

Abstract

01 september 2023, Contains fulltext : 295971.pdf (Publisher’s version ) (Open Access), BACKGROUND: Consensus on resectability criteria for colorectal cancer liver metastases (CRLM) is lacking, resulting in differences in therapeutic strategies. This study evaluated variability of resectability assessments and local treatment plans for patients with initially unresectable CRLM by the liver expert panel from the randomised phase III CAIRO5 study. METHODS: The liver panel, comprising surgeons and radiologists, evaluated resectability by predefined criteria at baseline and 2-monthly thereafter. If surgeons judged CRLM as resectable, detailed local treatment plans were provided. The panel chair determined the conclusion of resectability status and local treatment advice, and forwarded it to local surgeons. RESULTS: A total of 1149 panel evaluations of 496 patients were included. Intersurgeon disagreement was observed in 50% of evaluations and was lower at baseline than follow-up (36% vs. 60%, p < 0.001). Among surgeons in general, votes for resectable CRLM at baseline and follow-up ranged between 0-12% and 27-62%, and for permanently unresectable CRLM between 3-40% and 6-47%, respectively. Surgeons proposed different local treatment plans in 77% of patients. The most pronounced intersurgeon differences concerned the advice to proceed with hemihepatectomy versus parenchymal-preserving approaches. Eighty-four percent of patients judged by the panel as having resectable CRLM indeed received local treatment. Local surgeons followed the technical plan proposed by the panel in 40% of patients. CONCLUSION: Considerable variability exists among expert liver surgeons in assessing resectability and local treatment planning of initially unresectable CRLM. This stresses the value of panel-based decisions, and the need for consensus guidelines on resectability criteria and technical approach to prevent unwarranted variability in clinical practice.

Published
2023

6. ASO Visual Abstract: Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases-Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group.

Author

Bond, M.J.G., Kuiper, B.I., Bolhuis, K., Komurcu, A., Amerongen, M.J. van, Chapelle, T., Dejong, C.H.C., Engelbrecht, M.R.W., Gerhards, M.F., Grünhagen, D.J., Gulik, T. van, Hermans, J.J., Jong, K.P. de, Klaase, J.M., Kok, N.F.M., Leclercq, W.K.G., Liem, M.S.L., Lienden, K.P. van, Quintus Molenaar, I., Neumann, U.P., Patijn, G.A., Rijken, A.M., Ruers, T.M., Verhoef, C., Wilt, J.H.W. de, Kazemier, G., May, A.M., Punt, C.J.A., Swijnenburg, R.J., Bond, M.J.G., Kuiper, B.I., Bolhuis, K., Komurcu, A., Amerongen, M.J. van, Chapelle, T., Dejong, C.H.C., Engelbrecht, M.R.W., Gerhards, M.F., Grünhagen, D.J., Gulik, T. van, Hermans, J.J., Jong, K.P. de, Klaase, J.M., Kok, N.F.M., Leclercq, W.K.G., Liem, M.S.L., Lienden, K.P. van, Quintus Molenaar, I., Neumann, U.P., Patijn, G.A., Rijken, A.M., Ruers, T.M., Verhoef, C., Wilt, J.H.W. de, Kazemier, G., May, A.M., Punt, C.J.A., and Swijnenburg, R.J.

Abstract

01 september 2023, Item does not contain fulltext

Published
2023

7. First-line systemic treatment strategies in patients with initially unresectable colorectal cancer liver metastases (CAIRO5): an open-label, multicentre, randomised, controlled, phase 3 study from the Dutch Colorectal Cancer Group.

Author

Bond, M.J.G., Bolhuis, K., Loosveld, O.J.L., Groot, J.W.B. de, Droogendijk, H., Helgason, H.H., Hendriks, M.P, Klaase, J.M., Kazemier, G., Liem, M.S.L., Rijken, A.M., Verhoef, C., Wilt, J.H.W. de, Jong, K.P. de, Gerhards, M.F., Amerongen, M.J. van, Engelbrecht, M.R.W., Lienden, K.P. van, Molenaar, I.Q., Valk, B. de, Haberkorn, B.C.M., Kerver, E.D., Erdkamp, F., Alphen, R.J. van, Mathijssen-van Stein, D., Komurcu, A., Lopez-Yurda, M., Swijnenburg, R.J., Punt, C.J.A., Bond, M.J.G., Bolhuis, K., Loosveld, O.J.L., Groot, J.W.B. de, Droogendijk, H., Helgason, H.H., Hendriks, M.P, Klaase, J.M., Kazemier, G., Liem, M.S.L., Rijken, A.M., Verhoef, C., Wilt, J.H.W. de, Jong, K.P. de, Gerhards, M.F., Amerongen, M.J. van, Engelbrecht, M.R.W., Lienden, K.P. van, Molenaar, I.Q., Valk, B. de, Haberkorn, B.C.M., Kerver, E.D., Erdkamp, F., Alphen, R.J. van, Mathijssen-van Stein, D., Komurcu, A., Lopez-Yurda, M., Swijnenburg, R.J., and Punt, C.J.A.

Abstract

01 juli 2023, Item does not contain fulltext, BACKGROUND: Patients with initially unresectable colorectal cancer liver metastases might qualify for local treatment with curative intent after reducing the tumour size by induction systemic treatment. We aimed to compare the currently most active induction regimens. METHODS: In this open-label, multicentre, randomised, phase 3 study (CAIRO5), patients aged 18 years or older with histologically confirmed colorectal cancer, known RAS/BRAF(V600E) mutation status, WHO performance status of 0-1, and initially unresectable colorectal cancer liver metastases were enrolled at 46 Dutch and one Belgian secondary and tertiary centres. Resectability or unresectability of colorectal cancer liver metastases was assessed centrally by an expert panel of liver surgeons and radiologists, at baseline and every 2 months thereafter by predefined criteria. Randomisation was done centrally with the minimisation technique via a masked web-based allocation procedure. Patients with right-sided primary tumour site or RAS or BRAF(V600E) mutated tumours were randomly assigned (1:1) to receive FOLFOX or FOLFIRI plus bevacizumab (group A) or FOLFOXIRI plus bevacizumab (group B). Patients with left-sided and RAS and BRAF(V600E) wild-type tumours were randomly assigned (1:1) to receive FOLFOX or FOLFIRI plus bevacizumab (group C) or FOLFOX or FOLFIRI plus panitumumab (group D), every 14 days for up to 12 cycles. Patients were stratified by resectability of colorectal cancer liver metastases, serum lactate dehydrogenase concentration, choice of irinotecan versus oxaliplatin, and BRAF(V600E) mutation status (for groups A and B). Bevacizumab was administered intravenously at 5 mg/kg. Panitumumab was administered intravenously at 6 mg/kg. FOLFIRI consisted of intravenous infusion of irinotecan at 180 mg/m(2) with folinic acid at 400 mg/m(2), followed by bolus fluorouracil at 400 mg/m(2) intravenously, followed by continuous infusion of fluorouracil at 2400 mg/m(2). FOLFOX consisted of oxaliplatin at

Published
2023

8. Deep learning models for automatic tumor segmentation and total tumor volume assessment in patients with colorectal liver metastases.

