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Background and Objectives: Intrahepatic cholestasis of pregnancy (ICP) stands as one of the most prevalent concerns in maternal–fetal medicine, presenting a significant risk to fetal health and often associated with liver dysfunction. Concurrently, the coronavirus-19 (COVID-19) infection can lead to hepatic cell injury through both direct and indirect pathways. Hypothetically, these two conditions may coincide, influencing each other. This study aimed to comparatively assess the incidence and severity of ICP before and during the COVID-19 pandemic. Methods: A retrospective cohort study was conducted, comparing the incidence and severity of ICP between January 2018 and February 2020 (pre-COVID-19 period) and March 2020 to March 2022 (COVID-19 period) across two hospitals, encompassing 7799 deliveries. The diagnosis of ICP was established using the ICD-10 code and defined as total bile acids (BA) levels ≥ 10 μmol/L. Statistical analysis included descriptive statistics, Chi-square and Mann–Whitney U tests, as well as multiple or logistic regression analysis. Results: A total of 226 cases of ICP were identified. The incidence of mild cholestasis (BA < 40 μmol/L) was lower during the pandemic compared to before (3% before versus 2%, p < 0.05), while the incidence of moderate and severe ICP remained unchanged (0.6% before vs. 0.4%, p = 0.2). Overall, the total incidence of ICP was lower during the pandemic (3.6% before versus 2.4%, p = 0.01). No significant differences were observed in severity (as defined by BA and liver function test levels), rates of caesarean section, or neonatal birth weights. Conclusions: During the COVID-19 pandemic, the total incidence of ICP appeared to be lower. However, this reduction was primarily observed in cases of mild ICP, potentially indicating challenges in detection or reduced access to medical services during this period. The incidence of moderate and severe ICP remained unchanged, suggesting that these forms of the condition were unaffected by the pandemic’s circumstances.

In the pursuit of understanding the population of stellar remnants within the Milky Way, we analyze the sample of ∼950 microlensing events observed by the Spitzer Space Telescope between 2014 and 2019. In this study we focus on a subsample of nine microlensing events, selected based on their long timescales, small microlensing parallaxes, and joint observations by the Gaia mission, to increase the probability that the chosen lenses are massive and the mass is measurable. Among the selected events we identify lensing black holes and neutron star candidates, with potential confirmation through forthcoming release of the Gaia time-series astrometry in 2026. Utilizing Bayesian analysis and Galactic models, along with the Gaia Data Release 3 proper-motion data, four good candidates for dark remnants were identified: OGLE-2016-BLG-0293, OGLE-2018-BLG-0483, OGLE-2018-BLG-0662, and OGLE-2015-BLG-0149, with lens masses of ${3.0}_{-1.3}^{+1.8}\,{M}_{\odot }$ , ${4.7}_{-2.1}^{+3.2}\,{M}_{\odot }$ , ${3.15}_{-0.64}^{+0.66}\,{M}_{\odot }$ and ${1.40}_{-0.55}^{+0.75}\,{M}_{\odot }$ , respectively. Notably, the first two candidates are expected to exhibit astrometric microlensing signals detectable by Gaia, offering the prospect of validating the lens masses. The methodologies developed in this work will be applied to the full Spitzer microlensing sample, populating and analyzing the timescale ( t _E ) versus parallax ( π _E ) diagram to derive constraints on the population of lenses in general and massive remnants in particular.

We report the analysis of four unambiguous planets and one possible planet from the subprime fields (Γ ≤ 1 hr ^−1 ) of the 2017 Korea Microlensing Telescope Network (KMTNet) microlensing survey, to complete the KMTNet AnomalyFinder planetary sample for the 2017 subprime fields. They are KMT-2017-BLG-0849, KMT-2017-BLG-1057, OGLE-2017-BLG-0364, and KMT-2017-BLG-2331 (unambiguous), as well as KMT-2017-BLG-0958 (possible). For the four unambiguous planets, the mean planet–host mass ratios, q , are (1.0, 1.2, 4.6, 13) × 10 ^−4 , the median planetary masses are (6.4, 24, 76, 171) M _⊕ , and the median host masses are (0.19, 0.57, 0.49, 0.40) M _⊙ , respectively, found from a Bayesian analysis. We have completed the Anomaly Finder planetary sample from the first 4 yr of KMTNet data (2016–2019), with 112 unambiguous planets in total, which nearly tripled the microlensing planetary sample. The “sub-Saturn desert” ( $\mathrm{log}q=\left[-3.6,-3.0\right]$ ) found in the 2018 and 2019 KMTNet samples is confirmed by the 2016 and 2017 KMTNet samples.

