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364 results on '"Sykiotis, Gerasimos P."'

1. The impact of electronic versus paper-based data capture on data collection logistics and on missing scores in thyroid cancer patients

Author

Singer, Susanne, Sykiotis, Gerasimos, Al-Ibraheem, Akram, Pinto, Monica, Iakovou, Ioannis, Østhus, Arild Andre, Hammerlid, Eva, Locati, Laura Deborah, Gamper, Eva Maria, Arraras, Juan Ignacio, Jordan, Susan, Buettner, Matthias, Engesser, Deborah, Taylor, Katherine, Canotilho, Rita, Ioannidis, Georgios, Husson, Olga, Gama, Ricardo Ribeiro, Fanetti, Giuseppe, Moss, Laura, Inhestern, Johanna, Andry, Guy, Rimmele, Harald, and Kiyota, Naomi

Published
2024
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4. Comparative analysis through propensity score matching in thyroid cancer: unveiling the impact of multiple malignancies

Author

Al-Ibraheem, Akram, primary, Abdlkadir, Ahmed Saad, additional, Al-Adhami, Dhuha Ali, additional, Lopci, Egesta, additional, Al-Omari, Amal, additional, Al-Masri, Mahmoud, additional, Yousef, Yacoub, additional, Al-Hajaj, Nabeela, additional, Mohamad, Issa, additional, Singer, Susanne, additional, and Sykiotis, Gerasimos P., additional

Published
2024
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6. Parathyroid Imaging

Author

Lalonde, Marie Nicod, Correia, Ricardo Dias, Sykiotis, Gerasimos P., Schaefer, Niklaus, Matter, Maurice, and Prior, John O.

Published
2023
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8. Esophageal schwannoma mimicking non-functional parathyroid adenoma on 99mTc-sestamibi imaging: a case report.

Author

Fiore, Roberto, Gombert, Edwige, La Rosa, Stefano, Dunet, Vincent, Sykiotis, Gerasimos P., and Gorostidi, François

Subjects
PARATHYROID glands, RECURRENT laryngeal nerve, CORE needle biopsy, ADENOMA, COMPUTED tomography, NEEDLE biopsy
Abstract

Technetium-99m sestamibi single-photon emission computed tomography/ computed tomography (99mTc-sestamibi SPECT/CT) is a mainstay of the preoperative localization of parathyroid lesions. We report here the case of a 30 year-old woman with a fortuitously discovered 2 cm cervical mass for which a parathyroid origin was originally suspected due to its retro-thyroidal localization and a personal history of nephrolithiasis. Normal serum calcium and parathyroid hormone (PTH) levels excluded primary hyperparathyroidism, raising suspicion of a non-functional parathyroid adenoma, and SPECT/CT imaging showed that the mass was 99mTc-sestamibi-avid. Fine-needle aspiration (FNA) was performed; cytology was non-diagnostic but the needle washout was negative for thyroglobulin, calcitonin and PTH, arguing against a thyroidal or parathyroidal origin of the mass. Core needle biopsy revealed a schwannoma, ostensibly originating from the recurrent laryngeal nerve; upon surgical resection, it was finally found to arise from the esophageal submucosa. This case illustrates the fact that endocrinologists, radiologists, nuclear medicine, head and neck, and other specialists investigating patients with cervical masses should be aware that schwannomas need to be considered in the differential diagnosis of focal 99mTc-sestamibi uptake in the neck region. [ABSTRACT FROM AUTHOR]

Published
2024

9. The Impact of Levothyroxine on Cardiac Function in Older Adults With Mild Subclinical Hypothyroidism: A Randomized Clinical Trial

Author

Gencer, Baris, Moutzouri, Elisavet, Blum, Manuel R., Feller, Martin, Collet, Tinh-Hai, Delgiovane, Cinzia, da Costa, Bruno R., Buffle, Eric, Monney, Pierre, Gabus, Vincent, Müller, Hajo, Sykiotis, Gerasimos P., Kearney, Patricia, Gussekloo, Jacobijn, Westendorp, Rudi, Stott, David J., Bauer, Douglas C., and Rodondi, Nicolas

Published
2020
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10. Long-Term Survival Analysis and Prognostic Factors of Arabic Patients with Differentiated Thyroid Carcinoma: A 20-Year Observational Study at the King Hussein Cancer Center (KHCC) Involving 528 Patients

Author

Al-Ibraheem, Akram, primary, Al-Rasheed, Ula, additional, Mashhadani, Noor, additional, Abdlkadir, Ahmed Saad, additional, Al-Adhami, Dhuha Ali, additional, Ruzzeh, Saad, additional, Istatieh, Feras, additional, Mansour, Areen, additional, Hamdan, Basem, additional, Kheetan, Reem, additional, Al-Shatti, Marwa, additional, Mohamad, Issa, additional, Juweid, Malik E., additional, Abu Sheikha, Areej, additional, Al-Rabi, Kamal, additional, Sykiotis, Gerasimos P., additional, Kreissl, Michael C., additional, Ismael, Taleb, additional, Sultan, Iyad, additional, and Abdel-Razeq, Hikmat, additional