Author

Wesdorp, N.J., Zeeuw, J.M., Postma, S.C.J., Roor, J., Waesberghe, J.H. van, Bergh, J.E. van den, Nota, I.M., Moos, S., Kemna, R., Vadakkumpadan, F., Ambrozic, C., Dieren, S. van, Amerongen, M.J. van, Chapelle, T., Engelbrecht, M.R.W., Gerhards, M.F., Grunhagen, D., Gulik, T.M. van, Hermans, J.J., Jong, K.P. de, Klaase, J.M., Liem, M.S.L., Lienden, K.P. van, Molenaar, I.Q., Patijn, G.A., Rijken, A.M., Ruers, T.M., Verhoef, C., Wilt, J.H.W. de, Marquering, H.A., Stoker, J., Swijnenburg, R.J., Punt, C.J.A., Huiskens, J., Kazemier, G., Wesdorp, N.J., Zeeuw, J.M., Postma, S.C.J., Roor, J., Waesberghe, J.H. van, Bergh, J.E. van den, Nota, I.M., Moos, S., Kemna, R., Vadakkumpadan, F., Ambrozic, C., Dieren, S. van, Amerongen, M.J. van, Chapelle, T., Engelbrecht, M.R.W., Gerhards, M.F., Grunhagen, D., Gulik, T.M. van, Hermans, J.J., Jong, K.P. de, Klaase, J.M., Liem, M.S.L., Lienden, K.P. van, Molenaar, I.Q., Patijn, G.A., Rijken, A.M., Ruers, T.M., Verhoef, C., Wilt, J.H.W. de, Marquering, H.A., Stoker, J., Swijnenburg, R.J., Punt, C.J.A., Huiskens, J., and Kazemier, G.

Abstract

Contains fulltext : 300064.pdf (Publisher’s version ) (Open Access), BACKGROUND: We developed models for tumor segmentation to automate the assessment of total tumor volume (TTV) in patients with colorectal liver metastases (CRLM). METHODS: In this prospective cohort study, pre- and post-systemic treatment computed tomography (CT) scans of 259 patients with initially unresectable CRLM of the CAIRO5 trial (NCT02162563) were included. In total, 595 CT scans comprising 8,959 CRLM were divided into training (73%), validation (6.5%), and test sets (21%). Deep learning models were trained with ground truth segmentations of the liver and CRLM. TTV was calculated based on the CRLM segmentations. An external validation cohort was included, comprising 72 preoperative CT scans of patients with 112 resectable CRLM. Image segmentation evaluation metrics and intraclass correlation coefficient (ICC) were calculated. RESULTS: In the test set (122 CT scans), the autosegmentation models showed a global Dice similarity coefficient (DSC) of 0.96 (liver) and 0.86 (CRLM). The corresponding median per-case DSC was 0.96 (interquartile range [IQR] 0.95-0.96) and 0.80 (IQR 0.67-0.87). For tumor segmentation, the intersection-over-union, precision, and recall were 0.75, 0.89, and 0.84, respectively. An excellent agreement was observed between the reference and automatically computed TTV for the test set (ICC 0.98) and external validation cohort (ICC 0.98). In the external validation, the global DSC was 0.82 and the median per-case DSC was 0.60 (IQR 0.29-0.76) for tumor segmentation. CONCLUSIONS: Deep learning autosegmentation models were able to segment the liver and CRLM automatically and accurately in patients with initially unresectable CRLM, enabling automatic TTV assessment in such patients. RELEVANCE STATEMENT: Automatic segmentation enables the assessment of total tumor volume in patients with colorectal liver metastases, with a high potential of decreasing radiologist's workload and increasing accuracy and consistency. KEY POINTS: • Tumor response eval

Published
2023

11. Value of routine intraoperative frozen sections of proximal bile duct margins in perihilar cholangiocarcinoma, a retrospective multicenter and matched case-control study

Author

Nooijen, L.E., primary, Franken, L.C., additional, de Boer, M.T., additional, Buttner, S., additional, van Dieren, S., additional, Koerkamp, B. Groot, additional, Hoogwater, F.J.H., additional, Kazemier, G., additional, Klümpen, H.J., additional, Kuipers, H., additional, Olthof, P.B., additional, Swijnenburg, R.J., additional, Verheij, J., additional, Zonderhuis, B.M., additional, van Gulik, T.M., additional, and Erdmann, J.I., additional

Published
2022
Full Text
View/download PDF

12. Integration of Three-Dimensional Liver Models in a Multimodal Image-Guided Robotic Liver Surgery Cockpit

Author

Bijlstra, O.D., Broersen, A., Oosterveer, T.T.M., Faber, R.A., Achterberg, F.B., Hurks, R., Burgmans, M.C., Dijkstra, J., Mieog, J.S.D., Vahrmeijer, A.L., Swijnenburg, R.J., Surgery, CCA - Imaging and biomarkers, Radiology and Nuclear Medicine, CCA - Cancer biology and immunology, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
image-guided surgery, Paleontology, multimodal imaging, General Medicine, General Biochemistry, Genetics and Molecular Biology, Oncology, robotic surgery, liver surgery, virtual reality, 3D, Space and Planetary Science, Surgery, Ecology, Evolution, Behavior and Systematics
Abstract

