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1. Pegylated interferon-alfa plus ribavirin therapies for chronic hepatitis C

Author

T Kanda and O Yokosuka

Subjects
Medicine (General), R5-920
Abstract

Until HCV NS3/4A protease inhibitors become available at the end of 2011, the combination pegylated-interferon (PEG-IFN)-alfa and ribavirin (RBV) will remain the standard treatment for chronic hepatitis C patients. In some hepatitis C virus-infected patients, PEG-IFN plus RBV treatment against HCV should continue to be used because of side effects of new drugs such as anemia. Our Japanese experiences should provide new information for the treatment of chronic hepatitis C. Keywords: Direct-acting antiviral agents (DAA), HCV, pegylated interferon, ribavirin, standard of care (SOC ).

Published
2011
Full Text
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5. Infants’ Prediction of Humanoid Robot’s Goal-Directed Action

Author

F. Manzi, M. Ishikawa, C. Di Dio, S. Itakura, T. Kanda, H. Ishiguro, D. Massaro, and A. Marchetti

Subjects
Human-Computer Interaction, Philosophy, Settore M-PSI/04 - PSICOLOGIA DELLO SVILUPPO E PSICOLOGIA DELL'EDUCAZIONE, General Computer Science, Social Psychology, Control and Systems Engineering, Goal-directed action, Humanoid robot, Robot’s face, Electrical and Electronic Engineering, Infants, Action prediction
Abstract

Several studies have shown that infants anticipate human goal-directed actions, but not robot’s ones. However, the studies focusing on the robot goal-directed actions have mainly analyzed the effect of mechanical arms on infant’s attention. To date, the prediction of goal-directed actions in infants has not yet been studied when the agent is a humanoid robot. Given this lack of evidence in infancy research, the present study aims at analyzing infants’ action anticipation of both a human’s and a humanoid robot’s goal-directed action. Data were acquired on thirty 17-month-old infants, watching four video clips, where either a human or a humanoid robot performed a goal-directed action, i.e. reaching a target. Infants looking behavior was measured through the eye-tracking technique. The results showed that infants anticipated the goal-directed action of both the human and the robot and there were no differences in the anticipatory gaze behavior between the two agents. Furthermore, the findings indicated different attentional patterns for the human and the robot, showing a greater attention paid to the robot's face than the human’s face. Overall, the results suggest that 17-month-old infants may infer also humanoid robot’ underlying action goals.

Published
2022

10. Predicting Stock Market Movements in the United States: The Role of Presidential Approval Ratings*

Author

Patrick T. Kanda, Mark E. Wohar, and Rangan Gupta

Subjects
Economics and Econometrics, Heteroscedasticity, 050208 finance, Realized variance, 05 social sciences, Linear model, Granger causality, 0502 economics and business, Econometrics, Economics, Stock market, 050207 economics, Predictability, Volatility (finance), Finance, Stock (geology)
Abstract

In this paper we analyze whether presidential approval ratings can predict the S&P500 returns over the monthly period of 1941:07 to 2018:04, using a dynamic conditional correlation multivariate generalized autoregressive conditional heteroscedasticity (DCC-MGARCH) model. Our results show that, standard linear Granger causality test fail to detect any evidence of predictability. However, the linear model is found to be misspecified due to structural breaks and nonlinearity, and hence, the result of no causality from presidential approval ratings to stock returns cannot be considered reliable. When we use the DCC-MGARCH model, which is robust to such misspecifications, in 69 percent of the sample period, approval ratings in fact do strongly predict the S&P500 stock return. Moreover, using the DCC-MGARCH model we find that presidential approval rating is also a strong predictor of the realized volatility of S&P500. Overall, our results highlight that presidential approval ratings is helpful in predicting stock return and volatility, when one accounts for nonlinearity and regime changes through a robust time-varying model.

