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4 results on '"Sylvest Meyhoff, Tine"'

1. Effects of restrictive fluid therapy on the time to resolution of hyperlactatemia in ICU patients with septic shock. A secondary post hoc analysis of the CLASSIC randomized trial

Author

Ahlstedt, Christian, Sivapalan, Praleene, Kriz, Miroslav, Jacobson, Gustaf, Sylvest Meyhoff, Tine, Skov Kaas-Hansen, Benjamin, Holm, Manne, Hollenberg, Jacob, Nalos, Marek, Rooijackers, Olav, Hylander Møller, Morten, Cronhjort, Maria, Perner, Anders, and Grip, Jonathan

Published
2024
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3. Higher vs lower doses of dexamethasone in patients with COVID-19 and severe hypoxia (COVID STEROID 2) trial:Protocol and statistical analysis plan

Author

Warrer Munch, Marie, Granholm, Anders, Nainan Myatra, Sheila, Kumar Tirupakuzhi Vijayaraghavan, Bharath, Cronhjort, Maria, Rubenson Wahlin, Rebecka, Jakob, Stephan M., Cioccari, Luca, Nørregaard Kjær, Maj Brit, Kingo Vesterlund, Gitte, Sylvest Meyhoff, Tine, Helleberg, Marie, Hylander Møller, Morten, Benfield, Thomas, Venkatesh, Balasubramanian, Hammond, Naomi, Micallef, Sharon, Bassi, Abhinav, John, Oommen, Jha, Vivekanand, Tjelle Kristiansen, Klaus, Suppli Ulrik, Charlotte, Lind Jørgensen, Vibeke, Smitt, Margit, Bestle, Morten H., Sofie Andreasen, Anne, Musaeus Poulsen, Lone, Steen Rasmussen, Bodil, Craveiro Brøchner, Anne, Strøm, Thomas, Møller, Anders, Saif Khan, Mohd, Padmanaban, Ajay, Vasishtha Divatia, Jigeeshu, Saseedharan, Sanjith, Borawake, Kapil, Kapadia, Farhad, Dixit, Subhal, Chawla, Rajesh, Shukla, Urvi, Amin, Pravin, Chew, Michelle S., Gluud, Christian, Lange, Theis, Perner, Anders, Warrer Munch, Marie, Granholm, Anders, Nainan Myatra, Sheila, Kumar Tirupakuzhi Vijayaraghavan, Bharath, Cronhjort, Maria, Rubenson Wahlin, Rebecka, Jakob, Stephan M., Cioccari, Luca, Nørregaard Kjær, Maj Brit, Kingo Vesterlund, Gitte, Sylvest Meyhoff, Tine, Helleberg, Marie, Hylander Møller, Morten, Benfield, Thomas, Venkatesh, Balasubramanian, Hammond, Naomi, Micallef, Sharon, Bassi, Abhinav, John, Oommen, Jha, Vivekanand, Tjelle Kristiansen, Klaus, Suppli Ulrik, Charlotte, Lind Jørgensen, Vibeke, Smitt, Margit, Bestle, Morten H., Sofie Andreasen, Anne, Musaeus Poulsen, Lone, Steen Rasmussen, Bodil, Craveiro Brøchner, Anne, Strøm, Thomas, Møller, Anders, Saif Khan, Mohd, Padmanaban, Ajay, Vasishtha Divatia, Jigeeshu, Saseedharan, Sanjith, Borawake, Kapil, Kapadia, Farhad, Dixit, Subhal, Chawla, Rajesh, Shukla, Urvi, Amin, Pravin, Chew, Michelle S., Gluud, Christian, Lange, Theis, and Perner, Anders