Background: Robotic liver surgery represents the most recent evolution in the field of minimally-invasive liver surgery. For planning and guidance of liver resections, surgeons currently rely on preoperative 2-dimensional (2D) CT and/or MR imaging and intraoperative ultrasonography. Translating 2D images into digital 3-dimensional (3D) models may improve both preoperative planning and surgical guidance. The da Vinci® robotic surgical system is a platform suitable for the integration of multiple imaging modalities into one single view. In this study, we describe multimodal imaging options and introduce the Robotic Liver Surgery Cockpit; Methods: in-house developed software was used and validated for segmentation and registration to create a virtual reality 3D model of the liver based on preoperative imaging. The accuracy of the 3D models in the clinical setting was objectively assessed in 15 patients by measuring tumor diameters and subjectively with a postoperative conducted questionnaire; Results: Implementation and applicability of the 3D model in the surgical cockpit was feasible in all patients and the quality of the 3D reconstructions was high in 14 (93%) of cases. Tumor diameters measured on CT and/or MR imaging were comparable to automated measurements using the segmentation software and 3D models; Conclusions: the 3D model was successfully incorporated in the robotic surgery console as part of a multimodality imaging platform and aided the surgeon in planning and guidance of the resection. Future studies should focus on further automation of 3D rendering and progress into augmented reality.

Published
2022
Full Text
View/download PDF

13. Defining Textbook Outcome in liver surgery and assessment of hospital variation: A nationwide population-based study

Author

Graaff, M.R. de, Elfrink, A.K., Buis, C.I., Swijnenburg, R.J., Erdmann, J.I., Kazemier, G., Verhoef, C., Mieog, J.Sven D., Derksen, W.J.M., Boezem, P.B. van den, Ayez, N., Liem, M.S., Leclercq, W.K., Kuhlmann, K.F., Marsman, H.A., Duijvendijk, P. van, Kok, N.F.M., Klaase, J.M., Dejong, C.H.C., Grünhagen, D.J., Dulk, Marcel den, Graaff, M.R. de, Elfrink, A.K., Buis, C.I., Swijnenburg, R.J., Erdmann, J.I., Kazemier, G., Verhoef, C., Mieog, J.Sven D., Derksen, W.J.M., Boezem, P.B. van den, Ayez, N., Liem, M.S., Leclercq, W.K., Kuhlmann, K.F., Marsman, H.A., Duijvendijk, P. van, Kok, N.F.M., Klaase, J.M., Dejong, C.H.C., Grünhagen, D.J., and Dulk, Marcel den

Abstract

Item does not contain fulltext, INTRODUCTION: Textbook outcome (TO) is a composite outcome measure covering the surgical care process in a single outcome measure. TO has an advantage over single outcome parameters with low event rates, which have less discriminating impact to detect differences between hospitals. This study aimed to assess factors associated with TO, and evaluate hospital and network variation after case-mix correction in TO rates for liver surgery. METHODS: This was a population-based retrospective study of all patients who underwent liver resection for malignancy in the Netherlands in 2019 and 2020. TO was defined as absence of severe postoperative complications, mortality, prolonged length of hospital stay, and readmission, and obtaining adequate resection margins. Multivariable logistic regression was used for case-mix adjustment. RESULTS: 2376 patients were included. TO was accomplished in 1380 (80%) patients with colorectal liver metastases, in 192 (76%) patients with other liver metastases, in 183 (74%) patients with hepatocellular carcinoma and 86 (51%) patients with biliary cancers. Factors associated with lower TO rates for CRLM included ASA score ≥3 (aOR 0.70, CI 0.51-0.95 p = 0.02), extrahepatic disease (aOR 0.64, CI 0.44-0.95, p = 0.02), tumour size >55 mm on preoperative imaging (aOR 0.56, CI 0.34-0.94, p = 0.02), Charlson Comorbidity Index ≥2 (aOR 0.73, CI 0.54-0.98, p = 0.04), and major liver resection (aOR 0.50, CI 0.36-0.69, p < 0.001). After case-mix correction, no significant hospital or oncological network variation was observed. CONCLUSION: TO differs between indications for liver resection and can be used to assess between hospital and network differences.

Published
2022

14. Adjuvant Hepatic Arterial Infusion Pump Chemotherapy after Resection of Colorectal Liver Metastases; Surgical Complications, Toxicity, and Survival in a Prospective Study in the Netherlands

Author

Filipe, W.F., primary, Buisman, F.E., additional, Grünhagen, D.J., additional, Bennink, R.J., additional, Rinkes, I.HM Borel, additional, Bruijnen, R.C.G., additional, van Delden, O.M., additional, Grootscholten, C., additional, Hagendoorn, J., additional, Kok, N., additional, Kuhlmann, K.F.D., additional, Lam, M.G.E., additional, Moelker, A., additional, Roodhart, J.M.L., additional, Buffart, T., additional, Swijnenburg, R.J., additional, Versleijen, M., additional, Klompenhouwer, E.G., additional, Erdmann, J.I., additional, Punt, C.J.A., additional, Emmering, J., additional, Verhoef, C., additional, Homs, M.Y.V., additional, and Koerkamp, B. Groot, additional

Published
2022
Full Text
View/download PDF

15. Implementation and Outcomes of Robotic Liver Surgery in the Netherlands (LAELIVE-Robot): A Nationwide Retrospective Cohort

Author

Gorgec, B., primary, Zwart, M., additional, Nota, C.L., additional, Bosscha, K., additional, Mieog, S., additional, Terkivatan, T., additional, IJzermans, J.N.M., additional, Te Riele, W., additional, De Boer, M.T., additional, Buis, C.I., additional, Gerhards, M.F., additional, Marsman, H.A., additional, Liem, M.S., additional, Lips, D.J., additional, Rinkes, I., additional, Molenaar, Q.I., additional, Besselink, M.G., additional, Swijnenburg, R.J., additional, and Hagendoorn, J., additional

Published
2022
Full Text
View/download PDF

16. Clinical Added Value of MRI to CT in Patients Scheduled for Local Therapy of Colorectal Liver Metastases (CAMINO): An International Multicenter Prospective Diagnostic Accuracy Study

Author

Gorgec, B., primary, Hansen, I.S., additional, Kemmerich, G., additional, Syversveen, T., additional, Hilal, M Abu, additional, Bosscha, K., additional, Burgmans, M.C., additional, Edwin, B., additional, D'Hondt, M., additional, Gobardhan, P., additional, Gielkens, H., additional, Hartgrink, H.H., additional, Marsman, H.A., additional, Morone, M., additional, Kint, P.A.M., additional, Kok, N., additional, Kuhlmann, K., additional, Lips, D.J., additional, Peringa, J., additional, Willemssen, F., additional, Fretland, A.A., additional, Swijnenburg, R.J., additional, Verhoef, C., additional, Besselink, M.G., additional, and Stoker, J., additional