Published
2023
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13. Use of lenvatinib in the treatment of radioiodine-refractory differentiated thyroid cancer: a multidisciplinary perspective for daily practice

Author

Capdevila, Jaume, primary, Deandreis, Desiree’, additional, Durante, Cosimo, additional, Leboulleux, Sophie, additional, Luster, Markus, additional, Netea-Maier, Romana, additional, Newbold, Kate, additional, Singer, Susanne, additional, Sykiotis, Gerasimos P, additional, Bartes, Beate, additional, Farnell, Kate, additional, and Locati, Laura Deborah, additional

Published
2023
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16. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 Are Identified in Individuals with Congenital Hypogonadotropic Hypogonadism

Author

Miraoui, Hichem, Dwyer, Andrew A, Sykiotis, Gerasimos P, Plummer, Lacey, Chung, Wilson, Feng, Bihua, Beenken, Andrew, Clarke, Jeff, Pers, Tune H, Dworzynski, Piotr, Keefe, Kimberley, Niedziela, Marek, Raivio, Taneli, Crowley, William F, Seminara, Stephanie B, Quinton, Richard, Hughes, Virginia A, Kumanov, Philip, Young, Jacques, Yialamas, Maria A, Hall, Janet E, Van Vliet, Guy, Chanoine, Jean-Pierre, Rubenstein, John, Mohammadi, Moosa, Tsai, Pei-San, Sidis, Yisrael, Lage, Kasper, and Pitteloud, Nelly

Subjects
Rare Diseases, Genetics, Aetiology, 2.1 Biological and endogenous factors, Algorithms, Animals, Base Sequence, Computational Biology, Dual Specificity Phosphatase 6, Female, Fibroblast Growth Factors, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Hypogonadism, Immunohistochemistry, Inheritance Patterns, Intracellular Signaling Peptides and Proteins, Male, Membrane Glycoproteins, Membrane Proteins, Mice, Molecular Sequence Data, Mutation, Nerve Tissue Proteins, Receptors, Interleukin, Sequence Analysis, DNA, Sequence Homology, Surface Plasmon Resonance, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Congenital hypogonadotropic hypogonadism (CHH) and its anosmia-associated form (Kallmann syndrome [KS]) are genetically heterogeneous. Among the >15 genes implicated in these conditions, mutations in FGF8 and FGFR1 account for ~12% of cases; notably, KAL1 and HS6ST1 are also involved in FGFR1 signaling and can be mutated in CHH. We therefore hypothesized that mutations in genes encoding a broader range of modulators of the FGFR1 pathway might contribute to the genetics of CHH as causal or modifier mutations. Thus, we aimed to (1) investigate whether CHH individuals harbor mutations in members of the so-called "FGF8 synexpression" group and (2) validate the ability of a bioinformatics algorithm on the basis of protein-protein interactome data (interactome-based affiliation scoring [IBAS]) to identify high-quality candidate genes. On the basis of sequence homology, expression, and structural and functional data, seven genes were selected and sequenced in 386 unrelated CHH individuals and 155 controls. Except for FGF18 and SPRY2, all other genes were found to be mutated in CHH individuals: FGF17 (n = 3 individuals), IL17RD (n = 8), DUSP6 (n = 5), SPRY4 (n = 14), and FLRT3 (n = 3). Independently, IBAS predicted FGF17 and IL17RD as the two top candidates in the entire proteome on the basis of a statistical test of their protein-protein interaction patterns to proteins known to be altered in CHH. Most of the FGF17 and IL17RD mutations altered protein function in vitro. IL17RD mutations were found only in KS individuals and were strongly linked to hearing loss (6/8 individuals). Mutations in genes encoding components of the FGF pathway are associated with complex modes of CHH inheritance and act primarily as contributors to an oligogenic genetic architecture underlying CHH.

