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34 results on '"Syguda, Anna"'

26. Effects of ammonium-based ionic liquids and 2,4-dichlorophenol on the phospholipid fatty acid composition of zebrafish embryos

Author

Piotrowska, Aleksandra, Syguda, Anna, Wyrwas, Bogdan, Chrzanowski, Lukasz, Luckenbach, Till, and Heipieper, Hermann J.

Subjects
Embryology, animal structures, Embryo, Nonmammalian, lcsh:Medicine, Ionic Liquids, Research and Analysis Methods, Toxicology, Pathology and Laboratory Medicine, Biochemistry, Model Organisms, Ammonium Compounds, Medicine and Health Sciences, Animals, lcsh:Science, Zebrafish, Phospholipids, Toxicity, Organic Compounds, Herbicides, lcsh:R, Embryos, Fatty Acids, Organic Chemistry, Organisms, Chemical Compounds, Biology and Life Sciences, Eukaryota, Animal Models, Lipids, Chemistry, Fish, Experimental Organism Systems, Osteichthyes, Fertilization, embryonic structures, Vertebrates, Physical Sciences, lcsh:Q, Chloroform, Hydrophobic and Hydrophilic Interactions, Research Article, Developmental Biology, Chlorophenols
Abstract

Ionic liquids consisting of a combination of herbicidal anions with a quaternary ammonium cation act as efficient herbicides, which are under consideration to be used in the agriculture. In the present study, we used embryos of the zebrafish (Danio rerio) as a model to assess the toxic potential of ammonium-based ionic liquids for aquatic organisms. As we assumed interference of the partially hydrophobic ionic liquid cation with lipids, we investigated the adaptation response in the lipid composition of the zebrafish embryos, triggered by the ionic compound. Therefore, the impact of ammonium-based ionic liquids with different lengths of the alkyl chain ([C6,C6,C1,C1N][Br], [C8,C8,C1,C1N][Br]) on the phospholipid fatty acid (PLFA) profile of zebrafish embryos up to 72 hours post fertilization (hpf) was examined. Furthermore, the changes in the unsaturation index (UI) of PLFAs, as the sum parameter of membrane fluidity in eukaryotic cells, were presented. The PLFA's UI in the zebrafish embryos upon exposure to quaternary ammonium salts was compared to the UI of the embryos upon exposure to nonionic 2,4-dichlorophenol, which has a similar hydrophobicity but is structurally different to [C8,C8,C1,C1N][Br]. It was shown that for ammonium-based ionic liquid precursors non-specific mode of action occurs and the toxic effect on lipid composition of zebrafish embryos can be well predicted based on chemical properties, like hydrophobicity. Furthermore, the changes in PLFAs, expressed by the UI, can be useful to study toxic effects of organic contamination. However, for zebrafish embryos, after ionic liquids and 2,4-DCP exposure, the changes were observed at high lethal concentrations, which caused the incidence of lethality of 30 and 50% of a group of test animals.

Published
2018

32. Choline-Derivative-Based Ionic Liquids

Author

Pernak, Juliusz, primary, Syguda, Anna, additional, Mirska, Ilona, additional, Pernak, Anna, additional, Nawrot, Jan, additional, Pr??dzyńska, Aleksandra, additional, Griffin, Scott T., additional, and Rogers, Robin D., additional

Published
2007
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33. Ionic liquids - deanol derivatives as the Diels-Alder reaction solvents.

Author

Janus, Ewa, Syguda, Anna, and Materna, Katarzyna

Abstract

The Diels-Alder reaction between cyclopentadiene and dienophiles in deanol derivatives containing bis(trifluoromethylsulfonyl)imide anion as media have been studied. The effect of the substituents attached to the cation on the endo:exo selectivity as well as the reaction yield have been evaluated in the absence and presence of Lewis acid catalyst - Y(OTf). Catalytic activity of metal triflates and the recycling of chosen catalytic systems have also been investigated [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

Published
2010
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34. Choline-derivative-based ionic liquids.

Author

Pernak J, Syguda A, Mirska I, Pernak A, Nawrot J, Pradzyńska A, Griffin ST, and Rogers RD

Subjects
Animal Feed, Animals, Anti-Infective Agents chemical synthesis, Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Antifungal Agents chemical synthesis, Antifungal Agents chemistry, Antifungal Agents pharmacology, Blood Preservation, Choline chemical synthesis, Choline pharmacology, Crystallography, X-Ray, Electrons, Humans, Insecta drug effects, Middle Aged, Models, Molecular, Molecular Structure, Static Electricity, Tissue Preservation, Choline chemistry, Ionic Liquids chemistry
Abstract

A total of sixty-three choline derivative-based ionic liquids in the forms of chlorides, acesulfamates, and bis(trifluoromethylsulfonyl)imides have been prepared and their physical properties (density, viscosity, solubility, and thermal stability) have been determined. Thirteen of these salts are known chlorides: precursors to the 26 water-soluble acesulfamates, 12 acesulfamates only partially miscible with water, and 12 water-insoluble imides. The crystal structures for two of the chloride salts-(2-hydroxyethyl)dimethylundecyloxymethylammonium chloride and cyclododecyloxymethyl(2-hydroxyethyl)dimethylammonium chloride-were determined. The antimicrobial (cocci, rods, and fungi) activities of the new hydrophilic acesulfamate-based ILs were measured and 12 were found to be active. The alkoxymethyl(2-hydroxyethyl)dimethylammonium acesulfamates have been shown to be insect feeding deterrents and thus open up a new generation of synthetic deterrents based on ionic liquids. The alkoxymethyl(2-decanoyloxyethyl)dimethylammonium bis(trifluoromethylsulfonyl)imides have also been shown to act as fixatives for soft tissues and can furthermore be used as substitutes for formalin and also preservatives for blood.

Published
2007
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