Measurements of the microlensing optical depth and event rate toward the Large Magellanic Cloud (LMC) can be used to probe the distribution and mass function of compact objects in the direction toward that galaxy—in the Milky Way disk, the Milky Way dark matter halo, and the LMC itself. The previous measurements, based on small statistical samples of events, found that the optical depth is an order of magnitude smaller than that expected from the entire dark matter halo in the form of compact objects. However, these previous studies were not sensitive to long-duration events with Einstein timescales longer than 2.5–3 yr, which are expected from massive (10–100 M _⊙ ) and intermediate-mass (10 ^2 –10 ^5 M _⊙ ) black holes. Such events would have been missed by the previous studies and would not have been taken into account in calculations of the optical depth. Here, we present the analysis of nearly 20 yr long photometric monitoring of 78.7 million stars in the LMC by the Optical Gravitational Lensing Experiment (OGLE) from 2001 through 2020. We describe the observing setup, the construction of the 20 yr OGLE data set, the methods used for searching for microlensing events in the light-curve data, and the calculation of the event detection efficiency. In total, we find 16 microlensing events (13 using an automated pipeline and three with manual searches), all of which have timescales shorter than 1 yr. We use a sample of 13 events to measure the microlensing optical depth toward the LMC τ = (0.121 ± 0.037) × 10 ^−7 and the event rate Γ = (0.74 ± 0.25) × 10 ^−7 yr ^−1 star ^−1 . These numbers are consistent with lensing by stars in the Milky Way disk and the LMC itself, and they demonstrate that massive and intermediate-mass black holes cannot comprise a significant fraction of the dark matter.

Following Shin et al. (2023b), which is a part of the “Systematic KMTNet Planetary Anomaly Search” series (i.e., a search for planets in the 2016 KMTNet prime fields), we conduct a systematic search of the 2016 KMTNet subprime fields using a semi-machine-based algorithm to identify hidden anomalous events missed by the conventional by-eye search. We find four new planets and seven planet candidates that were buried in the KMTNet archive. The new planets are OGLE-2016-BLG-1598Lb, OGLE-2016-BLG-1800Lb, MOA-2016-BLG-526Lb, and KMT-2016-BLG-2321Lb, which show typical properties of microlensing planets, i.e., giant planets orbit M-dwarf host stars beyond their snow lines. For the planet candidates, we find planet/binary or 2L1S/1L2S degeneracies, which are an obstacle to firmly claiming planet detections. By combining the results of Shin et al. (2023b) and this work, we find a total of nine hidden planets, which is about half the number of planets discovered by eye in 2016. With this work, we have met the goal of the systematic search series for 2016, which is to build a complete microlensing planet sample. We also show that our systematic searches significantly contribute to completing the planet sample, especially for planet/host mass ratios smaller than 10 ^−3 , which were incomplete in previous by-eye searches of the KMTNet archive.

We use the spectroscopic data collected by the Magellanic Quasars Survey (MQS) and the photometric V - and I -band data from the Optical Gravitational Lensing Experiment (OGLE) to measure the physical parameters for active galactic nuclei (AGNs) located behind the Magellanic Clouds. The flux-uncalibrated MQS spectra were obtained with the 4 m Anglo-Australian Telescope and the AAOmega spectroscope ( R = 1300) in a typical ∼1.5 hr visit. They span a spectral range of 3700–8500 Å and have signal-to-noise ratios in a range of 3–300. We report the discovery and observational properties of 161 AGNs in this footprint, which expands the total number of spectroscopically confirmed AGNs by MQS to 919. After the conversion of the OGLE mean magnitudes to the monochromatic luminosities at 5100, 3000, and 1350 Å, we were able to reliably measure the black hole masses for 165 out of 919 AGNs. The remaining physical parameters we provide are the bolometric luminosities and the Eddington ratios. A fraction of these AGNs have been observed by the OGLE survey since 1997 (all of them since 2001), enabling studies of correlations between the variability and physical parameters of these AGNs.

