Search

Your search keyword '"Szendroedi, Julia"' showing total 668 results
Start Over Author "Szendroedi, Julia"
668 results on '"Szendroedi, Julia"'

3. Association of Small Fiber Function with Microvascular Perfusion of Peripheral Nerves in Patients with Type 2 Diabetes: Study using Quantitative Sensory Testing and Magnetic Resonance Neurography

Author

Mooshage, Christoph M., Schimpfle, Lukas, Kender, Zoltan, Tsilingiris, Dimitrios, Aziz-Safaie, Taraneh, Hohmann, Anja, Szendroedi, Julia, Nawroth, Peter, Sturm, Volker, Heiland, Sabine, Bendszus, Martin, Kopf, Stefan, Kurz, Felix T., and Jende, Johann M. E.

Published
2024
Full Text
View/download PDF

5. Depression symptoms, wellbeing, health-related quality of life, and diabetes-related distress in novel subtypes of recent-onset diabetes in Germany: a 5-year observational follow-up study

Author

Al-Hasani, Hadi, Belgardt, Bengt-Frederik, Bönhof, Gidon, Geerling, Gerd, Herder, Christian, Icks, Andrea, Jandeleit-Dahm, Karin, Kotzka, Jörg, Kuss, Oliver, Lammert, Eckhard, Rathmann, Wolfgang, Roden, Michael, Schlesinger, Sabrina, Schrauwen-Hinderling, Vera, Szendroedi, Julia, Trenkamp, Sandra, Wagner, Robert, Sommer, Jana, Borgmann, Sandra Olivia, Gontscharuk, Veronika, Zaharia, Oana Patricia, Maalmi, Haifa, Strassburger, Klaus, Schön, Martin, Burkart, Volker, Pfeiffer, Andreas F H, Bornstein, Stefan, Blüher, Matthias, Seissler, Jochen, Birkenfeld, Andreas L, and Meyhöfer, Svenja

Published
2024
Full Text
View/download PDF

7. Analysis of type 2 diabetes heterogeneity with a tree-like representation: insights from the prospective German Diabetes Study and the LURIC cohort

Author

Al-Hasani, Hadi, Belgardt, Bengt-Frederik, Bönhof, Gidon J., Geerling, Gerd, Herder, Christian, Icks, Andrea, Jandeleit-Dahm, Karin, Kotzka, Jörg, Kuss, Oliver, Lammert, Eckhard, Rathmann, Wolfgang, Roden, Michael, Schlesinger, Sabrina, Schrauwen-Hinderling, Vera, Szendroedi, Julia, Trenkamp, Sandra, Wagner, Robert, Schön, Martin, Prystupa, Katsiaryna, Mori, Tim, Zaharia, Oana P, Bódis, Kálmán, Bombrich, Maria, Möser, Clara, Yurchenko, Iryna, Kupriyanova, Yuliya, Strassburger, Klaus, Bobrov, Pavel, Nair, Anand T N, Bönhof, Gidon J, Strom, Alexander, Delgado, Graciela E, Kaya, Sema, Guthoff, Rainer, Stefan, Norbert, Birkenfeld, Andreas L, Hauner, Hans, Seissler, Jochen, Pfeiffer, Andreas, Blüher, Matthias, Bornstein, Stefan, Meyhöfer, Svenja, Burkart, Volker, Schrauwen-Hinderling, Vera B, Kleber, Marcus E, Niessner, Alexander, März, Winfried, and Pearson, Ewan R