Published
2019

12. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Author

S. Abiru, John F. Dillon, Yasuhiro Miyake, Piero Portincasa, Giancarlo Spinzi, R. Harvey, T. Ngatchu, Agostino Colli, M. Taniai, K. Flahive, Masanori Abe, B. Hoeroldt, S. Holder, Howard Curtis, María Isabel Colombo, C. MacNicol, Gang Xie, Andrew Chilton, H. Hussaini, Cristina Rigamonti, M. Kato, Shintaro Yagi, G. Abouda, D. Tyrer, Chris D. Evans, Christopher I. Amos, K. Koss, Kazuaki Chayama, P. Premchand, K. Migita, Simon Panter, Marco Marzioni, Silvia Colombo, Konstantinos N. Lazaridis, M. Yagura, Ashley Brown, D. Gocher, Domenico Alvaro, K. Murata, Mark Wright, Piero Luigi Almasio, C. Healey, A. Ciaccio, N. Wheatley, Vincenzo Cardinale, T. Delahooke, Chiara Milani, T. Shewan, W. Stableforth, S. Levi, Mark L. Green, James V. Jones, Y. Baird, Aftab Ala, Burroughs Ak, D. Williams, K. Ario, P. Sanghi, Hemant Gupta, P. Southern, L. Farrington, M. Hamilton, Andrew D. Higham, I. Yabuuchi, H. Yatsuhashi, Lorenzo Morini, T. Yamamoto, Douglas Thorburn, M. Carnahan, N. Nishida, Susan Slininger, M. Koga, K. Honda, Annarosa Floreani, Andrew Douglass, K. Netherton, M. Yasunami, Hirohito Tsubouchi, F. Donato, K. Walker, U. Shmueli, Paolo Muratori, Ray Mathew, J. Maiden, E. Dungca, Subramaniam Ramakrishnan, S. Vyas, Helen Sweeting, Subrata Saha, T. Komeda, T. Komatsu, H. J. Lee, Maria Consiglia Bragazzi, T. Komura, C. Thomas, C. Shallcross, C. Duggan, J. Kordula, F. Muscariu, Lourdes Cumlat, Imran Patanwala, Giulia Cardamone, L. Morgan, J. Brighton, Masao Honda, H. Nakamura, David Jones, Raj Srirajaskanthan, M. E. Gershwin, T. Muro, L. Stafford, N. Fukushima, Graham P. Butcher, Andrea Crosignani, George Lipscomb, K. Hirata, Y. Nagaoki, S. Mann, Paul G. Richardson, David A Elphick, M. Mupudzi, Y. Ohara, E. Grieve, Gayle Clifford, Claudio Tiribelli, M. Quinn, G. Van Duyvenvoorde, E. Archer, Tatsuki Ichikawa, J. Maltby, T. Arinaga-Hino, Simon Williams, A. King, Yasuni Nakanuma, H. Doyle, A. Brind, Nora Cazzagon, H. Ota, Daphne D’Amato, K. Hogben, H. Wooldridge, J. Wilkins, Shuichi Kaneko, L. Hankey, Gordon Wood, Andrew Fraser, K. Martin, A. Naqvi, M. Ninkovic, M. Patel, Yoshihiko Maehara, Kapil Kapur, I. Amey, Vincenza Calvaruso, Kenichi Harada, T. Yamashita, James Neuberger, N. Taylor, T. Lee, J. Featherstone, C. Lawlor, K. Seward, Satoshi Yamagiwa, Andrea Galli, L. Tan, Kentaro Kikuchi, K. Furuta, Mark A. Ainsworth, Hiromasa Ohira, Esther Unitt, Yosuke Kawai, N. Lancaster, D. Simpson, R. Shidrawi, I. Salam, A.J. Bell, Pietro Andreone, J. Ishida, Voi Shim Wong, N Fisher, Andrew C. Douds, R. Penn, Matthew Foxton, A. Watson, Andrew Mason, S. Walsh, Hiromi Ishibashi, Daniel M. Forton, Giovanni Casella, H. Takaki, K. Yamauchi, Pietro Lampertico, Osamu Yokosuka, M. Koda, M. Davies, H. Mitchison, P. Gyawali, G. Bird, M. Hughes, L. Jones, C. Hamilton, A. Hynes, R. Galaska, Fabio Marra, Debasish Das, C. Cowley, A. Fouracres, Yasuhiko Sugawara, E. Mita, T. Saoshiro, Akinobu Taketomi, Robert P. Myers, R. Przemioslo, F. Wright, L. Hobson, L. Currie, J. Allison, J. Hails, Noriyo Yamashiki, Massimo Zuin, C. Grimley, Alessio Gerussi, S. Besley, Stefano Duga, A. Piotrowicz, H. Kouno, L. Dali-kemmery, H. Sakai, M. Mizokami, Stefano Fagiuoli, Amy Davis, Pier Maria Battezzati, Masao Nagasaki, Luigi Muratori, A. Mori, S. Desmennu, S. Jones, R. Abrahams, Keith George, F. Makita, J. Brown, D. Gorard, Satoru Joshita, M. Mills, Pierluigi Toniutto, S. Campbell, J. Butterworth, S. Dyer, Filomena Morisco, Norihiro Kokudo, T. Yapp, C. Shorrock, Floriano Rosina, E. Walker, Shinji Uemoto, H. Takahashi, Simon M. Rushbrook, K. Amor, E. Marshall, J. Browning, S. Batham, Luca Fabris, Paul R. Banim, Meenakshi Narain, M. Harada, Dermot Gleeson, N. Hirashima, M. Kikuchi, T. Nikami, Gideon M. Hirschfield, Carlo Ferrari, G. Prasad, O. Chirag, Katsushi Tokunaga, M. Nasseri, Rosanna Asselta, Y. Lu, Ken Shirabe, D. Sirdefield, George F. Mells, K. Sugi, R. Ayres, G. Whatley, A. Singhal, M. Leoni, N. Sivaramakrishnan, T. Harding, Rupert Ransford, Anton V J Gunasekera, C. Mulvaney-Jones, D. Ramanaden, M. Mendall, Muhammad F. Dawwas, Dave Jones, Luca Valenti, Earl J. Williams, Markus Gess, Peter Bramley, A. McNair, E. Hashimoto, P. Townshend, C. Ford, Mario Strazzabosco, Luca Miele, Matthew J Brookes, J. Colley, Mark Wilkinson, H. Dewhurst, Charles Millson, E. Shpuza, Shinji Shimoda, T. Himoto, P. Kitchen, M. Nakamuta, Hiroaki Nishimura, Martin Lombard, Kevork M. Peltekian, M. Pitcher, G. Lim, L. Graves, C. Palmer, S. Lord, S. Katsushima, S. Tripoli, Andrew Austin, N. White, B. Grover, S. Congreave, M. Prince, Rebecca Jones, K. Hirano, A. Shepherd, Y. Mano, Michael A. Heneghan, Richard Sandford, L. O'Donohoe, Marco Carbone, S. A. Rolls, Patrick Goggin, M. L. Cowan, M. Crossey, A. Loftus, K. Young, Mesbah Rahman, Cameron N. Ghent, E. Nambela, M. Xiong, L. Grellier, Sunil Dolwani, Antonio Picciotto, Gill Watts, Alberto Mattalia, Elvezia Maria Paraboschi, J. Orpe, Takeji Umemura, Yuki Hitomi, Fiona H. Gordon, Shotaro Sakisaka, A. Dias, Chin Lye Ch'ng, M. Carter, A. Mandal, Yufang Shi, Takafumi Ichida, N. Masaki, M. Oblak, S. Nagaoka, Kevin Yoong, O. Gervais, Minoru Nakamura, Kazuhiko Nakao, S. Taylor-Robinson, L. Kent, Sushma Saksena, A. Affronti, K. Boulton, R. Ede, H. Pateman, K. Yoshizawa, G. Bray, H. Ebinuma, Yeng Ang, Akio Ido, John Ramage, Richard Sturgess, C. Gray, E. Durant, M. Hayes, A. Saeed, J. Keggans, J. Gitahi, T. Valliani, Edoardo G. Giannini, C. Foale, A. Palegwala, Lory Saveria Crocè, K. Matsushita, S. Shaukat, J. Mclindon, S. Pearson, A. Barnardo, A. Wright, Mirko Tarocchi, R Marley, M. Kent, C. Dickson, A. Gibbins, J. Whiteman, S. Singhal, Richard Aspinall, M. Ito, Laura Cristoferi, Maurizia Rossana Brunetto, J. Booth, A. Bathgate, Morikazu Onji, A. Grant, A. Paton, Y. Aiba, P. Chan, J. Sayer, S. Whalley, T. Mathialahan, J. Gotto, T. Kanda, B. Williams, K. Elliott, P. Raymode, Akinobu Takaki, V. Silvestre, I. Gee, C. Hovell, Graham R. Foster, D. Cotterill, G. Stansfield, Grazia Anna Niro, J. Conder, Yoshiyuki Ueno, A. Shah, Jane Metcalf, S. Hayashi, T. Sato, S. Jain, J. Subhani, Donatella Barisani, A. McKay, Kuniaki Arai, Jeremy Shearman, Torao Tanaka, S. Glenn, S. E. O'Donnell, Federica Malinverno, Denise O'Donnell, R. Casey, N. Sharer, J. Bowles, J. Kendall, Maria Cristina Vinci, Antonio Benedetti, George MacFaul, K. Houghton, Vincenzo Ronca, P. Desousa, B. Holbrook, F. Ali, B. Longhurst, Atsushi Tanaka, Marek Czajkowski, R. Tang, Kazuhide Yamamoto, Y. Watanabe, Graeme J.M. Alexander, R. Cloudsdale, F. Hines, M. Karmo, Brian D. Juran, I. Gooding, Y. Takeyama, J. Fraser, A. Mukhopadhya, Sumihito Tamura, Hajime Takikawa, R. Damant, E. Wilhelmsen, M. Kobayashi, J. Tregonning, V. Lambourne, D. Clement, D. Braim, M. Shimada, S. Sen, Shaun Greer, C. Innes, E. Gunter, C. Brown, H. Klass, A. Komori, Andy Li, H. Fairlamb, N. Ncube, Yoshinori Shimada, M. Harrison, S. Marriott, I. Grattagliano, Savino Bruno, A. Naganuma, Xiangjun Gu, Michael F. Seldin, S. Thornthwaite, Peter R. Mills, Katherine A. Siminovitch, X. Liu, Masataka Seike, J. Curtis, Carmela Cursaro, Z. Li, Mikio Zeniya, K. Warner, B. Bird, Jane Collier, Bridget Gunson, S. Tsuruta, E. Tanqueray, Richard Evans, H. Kamitsukasa, R. Sugimoto, Jeremy Tibble, D. Neal, S. Ducker, Francesco Azzaroli, K. Spurdle, K. Ocker, M. Senju, C. Collins, Y. Nakamura, Matthew E. Cramp, Yuji Soejima, I. Drake, K. Ueno, T. Mannami, Clara Mancuso, M. Kawashima, M. Cox, S. S. Kohn, H. Shibata, Stephen D. Ryder, Christopher Macdonald, J. Ridpath, Stephen P. Pereira, L. March, Barbara Coco, J. Morrison, A. Broad, J. Verheyden, Angelo Andriulli, N. Higuchi, J. Musselwhite, R. Bishop, Gwen Baxter, Richard A. Miller, Guido Colloredo, A. Eastick, I. Rees, Deb Ghosh, L. Winter, Sara Massironi, R. McCorry, Gianfranco Elia, T. Kobata, N. Naeshiro, K. Pollock, J. Gasem, S. Gallagher, K. Jing, S. Misra, B. Shinder, Harriet Gordon, E. Takesaki, J. Sadeghian, S. Tsunematsu, Ana Lleo, M. Aldersley, Elizabeth J. Atkinson, Pietro Invernizzi, Heather J. Cordell, Asselta, R., Paraboschi, E. M., Gerussi, A., Cordell, H. J., Mells, G. F., Sandford, R. N., Jones, D. E., Nakamura, M., Ueno, K., Hitomi, Y., Kawashima, M., Nishida, N., Tokunaga, K., Nagasaki, M., Tanaka, A., Tang, R., Li, Z., Shi, Y., Liu, X., Xiong, M., Hirschfield, G., Siminovitch, K. A., Walker, E., Xie, G., Mason, A., Myers, R., Peltekian, K., Ghent, C., Atkinson, E., Juran, B., Lazaridis, K., Lu, Y., Gu, X., Jing, K., Amos, C., Affronti, A., Brunetto, M., Coco, B., Spinzi, G., Elia, G., Ferrari, C., Lleo, A., Muratori, L., Muratori, P., Portincasa, P., Colli, A., Bruno, S., Colloredo, G., Azzaroli, F., Andreone, P., Bragazzi, M., Alvaro, D., Cardinale, V., Cazzagon, N., Rigamonti, C., Floreani, A., Rosina, F., Ciaccio, A., Cristoferi, L., D'Amato, D., Malinverno, F., Mancuso, C., Massironi, S., Milani, C., O'Donnell, S. E., Ronca, V., Barisani, D., Lampertico, P., Donato, F., Fagiuoli, S., Almasio, P. L., Giannini, E., Cursaro, C., Colombo, M., Valenti, L., Miele, L., Andriulli, A., Niro, G. A., Grattagliano, I., Morini, L., Casella, G., Vinci, M., Battezzati, P. M., Crosignani, A., Zuin, M., Mattalia, A., Calvaruso, V., Colombo, S., Benedetti, A., Marzioni, M., Galli, A., Marra, F., Tarocchi, M., Picciotto, A., Morisco, F., Fabris, L., Croce, L. S., Tiribelli, C., Toniutto, P., Strazzabosco, M., Ch'Ng, C. L., Rahman, M., Yapp, T., Sturgess, R., Healey, C., Czajkowski, M., Gunasekera, A., Gyawali, P., Premchand, P., Kapur, K., Marley, R., Foster, G., Watson, A., Dias, A., Subhani, J., Harvey, R., Mccorry, R., Ramanaden, D., Gasem, J., Evans, R., Mathialahan, T., Shorrock, C., Lipscomb, G., Southern, P., Tibble, J., Gorard, D., Palegwala, A., Jones, S., Dawwas, M., Alexander, G., Dolwani, S., Prince, M., Foxton, M., Elphick, D., Mitchison, H., Gooding, I., Karmo, M., Saksena, S., Mendall, M., Patel, M., Ede, R., Austin, A., Sayer, J., Hankey, L., Hovell, C., Fisher, N., Carter, M., Koss, K., Piotrowicz, A., Grimley, C., Neal, D., Lim, G., Levi, S., Ala, A., Broad, A., Saeed, A., Wood, G., Brown, J., Wilkinson, M., Gordon, H., Ramage, J., Ridpath, J., Ngatchu, T., Grover, B., Shaukat, S., Shidrawi, R., Abouda, G., Ali, F., Rees, I., Salam, I., Narain, M., Brown, A., Taylor-Robinson, S., Williams, S., Grellier, L., Banim, P., Das, D., Chilton, A., Heneghan, M., Curtis, H., Gess, M., Drake, I., Aldersley, M., Davies, M., Jones, R., Mcnair, A., Srirajaskanthan, R., Pitcher, M., Sen, S., Bird, G., Barnardo, A., Kitchen, P., Yoong, K., Chirag, O., Sivaramakrishnan, N., Macfaul, G., Jones, D., Shah, A., Evans, C., Saha, S., Pollock, K., Bramley, P., Mukhopadhya, A., Fraser, A., Mills, P., Shallcross, C., Campbell, S., Bathgate, A., Shepherd, A., Dillon, J., Rushbrook, S., Przemioslo, R., Macdonald, C., Metcalf, J., Shmueli, U., Davis, A., Naqvi, A., Lee, T., Ryder, S. D., Collier, J., Klass, H., Ninkovic, M., Cramp, M., Sharer, N., Aspinall, R., Goggin, P., Ghosh, D., Douds, A., Hoeroldt, B., Booth, J., Williams, E., Hussaini, H., Stableforth, W., Ayres, R., Thorburn, D., Marshall, E., Burroughs, A., Mann, S., Lombard, M., Richardson, P., Patanwala, I., Maltby, J., Brookes, M., Mathew, R., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Panter, S., Shearman, J., Bray, G., Butcher, G., Forton, D., Mclindon, J., Cowan, M., Whatley, G., Mandal, A., Gupta, H., Sanghi, P., Jain, S., Pereira, S., Prasad, G., Watts, G., Wright, M., Neuberger, J., Gordon, F., Unitt, E., Grant, A., Delahooke, T., Higham, A., Brind, A., Cox, M., Ramakrishnan, S., King, A., Collins, C., Whalley, S., Li, A., Fraser, J., Bell, A., Wong, V. S., Singhal, A., Gee, I., Ang, Y., Ransford, R., Gotto, J., Millson, C., Bowles, J., Thomas, C., Harrison, M., Galaska, R., Kendall, J., Whiteman, J., Lawlor, C., Gray, C., Elliott, K., Mulvaney-Jones, C., Hobson, L., Van Duyvenvoorde, G., Loftus, A., Seward, K., Penn, R., Maiden, J., Damant, R., Hails, J., Cloudsdale, R., Silvestre, V., Glenn, S., Dungca, E., Wheatley, N., Doyle, H., Kent, M., Hamilton, C., Braim, D., Wooldridge, H., Abrahams, R., Paton, A., Lancaster, N., Gibbins, A., Hogben, K., Desousa, P., Muscariu, F., Musselwhite, J., Mckay, A., Tan, L., Foale, C., Brighton, J., Flahive, K., Nambela, E., Townshend, P., Ford, C., Holder, S., Palmer, C., Featherstone, J., Nasseri, M., Sadeghian, J., Williams, B., Rolls, S. -A., Hynes, A., Duggan, C., Crossey, M., Stansfield, G., Macnicol, C., Wilkins, J., Wilhelmsen, E., Raymode, P., Lee, H. -J., Durant, E., Bishop, R., Ncube, N., Tripoli, S., Casey, R., Cowley, C., Miller, R., Houghton, K., Ducker, S., Wright, F., Bird, B., Baxter, G., Keggans, J., Hughes, M., Grieve, E., Young, K., Williams, D., Ocker, K., Hines, F., Martin, K., Innes, C., Valliani, T., Fairlamb, H., Thornthwaite, S., Eastick, A., Tanqueray, E., Morrison, J., Holbrook, B., Browning, J., Walker, K., Congreave, S., Verheyden, J., Slininger, S., Stafford, L., O'Donnell, D., Ainsworth, M., Lord, S., Kent, L., March, L., Dickson, C., Simpson, D., Longhurst, B., Hayes, M., Shpuza, E., White, N., Besley, S., Pearson, S., Wright, A., Jones, L., Gunter, E., Dewhurst, H., Fouracres, A., Farrington, L., Graves, L., Marriott, S., Leoni, M., Tyrer, D., Dali-kemmery, L., Lambourne, V., Green, M., Sirdefield, D., Amor, K., Colley, J., Shinder, B., Jones, J., Mills, M., Carnahan, M., Taylor, N., Boulton, K., Tregonning, J., Brown, C., Clifford, G., Archer, E., Hamilton, M., Curtis, J., Shewan, T., Walsh, S., Warner, K., Netherton, K., Mupudzi, M., Gunson, B., Gitahi, J., Gocher, D., Batham, S., Pateman, H., Desmennu, S., Conder, J., Clement, D., Gallagher, S., Orpe, J., Chan, P., Currie, L., O'Donohoe, L., Oblak, M., Morgan, L., Quinn, M., Amey, I., Baird, Y., Cotterill, D., Cumlat, L., Winter, L., Greer, S., Spurdle, K., Allison, J., Dyer, S., Sweeting, H., Kordula, J., Aiba, Y., Nakamura, H., Abiru, S., Nagaoka, S., Komori, A., Yatsuhashi, H., Ishibashi, H., Ito, M., Kawai, Y., Kohn, S. -S., Gervais, O., Migita, K., Katsushima, S., Naganuma, A., Sugi, K., Komatsu, T., Mannami, T., Matsushita, K., Yoshizawa, K., Makita, F., Nikami, T., Nishimura, H., Kouno, H., Ota, H., Komura, T., Nakamura, Y., Shimada, M., Hirashima, N., Komeda, T., Ario, K., Nakamuta, M., Yamashita, T., Furuta, K., Kikuchi, M., Naeshiro, N., Takahashi, H., Mano, Y., Tsunematsu, S., Yabuuchi, I., Shimada, Y., Yamauchi, K., Sugimoto, R., Sakai, H., Mita, E., Koda, M., Tsuruta, S., Kamitsukasa, H., Sato, T., Masaki, N., Kobata, T., Fukushima, N., Higuchi, N., Ohara, Y., Muro, T., Takesaki, E., Takaki, H., Yamamoto, T., Kato, M., Nagaoki, Y., Hayashi, S., Ishida, J., Watanabe, Y., Kobayashi, M., Koga, M., Saoshiro, T., Yagura, M., Hirata, K., Takikawa, H., Ohira, H., Zeniya, M., Abe, M., Onji, M., Kaneko, S., Honda, M., Arai, K., Arinaga-Hino, T., Hashimoto, E., Taniai, M., Umemura, T., Joshita, S., Nakao, K., Ichikawa, T., Shibata, H., Yamagiwa, S., Seike, M., Honda, K., Sakisaka, S., Takeyama, Y., Harada, M., Senju, M., Yokosuka, O., Kanda, T., Ueno, Y., Kikuchi, K., Ebinuma, H., Himoto, T., Yasunami, M., Murata, K., Mizokami, M., Shimoda, S., Miyake, Y., Takaki, A., Yamamoto, K., Hirano, K., Ichida, T., Ido, A., Tsubouchi, H., Chayama, K., Harada, K., Nakanuma, Y., Maehara, Y., Taketomi, A., Shirabe, K., Soejima, Y., Mori, A., Yagi, S., Uemoto, S., Tanaka, T., Yamashiki, N., Tamura, S., Sugawara, Y., Kokudo, N., Carbone, M., Cardamone, G., Duga, S., Gershwin, M. E., Seldin, M. F., Invernizzi, P., Asselta R., Paraboschi E.M., Gerussi A., Cordell H.J., Mells G.F., Sandford R.N., Jones D.E., Nakamura M., Ueno K., Hitomi Y., Kawashima M., Nishida N., Tokunaga K., Nagasaki M., Tanaka A., Tang R., Li Z., Shi Y., Liu X., Xiong M., Hirschfield G., Siminovitch K.A., Walker E., Xie G., Mason A., Myers R., Peltekian K., Ghent C., Atkinson E., Juran B., Lazaridis K., Lu Y., Gu X., Jing K., Amos C., Affronti A., Brunetto M., Coco B., Spinzi G., Elia G., Ferrari C., Lleo A., Muratori L., Muratori P., Portincasa P., Colli A., Bruno S., Colloredo G., Azzaroli F., Andreone P., Bragazzi M., Alvaro D., Cardinale V., Cazzagon N., Rigamonti C., Floreani A., Rosina F., Ciaccio A., Cristoferi L., D'Amato D., Malinverno F., Mancuso C., Massironi S., Milani C., O'Donnell S.E., Ronca V., Barisani D., Lampertico P., Donato F., Fagiuoli S., Almasio P.L., Giannini E., Cursaro C., Colombo M., Valenti L., Miele L., Andriulli A., Niro G.A., Grattagliano I., Morini L., Casella G., Vinci M., Battezzati P.M., Crosignani A., Zuin M., Mattalia A., Calvaruso V., Colombo S., Benedetti A., Marzioni M., Galli A., Marra F., Tarocchi M., Picciotto A., Morisco F., Fabris L., Croce L.S., Tiribelli C., Toniutto P., Strazzabosco M., Ch'ng C.L., Rahman M., Yapp T., Sturgess R., Healey C., Czajkowski M., Gunasekera A., Gyawali P., Premchand P., Kapur K., Marley R., Foster G., Watson A., Dias A., Subhani J., Harvey R., McCorry R., Ramanaden D., Gasem J., Evans R., Mathialahan T., Shorrock C., Lipscomb G., Southern P., Tibble J., Gorard D., Palegwala A., Jones S., Dawwas M., Alexander G., Dolwani S., Prince M., Foxton M., Elphick D., Mitchison H., Gooding I., Karmo M., Saksena S., Mendall M., Patel M., Ede R., Austin A., Sayer J., Hankey L., Hovell C., Fisher N., Carter M., Koss K., Piotrowicz A., Grimley C., Neal D., Lim G., Levi S., Ala A., Broad A., Saeed A., Wood G., Brown J., Wilkinson M., Gordon H., Ramage J., Ridpath J., Ngatchu T., Grover B., Shaukat S., Shidrawi R., Abouda G., Ali F., Rees I., Salam I., Narain M., Brown A., Taylor-Robinson S., Williams S., Grellier L., Banim P., Das D., Chilton A., Heneghan M., Curtis H., Gess M., Drake I., Aldersley M., Davies M., Jones R., McNair A., Srirajaskanthan R., Pitcher M., Sen S., Bird G., Barnardo A., Kitchen P., Yoong K., Chirag O., Sivaramakrishnan N., MacFaul G., Jones D., Shah A., Evans C., Saha S., Pollock K., Bramley P., Mukhopadhya A., Fraser A., Mills P., Shallcross C., Campbell S., Bathgate A., Shepherd A., Dillon J., Rushbrook S., Przemioslo R., Macdonald C., Metcalf J., Shmueli U., Davis A., Naqvi A., Lee T., Ryder S.D., Collier J., Klass H., Ninkovic M., Cramp M., Sharer N., Aspinall R., Goggin P., Ghosh D., Douds A., Hoeroldt B., Booth J., Williams E., Hussaini H., Stableforth W., Ayres R., Thorburn D., Marshall E., Burroughs A., Mann S., Lombard M., Richardson P., Patanwala I., Maltby J., Brookes M., Mathew R., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Panter S., Shearman J., Bray G., Butcher G., Forton D., Mclindon J., Cowan M., Whatley G., Mandal A., Gupta H., Sanghi P., Jain S., Pereira S., Prasad G., Watts G., Wright M., Neuberger J., Gordon F., Unitt E., Grant A., Delahooke T., Higham A., Brind A., Cox M., Ramakrishnan S., King A., Collins C., Whalley S., Li A., Fraser J., Bell A., Wong V.S., Singhal A., Gee I., Ang Y., Ransford R., Gotto J., Millson C., Bowles J., Thomas C., Harrison M., Galaska R., Kendall J., Whiteman J., Lawlor C., Gray C., Elliott K., Mulvaney-Jones C., Hobson L., Van Duyvenvoorde G., Loftus A., Seward K., Penn R., Maiden J., Damant R., Hails J., Cloudsdale R., Silvestre V., Glenn S., Dungca E., Wheatley N., Doyle H., Kent M., Hamilton C., Braim D., Wooldridge H., Abrahams R., Paton A., Lancaster N., Gibbins A., Hogben K., Desousa P., Muscariu F., Musselwhite J., McKay A., Tan L., Foale C., Brighton J., Flahive K., Nambela E., Townshend P., Ford C., Holder S., Palmer C., Featherstone J., Nasseri M., Sadeghian J., Williams B., Rolls S.-A., Hynes A., Duggan C., Crossey M., Stansfield G., MacNicol C., Wilkins J., Wilhelmsen E., Raymode P., Lee H.-J., Durant E., Bishop R., Ncube N., Tripoli S., Casey R., Cowley C., Miller R., Houghton K., Ducker S., Wright F., Bird B., Baxter G., Keggans J., Hughes M., Grieve E., Young K., Williams D., Ocker K., Hines F., Martin K., Innes C., Valliani T., Fairlamb H., Thornthwaite S., Eastick A., Tanqueray E., Morrison J., Holbrook B., Browning J., Walker K., Congreave S., Verheyden J., Slininger S., Stafford L., O'Donnell D., Ainsworth M., Lord S., Kent L., March L., Dickson C., Simpson D., Longhurst B., Hayes M., Shpuza E., White N., Besley S., Pearson S., Wright A., Jones L., Gunter E., Dewhurst H., Fouracres A., Farrington L., Graves L., Marriott S., Leoni M., Tyrer D., Dali-kemmery L., Lambourne V., Green M., Sirdefield D., Amor K., Colley J., Shinder B., Jones J., Mills M., Carnahan M., Taylor N., Boulton K., Tregonning J., Brown C., Clifford G., Archer E., Hamilton M., Curtis J., Shewan T., Walsh S., Warner K., Netherton K., Mupudzi M., Gunson B., Gitahi J., Gocher D., Batham S., Pateman H., Desmennu S., Conder J., Clement D., Gallagher S., Orpe J., Chan P., Currie L., O'Donohoe L., Oblak M., Morgan L., Quinn M., Amey I., Baird Y., Cotterill D., Cumlat L., Winter L., Greer S., Spurdle K., Allison J., Dyer S., Sweeting H., Kordula J., Aiba Y., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Kawai Y., Kohn S.-S., Gervais O., Migita K., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Higuchi N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Takikawa H., Ohira H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Carbone M., Cardamone G., Duga S., Gershwin M.E., Seldin M.F., Invernizzi P., Asselta, R, Paraboschi, E, Gerussi, A, Cordell, H, Mells, G, Sandford, R, Jones, D, Nakamura, M, Ueno, K, Hitomi, Y, Kawashima, M, Nishida, N, Tokunaga, K, Nagasaki, M, Tanaka, A, Tang, R, Li, Z, Shi, Y, Liu, X, Xiong, M, Hirschfield, G, Siminovitch, K, Walker, E, Xie, G, Mason, A, Myers, R, Peltekian, K, Ghent, C, Atkinson, E, Juran, B, Lazaridis, K, Lu, Y, Gu, X, Jing, K, Amos, C, Affronti, A, Brunetto, M, Coco, B, Spinzi, G, Elia, G, Ferrari, C, Lleo, A, Muratori, L, Muratori, P, Portincasa, P, Colli, A, Bruno, S, Colloredo, G, Azzaroli, F, Andreone, P, Bragazzi, M, Alvaro, D, Cardinale, V, Cazzagon, N, Rigamonti, C, Floreani, A, Rosina, F, Ciaccio, A, Cristoferi, L, D'Amato, D, Malinverno, F, Mancuso, C, Massironi, S, Milani, C, O'Donnell, S, Ronca, V, Barisani, D, Lampertico, P, Donato, F, Fagiuoli, S, Almasio, P, Giannini, E, Cursaro, C, Colombo, M, Valenti, L, Miele, L, Andriulli, A, Niro, G, Grattagliano, I, Morini, L, Casella, G, Vinci, M, Battezzati, P, Crosignani, A, Zuin, M, Mattalia, A, Calvaruso, V, Colombo, S, Benedetti, A, Marzioni, M, Galli, A, Marra, F, Tarocchi, M, Picciotto, A, Morisco, F, Fabris, L, Croce, L, Tiribelli, C, Toniutto, P, Strazzabosco, M, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Alexander, G, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Taylor-Robinson, S, Williams, S, Grellier, L, Banim, P, Das, D, Chilton, A, Heneghan, M, Curtis, H, Gess, M, Drake, I, Aldersley, M, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Bathgate, A, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Thorburn, D, Marshall, E, Burroughs, A, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Neuberger, J, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney-Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Williams, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, O'Donnell, D, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali-kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, O'Donohoe, L, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordula, J, Aiba, Y, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Kawai, Y, Kohn, S, Gervais, O, Migita, K, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Higuchi, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Takikawa, H, Ohira, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Carbone, M, Cardamone, G, Duga, S, Gershwin, M, Seldin, M, Invernizzi, P, Asselta R, Paraboschi EM, Gerussi A, Cordell HJ, Mells GF, Sandford RN, Jones DE, Nakamura M, Ueno K, Hitomi Y, Kawashima M, Nishida N, Tokunaga K, Nagasaki M, Tanaka A, Tang R, Li Z, Shi Y, Liu X, Xiong M, Hirschfield G, Siminovitch KA, Canadian-US PBC Consortium, Italian PBC Genetics Study Group, UK-PBC Consortium, Japan PBC-GWAS Consortium, Carbone M, Cardamone G, Duga S, Gershwin ME, Seldin MF, Invernizzi P, and LiveR North

