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Electric vertical takeoff and landing (eVTOL) aircraft manufacturers await numerous pre-orders for eVTOLs and expect demand for such advanced air mobility (AAM) aircraft to rise dramatically soon. However, eVTOL manufacturers (EMs) cannot commence mass production of commercial eVTOLs due to a lack of supply chain planning for eVTOL manufacturing. The eVTOL supply chain differs from traditional ones due to stringent quality standards and limited suppliers for eVTOL parts, shortages in skilled labor and machinery, and contract renegotiations with major aerospace suppliers. The emerging AAM aircraft market introduces uncertainties in supplier pricing and capacities, eVTOL manufacturing costs, and eVTOL demand, further compounding the supply chain planning challenges for EMs. Despite this critical need, no study has been conducted to develop a comprehensive supply chain planning model for EMs. To address this research gap, we propose a stochastic optimization model for integrated supply chain planning of EMs while maximizing their operating profits under the abovementioned uncertainties. We conduct various numerical cases to analyze the impact of 1) endogenous eVTOL demand influenced by the quality of eVTOLs, 2) supply chain disruptions caused by geopolitical conflicts and resource scarcity, and 3) high-volume eVTOL demand similar to that experienced by automotive manufacturers, on EM supply chain planning. The results indicate that our proposed model is adaptable in all cases and outperforms established benchmark stochastic models. The findings suggest that EMs can commence mass eVTOL production with our model, enabling them to make optimal decisions and profits even under potential disruptions.

Abstract Diphenylalanine (FF) demonstrates a robust ability to self‐assemble at the nanoscale forming a variety of structures ranging from nanospheres to nano‐ and microtubes resulting in outstanding functional properties including pyro‐ and piezoelectricity. FF nanotubes mimic the structure of β‐amyloid fibrils characteristic of Alzheimer's disease and thus can serve as a model material in biology and medicine. In this work, we report experimental proof that water trapped inside nanotubes exhibits dielectric properties similar to that of bulk water despite being confined in an ∼1 nm internal cavity. FF peptides thus provide a suitable template for the stabilization of the tetrahedral configuration of bulk water. Several phase transitions were observed via broadband dielectric spectroscopy and differential scanning calorimetry. Of these, two glass transitions at 205 K and 133 K related to different phases of water were found. The presence of α‐relaxation in the so‐called “no man's land” leads to a global glass transition at Tg = 133 K and structural phase transition at 230 K characteristic of tetrahedral water. The characterized collective response of water dipoles to an external electric field renders high pyro‐ and piezoelectric activity and non‐linear optical effects in FF dipeptides, conferring polarization‐dependent functionality to this important class of biomaterials.

Recently lots of efforts have been taken to develop superparamagnetic iron oxide nanoparticles (SPIONs) for biomedical applications. So it is utmost necessary to have in depth knowledge of the toxicity occurred by this material. This article is designed in such way that it covers all the associated toxicity issues of SPIONs. It mainly emphasis on toxicity occurred at different levels including cellular alterations in the form of damage to nucleic acids due to oxidative stress and altered cellular response. In addition focus is been devoted for in vitro and in vivo toxicity of SPIONs, so that a better therapeutics can be designed. At the end the time dependent nature of toxicity and its ultimate faith inside the body is being discussed. Keywords: SPIONs, Toxicity, Cellular alteration, Biomedical applications

This data article contains data related to the research article entitled “Substrate topography: A valuable in vitro tool, but a clinical red herring for in vivo tenogenesis” [1]. We report measurements on tenocyte viability, metabolic activity and proliferation on substrates with different topographies. We also report the effect of substrates with different topographies on host cells in a subcutaneous model.

Several dimensions have been added since the idea of Semantic web was conceived by Tim B. Lee, to the previously linear representation of the World Wide Web that consisted of web resources like web pages and hyperlinks. These dimensions allow for software agents/machines to make knowledgeable decisions and retrieve relevant resources which are related in meaning and not only by named links. The new infrastructure consists of semantic repositories like network of ontologies, also called semantic networks. Some interesting research issues have emerged in the context of these semantic repositories and these are their creation, bootstrapping and interoperability to make semantic web a reality. A novel approach is proposed to deal with the issue of creation of ontologies from existing online semantic repositories by using Swoogle API. The aim is to discover concepts from online resources indexed by the Swoogle Search Engine by using advanced techniques of Word Sense Disambiguation in Computational Linguistics Techniques.

Small surgical residency programs like plastic surgery can be challenging environments to accommodate parental leave. This study aimed to report the experiences, attitudes and perceived support of Canadian plastic surgery residents, recent graduates and staff surgeons with respect to pregnancy and parenting during training. Residents and staff surgeons were invited via email to participate in an online survey. The results presented here explore experiences of pregnancy and parental leave of current plastic surgery residents and staff surgeons. Residents' and staff surgeons' perceptions of program director support, policies, negative comments and the impact of parental leave on the workload of others were also explored. Although the findings suggest that there may be improvements in the support of program directors, there continues to be a negative attitude in surgical culture toward pregnancy during residency. The perceived confusion of respondents with respect to program-specific policies emphasizes the need for open conversations and standardization of parental leave., On average, following the completion of a surgical residency, exiting trainees in Canada are 33.2 years of age. (1) The average age at which mothers in Canada had their first [...]