Published
2024
Full Text
View/download PDF

9. Mechanisms of weight loss-induced remission in people with prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS)

Author

Sandforth, Arvid, von Schwartzenberg, Reiner Jumpertz, Arreola, Elsa Vazquez, Hanson, Robert L, Sancar, Gencer, Katzenstein, Sarah, Lange, Karl, Preißl, Hubert, Dreher, Simon I, Weigert, Cora, Wagner, Robert, Kantartzis, Kostantinos, Machann, Jürgen, Schick, Fritz, Lehmann, Rainer, Peter, Andreas, Katsouli, Nikoletta, Ntziachristos, Vasilis, Dannecker, Corinna, Fritsche, Louise, Perakakis, Nikolaos, Heni, Martin, Nawroth, Peter Paul, Kopf, Stefan, Pfeiffer, Andreas F H, Kabisch, Stefan, Stumvoll, Michael, Schwarz, Peter E H, Hauner, Hans, Lechner, Andreas, Seissler, Jochen, Yurchenko, Iryna, Icks, Andrea, Solimena, Michele, Häring, Hans-Ulrich, Szendroedi, Julia, Schürmann, Annette, de Angelis, Martin Hrabé, Blüher, Matthias, Roden, Michael, Bornstein, Stefan R, Stefan, Norbert, Fritsche, Andreas, and Birkenfeld, Andreas L

Published
2023
Full Text
View/download PDF

11. Effects of TM6SF2 rs58542926 polymorphism on hepatocellular lipids and insulin resistance in early type 2 diabetes

Author

Bódis, Kálmán, Bombrich, Maria, Schön, Martin, Knebel, Birgit, Zaharia, Oana-Patricia, Bönhof, Gidon, Karusheva, Yanislava, Strassburger, Klaus, Kupriyanova, Yuliya, Kotzka, Jörg, Guthoff, Rainer, Schrauwen-Hinderling, Vera, Al-Hasani, Hadi, Burkart, Volker, Szendroedi, Julia, Wagner, Robert, Markgraf, Daniel F., and Roden, Michael

Published
2023
Full Text
View/download PDF

15. Relative validity of a glycemic index extended food-frequency questionnaire

Author

M.Roden, Al-Hasani, H., Belgardt, B., Burkart, V., Buyken, A.E., Geerling, G., Herder, C., Icks, A., Jandeleit-Dahm, K., Kahl, S., Kotzka, J., Kuß, O., Lammert, E., Rathmann, W., Schrauwen-Hinderling, V., Szendroedi, J., Trenkamp, S., Ziegler, D., Goletzke, Janina, Weber, Katharina S., Kössler, Theresa, Zaharia, Oana-Patricia, Bódis, Kálmán, Müssig, Karsten, Szendroedi, Julia, Burkart, Volker, Stutz, Bianca, Nöthlings, Ute, Buyken, Anette E., and Roden, Michael

Published
2022
Full Text
View/download PDF

16. Elevated markers of DNA damage and senescence are associated with the progression of albuminuria and restrictive lung disease in patients with type 2 diabetesResearch in context

Author

Kumar Varun, Kender Zoltan, Sulaj Alba, Blume Manuel, Kliemank Elisabeth, Tsilingiris Dimitrios, Groener Jan B, Brune Maik, Shahzad Khurrum, Isermann Berend, Herzig Stephen, Fleming Thomas, Szendroedi Julia, Nawroth Peter, and Kopf Stefan

Subjects
Type 2 diabetes mellitus, Diabetic complications, DNA-damage, Senescence, Senescence-associated secretory phenotype, Diabetic kidney disease, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: This study was conducted to investigate the cascade involving DNA damage, senescence, and senescence-associated secretory phenotype (SASP) in experimental diabetes and in a four-year follow-up study in patients with pre-diabetes and type 2 diabetes. Methods: Kidney, lung, and liver were studied in 4 months diabetic db/db mice and age-matched controls for the presence of DNA damage and fibrosis. DNA damage (comet-tail-length and ɤH2Ax-positivity in white blood cells), urinary p21-excretion, and plasma IL-6 and TGF-β1 were determined from 115 healthy participants, 34 patients with pre-diabetes and 221 with type 2 diabetes. Urinary albumin-creatinine-ratio, lung function, and transient elastography of the liver were performed in a prospective follow-up study over 4 years. Findings: db/db mice showed an increased nuclear ɤH2AX signal in all tissues as compared to the background control. Markers for DNA damage, senescence, and SASP were increased in patients with diabetes. The presence of nephropathy, restrictive lung disease (RLD), and increased liver stiffness was in a cross-sectional design associated with increased markers for DNA damage, senescence, and SASP. The progression of nephropathy over 4 years was predicted by increased DNA damage, senescence, and SASP, while the progression of RLD was associated with increased DNA damage and IL-6 only. The progression of liver stiffness was not associated with any of these parameters. HbA1c was not predictive for progression. Interpretation: In db/db mice, the cascade of DNA damage is associated with diabetes-related complications. In patients with diabetes, the progression of complications in the kidney and lung is predicted by markers reflecting DNA damage, and senescence-triggered organ fibrosis. Funding: This work was supported by the German Research Foundation (DFG) in the CRC 1118 and CRC 1158, by the GRK DIAMICOM, by the German Center for Diabetes Research (DZD e.V.), and by the Ministry of Science, Research and the Arts, Baden-Württemberg (Kompetenznetzwerk Präventivmedizin).