Published
2022
Full Text
View/download PDF

17. Single-Center Experience of 500+ Minimally Invasive Pancreatic and Liver Resections: Insights into Implementing a MIS-HPB Practice

Author

Emmen, A.M.L.H., primary, Görgec, B., additional, Zwart, M.J.W., additional, Lof, S., additional, Van Hilst, J., additional, Sussenbach, S., additional, Tanis, P.J., additional, Erdmann, J.I., additional, Daams, F., additional, Festen, S., additional, van Gulik, T.M., additional, Gouma, D.J., additional, Busch, O.R., additional, Swijnenburg, R.J., additional, and Besselink, M.G., additional

Published
2022
Full Text
View/download PDF

18. Pan-European Survey on the Implementation of Robotic and Laparoscopic Minimally Invasive Liver Surgery

Author

Zwart, M.J.W., primary, Görgec, B., additional, Arabiyat, A., additional, Nota, C.L.M., additional, van der Poel, M.J., additional, Fichtinger, R.S., additional, Berrevoet, F., additional, van Dam, R.M., additional, Aldrighetti, L., additional, Fuks, D., additional, Hoti, E., additional, Edwin, B., additional, Besselink, M.G., additional, Abu Hilal, M., additional, Hagendoorn, J., additional, and Swijnenburg, R.J., additional

Published
2022
Full Text
View/download PDF

19. Defining Textbook Outcome in liver surgery and an assessment of hospital variation: a nationwide population-based study.

Author

de Graaff, M.R., primary, Elfrink, A.K.E., additional, Buis, C.I., additional, Swijnenburg, R.J., additional, Erdmann, J.L., additional, Kazemier, G., additional, Mieog, J.S.D., additional, Derksen, W.J.M., additional, van den Boezem, P., additional, Ayez, N., additional, Liem, M.S., additional, Leclerq, W., additional, Kuhlmann, K.F., additional, Marsman, H.A., additional, van Duijvendijk, P., additional, Kok, N.F.M., additional, Klaase, J.M., additional, Dejong, C.H.C., additional, Grünhagen, D.J., additional, and Dulk, M. den, additional

Published
2022
Full Text
View/download PDF

20. Factors associated with failure to rescue after liver resection and impact on hospital variation: a nationwide population-based study

Author

Elfrink, A.K., Olthof, P.B., Swijnenburg, R.J., Dulk, M den, Boer, M.T. De, Mieog, J.Sven D., Hagendoorn, J., Kazemier, G., Boezem, P.B. van den, Rijken, A.M., Liem, M.S., Leclercq, W.K., Kuhlmann, K.F., Marsman, H.A., Ijzermans, J.N., Duijvendijk, P. van, Erdmann, J.I., Kok, N.F.M., Grünhagen, D.J., Klaase, J.M., Elfrink, A.K., Olthof, P.B., Swijnenburg, R.J., Dulk, M den, Boer, M.T. De, Mieog, J.Sven D., Hagendoorn, J., Kazemier, G., Boezem, P.B. van den, Rijken, A.M., Liem, M.S., Leclercq, W.K., Kuhlmann, K.F., Marsman, H.A., Ijzermans, J.N., Duijvendijk, P. van, Erdmann, J.I., Kok, N.F.M., Grünhagen, D.J., and Klaase, J.M.

Abstract

Item does not contain fulltext, BACKGROUND: Failure to rescue (FTR) is defined as postoperative complications leading to mortality. This nationwide study aimed to assess factors associated with FTR and hospital variation in FTR after liver surgery. METHODS: All patients who underwent liver resection between 2014 and 2017 in the Netherlands were included. FTR was defined as in-hospital or 30-day mortality after complications Dindo grade ≥3a. Variables associated with FTR and nationwide hospital variation were assessed using multivariable logistic regression. RESULTS: Of 4961 patients included, 3707 (74.4%) underwent liver resection for colorectal liver metastases, 379 (7.6%) for other metastases, 526 (10.6%) for hepatocellular carcinoma and 349 (7.0%) for biliary cancer. Thirty-day major morbidity was 11.5%. Overall mortality was 2.3%. FTR was 19.1%. Age 65-80 (aOR: 2.86, CI:1.01-12.0, p = 0.049), ASA 3+ (aOR:2.59, CI: 1.66-4.02, p < 0.001), liver cirrhosis (aOR:4.15, CI:1.81-9.22, p < 0.001), biliary cancer (aOR:3.47, CI: 1.73-6.96, p < 0.001), and major resection (aOR:6.46, CI: 3.91-10.9, p < 0.001) were associated with FTR. Postoperative liver failure (aOR: 26.9, CI: 14.6-51.2, p < 0.001), cardiac (aOR: 2.62, CI: 1.27-5.29, p = 0.008) and thromboembolic complications (aOR: 2.49, CI: 1.16-5.22, p = 0.017) were associated with FTR. After case-mix correction, no hospital variation in FTR was observed. CONCLUSION: FTR is influenced by patient demographics, disease and procedural burden. Prevention of postoperative liver failure, cardiac and thromboembolic complications could decrease FTR.

Published
2021

21. Survival Benefit of Repeat Local Treatment in Patients Suffering From Early Recurrence of Colorectal Cancer Liver Metastases.

Author

Hellingman, T., Kuiper, B.I., Buffart, L.M., Meijerink, M.R., Versteeg, K.S., Swijnenburg, R.J., Delden, O.M. van, Haasbeek, C.J.A., Vries, J.J.J. de, Waesberghe, J.H. van, Zonderhuis, B.M., Vliet, H.J. van der, Kazemier, G., Hellingman, T., Kuiper, B.I., Buffart, L.M., Meijerink, M.R., Versteeg, K.S., Swijnenburg, R.J., Delden, O.M. van, Haasbeek, C.J.A., Vries, J.J.J. de, Waesberghe, J.H. van, Zonderhuis, B.M., Vliet, H.J. van der, and Kazemier, G.

