1. Outcomes of lung and heart-lung transplants utilizing donor after circulatory death with thoracoabdominal normothermic regional perfusion
- Author
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Stephanie H. Chang, MD, Travis C. Geraci, MD, Greta L. Piper, MD, Justin Chan, MD, Les James, MD, Darien Paone, MD, Philip M. Sommer, Jake Natalini, MD, Darya Rudym, MD, Melissa Lesko, MD, Syed T. Hussain, MD, Alex Reyentovich, MD, Nader Moazami, MD, Deane E. Smith, MD, and Luis Angel, MD
- Subjects
lung transplant ,heart-lung transplant ,donation after circulatory death ,thoracoabdominal normothermic regional perfusion ,primary graft dysfunction ,Surgery ,RD1-811 ,Specialties of internal medicine ,RC581-951 - Abstract
Background: Donation after circulatory death with thoracoabdominal normothermic regional perfusion (DCD-NRP) for cardiac transplant has promising results, though data for lung transplant is lacking. This study evaluates lung transplant outcomes using DCD-NRP allografts. Methods: All patients who underwent lung transplantation (LT) from June 1, 2020, to July 5, 2023, at a single institution were evaluated. Recipients received organs from DCD-NRP or brain dead (control) donors (donation after brain death (DBD)). All DCD-NRP were adult, primary bilateral LT (BLT) without preoperative extracorporeal membrane oxygenation (ECMO). Inclusion criteria for controls were age >18 years, BLT, no preoperative ECMO, and primary transplantation. Comparison was separated by LT or heart-lung transplant (HLT). The primary outcome was primary graft dysfunction (PGD) grade 3 at 72 hours. Results: There were 8 LT and 3 HLT in the DCD-NRP cohort, and 138 BLT and 7 HL DBD controls. PGD grade 3 at 72 hours was 0% in the entire DCD-NRP cohort (vs control: 9.4% LT and 0% HLT). There were no statistically significant differences in donor and recipient characteristics, though DCD-NRP HLT had significantly shorter ischemic time (85 vs 200 minutes, p
- Published
- 2024
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