Published
2023
Full Text
View/download PDF

17. Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function

Author

Wolff, Gretchen, Sakurai, Minako, Mhamane, Amit, Troullinaki, Maria, Maida, Adriano, Deligiannis, Ioannis K., Yin, Kelvin, Weber, Peter, Morgenstern, Jakob, Wieder, Annika, Kwon, Yun, Sekar, Revathi, Zeigerer, Anja, Roden, Michael, Blüher, Matthias, Volk, Nadine, Poth, Tanja, Hackert, Thilo, Wiedmann, Lena, De Angelis Rigotti, Francesca, Rodriguez-Vita, Juan, Fischer, Andreas, Mukthavaram, Rajesh, Limphong, Pattraranee, Tachikawa, Kiyoshi, Karmali, Priya, Payne, Joseph, Chivukula, Padmanabh, Ekim-Üstünel, Bilgen, Martinez-Jimenez, Celia P., Szendrödi, Julia, Nawroth, Peter, and Herzig, Stephan

Published
2022
Full Text
View/download PDF

19. Phase Angle of Bioelectrical Impedance Analysis as an Indicator for Diabetic Polyneuropathy in Type 2 Diabetes Mellitus.

Author

Schimpfle, Lukas, Tsilingiris, Dimitrios, Mooshage, Christoph M, Kender, Zoltan, Sulaj, Alba, Rauchhaupt, Ekatherina von, Szendroedi, Julia, Herzig, Stephan, Goepfert, Jens, Groener, Jan, Nawroth, Peter P, Bendszus, Martin, Heiland, Sabine, Kurz, Felix T, Jende, Johann M E, and Kopf, Stefan

Subjects
MAGNETIC resonance neurography, NERVE conduction studies, TYPE 2 diabetes, BIOELECTRIC impedance, PERIPHERAL nervous system
Abstract

Context Due to the heterogenous clinical symptoms and deficits, the diagnosis of diabetic polyneuropathy (DPN) is still difficult in clinical routines, leading to increased morbidity and mortality. Objective We studied the correlation of phase angle (PhA) of bioelectrical impedance analysis (BIA) with clinical, laboratory, and physical markers of DPN to evaluate PhA as a possible diagnostic method for DPN. Materials and methods In this cross-sectional observational study as part of the Heidelberg Study on Diabetes and Complications, we examined 104 healthy individuals and 205 patients with type 2 diabetes mellitus (T2D), among which 63 had DPN. The PhA was calculated from multifrequency BIA. Nerve conduction studies, quantitative sensory testing (QST) and diffusion-weighted magnetic resonance neurography to determine fractional anisotropy (FA) reflecting peripheral nerve integrity were performed. Results T2D patients with DPN had lower PhA values (5.71 ± 0.10) compared to T2D patients without DPN (6.07 ± 0.08, P =.007, + 6.1%) and healthy controls (6.18 ± 0.08, P <.001, + 7.9%). Confounder-adjusted analyses showed correlations of the PhA with conduction velocities and amplitudes of the peroneal (β=.28; β=.31, P <.001) and tibial nerves (β=.28; β=.32, P <.001), Z-scores of QST (thermal detection β=.30, P <.05) and the FA (β=.60, P <.001). Receiver-operating characteristic analysis showed similar performance of PhA in comparison to the mentioned diagnostic methods. Conclusion The study shows that PhA is, in comparison to other test systems used, at least an equally good and much easier to handle investigator-independent marker for detection of DPN. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

20. Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet is associated with lower visceral and hepatic lipid content in recent‐onset type 1 diabetes and type 2 diabetes.