Published
2013

19. Autophagy activation can partially rescue proteasome dysfunction‐mediated cardiac toxicity

Author

Papanagnou, Eleni‐Dimitra, primary, Gumeni, Sentiljana, additional, Sklirou, Aimilia D., additional, Rafeletou, Alexandra, additional, Terpos, Evangelos, additional, Keklikoglou, Kleoniki, additional, Kastritis, Efstathios, additional, Stamatelopoulos, Kimon, additional, Sykiotis, Gerasimos P., additional, Dimopoulos, Meletios A., additional, and Trougakos, Ioannis P., additional

Published
2022
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23. KLB, encoding β‐Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism

Author

Xu, Cheng, Messina, Andrea, Somm, Emmanuel, Miraoui, Hichem, Kinnunen, Tarja, Acierno, James, Jr, Niederländer, Nicolas J, Bouilly, Justine, Dwyer, Andrew A, Sidis, Yisrael, Cassatella, Daniele, Sykiotis, Gerasimos P, Quinton, Richard, De Geyter, Christian, Dirlewanger, Mirjam, Schwitzgebel, Valérie, Cole, Trevor R, Toogood, Andrew A, Kirk, Jeremy MW, Plummer, Lacey, Albrecht, Urs, Crowley, William F, Jr, Mohammadi, Moosa, Tena‐Sempere, Manuel, Prevot, Vincent, and Pitteloud, Nelly

Published
2017
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25. Denosumab for the Treatment of Hypercalcemia in a Patient With Parathyroid Carcinoma: A Case Report

Author

Roukain, Abdallah, Alwan, Heba, Bongiovanni, Massimo, Sykiotis, Gerasimos P, and Kopp, Peter A

Subjects
Aged, 80 and over, calcimimetics, RANKL, 610 Medicine & health, parathyroid carcinoma, RC648-665, Diseases of the endocrine glands. Clinical endocrinology, Parathyroid Neoplasms, 360 Social problems & social services, Hypercalcemia, Humans, Calcium, Female, Denosumab, hormones, hormone substitutes, and hormone antagonists
Abstract

Background Refractory hypercalcemia is one of the major complications of parathyroid carcinoma. Case report An 84-year old female patient presented with an acute confusional state due to hypercalcemia. This led to the diagnosis of primary hyperparathyroidism for which she underwent surgery. The initial histological diagnosis was interpreted as atypical parathyroid adenoma; the resection was microscopically incomplete. One year later, the patient presented with elevated calcium levels up to 3.89 mmol/l. Recurrent severe hypercalcemia required multiple hospitalizations. Review of the histology slides revealed that the initially resected lesion was in fact a parathyroid carcinoma. Treatment with the calcimimetic drug cinacalcet was poorly tolerated. Repeated administration of zoledronic acid only had transient effects on calcium levels, and bisphosphonate treatment was ultimately discontinued because of chronic renal failure. The patient then received denosumab (60 or 120 mg) when needed (nine doses over twenty months), the last dose in November 2020, which led to a reduction and control of here calcium levels. Currently, at three years after initial surgery, calcium levels are stable between 2.7-2.8 mmol/l and the patient has not required hospitalization for hypercalcemia for 10 months. Discussion In case of parathyroid carcinoma, en-bloc resection is the first treatment. Denosumab has proven its efficiency in treating hypercalcemia in malignancy. Several case reports studied denosumab in hypercalcemia due to parathyroid carcinoma, and the treatment were efficient to decrease levels of calcium when repeated as needed or monthly. We report another case of refractory hypercalcemia treated with several doses of denosumab in a patient with parathyroid carcinoma.

Published
2022

30. Oligogenic basis of isolated gonadotropin-releasing hormone deficiency

Author

Sykiotis, Gerasimos P., Plummer, Lacey, Hughes, Virginia A., Au, Margaret, Durrani, Sadia, Nayak-Young, Sadhana, Dwyer, Andrew A., Quinton, Richard, Hall, Janet E., Gusella, James F., Seminara, Stephanie B., Crowley, William F., Pitteloud, Nelly, and Donahoe, Patricia K.

Published
2010

34. The impact of electronic versus paper-based data capture on data collection logistics and on missing scores in thyroid cancer patients

Author

Singer, Susanne, Sykiotis, Gerasimos, Al-Ibraheem, Akram, Pinto, Monica, Iakovou, Ioannis, Østhus, Arild Andre, Hammerlid, Eva, Locati, Laura Deborah, Gamper, Eva Maria, Arraras, Juan Ignacio, Jordan, Susan, Buettner, Matthias, Engesser, Deborah, Taylor, Katherine, Canotilho, Rita, Ioannidis, Georgios, Husson, Olga, Gama, Ricardo Ribeiro, Fanetti, Giuseppe, Moss, Laura, Inhestern, Johanna, Andry, Guy, Rimmele, Harald, and Kiyota, Naomi