Abstract

01 december 2021, Contains fulltext : 244864.pdf (Publisher’s version ) (Open Access), BACKGROUND: A uniform treatment strategy for patients suffering from early recurrence after local treatment of CRLM is currently lacking. The aim of this observational cohort study was to assess the potential survival benefit of repeat local treatment compared to systemic therapy in patients suffering from early recurrence of CRLM. PATIENTS AND METHODS: Patients who developed recurrent CRLM within 12 months after initial local treatment with curative intent were retrospectively identified in Amsterdam University Medical Centers between 2009-2019. Differences in overall and progression-free survival among treatment strategies were assessed using multivariable Cox regression analyses. RESULTS: A total of 135 patients were included. Median overall survival of 41 months [range 4-135] was observed in patients who received repeat local treatment, consisting of upfront or repeat local treatment after neoadjuvant systemic therapy, compared to 24 months [range 1-55] in patients subjected to systemic therapy alone (adjusted HR = 0.42 [95%-CI: 0.25-0.72]; P = .002). Prolonged progression-free survival was observed after neoadjuvant systemic therapy followed by repeat local treatment, as compared to upfront repeat local treatment in patients with recurrent CRLM within 4 months following initial local treatment of CRLM (adjusted HR = 0.36 [95%-CI: 0.15-0.86]; P = .021). CONCLUSION: Patients with early recurrence of CRLM should be considered for repeat local treatment strategies. A multimodality approach, consisting of neoadjuvant systemic therapy followed by repeat local treatment, appeared favorable in patients with recurrence within 4 months following initial local treatment of CRLM.

Published
2021

22. Comparing practice and outcome of laparoscopic liver resection between high-volume expert centres and nationwide low-to-medium volume centres

Author

Görgec, B., Fichtinger, R.S., Ratti, F., Aghayan, D., Poel, M.J.C.M. van der, Al-Jarrah, R., Armstrong, T., Cipriani, F., Fretland, A.A., Suhool, A., Bemelmans, M., Bosscha, K., Braat, A.E., Boer, M.T. De, Dejong, C.H.C., Doornebosch, P.G., Draaisma, W.A., Gerhards, M.F., Gobardhan, P.D., Hagendoorn, J., Kazemier, G., Klaase, J., Leclercq, W.K., Liem, M.S., Lips, D.J., Marsman, H.A., Mieog, J.Sven D., Molenaar, Q.I., Nieuwenhuijs, V.B., Nota, C.L., Patijn, G.A., Rijken, A.M., Slooter, G.D., Stommel, M.W.J., Swijnenburg, R.J., Tanis, P.J., Riele, W.W. ter, Terkivatan, T., Tol, P.M.P. van den, Boezem, P.B. van den, Hoeven, Jacobus van der, Vermaas, M., Edwin, B., Aldrighetti, L.A., Dam, R.M. van, Hilal, M. Abu, Besselink, M.G.H., Görgec, B., Fichtinger, R.S., Ratti, F., Aghayan, D., Poel, M.J.C.M. van der, Al-Jarrah, R., Armstrong, T., Cipriani, F., Fretland, A.A., Suhool, A., Bemelmans, M., Bosscha, K., Braat, A.E., Boer, M.T. De, Dejong, C.H.C., Doornebosch, P.G., Draaisma, W.A., Gerhards, M.F., Gobardhan, P.D., Hagendoorn, J., Kazemier, G., Klaase, J., Leclercq, W.K., Liem, M.S., Lips, D.J., Marsman, H.A., Mieog, J.Sven D., Molenaar, Q.I., Nieuwenhuijs, V.B., Nota, C.L., Patijn, G.A., Rijken, A.M., Slooter, G.D., Stommel, M.W.J., Swijnenburg, R.J., Tanis, P.J., Riele, W.W. ter, Terkivatan, T., Tol, P.M.P. van den, Boezem, P.B. van den, Hoeven, Jacobus van der, Vermaas, M., Edwin, B., Aldrighetti, L.A., Dam, R.M. van, Hilal, M. Abu, and Besselink, M.G.H.

Abstract

Contains fulltext : 238990.pdf (Publisher’s version ) (Closed access), BACKGROUND: Based on excellent outcomes from high-volume centres, laparoscopic liver resection is increasingly being adopted into nationwide practice which typically includes low-medium volume centres. It is unknown how the use and outcome of laparoscopic liver resection compare between high-volume centres and low-medium volume centres. This study aimed to compare use and outcome of laparoscopic liver resection in three leading European high-volume centres and nationwide practice in the Netherlands. METHOD: An international, retrospective multicentre cohort study including data from three European high-volume centres (Oslo, Southampton and Milan) and all 20 centres in the Netherlands performing laparoscopic liver resection (low-medium volume practice) from January 2011 to December 2016. A high-volume centre is defined as a centre performing >50 laparoscopic liver resections per year. Patients were retrospectively stratified into low, moderate- and high-risk Southampton difficulty score groups. RESULTS: A total of 2425 patients were included (1540 high-volume; 885 low-medium volume). The median annual proportion of laparoscopic liver resection was 42.9 per cent in high-volume centres and 7.2 per cent in low-medium volume centres. Patients in the high-volume centres had a lower conversion rate (7.4 versus 13.1 per cent; P < 0.001) with less intraoperative incidents (9.3 versus 14.6 per cent; P = 0.002) as compared to low-medium volume centres. Whereas postoperative morbidity and mortality rates were similar in the two groups, a lower reintervention rate (5.1 versus 7.2 per cent; P = 0.034) and a shorter postoperative hospital stay (3 versus 5 days; P < 0.001) were observed in the high-volume centres as compared to the low-medium volume centres. In each Southampton difficulty score group, the conversion rate was lower and hospital stay shorter in high-volume centres. The rate of intraoperative incidents did not differ in the low-risk group, whilst in the moderate-risk

Published
2021

23. Expression of integrin ανβ6 differentiates perihilar cholangiocarcinoma (PHC) from benign disease mimicking PHC

Author

Franken, L.C., primary, Vuijk, F.A., additional, Soer, E.C., additional, Roos, E., additional, Erdmann, J.I., additional, Hooijer, G.K.J., additional, Vahrmeijer, A.L., additional, Gambhir, S.S., additional, van Gulik, T.M., additional, Sarasqueta, A. Farina, additional, Verheij, J., additional, and Swijnenburg, R.J., additional

Published
2021
Full Text
View/download PDF

26. Population-based study on practice variation regarding preoperative systemic chemotherapy in patients with colorectal liver metastases and impact on short-term outcomes