Author

Schaefer, Edyta, Lang, Alexander, Kupriyanova, Yuliya, Bódis, Kálmán B., Weber, Katharina S., Buyken, Anette E., Barbaresko, Janett, Kössler, Theresa, Kahl, Sabine, Zaharia, Oana‐Patricia, Szendroedi, Julia, Herder, Christian, Schrauwen‐Hinderling, Vera B., Wagner, Robert, Kuss, Oliver, Roden, Michael, and Schlesinger, Sabrina

Subjects
DASH diet, TYPE 2 diabetes, TYPE 1 diabetes, PEOPLE with diabetes, BODY mass index, ADIPOSE tissues
Abstract

Aim: To investigate the associations of the Dietary Approaches to Stop Hypertension (DASH) score with subcutaneous (SAT) and visceral (VAT) adipose tissue volume and hepatic lipid content (HLC) in people with diabetes and to examine whether changes in the DASH diet were associated with changes in these outcomes. Methods: In total, 335 participants with recent‐onset type 1 diabetes (T1D) and type 2 diabetes (T2D) from the German Diabetes Study were included in the cross‐sectional analysis, and 111 participants in the analysis of changes during the 5‐year follow‐up. Associations between the DASH score and VAT, SAT and HLC and their changes were investigated using multivariable linear regression models by diabetes type. The proportion mediated by changes in potential mediators was determined using mediation analysis. Results: A higher baseline DASH score was associated with lower HLC, especially in people with T2D (per 5 points: −1.5% [−2.7%; −0.3%]). Over 5 years, a 5‐point increase in the DASH score was associated with decreased VAT in people with T2D (−514 [−800; −228] cm3). Similar, but imprecise, associations were observed for VAT changes in people with T1D (−403 [−861; 55] cm3) and for HLC in people with T2D (−1.3% [−2.8%; 0.3%]). Body mass index and waist circumference changes explained 8%‐48% of the associations between DASH and VAT changes in both groups. In people with T2D, adipose tissue insulin resistance index (Adipo‐IR) changes explained 47% of the association between DASH and HLC changes. Conclusions: A shift to a DASH‐like diet was associated with favourable VAT and HLC changes, which were partly explained by changes in anthropometric measures and Adipo‐IR. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

21. A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis

Author

Loft, Anne, Schmidt, Søren Fisker, Caratti, Giorgio, Stifel, Ulrich, Havelund, Jesper, Sekar, Revathi, Kwon, Yun, Sulaj, Alba, Chow, Kan Kau, Alfaro, Ana Jimena, Schwarzmayr, Thomas, Rittig, Nikolaj, Svart, Mads, Tsokanos, Foivos-Filippos, Maida, Adriano, Blutke, Andreas, Feuchtinger, Annette, Møller, Niels, Blüher, Matthias, Nawroth, Peter, Szendrödi, Julia, Færgeman, Nils J., Zeigerer, Anja, Tuckermann, Jan, and Herzig, Stephan

Published
2022
Full Text
View/download PDF

27. Improving insulin sensitivity, liver steatosis and fibrosis in type 2 diabetes by a food-based digital education-assisted lifestyle intervention program: a feasibility study

Author

Zaharia, Oana P., Kupriyanova, Yuliya, Karusheva, Yanislava, Markgraf, Daniel F., Kantartzis, Konstantinos, Birkenfeld, Andreas L., Trenell, Michael, Sahasranaman, Aarti, Cheyette, Chris, Kössler, Theresa, Bódis, Kálmán, Burkart, Volker, Hwang, Jong-Hee, Roden, Michael, Szendroedi, Julia, and Pesta, Dominik H.