Subjects
Canadian-US PBC Consortium, 0301 basic medicine, Male, Linkage disequilibrium, Genome-wide association study, Disease, PBC, Settore MED/03 - GENETICA MEDICA, Linkage Disequilibrium, 0302 clinical medicine, UK-PBC Consortium, Genotype, Mitochondrial Precursor Protein Import Complex Proteins, Italian PBC Genetics Study Group, Odds Ratio, X-Wide Association Study, Japan PBC-GWAS Consortium, X chromosome, Genetics, Liver Cirrhosis, Biliary, Gastroenterology, Forkhead Transcription Factors, DNA-Binding Proteins, Shal Potassium Channels, 030211 gastroenterology & hepatology, Female, Adult, Monosaccharide Transport Proteins, Superenhancer, Locus (genetics), Single-nucleotide polymorphism, Biology, Protein Serine-Threonine Kinases, Polymorphism, Single Nucleotide, Article, White People, 03 medical and health sciences, Asian People, Proto-Oncogene Proteins, Endopeptidases, Humans, Cell Lineage, Genetic Predisposition to Disease, Meta-analysi, Genetic association, Chromosomes, Human, X, Gastroenterology & Hepatology, Hepatology, 1103 Clinical Sciences, Meta-analysis, 030104 developmental biology, Genetic Loci, 1114 Paediatrics and Reproductive Medicine, 1109 Neurosciences, Carrier Proteins, Genome-Wide Association Study
Abstract

Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10-6; odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028-1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09-1.26; P = 9.93 × 10-8), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10-9; OR, 1.33; 95% CI, 1.21-1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). Conclusions: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.

Published
2021

13. Continuity and efficacy of real-world use of azacitidine

Author

E, Usami, M, Kimura, S, Takenaka, T, Kanda, H, Teramachi, and T, Yoshimura

Subjects
Aged, 80 and over, Male, Antimetabolites, Antineoplastic, Continuity of Patient Care, Middle Aged, Infections, Prognosis, Survival Analysis, Leukemia, Myeloid, Acute, Treatment Outcome, Azacitidine, Humans, Female, Aged, Retrospective Studies
Abstract

Long-term azacitidine (AZA) treatment is necessary for its maximal therapeutic effect. This study examined the continuity and efficacy of AZA treatment in real-world use. We conducted a retrospective study in 38 patients who had completed AZA treatment at the Ogaki Municipal Hospital between April 2011 and August 2019. The median number of AZA received cycles was 4. The number of AZA treatment cycles received was 1-3 cycles in 15 (39.5%), 4-6 cycles in 15 (39.5%), and ≥ 7 cycles in 8 (21.1%). The most common reason for discontinued AZA treatment was infection. Overall response rate was 33.3% in patients with discontinued AZA use (4 cycles) and 56.5% in patients with continued AZA (≥ 4). Median overall survival (OS) was 124 (15-529) days and 391 (132-2,825) days in the respective groups (p0.01). The presence of peripheral blood blasts (PBs) was a prognostic factor for continuation of treatment (

Published
2020

16. Time-varying causality between equity and currency returns in the United Kingdom: Evidence from over two centuries of data

Author

Michael Burke, Patrick T. Kanda, and Rangan Gupta

Subjects
Statistics and Probability, Test strategy, 050208 finance, Autoregressive conditional heteroskedasticity, 05 social sciences, Equity (finance), Condensed Matter Physics, Granger causality, Currency, 0502 economics and business, Econometrics, Economics, Foreign exchange, 050207 economics, Emerging market economies, Stock (geology)
Abstract

We analyse the dynamics of the causal interaction between the stock and foreign exchange markets for the United Kingdom using monthly data going as far back as 1791. First, we consider static causality tests, yielding mixed results. Given the evidence of structural breaks in the relationship between equity and currency returns, we use next the Dynamic Conditional Correlation-Multivariate Generalised Autoregressive Conditional Heteroskedasticity time-varying tests for Granger causality. The time-varying testing strategy we implement allows us to detect whether any causal relationship exists at each point in time between stock price and exchange rates returns. We find overwhelming evidence of time-varying information spillovers between the equity and currency returns. We check the robustness of our findings by running the entire battery of tests for two emerging market economies, namely, India and South Africa starting in 1920 and 1910 respectively. On the whole, the United Kingdom results are comparable to those in India and South Africa. As such, our results encompass the fragmented findings from our static tests as well as those in the extant literature.

Published
2018

17. Outcomes of grafting intrasynovial tendons of the toes to the hands in 10 patients: a preliminary report

Author

Shigeharu Uchiyama, Masanori Hayashi, Hiroyuki Ohi, Hiroyuki Kato, T Kanda, and M Mukoda

Subjects
Adult, Male, musculoskeletal diseases, medicine.medical_specialty, Tendon grafting, 030230 surgery, Thumb, Tendons, Young Adult, 03 medical and health sciences, Active motion, 0302 clinical medicine, Tendon Injuries, Preliminary report, Finger Injuries, medicine, Humans, Complication rate, Range of Motion, Articular, Tendon graft, Retrospective Studies, 030222 orthopedics, Flexor tendon, business.industry, Middle Aged, Toes, Surgery, body regions, Treatment Outcome, medicine.anatomical_structure, Female, Interphalangeal Joint, business, Joint Capsule
Abstract

Ten patients had intrasynovial tendon grafting harvested from the toes for secondary flexor tendon reconstruction in nine fingers and one thumb in our institutes from 2009 to 2014. These patients were followed for a mean of 15 (range: 8–36) months. The ranges of total active motion of the proximal and distal interphalangeal joints of these nine fingers were 143° (range: 108–175°) and of the metacarpophalangeal and interphalangeal joints of one thumb were 110°. In conclusion, this technique is feasible and gives a good result when successful but with a high complication rate.Level of Evidence IV

Published
2017

20. Blood hexokinase reduction in de novo Parkinson's disease and remodeling of glycolytic energy homeostasis with L-DOPA/Istradefylline combination therapy

Author

K. Nakachi, T. Kanda, A. Mori, S. Mochizuki, and N. Kanzato

Subjects
Hexokinase, Parkinson's disease, Combination therapy, business.industry, Istradefylline, Pharmacology, medicine.disease, Energy homeostasis, chemistry.chemical_compound, Neurology, chemistry, Medicine, Glycolysis, Neurology (clinical), Geriatrics and Gerontology, business
Published
2020

21. HIT Poster session 1P161E/e'*SV is a better predictor of outcome than E/e' in patients with heart failure with preserved left ventricular ejection fractionP162Subclinical left atrial and left ventricular structural and functional abnormalities in postmenopausal women with abdominal obesityP163Central obesity and hypertension: double burden to the left atrium of postmenopausal womenP164Comparison between 3-D blood pressure pulse analyser and pulsed-wave doppler echocardiography derived hemodynamic parameters in cardiac surgery patients - a pilot studyP165Paced-induced heart electrical activation modifies the orientation of left ventricular flow momentum: novel insights from echocardiographic particle image velocimetryP166Correlations between echocardiographic and CMR-derived parameters of right ventricular size and function in patients with COPDP167Longitudinal strain analysis allows the identification of subclinical deterioration of right ventricular myocardial function in patients with cancer therapy-related left ventricular dysfunctionP168Effect of atrial fibrillation to pulmonary hypertension and right ventricular function in patient with severe mitral stenosisP169Evolution of etiologic spectrum and clinical features of mitral regurgitation since 2007 until 2015P170Tricuspid annulus area correlates more with right atrial than right ventricular volumes in patients with different mechanisms of functional tricuspid regurgitation: a 3D echocardiography studyP171The effect of hemolysis on serum lipid levels in patients suffering from severe paravalvular leakageP172Right ventricular dysfunction in patients with hypertrophic cardiomyopathyP173Interest of variations of echocardiographic parameters after initiation of specific therapy in the risk stratification of patients with pulmonary hypertensionP174Comparison of left and right atrial size and function in elite adolescent male football playersP175Do pocket-size imaging devices allow for reliable bedside vascular screening?P176Evolution of tricuspid regurgitation after pulmonary valve replacement for pulmonary regurgitation in repaired tetralogy of fallotP177Effect of perindopril/amlodipine combination on post-exercise E/e' in patients with arterial hypertensionP178Relationship between pulmonary venous flow and prosthetic mitral valve thrombosis P179Mitral valve parameters derived from 3-dimensional transesophageal echocardiography dataset: correlation between qlab and tomtec softwareP180Non-invasive pulmonary transit time: a new parameter for global cardiac performanceP181Assessment of the positive work and mechanical dispersion: new methods to quantify left ventricular function in aortic stenosisP182Atrial function in Takotsubo cardiomyopathy: deformation analysisP183Cardiac syndrome X- proven left ventricular perfusion and kinetic abnormalities by SPECT-CT and pharmacological dobutamine stress testP184Impact of frailty assessment on myocardial perfusion imaging results: a prospective cohort study

Author

A. Ahmed, ST. Svetlin Nedkov Tsonev, M. Tavares Da Silva, A. Hubert, AGW De Lepper, R. Chokesuwattanaskul, S. Cersit, MY. Kolesnyk, J. Sanz Sanchez, D. Filipiak, JM. Luszczak, M. Di Meglio, AE. Demkina, M. Kalcik, E. Surkova, J. Sanchez, R` Ariani, DA. Cherata, M. Hajdu, F. Bianco, R. Zayat, A. Borizanova, T. Kanda, M. Fujita, O. Iida, M. Masuda, S. Okamoto, T. Ishihara, K. Nanto, M. Uematsu, E. Kinova, A. Goudev, A. Aljalloud, G. Musetti, HJ. Kang, SH. Jansen-Park, A. Goetzenich, R. Autschbach, N. Hatam, V. Cicchitti, V. Bucciarelli, E. Di Girolamo, G. Tonti, R. De Caterina, S. Gallina, V. Vertes, ZS. Meiszterics, S. Szabados, T. Simor, R. Faludi, D. Muraru, C. Palermo, G. Romeo, P. Aruta, G. Binotto, G. Semenzato, D. Carstea, S. Iliceto, LP. Badano, AM. Soesanto, M. Ruiz, D. Mesa, M. Delgado, G. Gutierrez, CH. Aristizabal, J. Fernandez, C. Ferreiro, E. Duran, M. Anguita, JC. Castillo, M. Pan, JM. Arizon, J. Suarez De Lezo, J. Bidviene, G. Brunello, F. Veronesi, G. Cavalli, V. Sokalskis, M. Yesin, E. Bayam, S. Gunduz, MO. Gursoy, S. Karakoyun, MA. Astarcioglu, O. Candan, M. Ozkan, NS. Krylova, NG. Poteshkina, EA. Kovalevskaya, FM. Hashieva, C. Venner, O. Huttin, A. Guillaumot, A. Chaouat, F. Chabot, Y. Juilliere, C. Selton-Suty, CA. Williams, AG. Stuart, GE. Pieles, JD. Kasprzak, P. Lipiec, A. Osa Saez, MA. Arnau Vives, F. Buendia Fuentes, M. Ferre Valverdu, A. Quesada Carmona, F. Serrano Martinez, A. Montero Argudo, L. Martinez Dolz, J. Rueda Soriano, OV. Nikitjuk, GV. Dzyak, M. Tabakci, O. Gursoy, S. Satitthummanid, S. Boonyaratavej, IHF Herold, S. Saporito, RA. Bouwman, M. Mischi, HHM Korsten, KD. Reesink, P. Houthuizen, E. Galli, G. Bouzille, E. Samset, E. Donal, G. Pestana, C. De Sousa, R. Pinto, V. Ribeiro, M. Vasconcelos, PB. Almeida, F. Macedo, MJ. Maciel, E. Manov, N. Runev, R. Shabani, M. Gartcheva, T. Donova, I. Petrov, and M. Al-Mallah