The gravitational microlensing technique is most sensitive to planets in a Jupiter-like orbit and has detected more than 200 planets. However, only a few wide-orbit ( s > 2) microlensing planets have been discovered, where s is the planet-to-host separation normalized to the angular Einstein ring radius, θ _E . Here, we present the discovery and analysis of a strong candidate wide-orbit microlensing planet in the event OGLE-2017-BLG-0448. The whole light curve exhibits long-term residuals to the static binary-lens single-source model, so we investigate the residuals by adding the microlensing parallax, microlensing xallarap, an additional lens, or an additional source. For the first time, we observe a complex degeneracy between all four effects. The wide-orbit models with s ∼ 2.5 and a planet-to-host mass ratio of q ∼ 10 ^−4 are significantly preferred, but we cannot rule out the close models with s ∼ 0.35 and q ∼ 10 ^−3 . A Bayesian analysis based on a Galactic model indicates that, despite the complicated degeneracy, the surviving wide-orbit models all contain a super-Earth-mass to Neptune-mass planet at a projected planet-host separation of ∼6 au and the surviving close-orbit models all consist of a Jovian-mass planet at ∼1 au. The host star is probably an M or K dwarf. We discuss the implications of this dimension-degeneracy disaster on microlensing light-curve analysis and its potential impact on statistical studies.

We present the analysis of the microlensing event OGLE-2014-BLG-0221, a planetary candidate event discovered in 2014. The photometric light curve is best described by a binary-lens single-source model. Our light-curve modeling finds two degenerate models, with event timescales of t _E ∼ 70 days and ∼110 days. These timescales are relatively long, indicating that the discovered system would possess a substantial mass. The two models are similar in their planetary parameters with a Jupiter mass ratio of q ∼ 10 ^−3 and a separation of s ∼ 1.1. Bayesian inference is used to estimate the physical parameters of the lens, revealing that the shorter timescale model predicts 65% and 25% probabilities of a late-type star and white dwarf host, respectively, while the longer timescale model favors a black hole host with a probability ranging from 60% to 95%, under the assumption that stars and stellar remnants have equal probabilities of hosting companions with planetary mass ratios. If the lens is a remnant, this would be the second planet found by microlensing around a stellar remnant. The current separation between the source and lens stars is 41–139 mas depending on the models. This indicates the event is now ready for high-angular-resolution follow-up observations to rule out either of the models. If precise astrometric measurements are conducted in multiple bands, the centroid shift due to the color difference between the source and lens would be detected in the luminous lens scenario.

We complete the analysis of planetary candidates found by the KMT AnomalyFinder for the 2017 prime fields that cover ∼13 deg ^2 . We report three unambiguous planets: OGLE-2017-BLG-0640, OGLE-2017-BLG-1275, and OGLE-2017-BLG-1237. The first two of these were not previously identified, while the last was not previously published due to technical complications induced by a nearby variable. We further report that a fourth anomalous event, the previously recognized OGLE-2017-BLG-1777, is very likely to be planetary, although its light curve requires unusually complex modeling because the lens and source both have orbiting companions. One of the three unambiguous planets, OGLE-2017-BLG-1275, is the first AnomalyFinder discovery that has a Spitzer microlens parallax measurement, π _E ≃ 0.045 ± 0.015, implying that this planetary system almost certainly lies in the Galactic bulge. In the order listed, the four planetary events have planet-host mass ratios q and normalized projected separations s of $(\mathrm{log}q,s)=(-2.31,0.61)$ , (−2.06, 0.63/1.09), (−2.10, 1.04), and (−2.86, 0.72). Combined with previously published events, the 2017 prime fields contain 11 unambiguous planets with well-measured q and one very likely candidate, of which three are AnomalyFinder discoveries. In addition to these 12, there are three other unambiguous planets with large uncertainties in q .