Published
2021
Full Text
View/download PDF

28. Early changes in hepatic energy metabolism and lipid content in recent-onset type 1 and 2 diabetes mellitus

Author

Roden, M., Al-Hasani, H., Burkart, V., Buyken, A.E., Geerling, G., Hwang, J.H., Herder, C., Icks, A., Jandeleit-Dahm, K., Kahl, S., Kotzka, J., Kuss, O., Lammert, E., Trenkamp, S., Rathmann, W., Szendroedi, J., Ziegler, D., Kupriyanova, Yuliya, Zaharia, Oana Patricia, Bobrov, Pavel, Karusheva, Yanislava, Burkart, Volker, Szendroedi, Julia, Hwang, Jong-Hee, and Roden, Michael

Published
2021
Full Text
View/download PDF

30. Glucose Load Following Prolonged Fasting Increases Oxidative Stress– Linked Response in Individuals With Diabetic Complications.

Author

von Rauchhaupt, Ekaterina, Rodemer, Claus, Kliemank, Elisabeth, Bulkescher, Ruben, Campos, Marta, Kopf, Stefan, Fleming, Thomas, Herzig, Stephan, Nawroth, Peter P., Szendroedi, Julia, Zemva, Johanna, and Sulaj, Alba

Subjects
MONONUCLEAR leukocytes, TYPE 2 diabetes, CITRATE synthase, DIABETES complications, GENE expression, GLUCOSE tolerance tests
Abstract

OBJECTIVE: Prolonged catabolic states in type 2 diabetes (T2D), exacerbated by excess substrate flux and hyperglycemia, can challenge metabolic flexibility and antioxidative capacity. We investigated cellular responses to glucose load after prolonged fasting in T2D. RESEARCH DESIGN AND METHODS: Glucose-tolerant individuals (CON, n = 10) and individuals with T2D with (T2D+, n = 10) and without (T2D−, n = 10) diabetes complications underwent oral glucose tolerance test before and after a 5-day fasting-mimicking diet. Peripheral blood mononuclear cell (PBMC) resistance to ex vivo dicarbonyl methylglyoxal (MG) exposure after glucose load was assessed. Markers of dicarbonyl detoxification, oxidative stress, and mitochondrial biogenesis were analyzed by quantitative PCR, with mitochondrial complex protein expression assessed by Western blotting. RESULTS: T2D+ exhibited decreased PBMC resistance against MG, while T2D− resistance remained unchanged, and CON improved postglucose load and fasting (−19.0% vs. −1.7% vs. 12.6%; all P = 0.017). T2D+ showed increased expression in dicarbonyl detoxification (mRNA glyoxalase-1, all P = 0.039), oxidative stress (mRNA glutathione-disulfide-reductase, all P = 0.006), and mitochondrial complex V protein (all P = 0.004) compared with T2D− and CON postglucose load and fasting. Citrate synthase activity remained unchanged, indicating no change in mitochondrial number. Mitochondrial biogenesis increased in T2D− compared with CON postglucose load and fasting (mRNA HspA9, P = 0.032). T2D−, compared with CON, exhibited increased oxidative stress postfasting, but not postglucose load, with increased mRNA expression in antioxidant defenses (mRNA forkhead box O4, P = 0.036, and glutathione-peroxidase-2, P = 0.034), and compared with T2D+ (glutathione-peroxidase-2, P = 0.04). CONCLUSIONS: These findings suggest increased susceptibility to glucose-induced oxidative stress in individuals with diabetes complications after prolonged fasting and might help in diet interventions for diabetes management. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

31. Resource use and costs of transitioning from paediatric to adult care for patients with chronic endocrine disease.

Author

Choukair, Daniela, Mittnacht, Janna, Treiber, Dorothea, Hoffmann, Georg F., Grasemann, Corinna, Huebner, Angela, Berner, Reinhard, Burgard, Peter, Szendroedi, Julia, and Bettendorf, Markus

Subjects
ENDOCRINOLOGISTS, TRANSITIONAL care, ADULTS, CHRONICALLY ill, SOCIAL workers, YOUNG adults
Abstract