Author

Elfrink, A.K., Kok, N.F., Werf, L.R. van der, Krul, M.F., Marra, E., Wouters, M., Verhoef, C., Kuhlmann, K.F., Dulk, M. den, Swijnenburg, R.J., Riele, W.W. ter, Boezem, P.B. van den, Leclercq, W.K., Lips, D.J., Nieuwenhuijs, V.B., Gobardhan, P.D., Hartgrink, H.H., Buis, C.I., Grünhagen, D.J., Klaase, J.M., Elfrink, A.K., Kok, N.F., Werf, L.R. van der, Krul, M.F., Marra, E., Wouters, M., Verhoef, C., Kuhlmann, K.F., Dulk, M. den, Swijnenburg, R.J., Riele, W.W. ter, Boezem, P.B. van den, Leclercq, W.K., Lips, D.J., Nieuwenhuijs, V.B., Gobardhan, P.D., Hartgrink, H.H., Buis, C.I., Grünhagen, D.J., and Klaase, J.M.

Abstract

Contains fulltext : 225994.pdf (Publisher’s version ) (Closed access), INTRODUCTION: Definitions regarding resectability and hence indications for preoperative chemotherapy vary. Use of preoperative chemotherapy may influence postoperative outcomes. This study aimed to assess the variation in use of preoperative chemotherapy for CRLM and related postoperative outcomes in the Netherlands. MATERIALS AND METHODS: All patients who underwent liver resection for CRLM in the Netherlands between 2014 and 2018 were included from a national database. Case-mix factors contributing to the use of preoperative chemotherapy, hospital variation and postoperative outcomes were assessed using multivariable logistic regression. Postoperative outcomes were postoperative complicated course (PCC), 30-day morbidity and 30-day mortality. RESULTS: In total, 4469 patients were included of whom 1314 patients received preoperative chemotherapy and 3155 patients did not. Patients receiving chemotherapy were significantly younger (mean age (+SD) 66.3 (10.4) versus 63.2 (10.2) p < 0.001) and had less comorbidity (Charlson scores 2+ (24% versus 29%, p = 0.010). Unadjusted hospital variation concerning administration of preoperative chemotherapy ranged between 2% and 55%. After adjusting for case-mix factors, three hospitals administered significantly more preoperative chemotherapy than expected and six administered significantly less preoperative chemotherapy than expected. PCC was 12.1%, 30-day morbidity was 8.8% and 30-day mortality was 1.5%. No association between preoperative chemotherapy and PCC (OR 1.24, 0.98-1.55, p = 0.065), 30-day morbidity (OR 1.05, 0.81-1.39, p = 0.703) or with 30-day mortality (OR 1.22, 0.75-2.09, p = 0.467) was found. CONCLUSION: Significant hospital variation in the use of preoperative chemotherapy for CRLM was present in the Netherlands. No association between postoperative outcomes and use of preoperative chemotherapy was found.

Published
2020

27. Volume-outcome relationship of liver surgery: a nationwide analysis

Author

Olthof, P.B., Elfrink, A.K., Marra, E., Belt, E.J., Boezem, P.B. van den, Bosscha, K., Consten, E.C., Dulk, M den, Gobardhan, P.D., Hagendoorn, J., Heek, T.N.T. van, JNM, I.J., Klaase, J.M., Kuhlmann, K.F., Leclercq, W.K., Liem, M.S., Manusama, E.R., Marsman, H.A., Mieog, J.S., Oosterling, S.J., Patijn, G.A., Riele, W. Te, Swijnenburg, R.J., Torrenga, H., Duijvendijk, P. van, Vermaas, M., Kok, N.F., Grünhagen, D.J., Olthof, P.B., Elfrink, A.K., Marra, E., Belt, E.J., Boezem, P.B. van den, Bosscha, K., Consten, E.C., Dulk, M den, Gobardhan, P.D., Hagendoorn, J., Heek, T.N.T. van, JNM, I.J., Klaase, J.M., Kuhlmann, K.F., Leclercq, W.K., Liem, M.S., Manusama, E.R., Marsman, H.A., Mieog, J.S., Oosterling, S.J., Patijn, G.A., Riele, W. Te, Swijnenburg, R.J., Torrenga, H., Duijvendijk, P. van, Vermaas, M., Kok, N.F., and Grünhagen, D.J.

Abstract

Contains fulltext : 225683.pdf (publisher's version ) (Open Access), BACKGROUND: Evidence for an association between hospital volume and outcomes for liver surgery is abundant. The current Dutch guideline requires a minimum volume of 20 annual procedures per centre. The aim of this study was to investigate the association between hospital volume and postoperative outcomes using data from the nationwide Dutch Hepato Biliary Audit. METHODS: This was a nationwide study in the Netherlands. All liver resections reported in the Dutch Hepato Biliary Audit between 2014 and 2017 were included. Annual centre volume was calculated and classified in categories of 20 procedures per year. Main outcomes were major morbidity (Clavien-Dindo grade IIIA or higher) and 30-day or in-hospital mortality. RESULTS: A total of 5590 liver resections were done across 34 centres with a median annual centre volume of 35 (i.q.r. 20-69) procedures. Overall major morbidity and mortality rates were 11·2 and 2·0 per cent respectively. The mortality rate was 1·9 per cent after resection for colorectal liver metastases (CRLMs), 1·2 per cent for non-CRLMs, 0·4 per cent for benign tumours, 4·9 per cent for hepatocellular carcinoma and 10·3 per cent for biliary tumours. Higher-volume centres performed more major liver resections, and more resections for hepatocellular carcinoma and biliary cancer. There was no association between hospital volume and either major morbidity or mortality in multivariable analysis, after adjustment for known risk factors for adverse events. CONCLUSION: Hospital volume and postoperative outcomes were not associated.