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of deaths and overburdened healthcare systems worldwide. Systemic low-dose corticosteroids have proven clinical benefit in patients with severe COVID-19. Higher doses of corticosteroids are used in other inflammatory lung diseases and may offer additional clinical benefits in COVID-19. At present, the balance between benefits and harms of higher vs. lower doses of corticosteroids for patients with COVID-19 is unclear. Methods: The COVID STEROID 2 trial is an investigator-initiated, international, parallel-grouped, blinded, centrally randomised and stratified clinical trial assessing higher (12 mg) vs. lower (6 mg) doses of dexamethasone for adults with COVID-19 and severe hypoxia. We plan to enrol 1,000 patients in Denmark, Sweden, Switzerland and India. The primary outcome is days alive without life support (invasive mechanical ventilation, circulatory support or renal replacement therapy) at day 28. Secondary outcomes include serious adverse reactions at day 28; all-cause mortality at day 28, 90 and 180; days alive without life support at day 90; days alive and out of hospital at day 90; and health-related quality of life at day 180. The primary outcome will be analysed using the Kryger Jensen and Lange test adjusted for stratification variables and reported as adjusted mean differences and median differences. The full statistical analysis plan is outlined in this protocol. Discussion: The COVID STEROID 2 trial will provide evidence on the optimal dosing of systemic corticosteroids for COVID-19 patients with severe hypoxia with important implications for patients, their relatives and society.

Published
2021

4. Dexamethasone 12 mg Versus 6 mg for Patients With COVID-19 and Severe Hypoxia: An International, Randomised, Blinded Trial

Author

Warrer Munch, Marie, primary, Myatra, Sheila Nainan, additional, Kumar Tirupakuzhi Vijavaraghavan, Bharath, additional, Saseedharan, Sanjith, additional, Benfield, Thomas, additional, Rubenson Wahlin, Rebecka, additional, Steen Rasmussen, Bodil, additional, Andreasen, Anne Sofie, additional, M. Poulsen, Lone, additional, Cioccari, Luca, additional, Saif Khan, Mohd, additional, Kapadia, Farhad, additional, Divatia, Jigeeshu, additional, C. Brøncher, Anne, additional, H. Bestle, Morten, additional, Helleberg, Marie, additional, Michelsen, Jens, additional, Padmanaban, Ajay, additional, Bose, Neeta, additional, Møller, Anders, additional, Borawake, Kapil, additional, Tjelle Kristensen, Klaus, additional, Shukla, Urvi B., additional, Chew, Michelle S., additional, Dixit, Subhal, additional, Suppli Ulrik, Charlotte, additional, R. Amin, Pravin, additional, Chawla, Rajesh, additional, A. Wamberg, Christian, additional, S. Shah, Mehul, additional, S. Darfelt, Iben, additional, Lind Jørgensen, Vibeke, additional, Smitt, Margit, additional, Granholm, Anders, additional, N. Kjær, Maj-Brit, additional, Hylander Møller, Morten, additional, Sylvest Meyhoff, Tine, additional, Kingo Vesterlund, Gitte, additional, Hammond, Naomi, additional, Micallef, Sharon, additional, Bassi, Abhinav, additional, John, Oommen, additional, Jha, Anubhuti, additional, Cronhjort, Maria, additional, M. Jakob, Stephan, additional, Gluud, Christian, additional, Lange, Theis, additional, Kadam, Vaijayanti, additional, Vennick Marcussen, Klaus, additional, Hollenberg, Jacob, additional, Hedman, Anders, additional, Nielsen, Henrik, additional, L. Schjørring, Olav, additional, Qvist Jensen, Marie, additional, Wolfgang Leistner, Jens, additional, Bak Jonassen, Trine, additional, Meno Kristensen, Camilla, additional, Christensen Clapp, Esben, additional, Steensen Hjortsø, Carl Johan, additional, Steen Jensen, Thomas, additional, Sanggaard Halstad, Liv, additional, Rose Bak, Emilie, additional, Zabaalawi, Reem, additional, Metcalf-Clausen, Matias, additional, Abdi, Suhayb, additional, Victoria Hatley, Emma, additional, Aksnes, Tobias, additional, Gleipner-Andersen, Emil, additional, Alarcón, Arif F., additional, Yamin, Gabriel, additional, Heymowski, Adam, additional, Berggren, Anton, additional, La Cour, Kirstine, additional, Weihe, Sarah, additional, Holten Pind, Alison, additional, Engstrøm, Janus, additional, Jha, Vivekanand, additional, Venkatesh, Balasubramanian, additional, and Perner, Anders, additional

Published
2021
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