Objective: Structured transition of adolescents and young adults with a chronic endocrine disease from paediatric to adult care is important. Until now, no data on time and resources required for the necessary components of the transition process and the associated costs are available. Design, Patients and Measurements: In a prospective cohort study of 147 patients with chronic endocrinopathies, for the key elements of a structured transition pathway including (i) assessment of patients' disease‐related knowledge and needs, (ii) required education and counselling sessions, (iii) compiling an epicrisis and a transfer appointment of the patient together with the current paediatric and the future adult endocrinologist resource consumption and costs were determined. Results: One hundred and forty‐three of 147 enroled patients (97.3%) completed the transition pathway and were transferred to adult care. The mean time from the decision to start the transition process to the final transfer consultation was 399 ± 159 days. Transfer consultations were performed in 143 patients, including 128 patients jointly with the future adult endocrinologist. Most consultations were performed by a multidisciplinary team consisting of a paediatric and adult endocrinologist, psychologist, nurse, and a social worker acting also as a case manager with a median of three team members and lasted 87.6 ± 23.7 min. The mean cumulative costs per patient of all key elements were 519 ± 206 Euros. In addition, costs for case management through the transition process were 104.8 ± 28.0 Euros. Conclusions: Using chronic endocrine diseases as an example, it shows how to calculate the time and cost of a structured transition pathway from paediatric to adult care, which can serve as a starting point for sustainable funding for other chronic rare diseases. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

33. Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial

Author

Karusheva, Yanislava, Koessler, Theresa, Strassburger, Klaus, Markgraf, Daniel, Mastrototaro, Lucia, Jelenik, Tomas, Simon, Marie-Christine, Pesta, Dominik, Zaharia, Oana-Patricia, Bódis, Kálmán, Bärenz, Felix, Schmoll, Dieter, Wolkersdorfer, Martin, Tura, Andrea, Pacini, Giovanni, Burkart, Volker, Müssig, Karsten, Szendroedi, Julia, and Roden, Michael

Published
2019
Full Text
View/download PDF

34. Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study

Author

Belgardt, Bengt-Frederik, Buyken, Anette, Eckel, Jürgen, Geerling, Gerd, Al-Hasani, Hadi, Herder, Christian, Hwang, Jong-Hee, Icks, Andrea, Kotzka, Jörg, Kuss, Oliver, Lammert, Eckart, Markgraf, Daniel, Müssig, Karsten, Rathmann, Wolfgang, Roden, Michael, Szendroedi, Julia, Ziegler, Dan, Zaharia, Oana P, Strassburger, Klaus, Strom, Alexander, Bönhof, Gidon J, Karusheva, Yanislava, Antoniou, Sofia, Bódis, Kálmán, Markgraf, Daniel F, Burkart, Volker, Asplund, Olof, Groop, Leif, Ahlqvist, Emma, Seissler, Jochen, Nawroth, Peter, Kopf, Stefan, Schmid, Sebastian M, Stumvoll, Michael, Pfeiffer, Andreas F H, Kabisch, Stefan, Tselmin, Sergey, and Häring, Hans U

Published
2019
Full Text
View/download PDF

35. Accumulation of Non-Pathological Liver Fat Is Associated with the Loss of Glyoxalase I Activity in Humans.

Author

Peter, Andreas, Schleicher, Erwin, Kliemank, Elisabeth, Szendroedi, Julia, Königsrainer, Alfred, Häring, Hans-Ulrich, Nawroth, Peter P., and Fleming, Thomas

Subjects
GLYOXALASE, LIQUID chromatography-mass spectrometry, LIVER, SEXUAL dimorphism, LIVER proteins, INSULIN sensitivity
Abstract

