1. Association of serum globulin with all-cause mortality in incident hemodialysis patients.
- Author
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Pai, Alex Y, Sy, John, Kim, Joseph, Kleine, Carola-Ellen, Edward, Jessica, Hsiung, Jui-Ting, Kovesdy, Csaba P, Kalantar-Zadeh, Kamyar, and Streja, Elani
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Assistive Technology ,Kidney Disease ,Cardiovascular ,Genetics ,Bioengineering ,Zero Hunger ,Good Health and Well Being ,Albumins ,Biomarkers ,Humans ,Inflammation ,Kidney Failure ,Chronic ,Malnutrition ,Proportional Hazards Models ,Renal Dialysis ,Retrospective Studies ,Serum Globulins ,albumin-to-globulin ratio ,globulin ,hemodialysis ,mortality ,protein ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundSerum globulin is a major component of total protein and can be elevated in inflammatory disease states. While inflammation is common in hemodialysis patients and associated with mortality and morbidity, the association between serum globulin and mortality has never been examined in hemodialysis patients.MethodsIn a retrospective cohort of 104 164 incident hemodialysis patients treated by a large dialysis organization from 2007 to 2011, we explored the association between baseline serum globulin, albumin: globulin (A:G) ratio and serum protein levels and all-cause, cardiovascular and infection-related mortality with adjustments for demographic variables and laboratory markers of malnutrition and inflammation using Cox proportional hazards models.ResultsPatients with a globulin concentration >3.8 g/dL had a higher all-cause and infection-related mortality risk {hazard ratio [HR] 1.11 [95% confidence interval (CI) 1.06-1.16] and HR 1.28 [95% CI 1.09-1.51], respectively} in the fully adjusted model when compared with the reference group of 3.0-
- Published
- 2022