Subjects
Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine
Published
2016

22. Dynamics of Maximum Power Point Wind Energy Battery Charging Systems

Author

Casper Labuschagne, Maarten J. Kamper, T. Kanda, and Lethiwe P. Mdakane

Subjects
Battery (electricity), Generator (circuit theory), Wind power, Maximum power principle, Computer science, Duty cycle, DC-to-DC converter, business.industry, business, Maximum power point tracking, Wind speed, Automotive engineering
Abstract

In this paper the dynamics of a maximum power point wind energy battery charging system and the implementation of a DC to DC converter is investigated. The required design specifications for a sub 5 kW wind generator are discussed as well as the modelling of the different components of the wind energy system. The duty cycle control of the DC to DC converter for maximum power point tracking at different wind speeds is done by implementing a functional generator. The functional generator adjusts the duty cycle of the converter according to the generator speed. In order to investigate the duty cycle control method and the system’s stability the system is simulated with MATLAB Simulink to determine the response. It was found that the proposed duty cycle control method is effective in maximum power point tracking. Also, that the system’s response is stable for higher frequency disturbances.

Published
2019

24. Forecasting South African inflation using non-linearmodels: a weighted loss-based evaluation

Author

Rangan Gupta, Patrick T. Kanda, Pejman Bahramian, and Mehmet Balcilar

Subjects
Inflation, Economics and Econometrics, 050208 finance, Inflation targeting, media_common.quotation_subject, 05 social sciences, Non linear model, Salient, 0502 economics and business, Economics, Econometrics, Seasonal adjustment, 050207 economics, Emerging markets, Economic forecasting, media_common
Abstract

The conduct of inflation targeting is heavily dependent on accurate inflation forecasts. Non-linear models have increasingly featured, along with linear counterparts, in the forecasting literature. In this study, we focus on forecasting South African inflation by means of non-linear models and using a long historical dataset of seasonally adjusted monthly inflation rates spanning from 1921:02 to 2013:01. For an emerging market economy such as South Africa, non-linearities can be a salient feature of such long data, hence the relevance of evaluating non-linear models’ forecast performance. In the same vein, given the fact that 1969:10 marks the beginning of a protracted rising trend in South African inflation data, we estimate the models for an in-sample period of 1921:02–1966:09 and evaluate 1, 4, 12, and 24 step-ahead forecasts over an out-of-sample period of 1966:10–2013:01. In addition, using a weighted loss function specification, we evaluate the forecast performance of different non-linear mo...

Published
2016

25. High Performance Fiber Reinforced Cement Composite

Author

N. Sakata, D. Hayashi, T. Kanda, and M. Hashimoto

Subjects
Cement, Materials science, 021105 building & construction, Composite number, 0211 other engineering and technologies, 020101 civil engineering, General Materials Science, 02 engineering and technology, Fiber, Composite material, 0201 civil engineering
Published
2016

26. Club 35 Poster session 3: Friday 5 December 2014, 08:30-18:00 * Location: Poster area

Author

J.-H. Lee, O. Milanesi, B. Brekke, G. Giovanni Antonelli, S. Mulvagh, A. Guimaraes, N. Barrett, K. Ozawa, A. Revishvili, C. Lazaro Rivera, Sergio Mondillo, C. Carlo Gaetano Sassi, T. Chumarnaya, D. Vinereanu, K. Sveric, A. Alexandrescu, M. Y. Kolesnyk, J. Ovsianas, M. Masuda, M. Ozkan, B. Castaldi, R. Mccully, D. Dosen, O. Solovyova, V. Kochmasheva, O. Tautu, M. Yesin, C. Ball, M. Astarcioglu, N. Funabashi, C. Missant, C. Fernandez-Golfin, A. Assabiny, G. Cavalli, A. Stoylen, E. Reffo, S. Mihaila, F. Nomura, P. Haemers, A. Nagy, M. Kalcik, L. C. Lervik Nilsen, B. Cakal, Z. Valuckiene, J. Zamorano Gomez, N. Ioannou, G. Carr-White, J L Moya Mur, A. Carbonell Sanroman, E. Piasentini, C. Meadows, V. Kutyifa, E. Casas Rojo, S. Gunduz, F. Mantovani, G. Sutherland, K. Victor, M. Dorobantu, A. Ionescu, V. Mizariene, N. Maschietto, G. Stellin, S. Onciul, V. Reskovic Luksic, P. Aruta, T. Kamata, C. Langrish, F. Federico Alvino, R. Biffanti, S. Fernandez Santos, L. Tong, A. Argiolas, J. D'almeida, G. Cho, B. Ebner, D. Muraru, S. Mikhailov, B. Lakatos, A Garcia Martin, B. Merkely, J. D'hooge, C. Scott, V. Markhasin, M. Fujita, S. Cersit, O. Ostern, S. Iliceto, C. Toprak, D. Peluso, C. Santoro, A. Kovacs, T. Kanda, V. Zysek, A. Cerutti, A. Ladeia, M. M. Gurzun, S. Okamoto, H. Takaoka, D Rodriguez Munoz, L. Badano, K. Nanto, D. Lux, M. Takahara, A. Santoro, R. Strasser, A. Caldas, S. Karakoyun, O. Iida, T. Katova, I. Simova, S. Cekovic, L. Ucci, M. Rady, T. Ishihara, Y. Kobayashi, M. Gursoy, R. Onut, R. Huang, I. Lalov, S. Abdelmoneim Mohamed, V. Vida, I. Petre, T. Shiraki, D. Zamfir, A. Apor, R. Jurkevicius, S. Ulbrich, M. Padalino, A. Ortega, G. Glover, M. Galderisi, M. Valverde Gomez, Y. Alueva, M. Uematsu, and J. Separovic Hanzevacki

Subjects
Medical education, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Session (computer science), Club, Cardiology and Cardiovascular Medicine, business
Published
2014