The underlying molecular mechanisms for the development of non-alcoholic fatty liver (NAFL) and its progression to advanced liver diseases remain elusive. Glyoxalase 1 (Glo1) loss, leading to elevated methylglyoxal (MG) and dicarbonyl stress, has been implicated in various diseases, including obesity-related conditions. This study aimed to investigate changes in the glyoxalase system in individuals with non-pathological liver fat. Liver biopsies were obtained from 30 individuals with a narrow range of BMI (24.6–29.8 kg/m2). Whole-body insulin sensitivity was assessed using HOMA-IR. Liver biopsies were analyzed for total triglyceride content, Glo1 and Glo2 mRNA, protein expression, and activity. Liquid chromatography–tandem mass spectrometry determined liver dicarbonyl content and oxidation and glycation biomarkers. Liver Glo1 activity showed an inverse correlation with HOMA-IR and liver triglyceride content, but not BMI. Despite reduced Glo1 activity, no associations were found with elevated liver dicarbonyls or glycation markers. A sex dimorphism was observed in Glo1, with females exhibiting significantly lower liver Glo1 protein expression and activity, and higher liver MG-H1 content compared to males. This study demonstrates that increasing liver fat, even within a non-pathological range, is associated with reduced Glo1 activity. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

36. Impaired Detoxification of Trans, Trans‐2,4‐Decadienal, an Oxidation Product from Omega‐6 Fatty Acids, Alters Insulin Signaling, Gluconeogenesis and Promotes Microvascular Disease

Author

Qian, Xin, primary, Klatt, Stephan, additional, Bennewitz, Katrin, additional, Wohlfart, David Philipp, additional, Lou, Bowen, additional, Meng, Ye, additional, Buettner, Michael, additional, Poschet, Gernot, additional, Morgenstern, Jakob, additional, Fleming, Thomas, additional, Sticht, Carsten, additional, Hausser, Ingrid, additional, Fleming, Ingrid, additional, Szendroedi, Julia, additional, Nawroth, Peter Paul, additional, and Kroll, Jens, additional

Published
2023
Full Text
View/download PDF

37. Analysis of type 2 diabetes heterogeneity with a tree-like representation: insights from the prospective German Diabetes Study and the LURIC cohort

Author

Schön, Martin, primary, Prystupa, Katsiaryna, additional, Mori, Tim, additional, Zaharia, Oana P, additional, Bódis, Kálmán, additional, Bombrich, Maria, additional, Möser, Clara, additional, Yurchenko, Iryna, additional, Kupriyanova, Yuliya, additional, Strassburger, Klaus, additional, Bobrov, Pavel, additional, Nair, Anand T N, additional, Bönhof, Gidon J, additional, Strom, Alexander, additional, Delgado, Graciela E, additional, Kaya, Sema, additional, Guthoff, Rainer, additional, Stefan, Norbert, additional, Birkenfeld, Andreas L, additional, Hauner, Hans, additional, Seissler, Jochen, additional, Pfeiffer, Andreas, additional, Blüher, Matthias, additional, Bornstein, Stefan, additional, Szendroedi, Julia, additional, Meyhöfer, Svenja, additional, Trenkamp, Sandra, additional, Burkart, Volker, additional, Schrauwen-Hinderling, Vera B, additional, Kleber, Marcus E, additional, Niessner, Alexander, additional, Herder, Christian, additional, Kuss, Oliver, additional, März, Winfried, additional, Pearson, Ewan R, additional, Roden, Michael, additional, Wagner, Robert, additional, Al-Hasani, Hadi, additional, Belgardt, Bengt-Frederik, additional, Bönhof, Gidon J., additional, Geerling, Gerd, additional, Icks, Andrea, additional, Jandeleit-Dahm, Karin, additional, Kotzka, Jörg, additional, Lammert, Eckhard, additional, Rathmann, Wolfgang, additional, Schlesinger, Sabrina, additional, and Schrauwen-Hinderling, Vera, additional

Published
2023
Full Text
View/download PDF

38. A diminished sciatic nerve structural integrity is associated with distinct peripheral sensory phenotypes in individuals with type 2 diabetes

Author

Mooshage, Christoph M., primary, Tsilingiris, Dimitrios, additional, Schimpfle, Lukas, additional, Seebauer, Lukas, additional, Eldesouky, Omar, additional, Aziz-Safaie, Taraneh, additional, Hohmann, Anja, additional, Herzig, Stephan, additional, Szendroedi, Julia, additional, Nawroth, Peter, additional, Heiland, Sabine, additional, Bendszus, Martin, additional, Kurz, Felix T., additional, Kopf, Stefan, additional, Jende, Johann M. E., additional, and Kender, Zoltan, additional