Published
2020

29. Minimally invasive versus open distal pancreatectomy (LEOPARD): study protocol for a randomized controlled trial

Author

Rooij, T. de, Hilst, J. van, Vogel, J.A., Santvoort, H.C. van, Boer, M.T. de, Boerma, D., Boezem, P.B. van den, Bonsing, B.A., Bosscha, K., Coene, P.P., Daams, F., Dam, R.M. van, Dijkgraaf, M.G., Eijck, C.H. van, Festen, S., Gerhards, M.F., Koerkamp, B.G., Hagendoorn, J., Harst, E. van der, Hingh, I.H. de, Dejong, C.H., Kazemier, G., Klaase, J., Kleine, R.H. de, Laarhoven, C.J. van, Lips, D.J., Luyer, M.D., Molenaar, I.Q., Nieuwenhuijs, V.B., Patijn, G.A., Roos, D., Scheepers, J.J., Schelling, G.P. van der, Steenvoorde, P., Swijnenburg, R.J., Wijsman, J.H., Abu Hilal, M., Busch, O.R., Besselink, M.G., Dutch Pancreatic Canc Grp, CCA - Cancer Treatment and quality of life, AGEM - Re-generation and cancer of the digestive system, Surgery, Groningen Institute for Organ Transplantation (GIOT), Value, Affordability and Sustainability (VALUE), RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Gut-liver homeostasis, CCA - Cancer Treatment and Quality of Life, Other departments, APH - Methodology, Clinical Research Unit, and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Time Factors, medicine.medical_treatment, Cost-Benefit Analysis, Health Status, INTERNATIONAL STUDY-GROUP, Distal pancreatectomy, Medicine (miscellaneous), Administration, Oral, law.invention, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Study Protocol, Eating, 0302 clinical medicine, Superiority Trial, Randomized controlled trial, Quality of life, Clinical Protocols, Robotic Surgical Procedures, law, SURGERY ISGPS, Pharmacology (medical), 030212 general & internal medicine, Hospital Costs, Laparoscopy, Netherlands, Pain Measurement, Analgesics, Pain, Postoperative, lcsh:R5-920, medicine.diagnostic_test, MALIGNANT-DISEASE, Robot-assisted, 3. Good health, Treatment Outcome, Research Design, 030220 oncology & carcinogenesis, Pancreatectomy, lcsh:Medicine (General), Cohort study, medicine.medical_specialty, LONG-TERM, BENIGN, Pancreatic surgery, DUCTAL ADENOCARCINOMA, PANCREATOSPLENECTOMY, CLINICAL-TRIAL, 03 medical and health sciences, Laparoscopic, medicine, Journal Article, Humans, IDEAL FRAMEWORK, Minimally invasive, business.industry, Recovery of Function, Pancreatic cancer, Surgery, Clinical trial, DEFINITION, Quality of Life, Observational study, business, Energy Intake
Abstract

Background Observational cohort studies have suggested that minimally invasive distal pancreatectomy (MIDP) is associated with better short-term outcomes compared with open distal pancreatectomy (ODP), such as less intraoperative blood loss, lower morbidity, shorter length of hospital stay, and reduced total costs. Confounding by indication has probably influenced these findings, given that case-matched studies failed to confirm the superiority of MIDP. This accentuates the need for multicenter randomized controlled trials, which are currently lacking. We hypothesize that time to functional recovery is shorter after MIDP compared with ODP even in an enhanced recovery setting. Methods LEOPARD is a randomized controlled, parallel-group, patient-blinded, multicenter, superiority trial in all 17 centers of the Dutch Pancreatic Cancer Group. A total of 102 patients with symptomatic benign, premalignant or malignant disease will be randomly allocated to undergo MIDP or ODP in an enhanced recovery setting. The primary outcome is time (days) to functional recovery, defined as all of the following: independently mobile at the preoperative level, sufficient pain control with oral medication alone, ability to maintain sufficient (i.e. >50%) daily required caloric intake, no intravenous fluid administration and no signs of infection. Secondary outcomes are operative and postoperative outcomes, including clinically relevant complications, mortality, quality of life and costs. Discussion The LEOPARD trial is designed to investigate whether MIDP reduces the time to functional recovery compared with ODP in an enhanced recovery setting. Trial registration Dutch Trial Register, NTR5188. Registered on 9 April 2015 Electronic supplementary material The online version of this article (doi:10.1186/s13063-017-1892-9) contains supplementary material, which is available to authorized users.

Published
2017
Full Text
View/download PDF

30. EORTC 1409 GITCG / ESSO 01 - A prospective colorectal liver metastasis database with an integrated quality assurance program (CLIMB): Primary analysis of variations in European clinical practices and surgical complications after complex liver metastasis surgeries

Author

Caballero, C.I., primary, Alvarez, L. Carrion, additional, Nilsson, H., additional, Ruers, T., additional, Senellart, P., additional, Rivoire, M., additional, Staettner, S., additional, Primavesi, F., additional, Troisi, R., additional, Gruenberger, T., additional, Heil, J., additional, Schnitzbauer, A., additional, Rahbari, N., additional, Swijnenburg, R.J., additional, Malik, H., additional, Protic, M., additional, Neven, A., additional, Mauer, M., additional, Poston, G., additional, and Evrard, S., additional

Published
2019
Full Text
View/download PDF

31. First long-term follow-up study of near-infrared fluorescence-guided resection of colorectal liver metastases

Author

Handgraaf, H., primary, Boogerd, L., additional, Höppener, D., additional, Sibinga Mulder, B., additional, Hoogstins, C., additional, Liefers, G.J., additional, Hartgrink, H., additional, van de Velde, C., additional, Mieog, J.S.D., additional, Swijnenburg, R.J., additional, Putter, H., additional, Braat, A., additional, Frangioni, J., additional, and Vahrmeijer, A., additional

Published
2019
Full Text
View/download PDF

32. Tumor-specific intraoperative detection of pancreatic ductal adenocarcinoma using multimodal molecular imaging.

Author

Tummers, W., primary, Swijnenburg, R.J., additional, Miller, S., additional, Teraphongphom, T., additional, Gomez, A., additional, Kothapalli, R., additional, Steinberg, I., additional, Huland, D., additional, Bonsing, B., additional, Vahrmeijer, A., additional, Longacre, T., additional, Fisher, G., additional, Gambhir, S.S., additional, Poultsides, G., additional, and Rosenthal, E., additional

Published
2019
Full Text
View/download PDF

39. Long-term follow-up after near-infrared fluorescence-guided resection of colorectal liver metastases: A retrospective multicenter analysis

Author

Handgraaf, H.J.M., primary, Boogerd, L.S.F., additional, Höppener, D.J., additional, Peloso, A., additional, Sibinga Mulder, B.G., additional, Hoogstins, C.E.S., additional, Hartgrink, H.H., additional, van de Velde, C.J.H., additional, Mieog, J.S.D., additional, Swijnenburg, R.J., additional, Putter, H., additional, Maestri, M., additional, Braat, A.E., additional, Frangioni, J.V., additional, and Vahrmeijer, A.L., additional