27. MEDULLOBLASTOMA

Author

G. Vaidyanathan, S. Gururangan, D. Bigner, M. Zalutsky, M. Morfouace, A. Shelat, J. Megan, B. B. Freeman, S. Robinson, S. Throm, J. M. Olson, X.-N. Li, K. R. Guy, G. Robinson, C. Stewart, A. Gajjar, M. Roussel, N. Sirachainan, S. Pakakasama, U. Anurathapan, A. Hansasuta, M. Dhanachai, C. Khongkhatithum, S. Hongeng, A. Feroze, K.-S. Lee, S. Gholamin, Z. Wu, B. Lu, S. Mitra, S. Cheshier, P. Northcott, C. Lee, T. Zichner, P. Lichter, J. Korbel, R. Wechsler-Reya, S. Pfister, I. P. T. Project, K. K.-W. Li, T. Xia, F. M. T. Ma, R. Zhang, L. Zhou, K.-M. Lau, H.-K. Ng, L. Lafay-Cousin, S. Chi, J. Madden, A. Smith, E. Wells, E. Owens, D. Strother, N. Foreman, R. Packer, E. Bouffet, T. Wataya, J. Peacock, M. D. Taylor, D. Ivanov, M. Garnett, T. Parker, C. Alexander, L. Meijer, R. Grundy, P. Gellert, M. Ashford, D. Walker, J. Brent, F. Z. Cader, D. Ford, A. Kay, R. Walsh, G. Solanki, A. Peet, M. English, T. Shalaby, G. Fiaschetti, S. Baulande, N. Gerber, M. Baumgartner, M. Grotzer, T. Hayase, Y. Kawahara, M. Yagi, T. Minami, N. Kanai, T. Yamaguchi, A. Gomi, A. Morimoto, R. Hill, S. Kuijper, J. Lindsey, E. Schwalbe, K. Barker, J. Boult, D. Williamson, Z. Ahmad, A. Hallsworth, S. Ryan, E. Poon, R. Ruddle, F. Raynaud, L. Howell, C. Kwok, A. Joshi, S. L. Nicholson, S. Crosier, S. Wharton, K. Robson, A. Michalski, D. Hargrave, T. Jacques, B. Pizer, S. Bailey, F. Swartling, K. Petrie, W. Weiss, L. Chesler, S. Clifford, L. Kitanovski, T. Prelog, B. F. Kotnik, M. Debeljak, M. A. Grotzer, A. Gevorgian, E. Morozova, I. Kazantsev, T. Iukhta, S. Safonova, E. Kumirova, Y. Punanov, B. Afanasyev, O. Zheludkova, W. Grajkowska, M. Pronicki, B. Cukrowska, B. Dembowska-Baginska, M. Lastowska, A. Murase, S. Nobusawa, Y. Gemma, F. Yamazaki, A. Masuzawa, T. Uno, T. Osumi, Y. Shioda, C. Kiyotani, T. Mori, K. Matsumoto, H. Ogiwara, N. Morota, J. Hirato, A. Nakazawa, K. Terashima, T. Fay-McClymont, K. Walsh, D. Mabbott, D. Sturm, P. A. Northcott, D. T. W. Jones, A. Korshunov, S. M. Pfister, M. Kool, C. Hooper, S. Hawes, U. Kees, N. Gottardo, P. Dallas, A. Siegfried, A. I. Bertozzi, A. Sevely, N. Loukh, C. Munzer, C. Miquel, F. Bourdeaut, T. Pietsch, C. Dufour, M. B. Delisle, D. Kawauchi, J. Rehg, D. Finkelstein, F. Zindy, T. Phoenix, R. Gilbertson, J. Trubicka, M. Borucka-Mankiewicz, E. Ciara, K. Chrzanowska, M. Perek-Polnik, D. Abramczuk-Piekutowska, D. Jurkiewicz, S. Luczak, P. Kowalski, M. Krajewska-Walasek, C. Sheila, S. Lee, C. Foster, B. Manoranjan, M. Pambit, R. Berns, A. Fotovati, C. Venugopal, K. O'Halloran, A. Narendran, C. Hawkins, V. Ramaswamy, M. Taylor, A. Singhal, J. Hukin, R. Rassekh, S. Yip, S. Singh, C. Duhman, S. Dunn, T. Chen, S. Rush, H. Fuji, Y. Ishida, T. Onoe, T. Kanda, Y. Kase, H. Yamashita, S. Murayama, Y. Nakasu, T. Kurimoto, A. Kondo, S. Sakaguchi, J. Fujimura, M. Saito, T. Arakawa, H. Arai, T. Shimizu, E. Jurkiewicz, P. Daszkiewicz, M. Drogosiewicz, V. Hovestadt, I. Buchhalter, N. N. Jager, A. Stuetz, P. Johann, C. Schmidt, M. Ryzhova, P. Landgraf, M. Hasselblatt, U. Schuller, M.-L. Yaspo, A. von Deimling, R. Eils, A. Modi, M. Patel, M. Berk, L.-x. Wang, G. Plautz, H. Camara-Costa, A. Resch, C. Lalande, V. Kieffer, G. Poggi, C. Kennedy, K. Bull, G. Calaminus, J. Grill, F. Doz, S. Rutkowski, M. Massimino, R.-D. Kortmann, B. Lannering, G. Dellatolas, M. Chevignard, D. Solecki, P. McKinnon, J. Olson, J. Hayden, D. Ellison, M. Buss, M. Remke, J. Lee, T. Caspary, R. Castellino, M. Sabel, G. Gustafsson, G. Fleischhack, M. Benesch, A. Navajas, R. Reddingius, M.-B. Delisle, D. Lafon, N. Sevenet, G. Pierron, O. Delattre, J. Ecker, I. Oehme, R. Mazitschek, M. Lodrini, H. E. Deubzer, A. E. Kulozik, O. Witt, T. Milde, D. Patmore, N. Boulos, K. Wright, S. Boop, T. Janicki, S. Burzynski, G. Burzynski, A. Marszalek, J. Triscott, M. Green, S. R. Rassekh, B. Toyota, C. Dunham, S. E. Dunn, K.-W. Liu, Y. Pei, L. Genovesi, P. Ji, M. Davis, C. G. Ng, Y.-J. Cho, N. Jenkins, N. Copeland, B. Wainwright, Y. Tang, S. Schubert, B. Nguyen, S. Masoud, A. Lee, M. Willardson, P. Bandopadhayay, G. Bergthold, S. Atwood, R. Whitson, J. Qi, R. Beroukhim, J. Tang, A. Oro, B. Link, J. Bradner, S. G. Vallero, D. Bertin, M. E. Basso, C. Milanaccio, P. Peretta, A. Cama, A. Mussano, S. Barra, G. Morana, I. Morra, P. Nozza, F. Fagioli, M. L. Garre, A. Darabi, E. Sanden, E. Visse, N. Stahl, P. Siesjo, D. Vaka, F. Vasquez, B. Weir, G. Cowley, C. Keller, W. Hahn, I. C. Gibbs, S. Partap, K. Yeom, M. Martinez, H. Vogel, S. S. Donaldson, P. Fisher, S. Perreault, L. Guerrini-Rousseau, S. Pujet, V. Kieffer-Renaux, M. A. Raquin, P. Varlet, A. Longaud, C. Sainte-Rose, D. Valteau-Couanet, J. Staal, L. S. Lau, H. Zhang, W. J. Ingram, Y. J. Cho, Y. Hathout, K. Brown, B. R. Rood, M. Handler, T. Hankinson, B. K. Kleinschmidt-Demasters, S. Hutter, D. T. Jones, N. Kagawa, R. Hirayama, N. Kijima, Y. Chiba, M. Kinoshita, K. Takano, D. Eino, S. Fukuya, F. Yamamoto, K. Nakanishi, N. Hashimoto, Y. Hashii, J. Hara, T. Yoshimine, J. Wang, C. Guo, Q. Yang, Z. Chen, I. Filipek, E. Swieszkowska, M. Tarasinska, D. Perek, R. Kebudi, B. Koc, O. Gorgun, F. Y. Agaoglu, J. Wolff, E. Darendeliler, K. Kerl, J. Gronych, J. McGlade, R. Endersby, H. Hii, T. Johns, J. Sastry, D. Murphy, M. Ronghe, C. Cunningham, F. Cowie, R. Jones, A. Calisto, M. Sangra, C. Mathieson, J. Brown, K. Phuakpet, V. Larouche, U. Bartels, T. Ishida, D. Hasegawa, K. Miyata, S. Ochi, A. Saito, A. Kozaki, T. Yanai, K. Kawasaki, K. Yamamoto, A. Kawamura, T. Nagashima, Y. Akasaka, T. Soejima, M. Yoshida, Y. Kosaka, A. von Bueren, T. Goschzik, R. Kortmann, K. von Hoff, C. Friedrich, A. z. Muehlen, M. Warmuth-Metz, N. Soerensen, F. Deinlein, I. Zwiener, A. Faldum, J. Kuehl, K. KRAMER, N. P. -Taskar, P. Zanzonico, J. L. Humm, S. L. Wolden, N.-K. V. Cheung, S. Venkataraman, I. Alimova, P. Harris, D. Birks, I. Balakrishnan, A. Griesinger, N. K. Foreman, R. Vibhakar, A. Margol, N. Robison, J. Gnanachandran, L. Hung, R. Kennedy, M. Vali, G. Dhall, J. Finlay, A. Erdrich-Epstein, M. Krieger, R. Drissi, M. Fouladi, F. Gilles, A. Judkins, R. Sposto, S. Asgharzadeh, A. Peyrl, M. Chocholous, S. Holm, P. Grillner, K. Blomgren, A. Azizi, T. Czech, B. Gustafsson, K. Dieckmann, U. Leiss, I. Slavc, S. Babelyan, I. Dolgopolov, R. Pimenov, G. Mentkevich, S. Gorelishev, M. Laskov, A. O. von Bueren, J. Nowak, R. D. Kortmann, M. Mynarek, K. Muller, N. U. Gerber, H. Ottensmeier, R. Kwiecien, M. Yankelevich, V. Boyarshinov, I. Glekov, S. Ozerov, S. Gorelyshev, A. Popa, N. Subbotina, A. M. Martin, C. Nirschl, M. Polanczyk, R. Bell, D. Martinez, L. M. Sullivan, M. Santi, P. C. Burger, J. M. Taube, C. G. Drake, D. M. Pardoll, M. Lim, L. Li, W.-G. Wang, J.-X. Pu, H.-D. Sun, R. Ruggieri, M. H. Symons, M. I. Vanan, S. Bolin, S. Schumacher, R. Zeid, F. Yu, N. Vue, W. Gibson, B. Paolella, F. J. Swartling, M. W. Kieran, J. E. Bradner, O. Maher, S. Khatua, N. Tarek, W. Zaky, T. Gupta, S. Mohanty, S. Kannan, R. Jalali, E. Kapitza, D. Denkhaus, A. z. Muhlen, D. G. van Vuurden, M. Garami, J. Fangusaro, T. B. Davidson, M. J. G. da Costa, J. Sterba, S. C. Clifford, J. L. Finlay, R. Schmidt, J. Felsberg, H. Skladny, F. Cremer, G. Reifenberger, R. Kunder, E. Sridhar, A. A. Moiyadi, A. Goel, N. Goel, N. Shirsat, R. Othman, L. Storer, I. Kerr, B. Coyle, N. Law, M. L. Smith, M. Greenberg, S. Laughlin, D. Malkin, F. Liu, I. Moxon-Emre, N. Scantlebury, A. Nasir, D. Onion, A. Lourdusamy, A. Grabowska, Y. Cai, T. Bradshaw, R. S. S. de Medeiros, A. Beaugrand, S. Soares, S. Epelman, W. Wang, M. Sultan, R. J. Wechsler-Reya, M. Zapatka, B. Radlwimmer, D. Alderete, L. Baroni, F. Lubinieki, F. Auad, M. L. Gonzalez, W. Puya, P. Pacheco, O. Aurtenetxe, A. Gaffar, L. Gros, O. Cruz, C. Calvo, N. Shinojima, H. Nakamura, J.-i. Kuratsu, A. Hanaford, C. Eberhart, T. Archer, P. Tamayo, S. Pomeroy, E. Raabe, K. De Braganca, S. Gilheeney, Y. Khakoo, K. Kramer, S. Wolden, I. Dunkel, R. R. Lulla, J. Laskowski, S. Goldman, V. Gopalakrishnan, D. Shih, X. Wang, C. Faria, C. Raybaud, U. Tabori, J. Rutka, S. Jacobs, F. De Vathaire, I. Diallo, D. Llanas, C. Verez, F. Diop, A. Kahlouche, S. Puget, E. Thompson, E. Prince, V. Amani, P. Sin-Chan, M. Lu, C. Kleinman, T. Spence, D. Picard, K. C. Ho, J. Chan, J. Majewski, N. Jabado, P. Dirks, A. Huang, J. R. Madden, A. M. Donson, D. M. Mirsky, A. Dubuc, S. Mack, D. Gendoo, B. Luu, T. MacDonald, T. Van Meter, S. Croul, A. Laureano, W. Brugmann, C. Denman, H. Singh, H. Huls, J. Moyes, D. Sandberg, L. Silla, L. Cooper, and D. Lee

Subjects
Oncology, Abstracts, Cancer Research, medicine.medical_specialty, Cns pnet, business.industry, Internal medicine, Meta-analysis, medicine, Neurology (clinical), business
Published
2014

30. Time-varying predictability of oil market movements over a century of data: The role of US financial stress

Author

Aviral Kumar Tiwari, Rangan Gupta, Mark E. Wohar, and Patrick T. Kanda

Subjects
Economics and Econometrics, Heteroscedasticity, 050208 finance, Realized variance, West Texas Intermediate, 05 social sciences, Linear model, Granger causality, Autoregressive model, 0502 economics and business, Econometrics, 050207 economics, Volatility (finance), Predictability, Finance, Mathematics
Abstract

In this paper we analyze whether a news-based measure of financial stress index (FSI) in the US can predict West Texas Intermediate oil returns and (realized) volatility over the monthly period of 1889:01 to 2016:12, using a dynamic conditional correlation multivariate generalized autoregressive conditional heteroscedasticity (DCC-MGARCH) model. Our results show that, standard linear Granger causality test fail to detect any evidence of predictability. However, the linear model is found to be misspecified due to structural breaks and nonlinearity, and hence, the result of no causality from FSI to oil returns and volatility cannot be considered reliable. When we use the DCC-MGARCH model, which is robust to such misspecifications, in 75 percent and 80 percent of the sample periods, FSI in fact do strongly predict the oil returns and volatility respectively. Overall, our results highlight that FSI is helpful in predicting oil returns and volatility, when one accounts for nonlinearity and regime changes through a robust time-varying model.

Published
2019

32. Fire Protection Measures for Vehicle Fires in Road Tunnels

Author

O Kiyomiya and T Kanda

Subjects
Engineering, business.industry, Fire protection, Forensic engineering, General Materials Science, Fire resistance, business
Abstract

Not a few fire accidents in or on concrete structures such as tunnels, multipurpose ducts, and bridges, were reported, and various fire protection measures have being proposed. In many cases, the fires are caused by vehicles, and once damage is done, repairs take a long time and require significant expenses, posing a substantial burden on society. Rational fire-resistant design based on the fire behavior of concrete structures is required. The basic approaches to the fire resistance of concrete structures, the extent of damage upon occurrence of fires, and fire protection measures are described in this paper.コンクリート製のトンネル，共同溝，橋梁などで火災事故が少なからず発生しており，耐火対策が検討されてきている。火災原因は車両火災が多く一旦被害を生じると補修に長期間と高額な費用が必要となり社会的影響も大きい。コンクリート構造物の耐火性状を把握して合理的な耐火設計が要求されている。ここではコンクリート構造物の耐火に対する基本的な考え方と火害を受けた時の被害状況と耐火対策について述べる。

Published
2013

33. Development of Laboratory Experimental System to Clarify Solar Wind Charge Exchange Mechanism with TES Microcalorimeter

Author

T. Kanda, Yuichiro Ezoe, Hiroki Akamatsu, T. Enoki, Hajime Tanuma, Yoshitaka Ishisaki, T Ishida, Kazuhisa Mitsuda, Hayato Ohashi, Keisuke Shinozaki, and Takaya Ohashi

Subjects
Physics, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Ion source, Electron cyclotron resonance, Ion, Nuclear physics, Solar wind, Atom, General Materials Science, Emission spectrum, Atomic physics, Spectral resolution, Transition edge sensor
Abstract

著者人数: 11名, Accepted: 2012-01-04, 資料番号: SA1004266000

Published
2012

35. Do House Prices Impact Consumption and Interest Rates? Evidence from OECD Countries using an Agnostic Identification Procedure

Author

Patrick T. Kanda, Christophe André, and Rangan Gupta

Subjects
Private consumption, Delayed response, media_common.quotation_subject, Monetary policy, jel:E32, jel:E44, jel:C32, jel:E52, Oecd countries, Monetary economics, jel:E31, Interest rate, Nominal interest rate, House price, Demand shock, House Price, Monetary Policy, Consumption, Agnostic Identification, Development economics, Economics, General Economics, Econometrics and Finance, media_common
Abstract

This paper investigates the existence of significant spillovers from the housing sector onto the wider economy for eight OECD countries in a six-variable structural vector autoregressive model (SVAR). A housing demand shock is identified through the recursive Choleski decompostion and, subsequently by using Uhlig’s (2005) agnostic identification procedure. The latter allows a housing demand shock to be identified by imposing sign restrictions on the impulse responses of consumer prices, residential investment, real house prices and mortgage loans, while private consumption and nominal interest rate responses are left unrestricted. The results suggest that consumption responds positively and significantly to a house price shock in Canada, France, Japan, Spain and, the UK. A significant positive delayed response of nominal interest rates follows a house price shock in Germany, Japan, the UK and, the US, suggesting that while central banks do not seem to respond instantly and systematically to a housing demand shock, its repercussions on the economy tend to translate into higher policy rates after a few quarters.