Abstract Background In utero limb ischemia is a rare complication of the monochorionic twin pregnancies complicated with twin to twin transfusion syndrome (TTTS). The condition is more often seen in recipient twins. There are few theories of the pathogenesis including in utero venous thromboembolism, but the cause remains unclear. However, limb ischemia is thought to be unrelated with any prenatal intervention. Case Presentation We present a case of a monochorionic twin pregnancy complicated with TTTS admitted to the Clinic for selective fetoscopic laser photocoagulation. The invasive procedure failed due to poor visibility. In the following weeks of pregnancy, amnioreduction procedures were performed. At 28 weeks of gestation due to twin anemia-polycythemia sequence diagnosis the patient was qualified for cesarean section. Postnatally, the donor twin was diagnosed with lower right limb ischemic necrosis. The extremity was amputated 2 days later with an uncomplicated recovery. After speculations of the potential pathogeneses it was suggested that the ischemic limb occurred as a complication of the main condition – TTTS. Conclusions In literature, there have been no cases reported of TTTS stage I complicated with donor twin limb ischemia. The actual cause of the in utero limb ischemic necrosis in monochorionic twins remains unknown. Nevertheless, increased attention to the potential complication after failed invasive procedures or conservative treatment should be required.

We report on the discovery and analysis of the planetary microlensing event OGLE-2019-BLG-1180 with a planet-to-star mass ratio q ∼ 0.003. The event OGLE-2019-BLG-1180 has unambiguous cusp-passing and caustic-crossing anomalies, which were caused by a wide planetary caustic with s ≃ 2, where s is the star–planet separation in units of the angular Einstein radius θ _E . Thanks to well-covered anomalies by the Korea Micorolensing Telescope Network (KMTNet), we measure both the angular Einstein radius and the microlens parallax in spite of a relatively short event timescale of t _E = 28 days. However, because of a weak constraint on the parallax, we conduct a Bayesian analysis to estimate the physical lens parameters. We find that the lens system is a super-Jupiter-mass planet of ${M}_{{\rm{p}}}={1.75}_{-0.51}^{+0.53}\,{M}_{{\rm{J}}}$ orbiting a late-type star of ${M}_{{\rm{h}}}={0.55}_{-0.26}^{+0.27}\,{M}_{\odot }$ at a distance ${D}_{{\rm{L}}}={6.1}_{-1.3}^{+0.9}\,\mathrm{kpc}$ . The projected star–planet separation is ${a}_{\perp }={5.19}_{-1.23}^{+0.90}\,\mathrm{au}$ , which means that the planet orbits at about four times the snow line of the host star. Considering the relative lens–source proper motion of μ _rel = 6 mas yr ^−1 , the lens will be separated from the source by 60 mas in 2029. At that time one can measure the lens flux from adaptive optics imaging of Keck or a next-generation 30 m class telescope. OGLE-2019-BLG-1180Lb represents a growing population of wide-orbit planets detected by KMTNet, so we also present a general investigation into prospects for further expanding the sample of such planets.

We present an analysis of microlensing event OGLE-2019-BLG-0825. This event was identified as a planetary candidate by preliminary modeling. We find that significant residuals from the best-fit static binary-lens model exist and a xallarap effect can fit the residuals very well and significantly improves χ ^2 values. On the other hand, by including the xallarap effect in our models, we find that binary-lens parameters such as mass ratio, q , and separation, s , cannot be constrained well. However, we also find that the parameters for the source system such as the orbital period and semimajor axis are consistent between all the models we analyzed. We therefore constrain the properties of the source system better than the properties of the lens system. The source system comprises a G-type main-sequence star orbited by a brown dwarf with a period of P ∼ 5 days. This analysis is the first to demonstrate that the xallarap effect does affect binary-lens parameters in planetary events. It would not be common for the presence or absence of the xallarap effect to affect lens parameters in events with long orbital periods of the source system or events with transits to caustics, but in other cases, such as this event, the xallarap effect can affect binary-lens parameters.