Published
2017
Full Text
View/download PDF

45. Dose optimization for near-infrared fluorescence sentinel lymph node mapping in patients with melanoma

Author

Vorst, J.R. van der, Schaafsma, B.E., Verbeek, F.P.R., Swijnenburg, R.J., Hutteman, M., Liefers, G.J., Velde, C.J.H. van de, Frangioni, J.V., Vahrmeijer, A.L., and Academic Medical Center

Abstract

Background Regional lymph node involvement is the most important prognostic factor in cutaneous melanoma. As only 20% of patients with melanoma have occult nodal disease and would benefit from a regional lymphadenectomy, the sentinel lymph node (SLN) biopsy was introduced. Near-infrared (NIR) fluorescence has been hypothesized to improve SLN mapping. Objectives To assess the potential of intraoperative NIR fluorescence imaging to improve SLN mapping in patients with melanoma and to examine the optimal dose of indocyanine green adsorbed to human serum albumin (ICG:HSA). Methods Fifteen consecutive patients with cutaneous melanoma underwent the standard SLN procedure using 99mtechnetium- nancolloid and patent blue. In addition, intraoperative NIR fluorescence imaging was performed after injection of 1·6 mL of 600, 800, 1000 or 1200 μmol L-1 of ICG:HSA in four quadrants around the primary excision scar. Results NIR fluorescence SLN mapping was successful in 93% of patients. In one patient, no SLN could be identified using either conventional methods or NIR fluorescence. A total of 30 SLNs (average 2·0, range 1-7) were detected, 30 radioactive (100%), 27 blue (73%) and 30 NIR fluorescent (100%). With regard to the effect of concentration on signal-to-background ratios a trend (P = 0·066) was found favouring the 600, 800 and 1000 μmol L-1 groups over the 1200 μmol L-1 group. Conclusion This study demonstrates feasibility and accuracy of SLN mapping using ICG:HSA. Considering safety, cost and pharmacological characteristics, an ICG:HSA concentration of 600 μmol L-1 appears optimal for SLN mapping in cutaneous melanoma, although lower doses need to be assessed. © 2012 The Authors. BJD © 2012 British Association of Dermatologists.

Published
2013

46. Dose Optimization for Near-Infrared Fluorescence Sentinel Lymph Node Mapping in Melanoma Patients

Author

van der Vorst, J.R., Schaafsma, B.E., Verbeek, F.P.R., Swijnenburg, R.J., Hutteman, M., Liefers, G.J., van de Velde, C.J.H., Frangioni, J.V., and Vahrmeijer, A.L.

Subjects
Adult, Indocyanine Green, Male, Intraoperative Care, Skin Neoplasms, Spectroscopy, Near-Infrared, Sentinel Lymph Node Biopsy, Dose-Response Relationship, Radiation, Middle Aged, Article, Fluorescence, Young Adult, Lymphatic Metastasis, Feasibility Studies, Humans, Lymph Node Excision, Female, Lymph Nodes, Coloring Agents, Melanoma, Serum Albumin, Aged
Abstract

Regional lymph node involvement is the most important prognostic factor in cutaneous melanoma. As only 20% of patients with melanoma have occult nodal disease and would benefit from a regional lymphadenectomy, the sentinel lymph node (SLN) biopsy was introduced. Near-infrared (NIR) fluorescence has been hypothesized to improve SLN mapping. To assess the potential of intraoperative NIR fluorescence imaging to improve SLN mapping in patients with melanoma and to examine the optimal dose of indocyanine green adsorbed to human serum albumin (ICG:HSA). Fifteen consecutive patients with cutaneous melanoma underwent the standard SLN procedure using (99m) technetium-nancolloid and patent blue. In addition, intraoperative NIR fluorescence imaging was performed after injection of 1·6 mL of 600, 800, 1000 or 1200 μmolL(-1) of ICG: HSA in four quadrants around the primary excision scar. NIR fluorescence SLN mapping was successful in 93% of patients. In one patient, no SLN could be identified using either conventional methods or NIR fluorescence. A total of 30 SLNs (average 2·0, range 1-7) were detected, 30 radioactive (100%), 27 blue (73%) and 30 NIR fluorescent (100%). With regard to the effect of concentration on signal-to-background ratios a trend (P=0·066) was found favouring the 600, 800 and 1000 μmol L(-1) groups over the 1200 μmol L(-1) group. This study demonstrates feasibility and accuracy of SLN mapping using ICG: HSA. Considering safety, cost and pharmacological characteristics, an ICG: HSA concentration of 600 μmolL(-1) appears optimal for SLN mapping in cutaneous melanoma, although lower doses need to be assessed.

Published
2013

49. Characterization of embryonic stem cell transplantation immunobiology using molecular imaging

Author

Swijnenburg, R.J., Hamming, J.F., Robbins, R.C., Wu, J.C., and Leiden University

Subjects
Embryonic stem cells, Myocardial infarction, embryonic structures, Molecular imaging, Translantation, biological phenomena, cell phenomena, and immunity, Immune response, reproductive and urinary physiology
Abstract

Given their self-renewing and pluripotent capabilities, embryonic stem cells (ESCs) are well-poised as a cellular source for tissue regeneration therapy. Successful in vitro differentiation of both mouse (m) and human (h) ESCs into multiple somatic cell types has been reported, including cardiomyocytes, neurons and pancreatic islet cells. However, the host immune response against transplanted ESCs is not well characterized. In fact, controversy remains as to whether ESCs have immune-privileged properties. The scope of the current thesis is to gain insight into immunological aspects of transplantation of embryonic stem cells or their differentiated progeny by using molecular imaging techniques to follow cell fate. Specifically, this thesis presents evidence that: (1) molecular imaging can be used to quantify organ and ESC survival following transplantation and non-invasively follow donor graft fate; (2) ESCs express MHC and co-signaling molecules that are upregulated upon differentiation; (3) mESCs and hESCs can trigger potent cellular and humoral immune responses following allogeneic and/or xenogeneic transplantation, leading to rejection; and (4) immunosuppressive drugs can significantly mitigate the host immune response to prolong hESC survival in immunocompetent mice. These results clearly indicate that ESC immunogenicity is a significant hurdle that must be overcome before successful clinical application can be accomplished.

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results