Published
2012

38. INTERNAL MEDICINE * P34 * THIAMINE DOSE FOR SUSPECTED WERNICKE ENCEPHALOPATHY?

Author

M. McDonough, P. S. Pronko, T. I. Khomich, V. I. Satanovskaya, A. H. Shlyahtun, R. Y. Lis, A. V. Gaishmanova, N. I. Kondyba, O. J. Lukivskaya, E. A. Poplavskaya, H. Quin, P. R. G. Chavez, G. Millonig, F. Lian, H. Mernitz, C. Liu, S. Mueller, X. D. Wang, H. K. Seitz, V. Buko, F. Stickel, T. Longerich, P. Schirmacher, P. P. Voronov, V. U. Buko, A. A. Samoilyk, O. Y. Lukivskaya, E. B. Belanovskaya, E. E. Naruto, S. N. Kirko, N. V. Kaloshyna, M. L. Attilia, C. Rotondo, P. Pizzelli, F. Attilia, C. Codazzo, R. Tavoletti, M. Romeo, M. Ceccanti, E. S. O'Brien, A. Foglia, S. Alaux-Cantin, M. Naassila, C. Vilpoux, S. Oshima, C. Masuda, E. Kakimi, M. Sami, T. Kanda, T. Haseba, Y. Ohno, K. P. Nummi, M. Salaspuro, S. Vakevainen, D. Gyamfi, D. Clemens, V. B. Patel, A. G. Shlyakhtun, and I. V. Liakh

Subjects
medicine.medical_specialty, Wernicke Encephalopathy, business.industry, Internal medicine, medicine, Thiamine, General Medicine, business, Gastroenterology, Surgery
Published
2011

39. Analysing the trade effects of the EU-SA & SADC trading agreements: a panel data approach

Author

Patrick T. Kanda and Andre Cillie Jordaan

Subjects
Economic integration, lcsh:Management. Industrial management, gravity model of bilateral, preferential trade agreement, International trade, lcsh:Business, Trade agreement, trade diversion, Economics, Trade barrier, Commercial policy, lcsh:HB71-74, business.industry, Trade creation, lcsh:Economics as a science, International economics, jel:F14, General Business, Management and Accounting, panel data estimation, Bilateral trade, jel:F15, International free trade agreement, lcsh:HD28-70, trade creation, lcsh:HF5001-6182, Trade diversion, business, trade creation, trade diversion, preferential trade agreement, panel data estimation, gravity model of bilateral trade, General Economics, Econometrics and Finance
Abstract

This study investigates the trade effects of the EU-SA and SADC preferential trade agreements of which South Africa is a member. Using a panel data estimation of the gravity model of bilateral trade and based on data from 1994 to 2008, the study finds the EU-SA preferential trade agreement to have a significant trade expansion effect. The study further reveals that an informative conclusion on trade effects of the SADC preferential trade agreement can only be reached once the agreement has been fully operational. The study also recommends that trade policy in South Africa should increasingly be geared towards broad-based multilateral liberalisation. In addition, South Africa should promote regional economic stability and development through supporting regional trade agreements initiatives. Keywords: Trade creation, trade diversion, preferential trade agreement, panel data estimation, gravity model of bilateral trade

Published
2011

40. INTERNATIONAL ARTICLES: BUBBLES IN SOUTH AFRICAN HOUSE PRICES AND THEIR IMPACT ON CONSUMPTION

Author

Rangan Gupta, Sonali Das, and Patrick T. Kanda

Subjects
House price, Economy, Unit root test, Economics, Econometrics and Finance (miscellaneous), Economics, Business, Management and Accounting (miscellaneous), Agricultural economics
Abstract

This study tests for house price bubbles in the South African housing market using quarterly data from 1969:Q2 to 2009:Q3, based on the unit root test developed by Phillips, Wu, and Yu (2010). The ...

Published
2011

42. Immunity to protozoan parasite infection (PP-002)

Author

H. Watanabe, P. Salotra, A. Yano, Mohsen Abolhassani, Mohammad Hossein Alimohammadian, M. Abdul Hafeez, F. Afrin, H. M. Snider, Amir Mizbani, C. H. N. Costa, Ali Khamesipour, M. Razavi, H. Xia, A. Zavaran Hoseini, R. Burchmore, Christopher A. Hunter, M. Makino, R. Correa-Oliveira, C. Shimokawa, A. P. Barral, M. Narita, E. M. Silva, R. K. M. T. Bairam, A. M. Silva, H. Borges, K. Nagamune, M. Suzuki, P. Hagan, R. M. A. Carvalho, M. Nakaya, F. Jafari, Fabio T. M. Costa, M. A. H. Khan, N. Ohta, P. Guirnalda, L. S. Elias, K. Takeshima, K. Hirayama, R. S. Vaz, D. Dasgupta, Gerson Chadi, T. K. Khiong, L. Cui, I. Bechmann, V. Dara, A. Östlund Farrants, Tajie H. Harris, P. Giusti, R. H. Panatieri, S. Rebelo, J. Uzonna, L. I. A. Pereira, K. Suzue, E. N. Miller, K. Suzuki, J. S. Wiley, Arlene H. Sharpe, Y. Kitamura, S. M. B. Jeronimo, M. P. Lees, F. D. Pretel, C. D. Gowda, L. Renia, L. M. G. Bahia-Oliveira, M. M. Molaei, Joseph Barbi, J. Argueta, S. Kobayashi, Z. Mou, N. C. Smith, Kayhan Azadmanesh, L. C. Ndhlovu, Y. Beuzard, J. Chavatte, Caroline C. Whitacre, M. Tasleem, Stephanie Seveau, A. Dolo, P. Giri, S. I. Castillo-Mendéz, S. Ajdary, Farnaz Zahedifard, G. A. DosReis, Houri Rezvan, X. Olivares López, F. Aosai, S. G. Yasawardene, M. Akhtar, A. U. Haq, J. Tavares, Jude E. Uzonna, M. I. Hiyane, L. Gutiérrez-Kobeh, S. Hamano, R. L. Rocha, C. M. V. Vendrame, C. E. Rosas-Jorquera, B. Niang, M. Islamuddin, E. Vannier, M. Rasouli, Bahram Kazemi, N. Khansari, Samaneh Saberi, S. A. Kaba, S. Dias, B. Mbengue, M. Mauduit, Hiva Azizi, D. E. Lanar, N. R. Palha, A. Ferreira, H. Goto, B. Lu, A. Yoshida, Y. Hamzavi, Kazumi Norose, S. Soeng, A. Gorgin karaji, Y. Chinzei, G. K. Katara, A. Dieye, Luiz Roberto Sardinha, Nicholas Zorko, M. Troye-Blomberg, Karina R. Bortoluci, A. A. Oeij, O. Doumbo, Y. Yamaguchi, L. Castellucci, M. Takahashi, Tahere Taheri, A. Gruner, H. Yoshida, Yasaman Taslimi, B. S. Dwarakanath, S. Rojas Hernández, N. Ishii, K. Honma, A. A. A. Mohammady, A. Latifynia, A. Khodadadi, N. Vega Martínez, S. Koyasu, B. Malleret, Akitoshi Kikumura, M. F. Lopes, E. Houpt, Masoud Moradi, J. V. Weyenbergh, N. Uemura, R. M. Siegel, S. Magez, C. Brando, E. Salles, K. Sugamura, Y. Miyahira, M. Moroda, A. Shibuya, Q. Guo, M. M. Awais, Samar Kumar Guha, Tracy L. Keiser, D. Liu, S. Boström, B. Traoré, L. D. Souza, M. R. D'Império-Lima, W. F. Pereira, P. Burkhard, L. V. C. Guillermo, Carlos Penha-Gonçalves, M. Carrasco Yépez, C. Mittelholzer, C. M. Gomes, Abhay R. Satoskar, H. Daneshvar, H. Hara, A. Kanayama, M. Kayibanda, H. Maruyama, C. Arama, A. Asao, T. Tamura, M. Barral-Netto, N. T. Huy, H. Kamiabi, S. A. Pinto, C. Claser, José M. Alvarez, R. Ramasamy, T. Kanda-Taniguchi, M. Kikuchi, T. Susy, Lígia A. Gonçalves, F. Ginhoux, Abdolmajid Fata, Srijit Khan, H. Nekouie, M. L. Dorta, A. Lima-Neto, A. L. Peixoto-Rangel, M. R. D'Império Lima, V. Khase Shahgoli, H. Hisaeda, S. Black, A. Raz, V. Bockstal, K. Salgado, R. Campos Rodríguez, W. V. Parreira, S. Varani, T. Ono, C. A. Zago, M. Miyakoda, M. Nateghi-Rostami, L. C. Reis, M. Yamazaki, F. Montalvão, Sedigheh Zakeri, M. Doroudian, M. D. T. Carvalho, A. Henri, F. L. Ribeiro-Gomes, D. Kimura, A. Montes de Oca, V. Ramesh, E. M. Carvalho, B. Diatta, Danuta Radzioch, Patrick K. Reville, L. Roubaix, L. F. Batista, A. Cordeiro-da-Silva, Mojtaba Sankian, M. E. McCoy, G. Chouhan, J. M. Blackwell, M. Irfan Anwar, P. Teo, Rima McLeod, R. Udomsangpetch, M. P. Soares, M. Udagawa, Q. Gao, F. Ribeiro-Dias, B. L. Lima, K. Kimura, Y. Inamine, E. Belnoue, Â. Chora, N. D. Jadid, M. Yasunami, A. R. K. Goldberg, S. Hejazi, S. E. Jamieson, P. Bonilla-us, J. Kalil, Mahmoud Eshagh Hosseini, M. J. Gharagozlou, L. C. Oliveira, A. Alborzi, M. Mahmoudian Sani, N. S. Vellozo, A. Farooque, Mohammad Ali Nilforoushzadeh, S. R. Phillips, Q. Fang, T. Imai, T. Taniguchi, S. Phompida, I. Bujila, D. Iravani, P. Jia, I. Hussain, F. Ahmad, M. Senba, T. Yanagi, N. Hosseini, R. Perraut, S. J. Fuller, Hannah E. Cummings, S. Umemoto, M. K. Mannoor, K. Jangpatarapongsa, K. Yui, C. Li, A. Varasteh, T. A. P. F. Pimentel, D. L. Costa, F. A. Asteal, A. Barral, E. Ramos Sanchez, Kenji Shibuya, Sima Rafati, M. N. Shuaibu, Saqib Ali, Barbara Papadopoulou, G. K. Helegbe, Nastaran Ansari, J. Sattabongkot, S. Kiany, Christian Rommel, T. Wickramarachchi, H. H. Wortis, J. Yamada, M. Inahuku, F. Abrishami, P. V. Udagama-Randeniya, E. P. Amaral, F. Muhammad, Thomas Rückle, B. Li, M. Resende, A. Vigario, A. F. Frade, Y. Yang, André Luis Bombeiro, M. Yuda, P. Reville, G. Snounou, Craig Gerard, H. M. Niknam, M. A. P. Oliveira, T. Hoshino, R. G. Peixe, S. Zavosh, V. Thomaz-Soccol, S. Inam, and Graham H. Coombs