As a part of the “Systematic KMTNet Planetary Anomaly Search” series, we report five new planets (namely, OGLE-2016-BLG-1635Lb, MOA-2016-BLG-532Lb, KMT-2016-BLG-0625Lb, OGLE-2016-BLG-1850Lb, and KMT-2016-BLG-1751Lb) and one planet candidate (KMT-2016-BLG-1855), which were found by searching 2016 KMTNet prime fields. These buried planets show a wide range of masses from Earth-class to super-Jupiter-class and are located in both the disk and the bulge. The ultimate goal of this series is to build a complete planet sample. Because our work provides a complementary sample to other planet detection methods, which have different detection sensitivities, our complete sample will help us to obtain a better understanding of planet demographics in our Galaxy.

We complete the publication of all microlensing planets (and “possible planets”) identified by the uniform approach of the KMT AnomalyFinder system in the 21 KMT subprime fields during the 2019 observing season, namely, KMT-2019-BLG-0298, KMT-2019-BLG-1216, KMT-2019-BLG-2783, OGLE-2019-BLG-0249, and OGLE-2019-BLG-0679 (planets), as well as OGLE-2019-BLG-0344 and KMT-2019-BLG-0304 (possible planets). The five planets have mean log mass ratio measurements of (−2.6, −3.6, −2.5, −2.2, −2.3), median mass estimates of (1.81, 0.094, 1.16, 7.12, 3.34) M _Jup , and median distance estimates of (6.7, 2.7, 5.9, 6.4, 5.6) kpc, respectively. The main scientific interest of these planets is that they complete the AnomalyFinder sample for 2019, which has a total of 25 planets that are likely to enter the statistical sample. We find statistical consistency with the previously published 33 planets from the 2018 AnomalyFinder analysis according to an ensemble of five tests. Of the 58 planets from 2018–2019, 23 were newly discovered by AnomalyFinder. Within statistical precision, half of the planets have caustic crossings, while half do not; an equal number of detected planets result from major- and minor-image light-curve perturbations; and an equal number come from KMT prime fields versus subprime fields.

We present the analysis of seven microlensing planetary events with planet/host mass ratios q < 10 ^−4 : KMT-2017-BLG-1194, KMT-2017-BLG-0428, KMT-2019-BLG-1806, KMT-2017-BLG-1003, KMT-2019-BLG-1367, OGLE-2017-BLG-1806, and KMT-2016-BLG-1105. They were identified by applying the Korea Microlensing Telescope Network (KMTNet) AnomalyFinder algorithm to 2016–2019 KMTNet events. A Bayesian analysis indicates that all the lens systems consist of a cold super-Earth orbiting an M or K dwarf. Together with 17 previously published and three that will be published elsewhere, AnomalyFinder has found a total of 27 planets that have solutions with q < 10 ^−4 from 2016–2019 KMTNet events, which lays the foundation for the first statistical analysis of the planetary mass-ratio function based on KMTNet data. By reviewing the 27 planets, we find that the missing planetary caustics problem in the KMTNet planetary sample has been solved by AnomalyFinder. We also find a desert of high-magnification planetary signals ( A ≳ 65), and a follow-up project for KMTNet high-magnification events could detect at least two more q < 10 ^−4 planets per year and form an independent statistical sample.

We study the three-dimensional structure of the Milky Way using 65,981 Mira variable stars discovered by the Optical Gravitational Lensing Experiment survey. The spatial distribution of the Mira stars is analyzed with a model containing three barred components that include the X-shaped boxy component in the Galactic center (GC) and an axisymmetric disk. We take into account the distance uncertainties by implementing the Bayesian hierarchical inference method. The distance to the GC is R _0 = 7.66 ± 0.01(stat.) ± 0.39(sys.) kpc, while the inclination of the major axis of the bulge to the Sun–GC line of sight is θ = 20.°2 ± 0.°6(stat.) ± 0.°7(sys.). We present, for the first time, a detailed three-dimensional map of the Milky Way composed of young and intermediate-age stellar populations. Our analysis provides independent evidence for both the X-shaped bulge component and the flaring disk (being plausibly warped). We provide the complete data set of properties of Miras that were used for calculations in this work. The table includes mean brightness and amplitudes in nine photometric bands (covering a range of wavelengths from 0.5 to 12 μ m), photometric chemical type, estimated extinction, and calculated distance with its uncertainty for each Mira variable. The median distance accuracy to a Mira star is at the level of 6.6%.