Abstract

Purpose: The purpose of this study was to investigate the impact of the type of data capture on the time and help needed for collecting patient-reported outcomes as well as on the proportion of missing scores. Methods: In a multinational prospective study, thyroid cancer patients from 17 countries completed a validated questionnaire measuring quality of life. Electronic data capture was compared to the paper-based approach using multivariate logistic regression. Results: A total of 437 patients were included, of whom 13% used electronic data capture. The relation between data capture and time needed was modified by the emotional functioning of the patients. Those with clinical impairments in that respect needed more time to complete the questionnaire when they used electronic data capture compared to paper and pencil (ORadj24.0; p= 0.006). This was not the case when patients had sub-threshold emotional problems (ORadj1.9; p= 0.48). The odds of having the researcher reading the questions out (instead of the patient doing this themselves) (ORadj0.1; p= 0.01) and of needing any help (ORadj0.1; p= 0.01) were lower when electronic data capture was used. The proportion of missing scores was equivalent in both groups (ORadj0.4, p= 0.42). Conclusions: The advantages of electronic data capture, such as real-time assessment and fewer data entry errors, may come at the price of more time required for data collection when the patients have mental health problems. As this is not uncommon in thyroid cancer, researchers need to choose the type of data capture wisely for their particular research question.

Published
2023
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36. Mice Hypomorphic forKeap1, a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels

Author

Ziros, Panos G., primary, Renaud, Cédric O., additional, Chartoumpekis, Dionysios V., additional, Bongiovanni, Massimo, additional, Habeos, Ioannis G., additional, Liao, Xiao-Hui, additional, Refetoff, Samuel, additional, Kopp, Peter A., additional, Brix, Klaudia, additional, and Sykiotis, Gerasimos P., additional

Published
2021
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43. Keap1/Nrf2 Signaling: A New Player in Thyroid Pathophysiology and Thyroid Cancer

Author

Renaud, Cedric O., Ziros, Panos G., Chartoumpekis, Dionysios V., Bongiovanni, Massimo, and Sykiotis, Gerasimos P.

Subjects
endocrine system, goiter, antioxidant, endocrine system diseases, Nrf2 (nuclear factor erythroid 2-related factor 2), Review, respiratory system, thyroglobulin, digestive system, environment and public health, thyroid, Endocrinology, Keap1 (Kelch-like ECH-associated protein 1), oxidative stress
Abstract

The Keap1/Nrf2 pathway is a key mediator of general redox and tissue-specific homeostasis. It also exerts a dual role in cancer, by preventing cell transformation of normal cells but promoting aggressiveness, and drug resistance of malignant ones. Although Nrf2 is well-studied in other tissues, its roles in the thyroid gland are only recently emerging. This review focuses on the involvement of Keap1/Nrf2 signaling in thyroid physiology, and pathophysiology in general, and particularly in thyroid cancer. Studies in mice and cultured follicular cells have shown that, under physiological conditions, Nrf2 coordinates antioxidant defenses, directly increases thyroglobulin production and inhibits its iodination. Increased Nrf2 pathway activation has been reported in two independent families with multinodular goiters due to germline loss-of-function mutations in KEAP1. Nrf2 pathway activation has also been documented in papillary thyroid carcinoma (PTC), due to somatic mutations, or epigenetic modifications in KEAP1, or other pathway components. In PTC, such Nrf2-activating KEAP1 mutations have been associated with tumor aggressiveness. Furthermore, polymorphisms in the prototypical Nrf2 target genes NQO1 and NQO2 have been associated with extra-thyroidal extension and metastasis. More recently, mutations in the Nrf2 pathway have also been found in Hürthle-cell (oncocytic) thyroid carcinoma. Finally, in in vitro, and in vivo models of poorly-differentiated, and undifferentiated (anaplastic) thyroid carcinoma, Nrf2 activation has been associated with resistance to experimental molecularly-targeted therapy. Thus, Keap1/Nrf2 signaling is involved in both benign and malignant thyroid conditions, where it might serve as a prognostic marker or therapeutic target.

Published
2019

45. The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System

Author

Chartoumpekis, Dionysios V., primary, Ziros, Panos G., additional, Georgakopoulos-Soares, Ilias, additional, Smith, Adam A. T., additional, Marques, Ana Claudia, additional, Ibberson, Mark, additional, A. Kopp, Peter, additional, Habeos, Ioannis, additional, Trougakos, Ioannis P., additional, Khoo, Nicholas K. H., additional, and Sykiotis, Gerasimos P., additional

Published
2020
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49. An ancient founder mutation in PROKR2 impairs human reproduction

Author

Avbelj Stefanija, Magdalena, Jeanpierre, Marc, Sykiotis, Gerasimos P., Young, Jacques, Quinton, Richard, Abreu, Ana Paula, Plummer, Lacey, Au, Margaret G., Balasubramanian, Ravikumar, Dwyer, Andrew A., Florez, Jose C., Cheetham, Timothy, Pearce, Simon H., Purushothaman, Radhika, Schinzel, Albert, Pugeat, Michel, Jacobson-Dickman, Elka E., Ten, Svetlana, Latronico, Ana Claudia, Gusella, James F., Dode, Catherine, Crowley, William F., Jr, and Pitteloud, Nelly

Published
2012
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