Subjects
Immunity, Immunology, Immunology and Allergy, General Medicine, Biology, Protozoan parasite, Microbiology
Published
2010

43. Psoriasis and skin diseases (PP-055)

Author

N. Esmaeil, K. Ruchusatsawat, L. Komorowski, Esther Reefman, T. Muta, S. Marzouk, Y. Muro, E. V. Kryukova, M. Masjedi, R. Maruyama, A. R. Rezaee, Y. Ogawa, K. Yanaba, Z. Bahloul, S. Yang, N. Hirankarn, T. Ohba, Y. Chan, C. Rose, S. Shibuya, K. Lin, E. Kanno, V. van de Walle, A. Shigeta, M. Ritsu, A. Zuurmond, J. DiGiovanni, Y. Avihingsanon, C. Dähnrich, F. Frikha, Y. Iwakura, S. Yooyongsatit, W. Stoecker, J. Tavakkol Afsahri, M. Mohebali, C. Probst, M. Frigui, A. Okuma, N. Valizadeh, M. Takaishi, S. Emami, T. Kataoka, F. Kuper, B. Tameazyfar, K. Nakajima, M. Chiang, T. Higuchi, S. Haghjoo, W. Schlumberger, I. Bloecker, T. Kanda, K. Miyoshi, A. K. Shirakawa, R. Ludwig, T. Nakayama, S. Aiba, F. Andaleeb, H. Tanno, Y. Tomita, H. Turki, N. Suzuki, A. Momeni, H. Masmoudi, N. Takenaka, N. Kaddour, S. Sato, T. H. Huyen, J. M. Benson, M. F. Naso, K. Hieshima, L. L. Gutshall, E. Schmidt, K. Futamura, H. Saito, H. Rafatpanah Baygi, Lex Nagelkerken, M. Oka, O. Yoshie, K. Fechner, K. Rentzsch, P. Layegh, K. van der Mark, A. Mutirangura, S. Toriyabe, C. Persoon-Deen, A. Uvarovskii, K. Sugiura, T. Takeichi, Z. Shaker, K. Kawakami, J. Wongpiyabovorn, A. Asylian, D. Zillikens, E. V. Svirshchevskaya, B. Esmaeili, Y. Inoue, H. Edamatsu, M. Ono, A. Plomp, K. Matsumoto, H. Lim, S. Hong, H. Kwon, S. Sano, M. Tachi, L. Hu, K. Ishii, O. Tatsiy, M. M. Elloso, A. Yoshizaki, and N. Worms

Subjects
medicine.medical_specialty, business.industry, Psoriasis, Immunology, Immunology and Allergy, Medicine, General Medicine, business, medicine.disease, Dermatology
Published
2010

44. [Untitled]

Author

T. Kanda, T. Yasumi, H. Momose, and Y. Suzuki

Subjects
General Materials Science
Published
2010

45. Development of Rapid Drying Shrinkage Evaluation System

Author

T. Kanda, H. Momose, H. Mihashi, and Keiichi Imamoto

Subjects
Ready mixed concrete, Evaluation system, Materials science, General Materials Science, Composite material, Shrinkage
Abstract

5週間の短期間で長期のコンクリートの乾燥収縮ひずみを判定する乾燥収縮迅速評価システムを開発し，多くの実工事に関連するレディーミクストコンクリートに適用した。本システムの開発にあたり，省力化の実現が可能な乾燥収縮の試験方法として省力化乾燥収縮試験法を提案するとともに，長期の乾燥収縮ひずみを短期データから予測する予測手法として外挿法を提案した。本システムを，実工事に関連する280調合のレディーミクストコンクリートに適用するとともに，長期の乾燥収縮ひずみを短期間の測定デ―タから高い精度で判定できることを確認した。

Published
2009

46. Loss of enterocyte mass is accompanied by diminished turnover of enterocytes after myeloablative therapy in haematopoietic stem-cell transplant recipients

Author

J. P. M. Derikx, T. Kanda, Wim A. Buurman, Erik Heineman, N. M. A. Blijlevens, J. P. Donnelly, A. A. van Bijnen, H. Fujii, Algemene Heelkunde, and RS: NUTRIM - R2 - Gut-liver homeostasis

Subjects
Adult, Male, Mucositis, medicine.medical_specialty, Time Factors, Transplantation Conditioning, Cyclophosphamide, Enterocyte, medicine.medical_treatment, Antineoplastic Agents, Enzyme-Linked Immunosorbent Assay, Hematopoietic stem cell transplantation, Fatty Acid-Binding Proteins, Gastroenterology, Cohort Studies, chemistry.chemical_compound, Translational research [ONCOL 3], Internal medicine, medicine, Citrulline, Idarubicin, Humans, Longitudinal Studies, Intestinal Mucosa, Aged, Membrane Glycoproteins, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, Total body irradiation, Middle Aged, Reference Standards, Transplantation, Molecular Weight, Haematopoiesis, medicine.anatomical_structure, Enterocytes, Oncology, chemistry, Hematologic Neoplasms, Immunology, Female, business, Carrier Proteins, Whole-Body Irradiation, medicine.drug
Abstract

Contains fulltext : 79933.pdf (Publisher’s version ) (Closed access) BACKGROUND: Intestinal mucosal barrier injury (MBI), resulting from myeloablative conditioning for haematopoietic stem-cell transplantation (HSCT), is an important cause of morbidity. Despite its frequency, recognition presents a challenge, while the aetiology needs still to be unravelled. The relationship between enterocyte mass and enterocyte loss was explored by examining citrulline serum levels and by assessing circulating intestinal fatty acid-binding protein (I-FABP) and ileal bile acid-binding protein (I-BABP), proteins released by dying mature enterocytes. PATIENTS AND METHODS: Thirty-four adult patients with haematological malignancy received allogeneic HSCT (HSCT day 0) 12 days after being given idarubicin, cyclophosphamide and total body irradiation as myeloablative conditioning, a regimen known to induce oral and intestinal MBI. Serum levels of citrulline, I-FABP and I-BABP were measured on HSCT days -12, -6, 0, +7, +14 and +21. RESULTS: Myeloablative conditioning resulted in a significant decrease in serum citrulline with the nadir on HSCT day +7; thereafter, levels rose gradually. Simultaneously, a significant decrease in I-FABP and I-BABP levels occurred from the day of transplant until day +14. CONCLUSIONS: Simultaneous reduction and subsequent increase of citrulline and I-FABP and I-BABP levels following cytotoxic treatment show that enterocyte mass corresponds to lower rate of dying enterocytes, indicating reduced turnover of enterocytes. Assessment of enterocyte turnover and mass offers opportunities for evaluation of new MBI therapies.

Published
2009

47. Bit Depth Needed for High Image Quality TV-Evaluation Using Color Distribution Index

Author

N. Ohta, M. Teragawa, Y. Yamamoto, M. Sugino, Y. Yoshida, T. Kanda, and T. Fujine

Subjects
Color difference, business.industry, Computer science, Image quality, Color space, Condensed Matter Physics, Luminance, Electronic, Optical and Magnetic Materials, Gamut, Color depth, Contrast ratio, Computer vision, Artificial intelligence, Electrical and Electronic Engineering, Chromaticity, business
Abstract

In this paper, we proposed a new image quality evaluation index-color distribution index (CDI). It considers color gamut, contrast ratio, maximum luminance, gamma characteristics, and just noticeable difference (JND) as human visual system to evaluate the ability for reproducing visually smooth gradation. When the CDI cell was defined, we verified JND from a fundamental matter, such as JND in luminance and chromaticity, using the latest TV sets. According to our investigations, luminance JND was AL/L = 0.01 and chromaticity JND was Au'v' = 0.001. We used these with unit CDI cell and evaluated bit depth needed for high image quality without any visible false contour. We clarified that 12 bit is needed for necessary and sufficient condition to reproduce high image quality with TV set designed based on BT.709. Also, we clarified that color gamut, contrast ratio, maximum luminance, gamma characteristics and bit depth should be balanced to achieve TV sets of high image quality from the viewpoint of the total image quality improvement.

Published
2008

49. Hop Bract Polyphenols Reduced Three-day Dental Plaque Regrowth

Author

Y. Kawaguchi, M. Tagashira, Kayoko Shinada, H. Watanabe, T. Kanda, A. Kanayama, Praweena Sopapornamorn, and M. Ikeda

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Colony Count, Microbial, Dental Plaque, Mouthwashes, Dentistry, Humulus, Placebo, Dental plaque, Oral hygiene, Gastroenterology, Hop (networking), law.invention, Streptococcus mutans, 03 medical and health sciences, Double-Blind Method, Phenols, law, Internal medicine, medicine, Humans, Flowering Tops, General Dentistry, Flavonoids, Cross-Over Studies, 030102 biochemistry & molecular biology, biology, Plant Extracts, business.industry, Polyphenols, biology.organism_classification, medicine.disease, Crossover study, 030104 developmental biology, Polyphenol, business, Phytotherapy
Abstract

Previous research has shown the inhibitory effects of hop bract polyphenols (HBP) on cariogenic streptococci in vitro, but their effects in humans have not been investigated. This double-blind, crossover clinical study tested the hypothesis that HBP delivered in a mouthrinse suppresses plaque regrowth in humans. Twenty-nine healthy male volunteers had all plaque removed, and refrained from all oral hygiene for 3 days, except for rinsing with a mouthrinse containing 0.1% HBP or a placebo. The results showed that the mean amount of plaque assessed by the Patient Hygiene Performance score after the volunteers used the HBP mouthrinse was significantly less than that after they used the placebo (p < 0.001). The number of mutans streptococci in the plaque samples after volunteers used the HBP mouthrinse was significantly lower than that after they used the placebo (p < 0.05). These findings suggested that HBP, delivered in a mouthrinse, successfully reduced dental plaque regrowth in humans.

Published
2007

50. Effects of annealing on TlGaAs/GaAs single hetero structures and TlGaAs/GaAs multiple quantum well structures grown by low-temperature MBE

Author

K. Ohnishi, H. Kiriyama, T. Kanda, and Yasutomo Kajikawa

Subjects
Inorganic Chemistry, Diffraction, Crystallography, Chemistry, Annealing (metallurgy), Multiple quantum, Materials Chemistry, Condensed Matter Physics, Epitaxy, Mole fraction, Crystallographic defect, Quantum well, Molecular beam epitaxy
Abstract

Annealing studies were performed on single hetero (SH) structures and multiple quantum well (MQW) structures of TlGaAs/GaAs grown by molecular-beam epitaxy (MBE) at a low growth temperature of 190 °C. X-ray diffraction (XRD) measurements on the SH structures revealed that the mole fraction of the antisite As in the low-temperature grown layers can be decreased to less than 0.1% by annealing at 450 °C for 30 min. Due to this annealing, however, decrease and inhomogeneity in Tl mole fraction were also caused. On the other hand, extending the total time of annealing at 400 °C to 16 h enabled us to decrease the antisite As mole fraction to about 0.1% without causing decrease and inhomogeneity in Tl mole fraction. It has also been confirmed that the well-defined MQW structures of TlGaAs/GaAs remain almost unchanged after annealing at 400 °C for 30 min.

Published
2007

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