Pregnancy is a well-known factor for vaccine hesitancy and immunization remains the most effective form of prevention against coronavirus disease (COVID-19) related complications. The objective was to estimate vaccine uptake and hesitancy rate, characteristics, and factors contributing to a decision-making process among pregnant and postpartum individuals. This was a prospective cross-sectional study on 1033 pregnant (54.1%) and postpartum (45.9%) women conducted between December 2021 and March 2022 in a tertiary center for maternal–fetal medicine. Logistic regression was used to assess characteristics related to the vaccination decision process. Among responders, 74% were vaccinated and 26% were hesitant (9% planning to vaccinate and 17% totally opposed). Only 59.8% were offered a vaccine by healthcare professionals. Women with higher levels of education (OR 2.26, p < 0.0001), who received positive feedback about vaccination (OR 2.74, p = 0.0172), or were informed about COVID-19 complications in pregnancy (OR 2.6, p < 0.0001) were most likely to accept the vaccination. Hesitancy was associated with multiparity (≥3, OR 4.76, p = 0.006), worse educational status (OR 2.29, p < 0.0001), and lack of previous COVID-19 infection (OR 1.89, p < 0.0001). The most common reason for rejection was insufficient safety data (57%). Understanding factors behind vaccination status is crucial in lowering complications in mothers and newborns and targeted action may facilitate the uptake.

Fetal growth restriction (FGR) is one of the most formidable challenges in present-day antenatal care. Pathological fetal growth is a well-known factor of not only in utero demise in the third trimester, but also postnatal morbidity and unfavorable developmental outcomes, including long-term sequalae such as metabolic diseases, diabetic mellitus or hypertension. In this review, the authors present the current state of knowledge about the genetic disturbances responsible for FGR diagnosis, divided into fetal, placental and maternal causes (including preeclampsia), as well as their impact on prenatal diagnostics, with particular attention on chromosomal microarray (CMA) and noninvasive prenatal testing technique (NIPT).

Background: Preeclampsia occurs more often in dichorionic than in monochorionic twin pregnancy. We hypothesize that serum concentrations of biomarkers: placental growth factor (PlGF), serum soluble fms-like tyrosine kinase-1 (sFlt-1), and endoglin (Eng) differ between monochorionic and dichorionic twin pregnancies. Methods: A prospective observational study including 43 monochorionic and 36 dichorionic twin gestation was conducted. Blood samples were collected twice from all participants: between 11 + 0 and 13 + 6 and between 32 + 0 and 34 + 0 weeks of gestation. PlGF, sFlt-1 and Eng were measured using immnunoenzymatic assays. Results: We found a significantly higher concentration of sFlt-1 in dichorionic in comparison to monochorionic pregnancies in both the first and third trimesters. PlGF and sEng levels did not differ between mono- and dichorionic gestation in both study periods. sFlt-1 level was related to twin gestation chorionicity, while PlGF expression was not. PlGF, sFlt-1 and sEng concentrations increased significantly during gestation and were much higher in the third trimester compared to the values measured in the first trimester. Conclusions: Angiogenic biomarkers expression differ between dichorionic and monochorionic twin pregnancy. The sFlt-1 level is related to chorionicity of a twin gestation.

We report the selection of blazar candidates behind the Large and Small Magellanic Clouds. Both flat spectrum radio quasar and BL Lacreate objects were selected based on the long-term, multi-colour Optical Gravitational Lensing Experiment photometric data. We cross-correlated the Magellanic Quasar Survey catalogue of spectroscopically confirmed quasars and quasar candidates located behind the Magellanic Clouds with the radio data at six frequencies from 0.8 to 20 GHz. Among the 1654 objects visible in optical range, we identified a sample of 44 newly selected blazar candidates, including 27 flat spectrum radio quasars and 17 BL Lacs. We examined selected objects with respect to their radio, optical, and mid-infrared properties.