Search

HHV‐6B is the subtype most often involved in the systemic manifestations of the DRESS, but also in myelosuppression in bone marrow transplant. We report a new observation of its myelosuppressive effect: a case of DRESS complicated by agranulocytosis with detectable HHV‐6 RNA in bone marrow. [ABSTRACT FROM AUTHOR]

Background: Allergic contact dermatitis to gloves is mostly induced by rubber accelerators. The European baseline series (EBS) appears insufficient to detect glove allergy. Since 2017, it is recommended to use the European rubber series (ERS) and to test the patients' own gloves. Objectives: To investigate the clinical profile of glove‐wearing patients with hand eczema (HE) and to evaluate their sensitisation profile to glove allergens and the value of testing the patients' own gloves. Methods: We conducted a French multicentre study of patients evaluated for HE between 2018 and 2020 and tested with the EBS, the ERS and their own gloves in patch tests and semi‐open (SO) tests. Results: A total of 279 patients were included; 32.6% of patients had positive tests to their own gloves or to glove allergens. Almost 45% of the sensitisations to glove allergens were detected only by the ERS. Among the patients tested both in patch tests and SO tests with their own gloves with positive results, 28% had positive SO tests only. Polyvinylchloride (PVC) gloves were positive in four patients. Conclusion: Our series confirms the need to test the ERS. All the patients' gloves must also be tested including PVC gloves. SO tests with gloves are useful as a complement to patch tests. [ABSTRACT FROM AUTHOR]

Background: An aqueous antiseptic containing "chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol" (CBB) is widely used in France. The only previous documented study dealing with allergic contact dermatitis (ACD) to this antiseptic is one small case series in children. The French Vigilance Network for Dermatology and Allergy (REVIDAL‐GERDA) has collected many cases in the last few years. Objectives: To evaluate the clinical and sensitization profiles of patients diagnosed with ACD to CBB. Methods: We performed a retrospective study of patients with contact dermatitis to CBB and positive tests to CBB and/or at least one of its components. All patients had to be tested with all components of CBB. Results: A total of 102 patients (71 adults and 31 children) were included. The lesions were extensive in 63% of patients and 55% had delayed time to diagnosis. CBB patch tests were positive in 93.8% of cases. The allergen was identified in 97% of patients, mainly benzyl alcohol in adults (81.7%) and chlorhexidine digluconate in children (54.8%). About 32.4% of the patients were sensitized to several components. Conclusion: CBB is a cause of ACD at all ages. The components of the antiseptic should be tested. The sensitization profile seems to be different between adults and children. [ABSTRACT FROM AUTHOR]

Laboratory tests also indicated past EBV infection (positive epstein-barr nuclear antigen (EBNA) and viral capsid antigen immunoglobulin G, negative EBNA immunoglobulin M) with EBV viral load in blood at 1254 copies/mL (normal: <250 copies/mL). Keywords: acute generalized exanthematous pustulosis; case report; drug reaction with eosinophilia and systemic symptoms; Epstein-Barr virus; miconazole EN acute generalized exanthematous pustulosis case report drug reaction with eosinophilia and systemic symptoms Epstein-Barr virus miconazole 474 476 3 05/06/21 20210601 NES 210601 Acute generalized exanthematous pustulosis (AGEP) is a severe and potentially life-threatening cutaneous reaction characterized by the rapid development of sterile pustules, especially on intertriginous regions. [Extracted from the article]

We recommended avoiding alcohol consumptions, using alcohol-free cosmetics, and disinfecting her hand with alcohol-free hand sanitizers. Keywords: alcohol; case report; contact urticaria; ethanol; hand sanitizer EN alcohol case report contact urticaria ethanol hand sanitizer 457 458 2 10/06/22 20221101 NES 221101 Hand disinfection is a milestone of hand hygiene highlighted in the context of the COVID-19 pandemic. [Extracted from the article]

Aims: Linear immunoglobin A (IgA) bullous dermatosis is a rare autoimmune dermatosis considered spontaneous or drug‐induced (DILAD). We assessed all DILAD cases, determined the imputability score of drugs and highlighted suspected drugs. Methods: Data for patients with DILAD were collected retrospectively from the French Pharmacovigilance network (from 1985 to 2017) and from physicians involved in the Bullous Diseases French Study Group and the French Investigators for Skin Adverse Reactions to Drugs. Drug causality was systematically determined by the French imputability method. Results: Of the 69 patients, 42% had mucous membrane involvement, 20% lesions mimicking toxic epidermal necrolysis (TEN), 21% eosinophil infiltrates and 10% keratinocytes necrosis. Direct immunofluorescence, in 80%, showed isolated linear IgA deposits. Vancomycin (VCM) was suspected in 39 cases (57%), 11 had TEN‐like lesions, as compared with three without VCM suspected. Among the 33 patients with a single suspected drug, 85% had an intrinsic imputability score of I4. Among them, enoxaparin, minocycline and vibramycin were previously unpublished. For all patients, the suspect drug was withdrawn; 15 did not receive any treatment. First‐line therapy for 31 patients was topical steroids. Among the 60 patients with available follow‐up, 52 achieved remission, 10 without treatment. Four patients experienced relapse, four died and five had positive accidental rechallenges. Conclusions: There is no major clinical difference between DILAD and idiopathic linear IgA bullous dermatosis, but the former features a higher prevalence of patients mimicking TEN. VCM, suspected in more than half of the cases, might be responsible for more severe clinical presentations. We report three new putative drugs. [ABSTRACT FROM AUTHOR]

Allergic contact dermatitis from sorbic acid contained in an oil-limestone liniment Allergic contact dermatitis, case report, leg ulcers, oil-limestone liniment, sorbic acid Keywords: allergic contact dermatitis; case report; leg ulcers; oil-limestone liniment; sorbic acid EN allergic contact dermatitis case report leg ulcers oil-limestone liniment sorbic acid 89 90 2 06/14/22 20220701 NES 220701 Oil-limestone liniment (OLL), also called oleo-calcareous liniment, is a pharmaceutical preparation that exhibits high emollient properties when applied to the skin. [Extracted from the article]

Keywords: case report; occupational allergy; podiatrists; resin EN case report occupational allergy podiatrists resin 521 522 2 11/26/20 20201201 NES 201201 The risk of developing hand dermatitis is significantly greater among healthcare professionals than in the general population, and the condition predominantly affects nurses, nursing auxiliaries, and cleaners.1 The combination in healthcare professionals of frequent handwashing and glove wearing may promote irritant contact dermatitis that can evolve into allergic contact dermatitis.2 Podiatrists are no exception, but in this occupation, other substances can cause allergies, and in particular resins used in the manufacture of insoles.3 We report two cases of allergic contact dermatitis in podiatrists caused by phenol-formaldehyde and epoxy resin, respectively. In conclusion, in podiatrists, it is important not to overlook any part of their activity, in particular the handling of insoles made with chemicals such as resins, which can cause contact dermatitis. [Extracted from the article]