Published
2023
Full Text
View/download PDF

39. Reduced insulin clearance differently relates to increased liver lipid content and worse glycemic control in recent-onset type 2 and type 1 diabetes mellitus

Author

Zaharia, Oana-Patricia, primary, Antoniou, Sofia, primary, Bobrov, Pavel, primary, Karusheva, Yanislava, primary, Bódis, Kálmán, primary, Kupriyanova, Yuliya, primary, Schrauwen-Hinderling, Vera B., primary, Gastaldelli, Amalia, primary, Szendroedi, Julia, primary, Wagner, Robert, primary, Burkart, Volker, primary, and Roden, Michael, primary

Published
2023
Full Text
View/download PDF

41. Analysis of type 2 diabetes heterogeneity with a tree-like representation: insights from the prospective German Diabetes Study and the LURIC cohort

Author

Schön, Martin, Prystupa, Katsiaryna, Mori, Tim, Zaharia, Oana P, Bódis, Kálmán, Bombrich, Maria, Möser, Clara, Yurchenko, Iryna, Kupriyanova, Yuliya, Strassburger, Klaus, Bobrov, Pavel, Nair, Anand T N, Bönhof, Gidon J, Strom, Alexander, Delgado, Graciela E, Kaya, Sema, Guthoff, Rainer, Stefan, Norbert, Birkenfeld, Andreas L, Hauner, Hans, Seissler, Jochen, Pfeiffer, Andreas, Blüher, Matthias, Bornstein, Stefan, Szendroedi, Julia, Meyhöfer, Svenja, Trenkamp, Sandra, Burkart, Volker, Schrauwen-Hinderling, Vera B, Kleber, Marcus E, Niessner, Alexander, Herder, Christian, Kuss, Oliver, März, Winfried, Pearson, Ewan R, Roden, Michael, Wagner, Robert, Al-Hasani, Hadi, Belgardt, Bengt-Frederik, Bönhof, Gidon J., Geerling, Gerd, Herder, Christian, Icks, Andrea, Jandeleit-Dahm, Karin, Kotzka, Jörg, Kuss, Oliver, Lammert, Eckhard, Rathmann, Wolfgang, Roden, Michael, Schlesinger, Sabrina, Schrauwen-Hinderling, Vera, Szendroedi, Julia, Trenkamp, Sandra, and Wagner, Robert

Abstract

Heterogeneity in type 2 diabetes can be represented by a tree-like graph structure by use of reversed graph-embedded dimensionality reduction. We aimed to examine whether this approach can be used to stratify key pathophysiological components and diabetes-related complications during longitudinal follow-up of individuals with recent-onset type 2 diabetes.

Published
2024
Full Text
View/download PDF

49. Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes.

Author

Mooshage, Christoph M, primary, Tsilingiris, Dimitrios, additional, Schimpfle, Lukas, additional, Kender, Zoltan, additional, Aziz-Safaie, Taraneh, additional, Hohmann, Anja, additional, Szendroedi, Julia, additional, Nawroth, Peter, additional, Sturm, Volker, additional, Heiland, Sabine, additional, Bendszus, Martin, additional, Kopf, Stefan, additional, Kurz, Felix T, additional, and Jende, Johann M E, additional

Published
2023
Full Text
View/download PDF

50. Association of Small Fiber Function with Microvascular Perfusion of Peripheral Nerves in Patients with Type 2 Diabetes

Author

Mooshage, Christoph M., primary, Schimpfle, Lukas, additional, Kender, Zoltan, additional, Tsilingiris, Dimitrios, additional, Aziz-Safaie, Taraneh, additional, Hohmann, Anja, additional, Szendroedi, Julia, additional, Nawroth, Peter, additional, Sturm, Volker, additional, Heiland, Sabine, additional, Bendszus, Martin, additional, Kopf, Stefan, additional, Kurz, Felix T., additional, and Jende, Johann M. E., additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results